Article
Clinical Neurology
Daniel Deuter, Tobias Mederer, Zacharias Kohl, Patricia Forras, Katharina Rosengarth, Mona Schlabeck, Daniela Roehrl, Christina Wendl, Claudia Fellner, Nils-Ole Schmidt, Juergen Schlaier
Summary: A significant correlation was found between the distance of the DBS electrode pole to the c-DRTT and the clinical efficacy in reducing Parkinsonian tremor, suggesting that the c-DRTT plays a major role in the mechanisms of tremor reduction and may serve as a potential DBS target for tremor-dominant PD in the future.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Melanie A. Morrison, Anthony T. Lee, Alastair J. Martin, Cameron Dietiker, Ethan G. Brown, Doris D. Wang
Summary: Direct intersectional targeting of the VIM using PD-weighted imaging and DRTT tractography is a feasible method for DBS placement in patients with ET. These advanced targeting techniques can supplement awake intraoperative testing or be used independently in asleep cases to improve surgical efficiency and confidence.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Andrew I. Yang, Drew Parker, Anupa A. Vijayakumari, Ashwin G. Ramayya, Melanie P. Donley-Fletcher, Darien Aunapu, Ronald L. Wolf, Gordon H. Baltuch, Ragini Verma
Summary: This study compared DRTT reconstructed with deterministic tracking to that reconstructed with probabilistic tracking. The results showed that probabilistic tracking was superior in spatial proximity to the DBS lead and the active contact chosen.
Article
Neurosciences
Xiaojie Duanmu, Jiaqi Wen, Sijia Tan, Tao Guo, Cheng Zhou, Haoting Wu, Jingjing Wu, Zhengye Cao, Xiaocao Liu, Jingwen Chen, Chenqing Wu, Jianmei Qin, Luyan Gu, Yaping Yan, Baorong Zhang, Minming Zhang, Xiaojun Guan, Xiaojun Xu
Summary: This study used multi-modality MRI to compare the dentato-rubro-thalamic (DRT) pathway between action tremor, rest tremor, and normal controls. The results showed excessive iron deposition in the bilateral dentate nucleus (DN) of the action tremor group and decreased diffusivity in the left non-decussating DRT tract (nd-DRTT), which correlated with tremor severity.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Ilona Lipp, Jilu Princy Mole, Leena Subramanian, David E. J. Linden, Claudia Metzler-Baddeley
Summary: Investigated the connections between the cerebellum and thalamus and their microstructural differences in Parkinson's disease patients, providing insights into the disease mechanism and potential treatment approaches.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Caroline Trompette, Caroline Giordana, Aurelie Leplus, David Grabli, Cecile Hubsch, Claire Marse, Denys Fontaine
Summary: The study suggests that combined stimulation of the ventral intermediate thalamic nucleus (VIM) and the globus pallidus interna (GPi) in deep brain stimulation (DBS) treatment shows better results for treating dystonic tremor (DT) symptoms compared to single stimulation of either VIM or GPi. Furthermore, by modulating the networks involved in DT pathophysiology, combined stimulation may provide comprehensive improvements in motor, functional, and activities of daily living.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Valeria Pozzilli, Massimo Marano, Alessandro Magliozzi, Carlo Augusto Mallio, Daniele Marruzzo, Francesca Romana Barbieri, Vincenzo Di Lazzaro, Riccardo Antonio Ricciuti
Summary: Deep brain stimulation (DBS) is an effective treatment for movement disorders such as Holmes tremor (HT). The ideal target for DBS in HT is still uncertain. Advanced neuroimaging techniques can help identify the target and achieve almost complete tremor suppression, providing new treatment options.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Victor J. Geraedts, Rogier A. P. van Ham, Jacobus J. van Hilten, Arne Mosch, Carel F. E. Hoffmann, Niels A. van der Gaag, Maria Fiorella Contarino
Summary: The study aimed to determine whether side-effects-thresholds from intraoperative test stimulation are indicative of postoperative stimulation findings. Results showed no significant differences between intraoperative and postoperative assessments of GPi and Vim DBS, although thresholds cannot be directly extrapolated at an individual level due to high variability.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
O. Parras, P. Dominguez, A. Tomas-Biosca, J. Guridi
Summary: This review compares the methods of using stereotactic procedures and tractography for locating the ventralis intermedius (Vim) nucleus in the treatment of tremor. Although tractography has limitations, it aids in the visualization of the target. However, further studies are needed to determine the long-term efficacy of direct targeting compared to indirect targeting.
Article
Clinical Neurology
Maarten Bot, Anne-Fleur van Rootselaari, Vincent Odekerken, Joke Dijk, Rob M. A. de Bie, Martijn Beudel, Pepijn van den Munckhof, P. Richard Schuurman
Summary: The optimal deterministic DRT tractography for DBS in ET patients involves including the motor cortex, posterior subthalamic area (PSA), ipsilateral superior cerebellar peduncle, and dentate nucleus in the region of interest. This technique shows strong correlation with optimal tremor control and can be implemented for prospective evaluation in DBS target planning.
OPERATIVE NEUROSURGERY
(2021)
Article
Clinical Neurology
Maarten Bot, Anne-Fleur van Rootselaari, Vincent Odekerken, Joke Dijk, Rob M. A. de Bie, Martijn Beudel, Pepijn van den Munckhof, P. Richard Schuurman
Summary: Optimized deterministic DRT tractography strongly correlates with optimal tremor control in DBS for essential tremor, suggesting its potential use in prospective evaluation for target planning.
OPERATIVE NEUROSURGERY
(2021)
Article
Neurosciences
Alexander Rau, Wolfgang H. Jost, Theo Demerath, Elias Kellner, Marco Reisert, Horst Urbach
Summary: This study analyzed diffusion microstructure imaging (DMI) in patients with suspected atypical Parkinson syndromes and healthy controls. The results showed widespread axonal loss in PSP patients, and the ROI-based approach had the highest accuracy in identifying PSP in the thalamus and frontal white matter.
Article
Neurosciences
Si-Qi Ou, Peng-Hu Wei, Xiao-Tong Fan, Yi-He Wang, Fei Meng, Mu-Yang Li, Yong-Zhi Shan, Guo-Guang Zhao
Summary: This study aimed to identify the decussating dentato-rubro-thalamic tract (d-DRTT) and its connections in healthy humans using DSI techniques. Results showed bilateral visualization of the d-DRTT in 28 subjects, with relatively symmetric left and right d-DRTT. Important afferent regions were found in the posterior cerebellum, while efferent fibers projected mainly to the contralateral frontal cortex, including motor and nonmotor regions.
Article
Clinical Neurology
Volker A. Coenen, Bastian E. Sajonz, Peter C. Reinacher, Christoph P. Kaller, Horst Urbach, M. Reisert
Summary: The study evaluated the validity of displaying the dentato-rubro-thalamic tract (DRT) using diffusion weighted imaging (dMRI) in different tracking environments. The results show that FT2 and GT methods can depict DRTu with good quality, but the reconstruction of DRTx remains unreliable.
ACTA NEUROCHIRURGICA
(2021)
Article
Clinical Neurology
Johanna Petra Szabo, Daniel Fabo, Nora Peto, Anna Sakovics, Robert Bodizs
Summary: Increased attention has been given to the structure and function of the anterior nucleus of the thalamus (ANT) in epilepsy treatment. The efficacy of the treatment varies among patients and the predictors of better outcomes are limited. Recent studies suggest a possible role of ANT in sleep processes, although the mechanisms are still unclear. This review aims to summarize the evidence on ANT activity during non-REM and REM sleep, and explore shared characteristics with sleep processes and ANT-related functions during wakefulness.
Review
Clinical Neurology
Yulu Song, Peter J. Lally, Maria Yanez Lopez, Georg Oeltzschner, Mary Beth Nebel, Borjan Gagoski, Steven Kecskemeti, Steve C. N. Hui, Helge J. Zollner, Deepika Shukla, Tomoki Arichi, Enrico De Vita, Vivek Yedavalli, Sudhin Thayyil, Daniele Fallin, Douglas C. Dean, P. Ellen Grant, Jessica L. Wisnowski, Richard A. E. Edden
Summary: J-difference-edited spectroscopy is a valuable tool for detecting low-concentration metabolites, especially in pediatric imaging research. It allows the study of rapid maturational changes in metabolic systems in early life, contributing to the understanding of structural and functional changes in children in the first years of life.
Article
Radiology, Nuclear Medicine & Medical Imaging
Haris Shuaib, Gareth J. Barker, Peter Sasieni, Enrico De Vita, Alysha Chelliah, Roman Andrei, Keyoumars Ashkan, Erica Beaumont, Lucy Brazil, Chris Rowland-Hill, Yue Hui Lau, Aysha Luis, James Powell, Angela Swampillai, Sean Tenant, Stefanie C. Thust, Stephen Wastling, Tom Young, Thomas C. Booth
Summary: This study analyzed MRI data from a random sample of five patients in the ZGBM consortium, aiming to understand the variation in imaging protocol and scheduling in routine care for glioblastoma patients. The results showed that there is variability in the imaging protocol and scheduling across different centers, making it challenging to develop deep-learning models that can perform consistently. However, structural imaging is performed consistently across all centers.
BRITISH JOURNAL OF RADIOLOGY
(2022)
Article
Neurosciences
Cameron Higgins, Diego Vidaurre, Nils Kolling, Yunzhe Liu, Tim Behrens, Mark Woolrich
Summary: The use of generative encoding model framework allows for the simultaneous inference of spatial patterns of brain activity and variable timing of these patterns in individual trials, providing insights into the dynamic characteristics of brain activity.
HUMAN BRAIN MAPPING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yannick Brackenier, Lucilio Cordero-Grande, Raphael Tomi-Tricot, Thomas Wilkinson, Philippa Bridgen, Anthony Price, Shaihan J. Malik, Enrico De Vita, Joseph Hajnal
Summary: This study developed a fully data-driven retrospective intrascan motion-correction framework for volumetric brain MRI at ultrahigh field (7 Tesla), which includes modeling of pose-dependent changes in polarizing magnetic (B-0) fields. The proposed framework showed improved image quality for strongly corrupted data at 7 Tesla in simulations and in vivo.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Review
Neurosciences
James C. R. Whittington, David McCaffary, Jacob J. W. Bakermans, Timothy E. J. Behrens
Summary: This article categorizes different cognitive map models into an ontology, revealing their connections and suggesting new approaches to understanding hippocampal-cortical interactions.
NATURE NEUROSCIENCE
(2022)
Article
Neurosciences
Veronika Samborska, James L. Butler, Mark E. Walton, Timothy E. J. Behrens, Thomas Akam
Summary: The study reveals that the prefrontal cortex and hippocampus play different roles in problem-solving in mice, with the former being more about generalization and the latter being more about specificity.
NATURE NEUROSCIENCE
(2022)
Editorial Material
Biology
Michael B. Eisen, Anna Akhmanova, Timothy E. Behrens, Jorn Diedrichsen, Diane M. Harper, Mihaela D. Iordanova, Detlef Weigel, Mone Zaidi
Summary: eLife is changing its editorial process to prioritize public reviews and assessments of preprints.
Review
Clinical Neurology
Anna Grossauer, Anna Hussl, Philipp Mahlknecht, Marina Peball, Anna Heidbreder, Florian Deisenhammer, Atbin Djamshidian, Klaus Seppi, Beatrice Heim
Summary: Anti-IgLON5 disease is an autoimmune encephalopathy characterized by sleep disturbances. It has a wide range of clinical symptoms, including movement disorders, bulbar dysfunction, autonomic disorders, and neurocognitive impairment. This study reports a case of an 87-year-old woman with isolated progressive hemichorea. A literature review identified multiple cases of anti-IgLON5 disease with chorea as an extrapyramidal movement disorder in their clinical phenotype. Screening for IgLON5 antibodies should be considered in patients with unexplained movement disorders, including isolated hemichorea.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Cristina Simonet, Philipp Mahlknecht, Kathrin Marini, Klaus Seppi, Aneet Gill, Jonathan P. Bestwick, Andrew J. Lees, Gavin Giovannoni, Anette Schrag, Alastair J. Noyce
Summary: The PREDICT-PD study utilized a risk algorithm to stratify individuals for future Parkinson's disease and found an association between risk scores and sub-threshold parkinsonism. The algorithm was able to identify individuals with motor decline over time.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Avital Hahamy, Haim Dubossarsky, Timothy E. J. Behrens
Summary: Hahamy et al. demonstrate that the human brain reactivates past relevant information at the transitions between narrative events to understand the current stage. This reactivation occurs in the hippocampus and default mode network, similar to offline replay in rodents. However, the reactivations occur at the boundaries between ongoing narrative events, rather than during prolonged offline periods. These results suggest that reactivations contribute to binding temporally distant information into a coherent understanding of ongoing experience.
NATURE NEUROSCIENCE
(2023)
Article
Clinical Neurology
Suzette Shahmoon, Patricia Limousin, Marjan Jahanshahi
Summary: This pilot study aimed to explore how caregiver spouses make sense of themselves one and five years after their partner's deep brain stimulation (DBS) surgery for Parkinson's disease. In the interviews, 8 out of 16 caregivers primarily focused on the impact of PD on their partners rather than reflecting on their own lived experience. A content analysis showed a bias in their responses towards their partner's experience, indicating a lack of self-awareness.
PARKINSONS DISEASE
(2023)
Article
Neurosciences
Andre Zacharia, Diego Kaski, Walid Bouthour, Viswas Dayal, Matthieu Bereau, Philipp Mahlknecht, Dejan Georgiev, Julie Peron, Tom Foltynie, Ludvic Zrinzo, Marjan Jahanshahi, John Rothwell, Patricia Limousin
Summary: This study investigated the effects of 80 Hz vs. 130 Hz frequency STN-DBS on eye movements and executive control in Parkinson's disease patients. The results showed that 80 Hz STN-DBS reduced the ability to maintain stable fixation, resulting in a higher antisaccade error rate, without affecting inhibition or motor state.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Anna Grossauer, Christoph Mueller, Anna Hussl, Florian Krismer, Michael Schocke, Elke Gizewski, Philipp Mahlknecht, Christoph Scherfler, Gregor K. Wenning, Werner Poewe, Klaus Seppi, Beatrice Heim
Summary: This study evaluated the diagnostic utility of 1.5T versus 3T magnetic resonance imaging for neurodegenerative parkinsonism, and found that the specificity of 1.5T imaging was insufficient to accurately distinguish patients from healthy controls.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Sabine Eschlboeck, Georg Goebel, Christine Eckhardt, Alessandra Fanciulli, Cecilia Raccagni, Sylvia Boesch, Atbin Djamshidian, Beatrice Heim, Philipp Mahlknecht, Katherina Mair, Wolfgang Nachbauer, Christoph Scherfler, Heike Stockner, Werner Poewe, Klaus Seppi, Stefan Kiechl, Gregor Wenning, Florian Krismer, EMSA SG NHS Investigators
Summary: This study developed a predictive model based on baseline clinical symptoms to estimate the 7-year survival probability for multiple system atrophy (MSA) patients.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Letter
Clinical Neurology
Philipp Mahlknecht, Wilhelm Eisner, Werner Poewe
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)