Mechanical Stimuli in the Local In Vivo Environment in Bone: Computational Approaches Linking Organ-Scale Loads to Cellular Signals

Osteocyte calcium signals encode strain magnitude and loading frequency in vivo

(2017) Karl J. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo Visualisation and Quantification of Bone Resorption and Bone Formation from Time-Lapse Imaging

(2017) Patrik Christen et al.   Current Osteoporosis Reports

Computer modelling of bone’s adaptation: the role of normal strain, shear strain and fluid flow

(2016) Abhishek Kumar Tiwari et al.   Biomechanics and Modeling in Mechanobiology

Nonlinear viscoelastic characterization of bovine trabecular bone

(2016) Krishnagoud Manda et al.   Biomechanics and Modeling in Mechanobiology

Comparison of solid and fluid constitutive models of bone marrow during trabecular bone compression

(2016) Thomas A. Metzger et al.   JOURNAL OF BIOMECHANICS

Primary cilia are not calcium-responsive mechanosensors

(2016) M. Delling et al.   NATURE

The roles of exercise in bone remodeling and in prevention and treatment of osteoporosis

(2016) Yu Yuan et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling

(2016) Susanne Nichterwitz et al.   Nature Communications

A multiscale mechanobiological model of bone remodelling predicts site-specific bone loss in the femur during osteoporosis and mechanical disuse

(2015) C. Lerebours et al.   Biomechanics and Modeling in Mechanobiology

Monitoring in vivo (re)modeling: A computational approach using 4D microCT data to quantify bone surface movements

(2015) Annette I. Birkhold et al.   BONE

Non-contact strain measurement in the mouse forearm loading model using digital image correlation (DIC)

(2015) Mark T. Begonia et al.   BONE

Quantifying the osteocyte network in the human skeleton

(2015) Pascal R. Buenzli et al.   BONE

Bone adaptation to cyclic loading in murine caudal vertebrae is maintained with age and directly correlated to the local micromechanical environment

(2015) Floor M. Lambers et al.   JOURNAL OF BIOMECHANICS

Strain energy density gradients in bone marrow predict osteoblast and osteoclast activity: A finite element study

(2015) Duncan Webster et al.   JOURNAL OF BIOMECHANICS

Pressure and shear stress in trabecular bone marrow during whole bone loading

(2015) Thomas A. Metzger et al.   JOURNAL OF BIOMECHANICS

Predicting cortical bone adaptation to axial loading in the mouse tibia

(2015) A. F. Pereira et al.   Journal of the Royal Society Interface

Effects of thirty elements on bone metabolism

(2015) Michael Dermience et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

A theory for bone resorption based on the local rupture of osteocytes cells connections: A finite element study

(2015) Hambli Ridha et al.   MATHEMATICAL BIOSCIENCES

Modeling trabecular bone adaptation to local bending load regulated by mechanosensing osteocytes

(2014) Yoshitaka Kameo et al.   ACTA MECHANICA

The Clinical Biomechanics Award 2012 — Presented by the European Society of Biomechanics: Large scale simulations of trabecular bone adaptation to loading and treatment

(2014) Alina Levchuk et al.   CLINICAL BIOMECHANICS

The In Situ Mechanics of Trabecular Bone Marrow: The Potential for Mechanobiological Response

(2014) Thomas A. Metzger et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Mechanomics: an emerging field between biology and biomechanics

(2014) Jiawen Wang et al.   Protein & Cell

Interstitial fluid flow in canaliculi as a mechanical stimulus for cancellous bone remodeling: in silico validation

(2013) Yoshitaka Kameo et al.   Biomechanics and Modeling in Mechanobiology

Fluid flow in the osteocyte mechanical environment: a fluid–structure interaction approach

(2013) Stefaan W. Verbruggen et al.   Biomechanics and Modeling in Mechanobiology

A quantitative framework for the 3D characterization of the osteocyte lacunar system

(2013) Kevin Scott Mader et al.   BONE

Diminished response to in vivo mechanical loading in trabecular and not cortical bone in adulthood of female C57Bl/6 mice coincides with a reduction in deformation to load

(2013) Bettina M. Willie et al.   BONE

Trabecular bone adapts to long-term cyclic loading by increasing stiffness and normalization of dynamic morphometric rates

(2013) Floor M. Lambers et al.   BONE

In situ intracellular calcium oscillations in osteocytes in intact mouse long bones under dynamic mechanical loading

(2013) Da Jing et al.   FASEB JOURNAL

Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes

(2013) Ted J. Vaughan et al.   International Journal for Numerical Methods in Biomedical Engineering

A fluid-structure interaction model to characterize bone cell stimulation in parallel-plate flow chamber systems

(2013) T. J. Vaughan et al.   Journal of the Royal Society Interface

Local Mechanical Stimuli Regulate Bone Formation and Resorption in Mice at the Tissue Level

(2013) Friederike A. Schulte et al.   PLoS One

Toward Mechanical Systems Biology in Bone

(2012) Andreas Trüssel et al.   ANNALS OF BIOMEDICAL ENGINEERING

Biomolecular Simulation: A Computational Microscope for Molecular Biology

(2012) Ron O. Dror et al.   Annual Review of Biophysics

Strain-adaptive in silico modeling of bone adaptation — A computer simulation validated by in vivo micro-computed tomography data

(2012) Friederike A. Schulte et al.   BONE

Longitudinal in vivo imaging of bone formation and resorption using fluorescence molecular tomography

(2012) F.M. Lambers et al.   BONE

Emerging role of primary cilia as mechanosensors in osteocytes

(2012) An M. Nguyen et al.   BONE

Coupling systems biology with multiscale mechanics, for computer simulations of bone remodeling

(2012) Stefan Scheiner et al.   COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING

The influence of bone surface availability in bone remodelling—A mathematical model including coupled geometrical and biomechanical regulations of bone cells

(2012) Peter Pivonka et al.   ENGINEERING STRUCTURES

Microscale fluid flow analysis in a human osteocyte canaliculus using a realistic high-resolution image-based three-dimensional model

(2012) Hiroshi Kamioka et al.   Integrative Biology

The effect of osteocyte apoptosis on signalling in the osteocyte and bone lining cell network: a computer simulation

(2012) Masoumeh Jahani et al.   JOURNAL OF BIOMECHANICS

Considerations for reporting finite element analysis studies in biomechanics

(2012) Ahmet Erdemir et al.   JOURNAL OF BIOMECHANICS

Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes

(2012) S. W. Verbruggen et al.   Journal of the Royal Society Interface

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

The amazing osteocyte

(2010) Lynda F Bonewald   JOURNAL OF BONE AND MINERAL RESEARCH

Integrins and Extracellular Matrix in Mechanotransduction

(2010) M. A. Schwartz   Cold Spring Harbor Perspectives in Biology

A novelin vivomouse model for mechanically stimulated bone adaptation – a combined experimental and computational validation study

(2008) Duncan J. Webster et al.   COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING

Idealization of pericellular fluid space geometry and dimension results in a profound underprediction of nano-microscale stresses imparted by fluid drag on osteocytes

(2008) Eric J. Anderson et al.   JOURNAL OF BIOMECHANICS

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY