Article
Materials Science, Ceramics
Tatiana Padrao, Joana Dias, Angela Carvalho, Marta T. Pinto, Fernando J. Monteiro, Susana R. Sousa
Summary: This study developed lyophilized vancomycin-loaded heparinized nanohydroxyapatite/collagen granules for clinical application, addressing infection eradication and bone regeneration. The local bone substitute delivery system provided an attractive alternative solution not yet commercially available. The lyophilization process effectively controlled the release of antibiotics, inhibiting the growth of MRSA. Additionally, the material promoted osteoblasts activity and induced neovascularization.
CERAMICS INTERNATIONAL
(2023)
Article
Materials Science, Biomaterials
Jing Qiao, Xuanbo Chen, Xingliang Xu, Ben Fan, Ying-Shi Guan, Hong Yang, Quan Li
Summary: Pathogenic bacteria like Staphylococcus aureus (S. aureus) pose a serious threat to human health. In this study, a metal-organic framework (MOF)-based fluorescence resonance energy transfer (FRET) nanoprobe was developed for ratiometric detection of S. aureus. The nanoprobe utilizes blue-emitting 7-hydroxycoumarin-4-acetic acid (HCAA) as the energy donor and green-emitting fluorescein isothiocyanate (FITC) as the energy acceptor. By calculating the fluorescence intensity ratio, S. aureus can be quantified with high selectivity and sensitivity. The method has great potential for portable applications and reducing the threat of pathogens to human health.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Multidisciplinary Sciences
Benjamin Jacob, Oliwia Makarewicz, Anita Hartung, Steffen Brodt, Eric Roehner, Georg Matziolis
Summary: The study aimed to demonstrate that dalbavancin has superior efficacy against staphylococcal biofilms on polyethylene (PE) disk devices compared to vancomycin, and exhibits additive behavior in combination with rifampicin for the treatment of periprosthetic joint infections.
SCIENTIFIC REPORTS
(2021)
Article
Instruments & Instrumentation
Sajjad Khan Einipour, Mehdi Sadrjahani, Alireza Rezapour
Summary: This study explores the use of dialdehyde starch nanoparticles loaded with vancomycin for the treatment of infected wounds. The synthesized dressing showed good biocompatibility and antibacterial properties against MRSA. The controlled release of vancomycin from the dressing may offer a new option for topical administration of antibiotics.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Materials Science, Ceramics
Jintian Huang, Sujeesh Sebastian, Mattias Collin, Magnus Tagil, Lars Lidgren, Deepak Bushan Raina
Summary: This study evaluated the drug release, biomaterial degradation, and antibacterial effects of tobramycin (TOB) incorporated in a biphasic calcium sulphate/hydroxyapatite (CaS/HA) carrier containing gentamicin (GEN) or vancomycin (VAN). The results showed that the CaS/HA + GEN + TOB combination delayed setting time and had good injectability. TOB was continuously released from CaS/HA for 35 days and showed a sustained antibacterial effect. Adding TOB to CaS/HA containing VAN extended the antimicrobial effect. The study suggests that CaS/HA can be used as a carrier for localized delivery of TOB in the treatment of bone infections.
CERAMICS INTERNATIONAL
(2023)
Article
Materials Science, Biomaterials
Hamidreza Motasadizadeh, Mohamadreza Tavakoli, Sheyda Damoogh, Fatemeh Mottaghitalab, Mahdi Gholami, Fatemeh Atyabi, Mehdi Farokhi, Rassoul Dinarvand
Summary: In this study, a pH-sensitive silk fibroin (SF)/sodium alginate (SA) hydrogel scaffold containing teicoplanin (TEC) and phenamil (PM) loaded SF nanoparticles (PMSFNPs) was introduced for the treatment of chronic osteomyelitis. The results showed sustained and pH-sensitive release of TEC and PM from the hydrogel scaffold, with higher release rates at alkaline pH compared to neutral and acidic pH. The released TEC maintained its antibacterial activity for 35 days at different pH values. Cell studies also demonstrated that the scaffolds containing PMSFNPs promoted cell viability, ALP activity, and matrix mineralization. In vivo evaluations on infected rat bones showed lower infection and higher regeneration in the group treated with the hydrogel scaffold containing PMSFNPs and TEC compared to other groups. Therefore, this dual-drug delivery system holds promise for effective treatment of chronic bone infection.
BIOMATERIALS ADVANCES
(2022)
Article
Materials Science, Multidisciplinary
W. H. Tse, S. Yang, J. Zhang
Summary: Biocompatible nanostructures provide new pathways for overcoming obstacles in conventional anti-angiogenic therapy. However, current technology is limited by therapeutics' bioavailability and imaging obstruction. In this paper, a theranostic system based on cubic lanthanide-based upconversion nanoparticles (UCNPs) has been developed. The UCNPs exhibit strong anti-angiogenic effects and cell imaging capabilities.
MATERIALS TODAY ADVANCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marina Lopez-Alvarez, Marjolein Heuker, Klaas A. Sjollema, Gooitzen M. van Dam, Jan Maarten van Dijl, Frank F. A. IJpma, Marleen van Oosten
Summary: This study demonstrates the clinical application of fluorescence imaging for the detection of FRI, showing that imaging with vanco-800CW can provide early, accurate, and real-time visual diagnostic information on FRI in the clinical setting, even in the case of low-grade infections.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Infectious Diseases
Danielle Nader, Fajer Yousef, Nicola Kavanagh, Benedict K. Ryan, Steven W. Kerrigan
Summary: Staphylococcus aureus can internalize and persist within endothelial cells, but nanoparticles loaded with antibiotics show great potential in reducing intracellular growth of the bacteria.
Article
Chemistry, Multidisciplinary
Xiaohan Gao, Zexian Xu, Shangbo Li, Lidi Cheng, Dian Xu, Li Li, Liqiang Chen, Yaoxiang Xu, Zijian Liu, Yanshan Liu, Jian Sun
Summary: In this study, polylactic acid/nano-hydroxyapatite scaffolds with good mechanical properties and antibiotic-controlled release were prepared using 3D printing technology. The addition of vancomycin-based chitosan hydrogel enhanced the mechanical properties and water contact angle of the composite scaffold. The composite scaffold exhibited sustained antibiotic release for more than 8 weeks and effectively inhibited the growth of Staphylococcus aureus in vitro, making it a promising strategy for treating infected bone defects.
Article
Engineering, Biomedical
Xiaojie Lian, Rui Xu, Shichao Liu, Zechuan Wang, Baolong Niu, Di Huang, Yan Wei, Liqin Zhao
Summary: In this study, a bioactive composite material based on calcium sulfate hemihydrate bone cement was developed, incorporating silk fibroin nanofibers and vancomycin silk fibroin microspheres. The mechanical performance was found to be better in composites containing 0.5% SFM/VCM, and all composites showed a cumulative drug release percentage of less than 55% after 4 weeks, indicating a promising prospect for use as bone substitute material.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Mingming Song, Bin Zhu, Shuang Qiu, Jiameng Tian, Jianning Li, Daling Chen, Chang Liu
Summary: IL4RPep-1-targeting peptide nanoparticles efficiently deliver afuresertib and celecoxib to melanoma cells, promoting cell apoptosis and immune response, while reducing adverse reactions.
APPLIED MATERIALS TODAY
(2023)
Article
Biotechnology & Applied Microbiology
Peng Zhang, Yusheng Sun, Haizhen Yang, Dong Liu, Feng Zhang, Yu Zhang, Wentao Zhong, Baoqi Zuo, Zhiqiang Zhou
Summary: In this study, a vancomycin delivery system for the treatment of chronic osteomyelitis was developed by entrapping silk fibroin microspheres loaded with vancomycin in an injectable silk hydrogel. The hydrogel exhibited sustained release of vancomycin for up to 25 days and showed strong antibacterial activity against both Escherichia coli and Staphylococcus aureus for 10 days without decrease in efficacy. Injection of the vancomycin-loaded silk fibroin microspheres entrapped in the hydrogel into the infected site of rat tibia resulted in reduced bone infection and improved bone regeneration as compared to other treatment groups.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Manuela Mulazzi, Elisabetta Campodoni, Giada Bassi, Monica Montesi, Silvia Panseri, Francesca Bonvicini, Giovanna Angela Gentilomi, Anna Tampieri, Monica Sandri
Summary: This study designed and investigated a medicated osteoinductive and bioresorbable bone graft to control antibiotic drug release in situ for the eradication or prevention of infection, while simultaneously repairing bone defects. Microbiological and in vitro tests showed that the MgHA/Coll scaffolds were safe and effective in prolonging therapy duration, promising results for the prevention of bone defect-related infections in orthopedic surgeries.
Article
Multidisciplinary Sciences
Gemma Egan, Suttinee Phuagkhaopong, Saphia A. L. Matthew, Patricia Connolly, F. Philipp Seib
Summary: Silk is a versatile material with various medical applications, including wound care. The dissolved silk fibroin in hydrogels is found to be responsible for their therapeutic response in wound healing. By manipulating the structure of silk fibroin, the biological response of hydrogels can be influenced.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Solmaz Mojarad-Jabali, Masoud Farshbaf, Salar Hemmati, Muhammad Sarfraz, Hamidreza Motasadizadeh, Javid Shahbazi Mojarrad, Fatemeh Atyabi, Parvin Zakeri-Milani, Hadi Valizadeh
Summary: The development of a modified liposomal formulation has shown promising results in facilitating brain targeted delivery and selective accumulation within glioma cells. Among the studied targeting ligands, T7-modified liposomes demonstrated superior BBB penetration, brain distribution, and increased accumulation in glioma cells, leading to improved anti-glioma outcomes through targeted cytotoxicity and apoptosis. These results suggest that T7-modified liposomes could serve as a potential platform for effective brain targeted delivery and glioma therapy in clinical settings.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Hassan Farhadnejad, Seyed Alireza Mortazavi, Sanaz Jamshidfar, Amir Rakhshani, Hamidreza Motasadizadeh, Yousef Fatahi, Athar Mahdieh, Behzad Darbasizadeh
Summary: The present study fabricated mucoadhesive bio-nanocomposite hydrogels to prolong the drug retention time in the stomach. These hydrogels exhibited controllable and sustainable drug release, enhanced mucoadhesion, and prolonged retention time in the stomach, leading to increased therapeutic efficacy and bioavailability.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Masoud Farshbaf, Solmaz Mojarad-Jabali, Salar Hemmati, Ahmad Yari Khosroushahi, Hamidreza Motasadizadeh, Amir Zarebkohan, Hadi Valizadeh
Summary: This study developed a targeted delivery system based on nanostructured lipid carriers, which can effectively overcome the blood-brain barrier and blood-brain tumor barrier, and deliver therapeutics to glioma cells with high selectivity. It represents a promising treatment for brain cancer.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Marjan Soleimanpour, Samaneh Sadat Mirhaji, Samira Jafari, Hossein Derakhshankhah, Fatemeh Mamashli, Hadi Nedaei, Mohammad Reza Karimi, Hamidreza Motasadizadeh, Yousef Fatahi, Atiyeh Ghasemi, Maryam Sadat Nezamtaheri, Mohadese Khajezade, Masoumeh Teimouri, Bahram Goliaei, Cedric Delattre, Ali Akbar Saboury
Summary: This study designed and fabricated an effective wound dressing by combining appropriate coagulating and anti-bacterial materials. The fabricated wound dressing exhibited stable structure, antibacterial activity, and high biocompatibility. In vivo experiments confirmed its effectiveness in promoting wound healing.
SCIENTIFIC REPORTS
(2022)
Article
Biophysics
Sareh Aghajanpour, Mehdi Esfandyari-Manesh, Tahmineh Ghahri, Mohammad Hossein Ghahremani, Fatemeh Atyabi, Mostafa Heydari, Hamidreza Motasadizadeh, Rassoul Dinarvand
Summary: This study developed a 3D bio-printed osteogenic scaffold using alginate hydrogel, human bone marrow-derived mesenchymal stem cells (hBM-MSCs), calcium peroxide nanoparticles (CPO NPs) for oxygen generation, and bone morphogenic protein-2 nanoparticles (BMP2 NPs) as an osteoinductive growth factor. The scaffold with 3% CPO NPs showed improved viability of embedded hBM-MSCs and upregulated osteogenic gene expression. This research contributes to the advancement of stem cell therapy and tissue healing in low oxygen pressure conditions.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Elham Jamshidifar, Mehdi Esfandyari-Manesh, Hamidreza Motasadizadeh, Sara Naderizadeh, Alaleh Yourdkhani, Nasrin Samadi, Rassoul Dinarvand
Summary: In this study, GelMA-alginate-gelatin scaffold loaded with antibacterial and osteoinductive agents showed promising potential for the treatment of osteomyelitis.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Chemistry, Applied
Hamidreza Motasadizadeh, Sara Azizi, Alireza Shaabani, Mostafa Ghodrati Sarvestani, Roya Sedghi, Rassoul Dinarvand
Summary: A novel wound healing system with multifunctional properties was prepared in this study, showing excellent mechanical, structural, and biological properties. The CS-g-PNVIM-based nanofibers exhibited promising potential for biocompatible antibacterial wound dressing applications.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Sepideh Yoosefi, Amir Rakhshani, Vahideh Montazeri, Mohamadreza Tavakoli, Amin Aliabadi, Yousef Fatahi, Helia Behrouzfar, Shadi Keihankhadiv, Behzad Darbasizadeh, Hamidreza Motasadizadeh, Hassan Farhadnejad
Summary: The present study aimed to improve wound healing rate using LDH-VAN/IBU/CMC-PEO bionanocomposite fibrous mats. The fabricated mats showed sustained drug release and no cytotoxicity, and could accelerate the wound healing process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Athar Mahdieh, Hamidreza Motasadizadeh, Hamid Yeganeh, Bo Nystrom, Rassoul Dinarvand
Summary: Clickable and cleavable nanomicelles with stimuli-responsiveness have been developed for targeted drug delivery to tumor tissues, showing potential value in breast cancer therapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Biomedical
Amirreza Mansoori-Kermani, Sadaf Khalighi, Iman Akbarzadeh, Fazeleh Ranjbar Niavol, Hamidreza Motasadizadeh, Athar Mahdieh, Vahid Jahed, Masoud Abdinezhad, Nikoo Rahbariasr, Mahshid Hosseini, Nima Ahmadkhani, Behnam Panahi, Yousef Fatahi, Masoud Mozafari, Alan Prem Kumar, Ebrahim Mostafavi
Summary: An optimized system of HA-coated nanocarriers has been developed for targeted breast cancer treatment. The system showed reduced drug release, increased cytotoxicity and apoptosis in vitro, and CD44-mediated cellular uptake mechanism. In vivo experiments demonstrated significant tumor volume reduction without side effects.
MATERIALS TODAY BIO
(2022)
Article
Biochemistry & Molecular Biology
Samaneh Sadat Mirhaji, Marjan Soleimanpour, Hossein Derakhshankhah, Samira Jafari, Fatemeh Mamashli, Meisam Rooki, Mohammad Reza Karimi, Hadi Nedaei, Mitra Pirhaghi, Hamidreza Motasadizadeh, Atiyeh Ghasemi, Maryam Sadat Nezamtaheri, Fatemeh Saadatpour, Bahram Goliaei, Cedric Delattre, Ali Akbar Saboury
Summary: We have developed an innovative wound dressing using chitosan, fibrinogen, nisin, and EDTA as an effective antibacterial scaffold for wound treatment. The hydrogel exhibited good mechanical properties, drug encapsulation and release, swelling behaviors, blood coagulation, cytotoxicity, and antibacterial activity. Cell studies demonstrated biocompatibility, non-toxicity, and promotion of cell migration. In vivo data showed enhanced tissue regeneration and recovery within 17 days. Overall, this innovatively designed hydrogel shows good potential as a candidate for wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Fatemeh Hassaninejad Farahani, Fatemeh Moraffah, Nasrin Samadi, Mohammad Sharifzadeh, Hamidreza Motasadizadeh, Alireza Vatanara
Summary: Lactiplantibacillus plantarum cells were encapsulated in a mixture of cationic and anionic polymers and freeze-dried, resulting in a stable composition. The effects of polymer concentrations and prebiotics on probiotic viability and swelling behavior were examined using a D-optimal design. The optimized formulation showed a viability percentage of over 82% and should be stored refrigerated. In vivo testing demonstrated improved wound healing indicators and the ability to modify wound inflammatory responses, making it comparable to silver sulfadiazine ointment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Mehrab Pourmadadi, Maryam Rajabzadeh-Khosroshahi, Mohammad Mahdi Eshaghi, Erfan Rahmani, Hamidreza Motasadizadeh, Rabia Arshad, Abbas Rahdar, Sadanand Pandey
Summary: In biomedical engineering, researchers are studying the modification of TiO2 (titania) to enhance its physiochemical properties. This comprehensive review focuses on the potential applications of nanoscale TiO2 and its nanocomposites in biomedical research, specifically in cancer therapeutics. The use of titania-based nanomaterials in biosensors, particularly in the electrochemical field, has been widely explored. Various bioimaging techniques, such as FL, PA, CT, PET, MR, and multi-mode imaging, have been evaluated for their applicability. Nanoscale titania has also emerged as a popular candidate for cancer treatment methods including phototherapy, chemotherapy, and microwave hyperthermia. Finally, a multifunctional nanoplatform combining different treatment methods has been developed for cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Materials Science, Biomaterials
Hamidreza Motasadizadeh, Mohamadreza Tavakoli, Sheyda Damoogh, Fatemeh Mottaghitalab, Mahdi Gholami, Fatemeh Atyabi, Mehdi Farokhi, Rassoul Dinarvand
Summary: In this study, a pH-sensitive silk fibroin (SF)/sodium alginate (SA) hydrogel scaffold containing teicoplanin (TEC) and phenamil (PM) loaded SF nanoparticles (PMSFNPs) was introduced for the treatment of chronic osteomyelitis. The results showed sustained and pH-sensitive release of TEC and PM from the hydrogel scaffold, with higher release rates at alkaline pH compared to neutral and acidic pH. The released TEC maintained its antibacterial activity for 35 days at different pH values. Cell studies also demonstrated that the scaffolds containing PMSFNPs promoted cell viability, ALP activity, and matrix mineralization. In vivo evaluations on infected rat bones showed lower infection and higher regeneration in the group treated with the hydrogel scaffold containing PMSFNPs and TEC compared to other groups. Therefore, this dual-drug delivery system holds promise for effective treatment of chronic bone infection.
BIOMATERIALS ADVANCES
(2022)
Article
Nanoscience & Nanotechnology
Ali Moammeri, Koorosh Abbaspour, Alireza Zafarian, Elham Jamshidifar, Hamidreza Motasadizadeh, Farnaz Dabbagh Moghaddam, Zeinab Salehi, Pooyan Makvandi, Rassoul Dinarvand
Summary: This study evaluated the anticancer effect of decorated niosomal nanocarriers loaded with cisplatin and epirubicin in breast cancer cells and mice, showing promising potential for breast cancer treatment.
ACS APPLIED BIO MATERIALS
(2022)
