4.3 Review

Current applications of antibody microarrays

Journal

CLINICAL PROTEOMICS
Volume 15, Issue -, Pages -

Publisher

BIOMED CENTRAL LTD
DOI: 10.1186/s12014-018-9184-2

Keywords

Antibody microarray; Signalling; Drug mechanism; Clinical application; Systems biology; Technology advances

Funding

  1. National Key Research and Development Program of China [2016YFA0500601]
  2. National Natural Science Foundation of China [31370813, 31670831]
  3. grants for KTH-SJTU seed-funding program
  4. Science for Life Laboratory
  5. Erling-Persson Family Foundation
  6. Knut and Alice Wallenberg Foundation

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The concept of antibody microarrays is one of the most versatile approaches within multiplexed immunoassay technologies. These types of arrays have increasingly become an attractive tool for the exploratory detection and study of protein abundance, function, pathways, and potential drug targets. Due to the properties of the antibody microarrays and their potential use in basic research and clinical analytics, various types of antibody microarrays have already been developed. In spite of the growing number of studies utilizing this technique, few reviews about antibody microarray technology have been presented to reflect the quality and future uses of the generated data. In this review, we provide a summary of the recent applications of antibody microarray techniques in basic biology and clinical studies, providing insights into the current trends and future of protein analysis.

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