Modulation of Dengue/Zika Virus Pathogenicity by Antibody-Dependent Enhancement and Strategies to Protect Against Enhancement in Zika Virus Infection

Prevention and Control Strategies to Counter Zika Virus, a Special Focus on Intervention Approaches against Vector Mosquitoes—Current Updates

(2018) Raj K. Singh et al.   Frontiers in Microbiology

Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice

(2017) Bin Cao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A relevant in vitro human model for the study of Zika virus antibody-dependent enhancement

(2017) Berlin Londono-Renteria et al.   JOURNAL OF GENERAL VIROLOGY

Structural Mimicry of the Dengue Virus Envelope Glycoprotein Revealed by the Crystallographic Study of an Idiotype–Anti-idiotype Fab Complex

(2017) Yee Hwa Wong et al.   JOURNAL OF VIROLOGY

Achieving safe, effective, and durable Zika virus vaccines: lessons from dengue

(2017) Scott B Halstead   LANCET INFECTIOUS DISEASES

Zika enhancement: a reality check

(2017) Suresh Mahalingam et al.   LANCET INFECTIOUS DISEASES

Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity

(2017) Susana V. Bardina et al.   SCIENCE

IgG antibodies to dengue enhanced for FcγRIIIA binding determine disease severity

(2017) Taia T. Wang et al.   SCIENCE

Characterization of Zika virus binding and enhancement potential of a large panel of flavivirus murine monoclonal antibodies

(2017) Elinor Willis et al.   VIROLOGY

A human antibody against Zika virus crosslinks the E protein to prevent infection

(2017) S. Saif Hasan et al.   Nature Communications

Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge

(2017) Jinsheng Wen et al.   Nature Communications

Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus

(2017) Petraleigh Pantoja et al.   Nature Communications

A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus

(2017) Diogo M. Magnani et al.   PLoS Neglected Tropical Diseases

Dengue virus specific IgY provides protection following lethal dengue virus challenge and is neutralizing in the absence of inducing antibody dependent enhancement

(2017) Ashley L. Fink et al.   PLoS Neglected Tropical Diseases

Anti-Idiotypic Antibodies Specific to prM Monoantibody Prevent Antibody Dependent Enhancement of Dengue Virus Infection

(2017) Miao Wang et al.   Frontiers in Cellular and Infection Microbiology

Advances in Developing Therapies to Combat Zika Virus: Current Knowledge and Future Perspectives

(2017) Ashok Munjal et al.   Frontiers in Microbiology

DNA-immunisation with dengue virus E protein domains I/II, but not domain III, enhances Zika, West Nile and Yellow Fever virus infection

(2017) Jose L. Slon Campos et al.   PLoS One

Prior Exposure to Zika Virus Significantly Enhances Peak Dengue-2 Viremia in Rhesus Macaques

(2017) Jeffy George et al.   Scientific Reports

Structural Basis of Zika Virus-Specific Antibody Protection

(2016) Haiyan Zhao et al.   CELL

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

(2016) Alesha Grant et al.   Cell Host & Microbe

Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy

(2016) Qiming Liang et al.   Cell Stem Cell

Dengue virus (DENV)-specific antibodies enhance Brazilian Zika virus (ZIKV) infection

(2016) Priscila MS Castanha et al.   JOURNAL OF INFECTIOUS DISEASES

Zika Virus–Induced Antibody Response Enhances Dengue Virus Serotype 2 Replication In Vitro

(2016) Anna B. Kawiecki et al.   JOURNAL OF INFECTIOUS DISEASES

Zika Virus: New Clinical Syndromes and Its Emergence in the Western Hemisphere

(2016) Helen M. Lazear et al.   JOURNAL OF VIROLOGY

A bispecific antibody effectively neutralizes all four serotypes of dengue virus by simultaneous blocking virus attachment and fusion

(2016) Xin Shi et al.   mAbs

Structural basis of potent Zika–dengue virus antibody cross-neutralization

(2016) Giovanna Barba-Spaeth et al.   NATURE

Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice

(2016) Gopal Sapparapu et al.   NATURE

Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus

(2016) Wanwisa Dejnirattisai et al.   NATURE IMMUNOLOGY

Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus

(2016) Lalita Priyamvada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions

(2016) Tilman Schlothauer et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Single serotype for Zika

(2016) L. D. Chong   SCIENCE

Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection

(2016) K. Stettler et al.   SCIENCE

Zika virus – emergence, evolution, pathology, diagnosis, and control: current global scenario and future perspectives – a comprehensive review

(2016) Raj Kumar Singh et al.   VETERINARY QUARTERLY

Dengue Virus Envelope Dimer Epitope Monoclonal Antibodies Isolated from Dengue Patients Are Protective against Zika Virus

(2016) J. A. Swanstrom et al.   mBio

Neutralization mechanism of a highly potent antibody against Zika virus

(2016) Shuijun Zhang et al.   Nature Communications

Broadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral Serotype

(2016) Kimberly A. Dowd et al.   Cell Reports

Antibody-dependent enhancement of dengue virus infection inhibits RLR-mediated Type-I IFN-independent signalling through upregulation of cellular autophagy

(2016) Xinwei Huang et al.   Scientific Reports

How antibodies alter the cell entry pathway of dengue virus particles in macrophages

(2016) Nilda V. Ayala-Nunez et al.   Scientific Reports

Antibody-Dependent Enhancement of Dengue Virus Infection in Primary Human Macrophages; Balancing Higher Fusion against Antiviral Responses

(2016) Jacky Flipse et al.   Scientific Reports

Antibody with an engineered Fc region as a therapeutic agent against dengue virus infection

(2015) Ririn Ramadhany et al.   ANTIVIRAL RESEARCH

Flavivirus Antagonism of Type I Interferon Signaling Reveals Prolidase as a Regulator of IFNAR1 Surface Expression

(2015) Kirk J. Lubick et al.   Cell Host & Microbe

Viral RNA detection by RIG-I-like receptors

(2015) Mitsutoshi Yoneyama et al.   CURRENT OPINION IN IMMUNOLOGY

Fc receptors in antibody-dependent enhancement of viral infections

(2015) Adam Taylor et al.   IMMUNOLOGICAL REVIEWS

Fcγ receptor pathways during active and passive immunization

(2015) Stylianos Bournazos et al.   IMMUNOLOGICAL REVIEWS

CD8+T Cells Can Mediate Short-Term Protection against Heterotypic Dengue Virus Reinfection in Mice

(2015) Raphaël M. Zellweger et al.   JOURNAL OF VIROLOGY

Recognition determinants of broadly neutralizing human antibodies against dengue viruses

(2015) Alexander Rouvinski et al.   NATURE

Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination

(2015) P. Robert Beatty et al.   Science Translational Medicine

A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins

(2015) Guntur Fibriansah et al.   Nature Communications

Protective Immune Responses to Dengue Virus Infection and Vaccines: Perspectives from the Field to the Bench

(2015) Scott B. Halstead et al.   Frontiers in Immunology

The Molecular Engineering of an Anti-Idiotypic Antibody for Pharmacokinetic Analysis of a Fully Human Anti-Infective

(2015) She Yah Lim et al.   PLoS One

Pathologic highlights of dengue hemorrhagic fever in 13 autopsy cases from Myanmar

(2014) Khin Saw Aye et al.   HUMAN PATHOLOGY

The Long Elusive IgM Fc Receptor, FcμR

(2014) Hiromi Kubagawa et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Dengue Viral Protease Interaction with NF- B Inhibitor  /  Results in Endothelial Cell Apoptosis and Hemorrhage Development

(2014) J.-C. Lin et al.   JOURNAL OF IMMUNOLOGY

CD8+T Cells Prevent Antigen-Induced Antibody-Dependent Enhancement of Dengue Disease in Mice

(2014) Raphaël M. Zellweger et al.   JOURNAL OF IMMUNOLOGY

Low Levels of Antibody-Dependent Enhancement in Vitro Using Viruses and Plasma from Dengue Patients

(2014) Panjaporn Chaichana et al.   PLoS One

Autophagy Facilitates Antibody-Enhanced Dengue Virus Infection in Human Pre-Basophil/Mast Cells

(2014) Yi-Ting Fang et al.   PLoS One

First Experimental In Vivo Model of Enhanced Dengue Disease Severity through Maternally Acquired Heterotypic Dengue Antibodies

(2014) Jowin Kai Wei Ng et al.   PLoS Pathogens

Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5

(2014) Stephanie Reikine et al.   Frontiers in Immunology

T-Cell Immunity to Infection with Dengue Virus in Humans

(2014) Daniela Weiskopf et al.   Frontiers in Immunology

Dengue virus neutralization and antibody-dependent enhancement activities of human monoclonal antibodies derived from dengue patients at acute phase of secondary infection

(2013) Tadahiro Sasaki et al.   ANTIVIRAL RESEARCH

Determination of antibody concentration as the main parameter in a dengue virus antibody-dependent enhancement assay using FcγR-expressing BHK cells

(2013) Meng Ling Moi et al.   ARCHIVES OF VIROLOGY

Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection

(2013) Maria G. Guzman et al.   ARCHIVES OF VIROLOGY

The Cholesterol-Binding Antibiotic Nystatin Induces Expression of Macrophage Inflammatory Protein-1 in Macrophages

(2013) Seungil Baek et al.   Biomolecules & Therapeutics

The Potent and Broadly Neutralizing Human Dengue Virus-Specific Monoclonal Antibody 1C19 Reveals a Unique Cross-Reactive Epitope on the bc Loop of Domain II of the Envelope Protein

(2013) S. A. Smith et al.   mBio

Dengue Virus Co-opts UBR4 to Degrade STAT2 and Antagonize Type I Interferon Signaling

(2013) Juliet Morrison et al.   PLoS Pathogens

Can non-human primates serve as models for investigating dengue disease pathogenesis?

(2013) Kristina B. Clark et al.   Frontiers in Microbiology

Low Oxygen Tension Enhances Hepatitis C Virus Replication

(2012) N. Vassilaki et al.   JOURNAL OF VIROLOGY

Trafficking and Replication Patterns Reveal Splenic Macrophages as Major Targets of Dengue Virus in Mice

(2012) T. R. Prestwood et al.   JOURNAL OF VIROLOGY

Mechanistic Study of Broadly Neutralizing Human Monoclonal Antibodies against Dengue Virus That Target the Fusion Loop

(2012) J. M. Costin et al.   JOURNAL OF VIROLOGY

Animal Models of Dengue Virus Infection

(2012) Simona Zompi et al.   Viruses-Basel

Regional genome transcriptional response of adult mouse brain to hypoxia

(2011) Huichun Xu et al.   BMC GENOMICS

Flavivirus NS4A-induced Autophagy Protects Cells against Death and Enhances Virus Replication

(2011) Jeffrey E. McLean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

(2011) Aude Carreau et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Downregulation of Interferon-β in Antibody-Dependent Enhancement of Dengue Viral Infections of Human Macrophages Is Dependent on Interleukin-6

(2011) Michael S. Rolph et al.   JOURNAL OF INFECTIOUS DISEASES

A Broadly Flavivirus Cross-Neutralizing Monoclonal Antibody that Recognizes a Novel Epitope within the Fusion Loop of E Protein

(2011) Yong-Qiang Deng et al.   PLoS One

Extensive complement-dependent enhancement of HIV-1 by autologous non-neutralising antibodies at early stages of infection

(2011) Suzanne Willey et al.   Retrovirology

Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo

(2010) M. C. Bosco et al.   BLOOD

The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity

(2010) Martina Beltramello et al.   Cell Host & Microbe

How Innate Immune Mechanisms Contribute to Antibody-Enhanced Viral Infections

(2010) S. Ubol et al.   Clinical and Vaccine Immunology

Mechanisms of Immune Evasion Induced by a Complex of Dengue Virus and Preexisting Enhancing Antibodies

(2010) Sukathida Ubol et al.   JOURNAL OF INFECTIOUS DISEASES

Cell Type Specificity and Host Genetic Polymorphisms Influence Antibody-Dependent Enhancement of Dengue Virus Infection

(2010) K. Boonnak et al.   JOURNAL OF VIROLOGY

Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes

(2010) Scott B Halstead et al.   LANCET INFECTIOUS DISEASES

Both Viremia and Cytokine Levels Associate with the Lack of Severe Disease in Secondary Dengue 1 Infection among Adult Chinese Patients

(2010) Yangbo Tang et al.   PLoS One

Subversion of Innate Defenses by the Interplay between DENV and Pre-Existing Enhancing Antibodies: TLRs Signaling Collapse

(2010) Naphak Modhiran et al.   PLoS Neglected Tropical Diseases

Lethal Antibody Enhancement of Dengue Disease in Mice Is Prevented by Fc Modification

(2010) Scott J. Balsitis et al.   PLoS Pathogens

On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes

(2009) R. Rajamanonmani et al.   JOURNAL OF GENERAL VIROLOGY

Involvement of the Fc  receptor IIA cytoplasmic domain in antibody-dependent enhancement of dengue virus infection

(2009) M. L. Moi et al.   JOURNAL OF GENERAL VIROLOGY

Antibody-dependent enhancement of dengue virus infection in U937 cells requires cholesterol-rich membrane microdomains

(2009) H. Puerta-Guardo et al.   JOURNAL OF GENERAL VIROLOGY

Development of an antibody-dependent enhancement assay for dengue virus using stable BHK-21 cell lines expressing FcγRIIA

(2009) Meng Ling Moi et al.   JOURNAL OF VIROLOGICAL METHODS

Corrigendum to “Mechanisms and results of the antibody-dependent enhancement of viral infections and role in the pathogenesis of coxsackievirus B-induced diseases.” [Microbes Infect. 11 (2009) 443–451]

(2009) Pierre Sauter et al.   MICROBES AND INFECTION

Viruses and autophagy

(2009) Sagar B. Kudchodkar et al.   REVIEWS IN MEDICAL VIROLOGY

Cholesterol biosynthesis modulation regulates dengue viral replication

(2009) Christopher Rothwell et al.   VIROLOGY

A Prospective Nested Case-Control Study of Dengue in Infants: Rethinking and Refining the Antibody-Dependent Enhancement Dengue Hemorrhagic Fever Model

(2009) Daniel H. Libraty et al.   PLOS MEDICINE

Autophagic machinery activated by dengue virus enhances virus replication

(2008) Ying-Ray Lee et al.   VIROLOGY