Article
Multidisciplinary Sciences
Gokhan Dalgin, Andrew K. Tryba, Ashley P. Cohen, Soo-Young Park, Louis H. Philipson, Siri Atma W. Greeley, Alfredo J. I. I. I. I. I. I. Garcia
Summary: This study utilized human induced pluripotent stem cells to generate cerebral organoids carrying a KCNJ11 mutation, demonstrating the impact of the mutation on neural network development and function. Differential analysis revealed a decrease in neuron number and reduced neural network synchronization due to the mutation, with partial improvement observed with continuous treatment of the K-ATP blocker.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Bo Wu, Wei Xu
Summary: Neonatal diabetes mellitus (NDM) is a rare form of monogenic diabetes. Most studies have focused on gene mutations associated with NDM and the therapeutic effects of SUs, while there is limited research on NDM-associated intracranial hemorrhage (ICH).
FRONTIERS IN NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Valentina Mancioppi, Erica Pozzi, Sara Zanetta, Anna Missineo, Silvia Savastio, Fabrizio Barbetti, Simona Mellone, Mara Giordano, Ivana Rabbone
Summary: Neonatal diabetes mellitus (NDM) is a rare genetic disease characterized by severe hyperglycemia. The disease can be temporary or permanent, and is often caused by abnormalities in specific genetic regions or mutations in certain genes. Insulin therapy can be switched to hypoglycemic sulfonylureas after the acute phase, but the timing of this switch can affect long-term complications.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Gregor Sachse, Elizabeth Haythorne, Thomas Hill, Peter Proks, Russell Joynson, Raul Terron-Exposito, Liz Bentley, Stephen J. Tucker, Roger D. Cox, Frances M. Ashcroft
Summary: The K23 variant in the K-ATP channel impairs insulin secretion and increases diabetes risk, especially in combination with a high-fat diet and obesity. This variant causes dysfunction in beta-cell insulin secretion, particularly at threshold glucose levels.
Article
Public, Environmental & Occupational Health
Tingting Sha, Yuqing Zhang, Changjun Li, Guanghua Lei, Jing Wu, Xiaoxiao Li, Zidan Yang, Chao Zeng, Jie Wei
Summary: Our study provides empirical evidence that initiation of metformin is associated with a lower risk of venous thromboembolism compared to sulfonylureas in patients with type 2 diabetes.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Yu-Jih Su, Jing-Yang Huang, Cong-Qiu Chu, James Cheng-Chung Wei
Summary: This study found that the use of sulfonylureas or biguanides is associated with a lower risk of rheumatoid arthritis (RA) development in patients with diabetes mellitus (DM).
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Antonios Douros, Frederike Basedow, Ying Cui, Jenny Dimakos, Jochen Walker, Dirk Enders, Vicky Tagalakis
Summary: Among octogenarians with venous thromboembolism, DOACs showed comparable effectiveness and safety compared to VKAs in preventing recurrent venous thromboembolism, major bleeding, and all-cause mortality. These results support the use of DOACs in this high-risk group.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Pamela Bowman, Frances Mathews, Fabrizio Barbetti, Maggie H. Shepherd, Janine Sanchez, Barbara Piccini, Jacques Beltrand, Lisa R. Letourneau-Freiberg, Michel Polak, Siri Atma W. Greeley, Eamon Rawlins, Tarig Babiker, Nicholas J. Thomas, Elisa De Franco, Sian Ellard, Sarah E. Flanagan, Andrew T. Hattersley
Summary: Treating ABCC8-PNDM patients with sulfonylureas long-term results in excellent glycemic control. Most patients show mild neurological features, which may improve after transfer to sulfonylureas, emphasizing the importance of genetic testing and neurodevelopmental assessment.
Article
Cardiac & Cardiovascular Systems
Marta Baviera, Andreana Foresta, Pierluca Colacioppo, Giulia Macaluso, Maria Carla Roncaglioni, Mauro Tettamanti, Ida Fortino, Stefano Genovese, Irene Caruso, Francesco Giorgino
Summary: This study compared the effectiveness and safety of GLP-1 RA and SGLT-2i in a large cohort of patients with type 2 diabetes. The results showed that GLP-1 RA was equally safe but more effective than SGLT-2i in reducing the risk of major adverse cardiovascular events and non-fatal myocardial infarction. The incidence of serious adverse events was low in both treatment groups.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Medicine, General & Internal
Hassan Alwafi, Ian C. K. Wong, Abdallah Y. Naser, Amitava Banerjee, Pajaree Mongkhon, Cate Whittlesea, Alaa Alsharif, Li Wei
Summary: This study investigates the association between concurrent use of oral anticoagulants (OACs) and sulfonylureas and the risk of hypoglycemia in individuals with type 2 diabetes mellitus (T2DM). The results suggest that concurrent use of warfarin and sulfonylureas may increase the risk of hypoglycemia, while there is no evidence of an association between concurrent use of DOACs and sulfonylureas and the risk of hypoglycemia.
FRONTIERS IN MEDICINE
(2022)
Article
Pediatrics
Ming Yue, Heying Yang, Mingxia Cui, Yuhang Yuan, Ning Zhang, Xiangyu Zhang, Yan Li
Summary: Santulli enterostomy is a simple and safe surgical procedure that provides early restoration of intestinal continuity without formal laparotomy. Compared to traditional ostomy procedures, Santulli enterostomy has shorter operative time, shorter hospital stay, and lower incidence of postoperative complications.
FRONTIERS IN PEDIATRICS
(2023)
Article
Clinical Neurology
Nir Giladi, Roy N. Alcalay, Gary Cutter, Thomas Gasser, Tanya Gurevich, Guenter U. Hoeglinger, Kenneth Marek, Claudio Pacchetti, Anthony H. Schapira, Clemens R. Scherzer, Tanya Simuni, Pascal Minini, S. Pablo Sardi, M. Judith Peterschmitt
Summary: The safety, efficacy, and target engagement of venglustat in early-stage Parkinson's disease patients with GBA1 variants were assessed. The study showed that venglustat had a satisfactory safety profile but did not show beneficial treatment effect compared with placebo. These findings suggest that glucosylceramide synthase inhibition with venglustat may not be a viable therapeutic approach for GBA1-associated Parkinson's disease.
Article
Pediatrics
Stefano C. Di Bernardo, Sebastiano A. G. Lava, Adina Mihaela Epure, Sandrine Estoppey Younes, Arnaud Chiolero, Nicole Sekarski
Summary: This study aimed to assess the effect of maternal gestational diabetes (GDM) on offsprings' cardiovascular health. The results showed that infants of mothers with GDM had some echocardiographic differences, suggesting altered myocardial physiology among these infants.
PEDIATRIC RESEARCH
(2023)
Article
Endocrinology & Metabolism
Can Thi Bich Ngoc, Tran Minh Dien, Elisa De Franco, Sian Ellard, Jayne A. L. Houghton, Nguyen Ngoc Lan, Bui Phuong Thao, Nguyen Ngoc Khanh, Sarah E. Flanagan, Maria E. Craig, Vu Chi Dung
Summary: Neonatal diabetes mellitus (NDM) patients with ABCC8 or KCNJ11 mutations are sensitive to sulfonylurea (SU) treatment, which can improve clinical management of diabetes, and SU treatment is more effective than insulin therapy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Ildem Akerman, Miguel Angel Maestro, Elisa De Franco, Vanessa Grau, Sarah Flanagan, Javier Garcia-Hurtado, Gerhard Mittler, Philippe Ravassard, Lorenzo Piemonti, Sian Ellard, Andrew T. Hattersley, Jorge Ferrer
Summary: The study shows that CC point mutations in the INS promoter cause recessive neonatal diabetes and inhibit the formation of active chromatin during pancreas development. Through investigation of the transcription factor GLIS3, it is found that it has the ability to derepress INS chromatin, which is impaired by the CC mutation.
Article
Endocrinology & Metabolism
Nicholas J. Thomas, Helen C. Walkey, Akaal Kaur, Shivani Misra, Nick S. Oliver, Kevin Colclough, Michael N. Weedon, Desmond G. Johnston, Andrew T. Hattersley, Kashyap A. Patel
Summary: By assessing the genetic risk of type 1 diabetes in autoantibody-negative and -positive individuals, the study found that autoantibody-negative adults with clinician-diagnosed type 1 diabetes had a lower genetic risk compared to autoantibody-positive adults but higher risk compared to type 2 diabetes. The presence of non-autoimmune diabetes was identified as the likely explanation for the lower rate of autoantibody positivity in adult-onset type 1 diabetes.
Article
Cell Biology
Maria C. Costanzo, Marcin von Grotthuss, Jeffrey Massung, Dongkeun Jang, Lizz Caulkins, Ryan Koesterer, Clint Gilbert, Ryan P. Welch, Parul Kudtarkar, Quy Hoang, Andrew P. Boughton, Preeti Singh, Ying Sun, Marc Duby, Annie Moriondo, Trang Nguyen, Patrick Smadbeck, Benjamin R. Alexander, MacKenzie Brandes, Mary Carmichael, Peter Dornbos, Todd Green, Kenneth C. Huellas-Bruskiewicz, Yue Ji, Alexandria Kluge, Aoife C. McMahon, Josep M. Mercader, Oliver Ruebenacker, Sebanti Sengupta, Dylan Spalding, Daniel Taliun, Philip Smith, Melissa K. Thomas, Beena Akolkar, M. Julia Brosnan, Andriy Cherkas, Audrey Y. Chu, Eric B. Fauman, Caroline S. Fox, Tania Nayak Kamphaus, Melissa R. Miller, Lynette Nguyen, Afshin Parsa, Dermot F. Reilly, Hartmut Ruetten, David Wholley, Norann A. Zaghloul, Goncalo R. Abecasis, David Altshuler, Thomas M. Keane, Mark I. McCarthy, Kyle J. Gaulton, Jose C. Florez, Michael Boehnke, Noel P. Burtt, Jason Flannick
Summary: This study aims to make the Type 2 Diabetes Knowledge Portal (T2DKP) more accessible and useful to both new and existing users. It evaluates the comprehensiveness of T2DKP by comparing its datasets with other repositories, guides researchers unfamiliar with human genetic data on how to interpret and use the data through T2DKP, and discusses the importance of democratizing access to complex disease genetic results.
Article
Critical Care Medicine
Sophie I. J. van Bakel, Hester A. Gietema, Patricia M. Stassen, Harry R. Gosker, Debbie Gach, Joop P. van den Bergh, Frits H. M. van Osch, Annemie M. W. J. Schols, Rosanne J. H. C. G. Beijers
Summary: This study found that CT scan-derived low pectoralis muscle CSA is significantly associated with higher 30-day in-hospital mortality in patients with COVID-19 independently of the 4C Mortality Score.
Article
Endocrinology & Metabolism
Xinyu Li, Anoukh van Giessen, James Altunkaya, Roderick C. Slieker, Joline W. J. Beulens, Leen M. 't Hart, Ewan R. Pearson, Petra J. M. Elders, Talitha L. Feenstra, Jose Leal
Summary: This study aimed to assess the impact of different methods of stratifying individuals with type 2 diabetes on lifetime health and economic outcomes, followed by treatment intensification targeting BMI and LDL in addition to HbA(1c). The study divided newly diagnosed individuals into data-driven clustering subgroups and risk-driven subgroups based on guidelines. The results showed that targeting BMI and LDL in addition to HbA(1c) could significantly increase quality-adjusted life-years gained.
Article
Endocrinology & Metabolism
Rosaria Gesuita, Ivana Rabbone, Vittorio Marconi, Luisa De Sanctis, Monica Marino, Valentina Tiberi, Antonio Iannilli, Davide Tinti, Lucia Favella, Carlo Giorda, Flavia Carle, Valentino Cherubini
Summary: This study analyzed the long-term trends in the incidence of type 1 diabetes in Italian children and adolescents from 1989 to 2019, and compared it with the incidence observed during the COVID-19 pandemic. The results showed an unexpected increase in new cases of type 1 diabetes in 2021, indicating the need for continuous monitoring to better understand the impact of COVID-19 on new-onset type 1 diabetes in children.
DIABETES OBESITY & METABOLISM
(2023)
Meeting Abstract
Endocrinology & Metabolism
S. Kahn, S. Del Prato, I. Pavo, D. R. Franco, Z. Yang, A. Hemmingway, R. J. Wiese, E. R. Pearson
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Correction
Endocrinology & Metabolism
Katherine G. Young, Andrew P. McGovern, Ines Barroso, Andrew T. Hattersley, Angus G. Jones, Beverley M. Shields, Nicholas J. Thomas, John M. Dennis
Editorial Material
Psychology, Developmental
Emma Grace Carey, Isobel Ridler, Tamsin Jane Ford, Argyris Stringaris
Summary: Reporting effect sizes is common in psychology and psychiatry research. However, interpreting these effect sizes can be misleading, as the evaluation of 'small', 'medium', and 'large' effect sizes can be inaccurate depending on the research context. Using simulations, this review demonstrates that even a small change in mean scores on mental health measures can indicate a significant change in the number of anxiety and depression cases when scaled up to the entire population.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Kitty Parker, Michael Nunns, ZhiMin Xiao, Tamsin Ford, Obioha C. Ukoumunne
Summary: This study aims to summarize intracluster correlation coefficient (ICC) estimates for pupil health outcomes from school-based cluster randomized trials (CRTs) across world regions. The findings showed that the distribution of school-level ICCs worldwide was similar to previous summaries from studies in the United States.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Health Care Sciences & Services
Jennifer S. Cox, Aidan Searle, Gail Thornton, Julian P. Hamilton-Shield, Elanor C. Hinton
Summary: This paper presents the development of an intervention called AIM2Change, which is based on acceptance and commitment therapy. The intervention aims to support weight-management in young people who have previously been unable to make changes while attending a weight management service for children and young people.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Endocrinology & Metabolism
Marco Marigliano, Riccardo Pertile, Enza Mozzillo, Alda Troncone, Claudio Maffeis, Elisa Morotti, Francesca Di Candia, Ludovica Fedi, Dario Iafusco, Angela Zanfardino, Vittoria Cauvin, Giulio Maltoni, Stefano Zucchini, Valentino Cherubini, Valentina Tiberi, Nicola Minuto, Marta Bassi, Ivana Rabbone, Silvia Savastio, Davide Tinti, Gianluca Tornese, Riccardo Schiaffini, Stefano Passanisi, Fortunato Lombardo, Riccardo Bonfanti, Andrea Scaramuzza, Roberto Franceschi
Summary: This study investigated the relationship between satisfaction with continuous glucose monitoring (CGM) and glucose control in pediatric patients with type 1 diabetes (T1D). The results showed that satisfaction was positively correlated with time in range and negatively correlated with glycemia risk index.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Review
Endocrinology & Metabolism
Theresa H. Moore, Sarah Dawson, Jessica Wheeler, Julian Hamilton-Shield, Timothy G. Barrett, Sabi Redwood, Ian Litchfield, Sheila M. Greenfield, Aidan Searle, Divers Diabet DID Consortium Members
Summary: This qualitative evidence synthesis aimed to explore the experiences and views of clinical encounters in diabetes care from the perspectives of children and young people with diabetes (CYPD) from underserved communities and their family/carers, as well as healthcare professionals. The study found that CYPD feel alienated in their social interactions and this impacts their experience in diabetes self-management and family/carer management. Additionally, the study highlights the importance of empowering CYPD and family/carers and integrating diabetes self-management into their daily lives.
Article
Endocrinology & Metabolism
Lieke Maas, Nele Raskin, Marloes van Onna, Dennis Cornelissen, Sandrine Bours, Trudy van der Weijden, Joop P. van den Bergh, Marsha van Oostwaard, Caroline E. Wyers, Mickael Hiligsmann, Annelies Boonen
Summary: This study describes the development of a decision aid to help patients decide whether to start anti-osteoporosis medication. The aid was well-received by patients and healthcare professionals, and could facilitate shared decision-making between patients and healthcare providers.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Richard David Leslie, Ronald Ching Wan Ma, Paul W. Franks, Kristen J. Nadeau, Ewan R. Pearson, Maria Jose Redondo
Summary: This article discusses the heterogeneity of diabetes and proposes different models for disease management. It emphasizes the importance of precision medicine in defining disease risk and complications risk, which can lead to improved health outcomes and new therapeutic approaches.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Review
Medicine, Research & Experimental
Dhanasekaran Bodhini, Robert W. Morton, Vanessa Santhakumar, Mariam Nakabuye, Hugo Pomares-Millan, Christoffer Clemmensen, Stephanie L. Fitzpatrick, Marta Guasch-Ferre, James S. Pankow, Mathias Ried-Larsen, Paul W. Franks
Summary: This systematic review examines whether sociodemographic, clinical, behavioral, and molecular factors modify the effectiveness of dietary or lifestyle interventions to prevent type 2 diabetes. The evidence suggests that individual characteristics have a low to very low impact on intervention effectiveness.
COMMUNICATIONS MEDICINE
(2023)