Review
Clinical Neurology
Danila Cristina Petian-Alonso, Camila Scarpino Barboza Franco, Emanuela Juvenal Martins, Karoliny Lisandra Teixeira Cruz, Roberta de Fatima Carreira Moreira Padovez, Ana Claudia Mattiello-Sverzut
Summary: This study aimed to identify the equipment and protocols commonly used to assess upper limb motor fatigability in patients with neuromuscular disease. The findings revealed that isokinetic and handgrip dynamometers were the most frequently used equipment, while the methodological quality of a majority of the studies was low.
ACTA NEUROLOGICA SCANDINAVICA
(2023)
Review
Clinical Neurology
Robert Patejdl, Uwe K. Zettl
Summary: Multiple Sclerosis (MS) is an immune mediated disease of the central nervous system (CNS) that results in fatigue, a common and disabling symptom. Studies on exercise interventions for MS patients have yielded heterogeneous results, most likely due to the heterogeneity of interventions and patients, as well as the non-uniform pathophysiology of fatigue among MS patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Sport Sciences
Nicolas Royer, Callum G. Brownstein, Djahid Kennouche, Loic Espeit, Anthony Teston, Claire Boutet, Leonard Feasson, Jean-philippe Camdessanche, Guillaume Y. Millet
Summary: This study aimed to investigate the correlates of MS-related fatigue in patients with relapsing-remitting multiple sclerosis (MS), with a particular focus on fatigability. The results revealed that the high fatigue group exhibited greater performance fatigability and higher perceived exertion than the low fatigue group during a dynamic task.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Orthopedics
Lieke Brauers, Rob Smeets, Peter Feys, Andrew M. Gordon, Yvonne Janssen-Potten, Els Ortibus, Hilde Feys, Eugene Rameckers, Katrijn Klingels
Summary: The study aimed to investigate differences in static and dynamic motor fatigability during grip and pinch tasks between children with unilateral spastic cerebral palsy (USCP) and children with typical development (TD), as well as between preferred and nonpreferred hands. Higher static fatigability was found in USCP group for grip and pinch, both within and between hands. Dynamic motor fatigability showed inconsistent results, with higher levels of fatigability in TD group for grip in nonpreferred hands and in the ratio of number of peaks in preferred hands. The findings suggest that static motor fatigability should be considered in comprehensive upper limb assessments and as a target for individualized interventions.
Review
Clinical Neurology
Nicolas Royer, Kyla Coates, Saied Jalal Aboodarda, Jean-Philippe Camdessanche, Guillaume Y. Millet
Summary: Fatigue is a common complaint of patients with multiple sclerosis, but its cause and the relationship between resistance to fatigability, disability level, and neuromuscular performance are not well understood. This review examines the effects of multiple sclerosis on corticospinal and muscular mechanisms of muscle contraction and their potential influence by disability level and fatigue. It suggests that impaired neuromuscular function during exercise is more pronounced with increased disability, and fatigue level is linked to resistance to fatigability, but not to rest-related neuromuscular function. Further research is needed to better understand the impact of fatigue and disability on fatigability, particularly at the corticospinal level.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biology
Helena Silva-Migueis, Eva Maria Martinez-Jimenez, Israel Casado-Hernandez, Adriano Dias, Ana Julia Monteiro, Rodrigo B. Martins, Carlos Romero-Morales, Daniel Lopez-Lopez, Juan Gomez-Salgado
Summary: This study aimed to understand the influence of an upper limb isometric task on fatigability behavior and the role of quality of life and physical activity in the fatigability of elderly participants. It was found that the upper limb isometric task produces changes in perceived and performance fatigability, which are related in the final stage of the activity. Perceived fatigability evolved progressively with a major increase in the second half of the activity. Changes in fatigability were related to BMI and health-related quality of life dimensions.
Article
Clinical Neurology
Fanny Van Geel, Lars G. Hvid, Pieter Van Noten, Bert O. Eijnde, Ulrik Dalgas, Peter Feys
Summary: The study found associations between muscle strength and various muscle fatigability protocols with walking capacity and walking fatigability in persons with MS, suggesting the importance of muscle function in walking performance in this population.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Medicine, Research & Experimental
Bianka Jakel, Claudia Kedor, Patricia Grabowski, Kirsten Wittke, Silvia Thiel, Nadja Scherbakov, Wolfram Doehner, Carmen Scheibenbogen, Helma Freitag
Summary: Repeat maximum handgrip strength assessment is a sensitive diagnostic test for evaluating muscular fatigue and fatigability in ME/CFS patients, and it is also an objective measure to assess the severity of the disease.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Computer Science, Artificial Intelligence
Camilla Pierella, Laura Pellegrino, Margit Muller, Matilde Inglese, Claudio Solaro, Martina Coscia, Maura Casadio
Summary: The study aimed to quantify upper limb motor deficits in asymptomatic MS subjects using a robot-based assessment. Results showed that MS subjects generated less smooth and accurate cursor trajectories when controlling force profiles, and had significantly different end-point errors in other environments.
FRONTIERS IN NEUROROBOTICS
(2022)
Article
Rehabilitation
John W. Farrell III, Robert W. Motl, Yvonne C. Learmonth, Lara A. Pilutti
Summary: This study aimed to characterize strength asymmetries in the upper and lower extremities in persons with multiple sclerosis (PwMS) with severe disability, and examine associations between asymmetries and functional, symptomatic, and participatory outcomes. The results showed a high prevalence of asymmetry and significant associations between asymmetries and certain functional and health indicators.
Article
Nutrition & Dietetics
Dawid Lochynski, Maciej Pawlak, Inge Everaert, Tomasz Podgorski, Magdalena Gartych, Anna-Maria Borucka, Jan Celichowski, Wim Derave, Dominik Kaczmarek
Summary: The study found that long-term carnosine supplementation can maintain the force of FF muscle units at a higher level during rapid decline and result in less rapid force decline in both FF and FR muscle units. Carnosine supplementation did not change muscle antioxidant potential, mortality rate, or muscle mass with aging.
Review
Neurosciences
Lewis A. Ingram, Annie A. Butler, Stephen R. Lord, Simon C. Gandevia
Summary: Profiling performance in the physiological domains underpinning upper limb function provides insight into an individual's specific impairments. A battery of tests were used to create a core upper limb physiological profile assessment (PPA). Individual performance in each test can be compared to a reference population score, and a composite score provides an overview of overall upper limb function.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Rehabilitation
Lewis A. Ingram, Annie A. Butler, Matthew A. Brodie, Phu Hoang, Simon C. Gandevia, Stephen R. Lord
Summary: The upper-limb Physiological Profile Assessment (PPA) is a valid and clinically suitable assessment for evaluating upper-limb function in people with multiple sclerosis (MS). Motor speed, fine motor control, and functional tasks are the most commonly and significantly impaired domains in upper-limb function among MS patients.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Pediatrics
Kim Kant-Smits, Erik H. J. Hulzebos, Laura E. Habets, Fay-Lynn Asselman, Esther S. Veldhoen, Ruben P. A. van Eijk, Janke F. de Groot, W. Ludo van der Pol, Bart Bartels
Summary: This study aimed to explore respiratory muscle fatigability (RMF) in patients with Spinal Muscular Atrophy (SMA). The results showed that there was a dose-dependent increase in RMF in SMA patients during the Respiratory Endurance Test (RET). Additionally, the fatigability response in SMA patients exhibited large variability in respiratory muscle pressure and a slight increase in perceived fatigue.
PEDIATRIC PULMONOLOGY
(2022)
Article
Engineering, Biomedical
Cintia Ramari, Lars G. Hvid, Ulrik Dalgas, Ana R. Diniz, Felipe von Glehn, Ana C. de David
Summary: This pilot study explores the deficits in muscle power/force in individuals with Multiple Sclerosis (MS) and their implications for physical function and walking-fatigability. The results show that muscle power and force are impaired in MS patients and are critical for their physical function. Additionally, muscle power/force from chair rise exercise appears to contribute to walking-fatigability, suggesting potential treatment targets.
CLINICAL BIOMECHANICS
(2022)
Review
Clinical Neurology
Cigdem Yilmazer, Ilse Lamers, Claudio Solaro, Peter Feys
Summary: This article provides an overview of the current knowledge on pain in multiple sclerosis, including its definitions, assessments, treatments, and rehabilitation. It also highlights the lack of experimental studies focusing on pain reduction.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Editorial Material
Clinical Neurology
Peter Feys, Eva Swinnen
MULTIPLE SCLEROSIS JOURNAL
(2021)
Correction
Computer Science, Artificial Intelligence
Lousin Moumdjian, Thomas Vervust, Joren Six, Ivan Schepers, Micheline Lesaffre, Peter Feys, Marc Leman
Summary: This correction provides the correct affiliations for the co-authors Dr. Thomas Vervust and Prof. Peter Feys, whose affiliations were previously incorrect.
JOURNAL ON MULTIMODAL USER INTERFACES
(2021)
Article
Computer Science, Artificial Intelligence
Lousin Moumdjian, Thomas Vervust, Joren Six, Ivan Schepers, Micheline Lesaffre, Peter Feys, Marc Leman
Summary: This study focuses on balance and gait impairments in the neurological population, developing a new Augmented Movement Platform for Embodied Learning (AMPEL) device that creates enriched sensory environments through interactive feedback. The device shows high reliability for outcome measures and flexible application of augmented feedback.
JOURNAL ON MULTIMODAL USER INTERFACES
(2021)
Article
Clinical Neurology
Kathleen M. Zackowski, Jennifer Freeman, Giampaolo Brichetto, Diego Centonze, Ulrik Dalgas, John DeLuca, Dawn Ehde, Sara Elgott, Vanessa Fanning, Peter Feys, Marcia Finlayson, Stefan M. Gold, Matilde Inglese, Ruth Ann Marrie, Michelle Ploughman, Christine N. Sang, Jaume Sastre-Garriga, Caroline Sincock, Jonathan Strum, Johan van Beek, Anthony Feinstein
Summary: This research emphasizes key symptoms for people with progressive MS and calls for high-quality studies focused on symptom management and rehabilitation. Through collaboration of an international expert group, four main symptoms and factors affecting treatment efficacy are highlighted. This coordinated call to action aims to address gaps in rehabilitation research for those affected by progressive MS.
MULTIPLE SCLEROSIS JOURNAL
(2021)
Review
Neurosciences
Bruno Bonnechere, Aki Rintala, Annemie Spooren, Ilse Lamers, Peter Feys
Summary: The development of mobile technology and mobile Internet presents new possibilities for rehabilitation and clinical assessment in managing multiple sclerosis. Studies have shown promising effects of mHealth in cognitive function and fatigue rehabilitation for patients with multiple sclerosis, though further research is needed to validate these solutions in other areas.
Article
Rehabilitation
Nastasia Marinus, Dominique Hansen, Peter Feys, Raf Meesen, Annick Timmermans, Joke Spildooren
Summary: This study analyzed the impact of television images on the motivation and exercise intensity of older adults in residential care during cycling exercises. The results indicated that the addition of television images may increase the exercise intensity and motivation of older adults.
DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Renee Veldkamp, Lousin Moumdjian, Kim van Dun, Joren Six, Antoine Vanbeylen, Daphne Kos, Peter Feys
Summary: Motor sequence learning in individuals with multiple sclerosis in a stepping task showed similar levels to healthy controls, regardless of learning conditions or group differences.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Multidisciplinary Sciences
Lousin Moumdjian, Joren Six, Renee Veldkamp, Jenke Geys, Channa Van der Linden, Mieke Goetschalckx, Johan Van Nieuwenhoven, Ilse Bosmans, Marc Leman, Peter Feys
Summary: This study investigated the effects of embodied learning on motor and cognitive functions in persons with multiple sclerosis (PwMS). The results showed that balance impairment and information processing speed predicted the speed of executing cognitive sequences. Furthermore, participants who learned performed the sequence faster in the melody condition and overall improved their speed over time.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Review
Rehabilitation
A. Rintala, O. Kossi, B. Bonnechere, L. Evers, E. Printemps, P. Feys
Summary: This study evaluated the effectiveness of mobile health applications (mHealth apps) with a physical training component on physical function and physical activity in stroke rehabilitation. The results showed that these apps have potential in improving physical function and physical activity in stroke survivors, but the impact on quality of life was limited.
DISABILITY AND REHABILITATION
(2022)
Review
Environmental Sciences
Elisabetta Brigo, Aki Rintala, Oyene Kossi, Fabian Verwaest, Olivier Vanhoof, Peter Feys, Bruno Bonnechere
Summary: This review analyzes the feasibility and effectiveness of telehealth solutions proposed during the COVID-19 pandemic to ensure the continuity of rehabilitation. The findings suggest that telerehabilitation is a feasible and effective solution for providing continuous rehabilitation while reducing the risk of infection and burden of travel. However, further research is needed to strengthen and confirm these findings.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Environmental Sciences
Zuhal Abasiyanik, Renee Veldkamp, Amber Fostier, Carolien Van Goubergen, Alon Kalron, Peter Feys
Summary: This review examines the patient perspective and assessment methods for dual-task (DT) impairment. Five patient-reported outcome measures (PROMs) were identified, and the Dual-Task-Impact on Daily-life Activities Questionnaire (DIDA-Q) showed the highest measurement quality in individuals with multiple sclerosis.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Rehabilitation
Elogni R. Amanzonwe, Lisa Tedesco Triccas, Leopold Codjo, Dominique Hansen, Peter Feys, Oyene Kossi
Summary: This study analyzed the optimal dosage and effectiveness of aerobic training (AT) and resistance training (RT) on balance, walking capacity, and quality of life (QoL) in stroke survivors. The results showed that AT was the most effective in improving walking capacity, while combining AT and RT was beneficial for improving QoL. High-dose aerobic exercise conducted in rehabilitation facilities was more effective in improving walking capacity in chronic stroke patients.
SOUTH AFRICAN JOURNAL OF PHYSIOTHERAPY
(2023)
Article
Medicine, General & Internal
Peter Feys, Marijke Duportail, Daphne Kos, Stephan Ilsbroukx, Ilse Lamers, Paul Van Asch, Werner Helsen, Lousin Moumdjian
Summary: This study investigated the effect of peripheral upper limb cooling on tremor severity and functional performance in multiple sclerosis patients with intention tremor. The results showed that cooling the forearm significantly reduced tremor severity and improved functional performance, and cooling the whole upper limb had a noticeable effect on tremor severity during the first half-hour after cooling.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Kyra Theunissen, Guy Plasqui, Annelies Boonen, Bente Brauwers, Annick Timmermans, Pieter Meyns, Kenneth Meijer, Peter Feys
Summary: The review found that pwMS and healthy subjects share similarities in energetically most optimal walking speed, but pwMS have higher Cw. Treadmill walking provides a similar optimum Cw compared to overground walking, but at a higher speed.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Clinical Neurology
Zahra Ghadimi Korka, Shohreh Noorizadeh Dehkordi, Soheil Mansour Sohani, Marzieh Yassin
Summary: The Trunk Impairment Scale (TIS) in Persian has been found to be a relevant and reliable tool for assessing trunk abnormalities in Persian-speaking people with multiple sclerosis (PWMS).
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Letter
Clinical Neurology
Daniele Caliendo, Maria Carmela Grassia, Antonio Carotenuto, Maria Petracca, Roberta Lanzillo, Vincenzo Brescia Morra, Marcello Moccia
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Article
Clinical Neurology
Maddalena Sparaco, Elisabetta Maida, Floriana Bile, Renato Vele, Luigi Lavorgna, Giuseppina Miele, Simona Bonavita
Summary: The SDQ was translated into Italian and validated for use in pwMS to detect swallowing disturbances. The 14-item SDQ demonstrated high internal consistency, good accuracy, and reliability in pwMS, making it a readily applicable tool for investigating dysphagia in MS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Article
Clinical Neurology
Leticia Rodrigues Gomes, Benito Pereira Damasceno, Brunno Machado de Campos, Alfredo Damasceno
Summary: This study found that patients with multiple sclerosis (MS) have more frequent work restrictions and impairment in money management and driving abilities compared to controls. Cognitive function, physical disability, and MS lesion burden are strongly associated with work restrictions, and social cognition can influence financial capacity. Cognitive and brain reserve can help retain some of these daily occupations.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Letter
Clinical Neurology
Kaitlin E. Riegler, John Beauvais, Lindsay O. Neto, Elizabeth S. Gromisch
Summary: This study examined the differences in resilience levels among individuals with multiple sclerosis (PwMS) who had sleep disorders, sleep problems, and no sleep disorders/problems. The results showed that PwMS with sleep disorders had significantly lower resilience, with the difference being driven by the support from family and friends. These findings highlight the connection between sleep and resilience in PwMS, emphasizing the importance of social support.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Article
Clinical Neurology
A. Maunula, S. Atula, Sm Laakso, Pj Tienari
Summary: This study aimed to investigate the frequency and risk factors of FTY rebound in a hospital district in Southern Finland. The results showed that 10.5% of patients experienced a rebound, and 28% of patients had relapses of any severity after discontinuing FTY. Younger age at diagnosis, longer exposure to FTY, lower lymphocyte count, and higher neutrophil to lymphocyte ratio after discontinuation were identified as risk factors for a rebound.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
