Article
Cell Biology
Feng Wang, Lan Zhang, Yue Xu, Yilin Xie, Shenglei Li
Summary: This study identified a series of differentially expressed genes (DEGs) between esophageal cancer (EC) and normal samples, as well as between esophageal adenocarcinoma (EA) and esophageal squamous cell carcinoma (ESCC). Key genes involved in the EC process were identified, with roles in cell cycle regulation and the PI3K/Akt signaling pathway. Furthermore, the study confirmed hub genes associated with overall survival in patients with EC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Xiaoyu Wang, Weichun Tang, Yilin Lu, Jun You, Yun Han, Yanli Zheng
Summary: This study identified AS events and protein-protein interaction information associated with CESC prognosis, as well as the correlation between tumor infiltrating immune cells and risk score.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Oncology
Chaoqun Xing, Huiming Yin, Zhi-Yong Yao, Xiao-Liang Xing
Summary: This study screened ferroptosis- and immune-related differentially expressed genes (FI-DEGs) associated with the progression of cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). A prognostic signature prediction model was constructed using eight FI-DEGs, which were found to be independently correlated with overall survival. These eight FI-DEGs may serve as prognostic signatures for CESC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Hongjun Guo, Siqiao Wang, Min Ju, Penghui Yan, Wenhuizi Sun, Zhenyu Li, Siyu Wu, Ruoyi Lin, Shuyuan Xian, Daoke Yang, Jun Wang, Zongqiang Huang
Summary: This study identified key genes associated with metastasis of cervical squamous cell carcinoma (CESC) through methods like WGCNA, constructed a metastasis-specific regulation network, and discovered potential bioactive small molecule inhibitors. VIM, positively regulated by NR5A2, affected EMT signaling pathways in metastatic CESC, and naringenin was highlighted as a potential inhibitor for the treatment of metastatic CESC by suppressing cancer stemness.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Spectroscopy
Yafeng Qi, Lin Yang, Bangxu Liu, Li Liu, Yuhong Liu, Qingfeng Zheng, Dameng Liu, Jianbin Luo
Summary: In this study, Raman spectroscopy and deep learning were utilized for accurate and stain-free intraoperative diagnosis. By treating Raman spectral signals as sequences and converting them into two-dimensional Raman spectrograms using short-time Fourier transform as input, high performance deep learning models were achieved, surpassing traditional methods in accuracy and sensitivity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Oncology
Yu Ma, Jie Chen, Xi Yao, Zhenzhen Li, Wensheng Li, Hongtao Wang, Jianfei Zhu
Summary: This study found that perineural invasion is prevalent and highly heterogeneous in squamous cell carcinoma, and it is associated with tumor depth and lymph node status. Perineural invasion is an independent factor affecting disease-free survival and overall survival in ESCC.
Article
Biochemistry & Molecular Biology
Matthew Uzelac, Yuxiang Li, Jaideep Chakladar, Wei Tse Li, Weg M. Ongkeko
Summary: The human microbiome is a collection of microbial species that exist throughout the body and regulate various bodily functions. The impact of archaea species in the microbiome has not been well explored, despite their potential metabolic interaction with host cells. This study investigates the correlation of specific archaeal species with lung adenocarcinoma and lung squamous cell carcinoma, and identifies potential molecular targets associated with the archaea microbiome. The abundance of archaeal species in lung tissue samples was assessed, revealing altered abundance in cancerous samples. Analysis of gene expression and oncogenic signaling pathways provides insights into the mechanisms of cancer development. Additionally, a machine-learning algorithm was developed to accurately distinguish lung cancer patients from healthy individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Chang Gu, Xin Shi, Wenli Qiu, Zhenyu Huang, Yan Yu, Feng Shen, Yumei Chen, Xufeng Pan
Summary: This study explored the prognostic role and mutational characteristics of m6A-related genes in LUSC, identifying three potential independent prognostic m6A-related genes (WTAP, YTHDC1, and YTHDF1) for OS in LUSC patients. The study used LUSC gene expression data and mutational data from The Cancer Genome Atlas database, identifying differentially expressed genes and exploring gene mutations in LUSC patients, investigating the correlations among m6A-related genes, and developing a nomogram model. The study also found significant co-occurrence frequencies among certain m6A-related genes and identified prognostic factors for OS in LUSC patients through multivariate Cox analysis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Jiao Qu, Qitai Zhao, Li Yang, Yu Ping, Kai Zhang, Qingyang Lei, Fengsen Liu, Yi Zhang
Summary: ESCC is the main pathological subtype of esophageal cancer with high incidence and mortality. Immune and stromal cells in the tumor microenvironment play a significant role in ESCC development. Through analyzing DEGs and functional annotations, this study revealed that C3AR1 may induce an immunosuppressive microenvironment by influencing macrophage polarization, suggesting C3AR1 as a potential target for immunotherapy in ESCC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Yusuke Amano, Atsushi Kihara, Masayo Hasegawa, Tamaki Miura, Daisuke Matsubara, Noriyoshi Fukushima, Hiroshi Nishino, Yoshiyuki Mori, Toshiro Niki
Summary: In this study, the clinicopathological and prognostic significance of stromal patterns (SP) in oral squamous cell carcinoma (OSCC) were explored. The study found that the SP category was significantly associated with various clinicopathological factors and was also a prognostic predictor for relapse-free survival (RFS) and overall survival (OS) in OSCC.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Leilei Shen, Juntang Guo, Weidong Zhang, Chaoyang Liang, Han Chen, Yang Liu
Summary: The necessity of performing 4L lymph node dissection (LND) remains uncertain and controversial. This study aimed to analyze the clinicopathological and survival outcomes of 4L LND from the perspective of histology.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Takashi Yamashita, Yusuke Takanashi, Asuka Uebayashi, Mikako Oka, Kiyomichi Mizuno, Akikazu Kawase, Soho Oyama, Takuya Kitamoto, Minako Kondo, Shiho Omori, Hong Tao, Yutaka Takahashi, Takumi Sakamoto, Tomoaki Kahyo, Haruhiko Sugimura, Mitsutoshi Setou, Norihiko Shiiya, Kazuhito Funai
Summary: In patients with unresectable non-small cell lung cancer, a novel diagnostic method independent of tissue morphology or conventional immunohistochemistry (IHC) markers is required. This study analyzed the lipid profiles of resected primary lung adenocarcinoma (ADC) and squamous cell carcinoma (SQCC) specimens and identified novel candidate lipid markers with high diagnostic abilities for ADC and SQCC. These lipid markers may contribute to a more accurate diagnosis and subsequent treatment strategy for unresectable NSCLC.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Xianfeng Li, Yan Wang, Qingjie Min, Weimin Zhang, Huajing Teng, Chao Li, Kun Zhang, Leisheng Shi, Bin Wang, Qimin Zhan
Summary: In this study, a comprehensive comparison of the transcriptomes of esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) was conducted, revealing shared and distinct transcriptomic signatures between these two cancer subtypes and uncovering possible common and unique mechanisms involved in tumorigenesis.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Oncology
Shoujing Zhang, Wenyi Zhang, Jian Zhang
Summary: Immunotherapy targeting the tumor microenvironment is effective in treating HNSCC, but there has been limited research on the relationship between HNSCC microenvironment and prognostic outcome. This study evaluated tumor immune cell infiltration and developed an immune-related prognostic signature and prediction model, providing promising clues for improving HNSCC survival prediction, individualized treatment strategies, and discovering immunotherapy biomarkers.
Article
Surgery
Cheng Shen, Guowei Che
Summary: Combined small cell lung carcinoma is a rare tumor that mainly consists of small cell lung cancer and non-small cell lung cancer components. We reported a case of an elderly patient diagnosed with combined small cell lung carcinoma with adenocarcinoma and summarized the clinical features of this disease.
FRONTIERS IN SURGERY
(2022)
Article
Multidisciplinary Sciences
Chih-Ping Chung, Yu-Chun Chang, Yan Ding, Kenneth Lim, Qinghua Liu, Langjing Zhu, Wei Zhang, Tzong-Shi Lu, Guerman Molostvov, Daniel Zehnder, Li-Li Hsiao