Article
Multidisciplinary Sciences
Mans Kadefors, Sara Rolandsson Enes, Emma Ahrman, Barbora Michalikova, Anna Lofdahl, Goran Dellgren, Stefan Scheding, Gunilla Westergren-Thorsson
Summary: Mesenchymal cells in the lung play crucial roles in tissue regeneration and repair, with dysregulation potentially leading to tissue remodeling in lung diseases. Two populations of CD105(+)CD90(+) mesenchymal cells, distinguished by their expression of CD13, show differences in clonogenic and proliferative capacity, with CD105(+)CD90(+)CD13(+) cells being more potent. Adventitial fibroblast subset is identified as the origin of these clonogenic mesenchymal cells in human lung through transcriptomic and spatial analysis.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Ye Cao, Scott M. Bolam, Anna L. Boss, Helen C. Murray, Jacob T. Munro, Raewyn C. Poulsen, Nicola Dalbeth, Anna E. S. Brooks, Brya G. Matthews
Summary: This study indicates considerable diversity in the non-hematopoietic cell populations within different tissue compartments of the adult human skeleton, and suggests that periosteal progenitor cells may reside within the CD90+CD34+ population.
Article
Medicine, General & Internal
Wenjie Zi, Jiaxing Song, Weilin Kong, Jiacheng Huang, Changwei Guo, Wencheng He, Yinquan Yu, Bo Zhang, Wanjie Geng, Xiaolin Tan, Yaoyu Tian, Zongtao Liu, Minghua Cao, Daoyou Cheng, Bo Li, Wenguo Huang, Junsheng Liu, Pengfei Wang, Zhou Yu, Hao Liang, Shuang Yang, Mingshan Tang, Wenhua Liu, Xianjun Huang, Shugai Liu, Yufeng Tang, Youlin Wu, Li Yao, Zhu Shi, Pengcheng He, Haojin Zhao, Zhuo Chen, Jun Luo, Yue Wan, Qiang Shi, Maorong Wang, De Yang, Xianglin Chen, Fang Huang, Jinlin Mu, Hao Li, Zhimin Li, Jingbang Zheng, Shunli Xie, Tieying Cai, Yuqi Peng, Weihua Xie, Zhongming Qiu, Chang Liu, Chengsong Yue, Linyu Li, Yan Tian, Dahong Yang, Jian Miao, Jie Yang, Jinrong Hu, Raul G. Nogueira, Duolao Wang, Jeffrey L. Saver, Fengli Li, Qingwu Yang
Summary: This study investigated the effects of tirofiban in patients with acute ischemic stroke. The results showed that tirofiban treatment improved outcomes and reduced the incidence of stroke.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Editorial Material
Surgery
Raphael Coscas, Maxime Dubosq, Johanna Charton, Salma El Batti, Julien Gaudric, Fabien Koskas, Laurent Chiche, Thibault Couture, Jean-Michel Davaine, Yves Castier, Pierre Cerceau, Mostafa El Hajjam, Patricia Samb, Alain Beauchet, Lamiae Grimaldi, Isabelle Javerliat, Olivier Goeau-Brissonniere, Jean-Marc Alsac, Ilaria Onorati, Emmanuel Martinod, Pascal Desgranges, Joseph Touma, Frederic Cochennec, Quentin Pellenc, Pierre Julia, Marc Coggia
Summary: COVID-19 infection is associated with arterial thromboses, but little is known about its incidence, topography, and prognosis. This study analyzed the experience of the Greater Paris University Hospitals during the first wave of the pandemic and found that arterial complications during COVID-19 infection are rare and mainly affect the aorta and limb arteries, with high morbidity and mortality rates.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Medicine, General & Internal
Fahrettin Ege, Omer Kazci, Sonay Aydin
Summary: This study compares sympathetic vasomotor activation of the brachial arteries in healthy subjects and patients with painful diabetic neuropathy, and finds that diabetic neuropathy leads to significant vasomotor dysfunction of medium sized peripheral arteries.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Cell Biology
Suneel Rallapalli, Soma Guhathakurta, Purna S. Korrapati
Summary: The discovery of CPCs has raised hopes for heart cell therapy, but there are still issues with defining CPC types and validating methods for generating high-quality CPC populations. Long-term culture may alter CPC immunophenotypes, highlighting the need for validated molecular signatures to assess the impact of ex vivo expansion on cell therapy products.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Xiuchun Li, Xiaoliang Wang, Pan He, Edward Bennett, Erin Haggard, Jianjie Ma, Chuanxi Cai
Summary: A subpopulation of human mesenchymal progenitor cells (hMPCs) sorted based on low mitochondrial membrane potential exhibit enhanced stemness and survival capacity, which could serve as a potential donor cell source for cellular therapy for ischemic heart disease.
Article
Genetics & Heredity
Huijuan Liu, Ping Li, Shaoyang Zhang, Jinnan Xiang, Ruichen Yang, Jiajia Liu, Md Shafiquzzaman, Soma Biswas, Zhanying Wei, Zhenlin Zhang, Xin Zhou, Feng Yin, Yangli Xie, Stephen P. Goff, Lin Chen, Baojie Li
Summary: Prrx1-expressing cells act as stem cells for bone, white adipose tissue, and dermis in adult mice, maintaining tissue homeostasis and repair. These cells' activities are regulated by Wnt signaling.
Article
Acoustics
Shengxian Kang, Cheuk Ming Mak, Dayi Ou, Yuanyuan Zhang
Summary: The study found that OPOs with lower spatial density of workstations or higher storey height have higher spatial decay rate of speech, lower speech level at 4 m distance, and shorter comfort distance. Perceived noise level has the greatest influence on employees' acoustic satisfaction, and speech interference is the main acoustic reason leading to work productivity decrease. Employees in MOPOs have higher acoustic satisfaction and lower disturbance levels of speech noises compared to LOPOs, with perceived speech privacy being a significant factor affecting work productivity in LOPOs.
Article
Energy & Fuels
Felix Zitzmann, Michael Reich
Summary: We conducted a study in six commercial short-rotation coppice (SRC) plantations in northern Germany to investigate the presence and activity of large- and medium-sized mammals. Using camera trapping, we detected eleven species, including roe deer, wild boar, and red fox. Our results suggest that while a wide range of mammal species can inhabit SRC, the current habitat value of the surveyed plantations is limited. We propose measures to enhance the habitat value of SRC, but further research is needed to test their effectiveness.
BIOENERGY RESEARCH
(2022)
Article
Materials Science, Biomaterials
Shih-Ying Sung, Yi-Wen Lin, Chin-Chen Wu, Chih-Yuan Lin, Po-Shun Hsu, Srinivasan Periasamy, Balaji Nagarajan, Dar-Jen Hsieh, Yi-Ting Tsai, Chien-Sung Tsai, Feng-Yen Lin
Summary: Currently, various techniques are used for decellularization of grafts. Decellularized xenogenic grafts have been proven to provide better outcomes compared to synthetic conduits. However, there are still defects in vascular grafts produced by these methods, such as defective vessel wall structures and detergent residues. Therefore, the use of supercritical carbon dioxide (ScCO2) in decellularization technologies is explored in this study to fabricate biocompatible vascular grafts.
BIOMATERIALS SCIENCE
(2023)
Article
Psychology, Applied
Nick Bacon, Kim Hoque
Summary: The size of the firm does not affect disability employment outcomes, as both formalized approaches of large firms and informal approaches of small firms can benefit disabled individuals. The study found that disability employment outcomes do not vary by firm size.
HUMAN RESOURCE MANAGEMENT
(2022)
Article
Parasitology
Atle Mysterud, Christian Hugli, Hildegunn Viljugrein
Summary: This study provides evidence that roe deer are indeed the main suitable reproduction host to adult I. ricinus ticks, and are likely a key to host limitation of the tick population in this northern ecosystem.
PARASITES & VECTORS
(2021)
Article
Environmental Studies
Yaoyao Li, Yuan Qi, Licheng Liu, Yuchen Hou, Shuya Fu, Jingtao Yao, Daolin Zhu
Summary: Balancing the housing supply structure is crucial for the healthy development of the real estate market. China has made significant efforts to improve the rental housing market, but the research shows that the impact of rental housing supply on house prices exhibits an asymmetric pattern. Under low substitutability, increasing the supply of rental housing leads to rising house prices, while in cities with high substitutability, increasing the supply of rental housing can lower house prices. Decision-makers should focus on irregularities in the rental market and stimulate the endogenous motivation of supply and demand.
Article
Ecology
Elaine Rios, Maira Benchimol, Pavel Dodonov, Kristel De Vleeschouwer, Eliana Cazetta
Summary: The study found that mammal richness decreased significantly with decreasing forest cover, but was not affected by patch size, number of patches, and edge density, with the exception of herbivore richness being affected by the number of patches. However, only herbivore richness was found to be affected by fragmentation per se.
Article
Cardiac & Cardiovascular Systems
Lingyao Zeng, Sylvain Moser, Nazanin Mirza-Schreiber, Claudia Lamina, Stefan Coassin, Christopher P. Nelson, Tarmo Annilo, Oscar Franzen, Marcus E. Kleber, Salome Mack, Till F. M. Andlauer, Beibei Jiang, Barbara Stiller, Ling Li, Christina Willenborg, Matthias Munz, Thorsten Kessler, Adnan Kastrati, Karl-Ludwig Laugwitz, Jeanette Erdmann, Susanne Moebus, Markus M. Noethen, Annette Peters, Konstantin Strauch, Martina Mueller-Nurasyid, Christian Gieger, Thomas Meitinger, Elisabeth Steinhagen-Thiessen, Winfried Maerz, Andres Metspalu, Johan L. M. Bjoerkegren, Nilesh J. Samani, Florian Kronenberg, Bertram Mueller-Myhsok, Heribert Schunkert
Summary: This study attempts to identify non-additive genetic effects associated with CAD, specifically epistatic interactions. A SNP pair located in cis at the LPA locus was found to be jointly associated with risk for CAD, peripheral arterial disease, aortic stenosis, hepatic lipoprotein(a) levels, and Lp(a) serum levels, while individual SNPs displayed no association. Further exploration revealed a strong dependency on a rare variant influencing risk through additive genetic as well as epistatic effects.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Alexander Maier, Steve Lin Liao, Thomas Lescure, Philip M. Robson, Naoki Hirata, Samantha Sartori, Navneet Narula, Vittoria Vergani, Georgios Soultanidis, Adam Morgenthau, Jason C. Kovacic, Maria Padilla, Jagat Narula, Adam Jacobi, Zahi A. Fayad, Maria G. Trivieri
Summary: This study found that the uptake of F-18-fluorodeoxyglucose in the pulmonary artery is associated with pulmonary hypertension and its intensity correlates with pulmonary artery pressure.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Ling Li, Zhifen Chen, Moritz von Scheidt, Shuangyue Li, Andrea Steiner, Ulrich Gueldener, Simon Koplev, Angela Ma, Ke Hao, Calvin Pan, Aldons J. Lusis, Shichao Pang, Thorsten Kessler, Raili Ermel, Katyayani Sukhavasi, Arno Ruusalepp, Julien Gagneur, Jeanette Erdmann, Jason C. Kovacic, Johan L. M. Bjorkegren, Heribert Schunkert
Summary: This study systematically identified susceptibility genes for coronary artery disease (CAD) using transcriptome-wide association studies (TWAS). The study prioritized candidate causal genes at known GWAS loci, identified 18 novel genes associated with CAD, and suggested potential tissues and pathways of action for these TWAS CAD genes.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ying Wang, Hua Gao, Fudi Wang, Zhongde Ye, Michal Mokry, Adam W. Turner, Jianqin Ye, Simon Koplev, Lingfeng Luo, Tom Alsaigh, Shaunak S. Adkar, Maria Elishaev, Xiangyu Gao, Lars Maegdefessel, Johan L. M. Bjorkegren, Gerard Pasterkamp, Clint L. Miller, Elsie G. Ross, Nicholas J. Leeper
Summary: This study reveals that vascular smooth muscle cells (SMCs) undergo dedifferentiation and activation of pro-inflammatory pathways during the development of atherosclerosis. ATF3, a transcription factor, is identified as an upstream regulator of this transition. ATF3 represses the transition of SMCs towards a subset of cells that promote vascular inflammation by activating the complement cascade. The expression of ATF3 is negatively correlated with complement component C3, and genetic variations that reduce ATF3 expression are associated with an increased risk for atherosclerosis.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Ke Hao, Raili Ermel, Katyayani Sukhavasi, Haoxiang Cheng, Lijiang Ma, Ling Li, Letizia Amadori, Simon Koplev, Oscar Franzen, Valentina D'Escamard, Nirupama Chandel, Kathryn Wolhuter, Nicole S. Bryce, Vamsidhar R. M. Venkata, Clint L. Miller, Arno Ruusalepp, Heribert Schunkert, Johan L. M. Bjorkegren, Jason C. Kovacic
Summary: This study developed a comprehensive integrative genomics analyses pipeline for CAD and provided a prioritized list of causal CAD genes. The study identified 162 unique candidate causal CAD genes and determined their tissue of effect.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2022)
Correction
Cardiac & Cardiovascular Systems
Ling Li, Zhifen Chen, Moritz von Scheidt, Shuangyue Li, Andrea Steiner, Ulrich Gueldener, Simon Koplev, Angela Ma, Ke Hao, Calvin Pan, Aldons J. Lusis, Shichao Pang, Thorsten Kessler, Raili Ermel, Katyayani Sukhavasi, Arno Ruusalepp, Julien Gagneur, Jeanette Erdmann, Jason C. Kovacic, Johan L. M. Bjorkegren, Heribert Schunkert
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Genetics & Heredity
Lijiang Ma, Nicole S. Bryce, Adam W. Turner, Antonio F. Di Narzo, Karishma Rahman, Yang Xu, Raili Ermel, Katyayani Sukhavasi, Valentina D'Escamard, Nirupama Chandel, Bhargavi V'Gangula, Kathryn Wolhuter, Daniella Kadian-Dodov, Oscar Franzen, Arno Ruusalepp, Ke Hao, Clint L. Miller, Johan L. M. Bjorkegren, Jason C. Kovacic
Summary: Genome wide association studies (GWAS) can identify single nucleotide polymorphisms (SNPs) associated with common disorders, but often do not provide causal mechanisms or tissue-specific effects. This study developed a data-driven informatics pipeline to gain insights on complex genetic loci, and applied it to understand a cluster of SNPs associated with coronary artery disease (CAD) near the HDAC9 gene. The pipeline demonstrated that this locus is causal for CAD by modulating TWIST1 expression levels in the arterial wall, and by governing a gene regulatory co-expression network related to metabolic function in skeletal muscle.
Review
Physiology
Yang Xu, Jason C. Kovacic
Summary: The dysfunction of endothelial cells (ECs) plays an important role in vascular aging and various cardiovascular diseases (CVDs). Endothelial to mesenchymal transition (EndMT) has been increasingly recognized as a potential disease-causal process in different CVDs, although it is also involved in physiological processes and vascular regeneration. Further molecular and translational research is needed to explore the clinical applications of EndMT.
ANNUAL REVIEW OF PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sul Ki Kim, Edwina Wing-Lun, Jaya Chandrasekhar, Aniket Puri, Sonya Burgess, Thomas J. Ford, Jason Kovacic, Robert M. Graham, Peter J. Psaltis, Sarah Zaman
Summary: This study aims to describe the clinical presentation, management, and outcomes of SCAD patients in Australia/New Zealand, as well as to identify predictors of acute deterioration and recurrence. It is a multi-center prospective and historical cohort study that will also pool international data. The study will provide valuable insights into SCAD care and help improve clinical practices.
HEART LUNG AND CIRCULATION
(2022)
Article
Biochemistry & Molecular Biology
Kathryn Wolhuter, Stephanie M. Y. Kong, Christopher P. Stanley, Jason C. Kovacic
Summary: Coronary artery disease (CAD) is commonly treated using percutaneous coronary interventions (PCI), but PCI with stent placement can damage the endothelium. This review examines the role of endothelial-derived oxidants and the effects of altered redox signaling on endothelial dysfunction (ED). It also explores the impact of PCI and stent placement on oxidant production and discusses how recent advances aim to mitigate oxidative damage and improve outcomes.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Cardiac & Cardiovascular Systems
Marina Wassif, Phillip Lo, Paul Satouris, Lucinda Swan, Daniel Tardo, Jason C. Kovacic, David Muller, Kavitha Muthiah, Eugene Kotlyar, Nicole K. Bart
Summary: This retrospective analysis examined patients with suspected COVID-19 vaccine-related myocarditis and pericarditis presenting at St Vincent's Hospital in Sydney, Australia. The results showed that the average age of onset in the vaccine group was 3369.0 years, and the most common symptom was chest pain. 80% of patients had abnormal electrocardiogram findings, and 50% had cardiac monitoring for more than 24 hours. Cardiac complications were rare, mild, and self-limiting, with a good response to oral anti-inflammatories.
HEART LUNG AND CIRCULATION
(2023)
Article
Cell Biology
Radoslav Savic, Jialiang Yang, Simon Koplev, Mahru C. An, Priyanka L. Patel, Robert N. O'Brien, Brittany N. Dubose, Tetyana Dodatko, Eduard Rogatsky, Katyayani Sukhavasi, Raili Ermel, Arno Ruusalepp, Sander M. Houten, Jason C. Kovacic, Andrew F. Stewart, Christopher B. Yohn, Eric E. Schadt, Remi-Martin Laberge, Johan L. M. Bjorkegren, Zhidong Tu, Carmen Argmann
Summary: Senescent cells play a significant role in age-dependent cardiovascular tissue dysfunction, but there is limited knowledge about their cell markers and tissue context. By integrating transcriptomes of senescent cell models and gene co-expression networks from multiple tissues, this study identifies senescence-associated modules and candidate senescence-associated secretory phenotype (SASP) factors.
