Review
Biochemical Research Methods
Linan Zhang, Chunchuan Gu, Jiajun Wen, Guangxian Liu, Hongying Liu, Lihua Li
Summary: Exosomes, actively secreted by eukaryotic cells, are promising biomarkers for cancer diagnosis and therapeutic response evaluation. The incorporation of nanomaterials into sensing systems can enhance sensitivity, selectivity, and stability, improving detection methods for exosomes.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Robert D. Crapnell, Nina C. Dempsey, Evelyn Sigley, Ascanio Tridente, Craig E. Banks
Summary: This review focuses on the potential benefits of rapid determination of important cardiac biomarkers and the challenges in the clinical application of electroanalytical sensing platforms.
Article
Engineering, Biomedical
Congran Jin, Ziqian Wu, John H. Molinski, Junhu Zhou, Yundong Ren, John X. J. Zhang
Summary: Advancement in material science, particularly in the development of nanomaterials, has led to the creation of plasmonic biosensors that enable real-time diagnosis of various diseases through biomarker screening. These versatile and portable devices can be used in point-of-care settings, allowing for convenient and efficient testing of biomarkers in homes or elsewhere. This article reviews the recent progress in the design of these biosensors, including the development of nanomaterials and the applications in point-of-care diagnosis. Additionally, challenges and opportunities, such as incorporating machine learning algorithms and the testing of Covid-19, are discussed.
MATERIALS TODAY BIO
(2022)
Article
Biochemical Research Methods
Supat Chupradit, Mahyuddin K. M. Nasution, Heshu Sulaiman Rahman, Wanich Suksatan, Abduladheem Turki Jalil, Walid Kamal Abdelbasset, Dmitry Bokov, Alexander Markov, Irina N. Fardeeva, Gunawan Widjaja, Mohammed Nader Shalaby, Marwan Mahmood Saleh, Yasser Fakri Mustafa, A. Surendar, Ramtin Bidares
Summary: Leukemia is a disease caused by dysfunctions in hematopoietic stem cells lineages, and different types of leukemia require different diagnosis and treatment options. Early detection is crucial for effective treatment, and genosensors and electrochemical sensors can help detect cancer cells and leukemia-related genes. The use of nanomaterials can increase the sensitivity of detection.
ANALYTICAL BIOCHEMISTRY
(2022)
Review
Chemistry, Analytical
Xiao-Fei Chen, Xin Zhao, Zifeng Yang
Summary: This review explores the design strategies and advanced technologies of aptasensor-based diagnostics for infectious pathogens, including the use of different signal transducers, the employment of aptamers as recognition moieties, the construction of versatile biosensing platforms, innovative reporting mechanisms, and signal enhancement approaches. The discussion also highlights the application of advanced point-of-care testing (POCT) in addressing the urgent needs of COVID-19. Additionally, future perspectives of aptasensors for practical application are provided.
Review
Biochemistry & Molecular Biology
Mantong Li, Feng Jiang, Liangyi Xue, Cheng Peng, Zhengzheng Shi, Zheng Zhang, Jia Li, Yupeng Pan, Xinya Wang, Chunqiong Feng, Dongfang Qiao, Zhenzhong Chen, Qizhi Luo, Xuncai Chen
Summary: This article discusses the application of biosensors in detecting tumor markers, including various types of sensors and common tumor markers, as well as the operating principles and applications of biosensors. In addition, it also explores the challenges and prospects for early cancer diagnosis.
Article
Chemistry, Analytical
Liyuan Zou, Xiaofeng Liu, Yuan Zhou, Wenjing Mei, Qing Wang, Xiaohai Yang, Kemin Wang
Summary: A colorimetric and photothermal point-of-care testing (POCT) biosensor based on rolling circle amplification (RCA) was developed for sensitive detection of cancerous exosomes. The biosensor showed colorimetric and photothermal responses, which were recorded using an optical fiber amplifier and a forehead thermometer, respectively, enabling hand-held detection. The biosensor exhibited excellent specificity and resistance to environmental interference.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Chemistry, Applied
Jae Hwan Shin, Y. Veera Manohara Reddy, Tae Jung Park, Jong Pil Park
Summary: Food allergies are abnormal immune responses that occur shortly after exposure to allergenic proteins in food. Treating food allergies is not well understood, so the main prevention method is avoidance. Recent advances in biosensors for on-site detection of food allergens with high selectivity and sensitivity have been explored, along with considerations for quantifying food allergens and global development trends.
Review
Biochemistry & Molecular Biology
Jiangen He, Shasha Jin, Weijiao Fan, Liang Wu, Subash C. B. Gopinath, Zhiwei Hu
Summary: Ischemic stroke is the second leading cause of disability globally due to reduced blood flow to the brain, and early identification is crucial for rehabilitation. Despite challenges in accurately identifying strokes, blood-based biomarker analysis in addition to imaging techniques plays a key role in early detection.
PROCESS BIOCHEMISTRY
(2022)
Review
Chemistry, Analytical
Sze Shin Low, Daizong Ji, Wai Siong Chai, Jingjing Liu, Kuan Shiong Khoo, Sadegh Salmanpour, Fatemeh Karimi, Balakrishnan Deepanraj, Pau Loke Show
Summary: miRNAs, as important non-coding RNAs in the human body, play crucial regulatory roles and are closely related to diseases. The use of electrochemical biosensors provides a fast and accurate detection method for miRNAs, offering new avenues for biological analysis and early disease diagnosis.
Article
Chemistry, Analytical
Mehrab Pourmadadi, Fatemeh Yazdian, Sohrabali Ghorbanian, Amin Shamsabadipour, Elham Khandel, Hamid Rashedi, Abbas Rahdar, Ana M. Diez-Pascual
Summary: The developed electrochemical aptasensor shows high selectivity for CA 15-3, with a detection limit of 0.2 UmL(-1) and a linear response between 1 and 9 UmL(-1).
Article
Biochemistry & Molecular Biology
Emadoddin Amin Sadrabadi, Ali Benvidi, Mostafa Azimzadeh, Leila Asgharnejad, Amin Shiralizadeh Dezfuli, Patricia Khashayar
Summary: In this study, a novel microRNA biosensor based on magnetic rod carbon paste electrodes was developed for breast cancer detection using a relatively new MOF structure as a substrate. The biosensor showed a very low detection limit and a wide dynamic range, indicating its potential for clinical diagnostics.
BIOELECTROCHEMISTRY
(2024)
Article
Chemistry, Analytical
Cheol-Kyun Choi, Samy M. Shaban, Byeong-Seok Moon, Do-Gi Pyun, Dong-Hwan Kim
Summary: This study developed a rapid and reliable colorimetric urea biosensor assisted by a smartphone, with high selectivity, sensitivity, and reliability. It enables direct diagnosis of human urine and paves the way for daily monitoring systems of renal and hepatic dysfunction diseases.
ANALYTICA CHIMICA ACTA
(2021)
Review
Biotechnology & Applied Microbiology
Ziyu He, Changsheng Liu, Zhongyu Li, Zhou Chu, Xiang Chen, Xupeng Chen, Yuan Guo
Summary: The outbreak of COVID-19 has highlighted the importance of quick and easy testing. Point-of-care testing (POCT) devices offer convenience, speed, and timely results, attracting strong interest from researchers. However, there are still challenges in the development of POCT devices, such as sample pretreatment, detection sensitivity, and specificity. The unique properties of nanomaterials, such as magnetic, optical, thermal, and electrically conductive features, are expected to address these deficiencies and improve the performance of POCT devices.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Food Science & Technology
Sakshi Seth, Pasuapthi Rathinasabapathi
Summary: Milk is an essential dietary component, but the imprudent usage of antibiotics in animal husbandry leads to their presence in milk, causing antibiotic resistance. Monitoring antibiotics in milk is crucial for controlling their spread. Biosensors have gained attention due to their sensitivity and simplicity, and the use of nanomaterials enhances their performance.
FOOD ANALYTICAL METHODS
(2022)
Review
Engineering, Biomedical
Hazhir Teymourian, Farshad Tehrani, Kuldeep Mahato, Joseph Wang
Summary: The latest trend in wearable devices is the development of microneedle-based transdermal sensors for real-time monitoring of health parameters at the molecular level. These sensors offer the advantages of extracting clinical indicators from interstitial fluid and painless skin pricking. The future focus is on assembling electrochemical biosensors on microneedles for direct continuous chemical measurements and overcoming existing challenges in commercializing these innovative products.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Analytical
Daphika S. Dkhar, Rohini Kumari, Supratim Mahapatra, Rahul Kumar, Pranjal Chandra
Summary: Viral infections have become a major global health concern, and the use of biosensors with aptamers as bio-recognition elements has provided a successful approach for rapid and specific detection, overcoming traditional challenges.
Article
Chemistry, Analytical
K. Yugender Goud, Kuldeep Mahato, Hazhir Teymourian, Katherine Longardner, Irene Litvan, Joseph Wang
Summary: Parkinson's disease is a progressive neurodegenerative disorder, commonly managed with pro-neurotransmitters or agonists. Due to the limitations in drug therapeutic window, continuous monitoring of administered drugs is essential for effective management.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Biomedical
Farshad Tehrani, Hazhir Teymourian, Brian Wuerstle, Jonathan Kavner, Ravi Patel, Allison Furmidge, Reza Aghavali, Hamed Hosseini-Toudeshki, Christopher Brown, Fangyu Zhang, Kuldeep Mahato, Zhengxing Li, Abbas Barfidokht, Lu Yin, Paul Warren, Nickey Huang, Zina Patel, Patrick P. Mercier, Joseph Wang
Summary: The study presents a fully integrated wearable array of microneedles for wireless and continuous real-time sensing of metabolites in interstitial fluid. The device shows robust analytical performance and good correlation with gold-standard measurements.
NATURE BIOMEDICAL ENGINEERING
(2022)
Review
Chemistry, Multidisciplinary
Juliane R. Sempionatto, Jose A. Lasalde-Ramirez, Kuldeep Mahato, Joseph Wang, Wei Gao
Summary: Wearable chemical sensors are effective tools for discovering new biomarkers, providing real-time analysis in non-invasive body fluids. They can enable personalized health monitoring at home and reduce healthcare costs.
NATURE REVIEWS CHEMISTRY
(2022)
Article
Chemistry, Analytical
Supratim Divya, Supratim Mahapatra, Pranjal Chandra
Summary: Creatinine is a common and specific biomarker for renal diseases. Researchers have developed an optical sensing device that can quantitatively detect creatinine through a change in color. The sensor has been integrated with a smartphone to create a palm-sized device for personalized creatinine analysis. The fabricated biosensor has been thoroughly characterized and shown to have excellent sensitivity and selectivity, with no cross-reactivity from interfering molecules. The system has been validated for quantifying creatinine in spiked serum samples, showing high reproducibility and stability.
Review
Chemistry, Analytical
Rohini Kumari, Daphika S. S. Dkhar, Supratim Mahapatra, Divya, Surinder P. P. Singh, Pranjal Chandra
Summary: Metallic dendrites, with their unique hierarchical structures and large active surface areas, have attracted significant attention. Due to their high catalytic activity and conductivity, metallic dendrites are increasingly used in sensor fabrication. This review summarizes various nanodendrite-engineered biosensors for monitoring different substances in real samples.
Review
Chemistry, Analytical
Nandita Singh, Daphika S. Dkhar, Pranjal Chandra, Uday Pratap Azad
Summary: Nanobiosensors are widely used electroanalytical tools for the timely detection of infectious diseases and fatal diseases at their early stage. They offer significant benefits compared to traditional methods and can be classified based on biological molecules or working principles.
Article
Pharmacology & Pharmacy
Rohini Kumari, Pranjal Chandra
Summary: Cephalexin, a first-generation cephalosporin, is commonly used to treat infectious diseases. However, its incorrect and excessive usage has led to side effects and antibiotic resistance. In this study, a trimetallic dendritic nanostructure was electrochemically imprinted on an electrode surface, which showed superior analytical performance for detecting CFX in complex biological matrices. The dendritic sensing probe exhibited minimal response to interfering compounds and yielded accurate results for real samples, making it a quick and efficient platform for drug analysis in clinical settings.
Article
Chemistry, Analytical
Harleen Kaur, Prasanthi Chittineedi, Ravi Shankar Bellala, Venkata Madhavi Bellala, Sandeep Singh, Rohini Kumari, Pranjal Chandra, Santhi Latha Pandrangi, Surinder P. Singh
Summary: An immunosensor based on graphene oxide nanosheets was fabricated to indirectly detect transferrin levels in cancer patients, showing excellent detection capability in a wide linear range and a lower limit of detection compared to the enzyme-linked immunosorbent assay. The immunosensor demonstrated clinical potential with a high degree of accuracy and correlation with other detection techniques.
Review
Chemistry, Analytical
Sumit K. Yadav, Damini Verma, Ujala Yadav, Ashish Kalkal, Nivedita Priyadarshini, Ashutosh Kumar, Kuldeep Mahato
Summary: The COVID-19 pandemic has highlighted the need for early and quick diagnostic tests. Paper-based point-of-care devices have gained attention for their rapid and low-cost detection capabilities, especially in distinguishing the virus from other illnesses. This review focuses on the development of detection modules for SARS-CoV-2 and discusses various strategies for viral detection, offering insights for future pandemics.
Article
Engineering, Biomedical
Yuchen Xu, Ernesto de la Paz, Akshay Paul, Kuldeep Mahato, Juliane R. Sempionatto, Nicholas Tostado, Min Lee, Gopabandhu Hota, Muyang Lin, Abhinav Uppal, William Chen, Srishty Dua, Lu Yin, Brian L. Wuerstle, Stephen Deiss, Patrick Mercier, Sheng Xu, Joseph Wang, Gert Cauwenberghs
Summary: An in-ear integrated array of sensors has been developed to concurrently monitor lactate levels and brain states. By taking advantage of the ear's sweat glands, the device detected elevated lactate levels in sweat while simultaneously recording changes in brain activity. This unobtrusive monitoring method may provide insights into the dynamic and synergetic interactions between brain and body biomarkers.
NATURE BIOMEDICAL ENGINEERING
(2023)
Review
Chemistry, Analytical
Rohini Kumari, Akanksha Singh, Uday Pratap Azad, Pranjal Chandra
Summary: In the past decade, microfluidic paper-based analytical devices (micro-PADs) have gained a lot of attention as a viable analytical platform. The advances in manufacturing processes and device integration have contributed to its expansion. Compared to traditional microfluidic methods, micro-PADs offer lower costs, shorter evaluation times, simplified fabrication, and easier operation. This review discusses the modern paper microfluidics-based electrochemical sensing devices for detecting macromolecules, small molecules, and cells in various real samples, and explores the design, fabrication, limitations, and potential of these analytical platforms.
Review
Chemistry, Analytical
Ananya Srivastava, Daphika S. Dkhar, Nandita Singh, Uday Pratap Azad, Pranjal Chandra
Summary: Borophene is a novel two-dimensional material with exceptional features, such as anisotropic metallic behavior and supple mechanical and optical capabilities. Its excellent electroactive surface area, high electron transport, anisotropic behavior, and controllable optical and electrochemical properties make it a sophisticated platform. It can be utilized to create highly sensitive biosensors for point-of-care diagnostics and has potential applications in nanobiosensing and therapeutics.
Article
Chemistry, Analytical
Ashutosh Kumar, Kuldeep Mahato, Daphika S. Dkhar, Ananya Srivastava, Pranjal Chandra
Summary: In this study, a self-reporting electrochemical biosensor was developed for the detection of cyfra-21-1 in saliva samples. The biosensor utilized synthesized nanoparticles, gold nanoparticles, and graphene oxide to create an electrochemically active surface for label-free detection. Extensive characterizations were performed to validate the biosensor's performance, and it was shown to accurately respond to changes in protein biomarker concentrations.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)