Review
Engineering, Biomedical
Sophia Dalfino, Paolo Savadori, Marco Piazzoni, Stephen Thaddeus Connelly, Aldo Bruno Gianni, Massimo Del Fabbro, Gianluca Martino Tartaglia, Lorenzo Moroni
Summary: Mandibular tissue engineering aims to develop synthetic substitutes for critical size defects in the mandible, and scaffold design and fabrication using additive manufacturing techniques have become the focus of research efforts. This review discusses scaffolds made with additive manufacturing techniques in mandibular tissue engineering applications, including their chemical composition, structural properties, and strategies to promote osteogenesis and vascularization. In vivo studies comparing new bone formation, defect dimensions, and animal models are also reviewed.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Jana Desnica, Sanja Vujovic, Dragana Stanisic, Irena Ognjanovic, Bojan Jovicic, Momir Stevanovic, Gvozden Rosic
Summary: This systematic review evaluated current research on regenerating critical-sized mandibular defects and discussed methodologies for mandibular bone tissue engineering. 88 studies were included and all studies that used a scaffold reported increased bone formation compared to negative controls. Combining scaffolds with growth factors and mesenchymal stem cells improved bone formation and healing. Bone morphogenic proteins were widely used and promoted significant bone formation compared to controls. However, discrepancies between studies exist due to the various methodologies and outcome measures used. The use of scaffolds with bioactive molecules and/or progenitor cells enhances success in mandibular bone engineering. Scaffold-based mandibular bone tissue engineering could be introduced into clinical practice due to its proven safety, convenience, and cost-effectiveness.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Applied
Zhixiao Yao, Yun Qian, Yi Jin, Shikun Wang, Juehong Li, Wei-En Yuan, Cunyi Fan
Summary: The use of MLT-loaded PCL/ALG composite scaffold can effectively promote tendon injury repair by controlled release of MLT, possibly relying on an antioxidant stress pathway, both in vivo and in vitro.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Biomedical
Srujan Singh, Ethan L. Nyberg, Aine N. O'Sullivan, Ashley Farris, Alexandra N. Rindone, Nicholas Zhang, Emma C. Whitehead, Yuxiao Zhou, Eszter Mihaly, Chukwuebuka C. Achebe, Wojciech Zbijewski, Will Grundy, David Garlick, Nicolette D. Jackson, Takashi Taguchi, Catherine Takawira, Joseph Lopez, Mandi J. Lopez, Michael P. Grant, Warren L. Grayson
Summary: This study evaluates a point-of-care treatment strategy for midfacial bone defects using autologous stromal vascular fraction (SVF) combined with 3D-printed bioactive scaffolds. The results demonstrate the efficacy of this approach in promoting bone regeneration and restoring the native bone structure.
Article
Nanoscience & Nanotechnology
Xinchen Wu, Olivia Gauntlett, Tengfei Zhang, Sanika Suvarnapathaki, Colleen McCarthy, Bin Wu, Gulden Camci-Unal
Summary: Scaffold-based bone regeneration using eggshell microparticles in protein-derived hydrogels significantly promotes bone regeneration by inducing osteogenic differentiation and supporting tissue infiltration over a 12-week period.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Yu Wei, Xing Yun, Yanjun Guan, Shunze Cao, Xiangling Li, Yu Wang, Haoye Meng, Yujie Liu, Qi Quan, Min Wei
Summary: This study developed a biodegradable polycaprolactone scaffold with Wnt3a protein delivery to improve tendon healing in a rat model of Achilles tendon defect. The results showed that the Wnt3a scaffold promoted the polarization of M2 macrophages, increased their recruitment and proportion, and improved tendon function and mechanical properties. This work highlights the beneficial role of local delivery of biological factors in directing inflammatory responses toward regenerative strategies in tendon healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Mansoureh Rezapourian, Nikhil Kamboj, Iwona Jasiuk, Irina Hussainova
Summary: This computational study introduces new biomimetic load-bearing implants for treating long bone critical-sized defects. The design incorporates a bone-mimicking approach for cortical bone and lattices based on triply periodic minimal surfaces (TPMS) for trabecular bone. The study explores the mechanical behavior of different structures and the effect of interior design on load-bearing capacity.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Engineering, Chemical
Ahmed Hendawy, Ayman Atiba, Walied Abdo, Amira Osman, Abdelfattah Sadakah, Ashraf Abou ElReash, Gamal Elsayad, Xiaoli Xie
Summary: The study found that MPM and Chitosan have significant effects in promoting tissue healing and regeneration in critical-sized mandibular bone defects, by enhancing bone formation and fibrous connective tissue proliferation. The downregulation of nuclear factor kappa p65 and upregulation of matrix metalloproteinase-9 were observed in both the MPM and Chitosan groups.
Article
Engineering, Biomedical
Dandan Xia, Yu Qin, Hui Guo, Peng Wen, Hong Lin, Maximilian Voshage, Johannes Henrich Schleifenbaum, Yan Cheng, Yufeng Zheng
Summary: This study fabricated pure Zn porous scaffolds with diamond structures using customized laser powder bed fusion technology. The results showed that these scaffolds have excellent mechanical properties, corrosion behavior, and biocompatibility, and promote osteogenesis, making them a promising solution for treating large bone defects.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Aakanksha Agarwal, Arun Kumar, Piyush Garg, Arnab Chakraborty, Ranjan Verma, Maryam Sarwat, Ajay Gupta, Pijus K. Sasmal, Yogesh Kumar Verma, Chiranjit Chowdhury, Monalisa Mukherjee
Summary: The study successfully loaded algal biomass into hydrogel scaffolds, creating AHS with wound healing and antibacterial properties. Experimental results showed that AHS accelerated wound healing and exhibited strong antibacterial activity on mouse wounds. Extensive characterization and studies on AHS demonstrated their excellent biocompatibility.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Xinlei Yang, Yu Zhang, Cheng Huang, Lei Lu, Junying Chen, Yajun Weng
Summary: This study proposes an innovative approach using functionalized RADA16 nanofiber to promote wound healing in diabetic patients. The functionalized nanofiber scaffold enhances adhesion and proliferation of endothelial cells and neovascularization, leading to accelerated wound closure, collagen deposition, and tissue remodeling.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jinhua Guo, Qingtao Li, Rongrong Zhang, Bing Li, Jie Zhang, Longtao Yao, Zefeng Lin, Lina Zhang, Xiaodong Cao, Bo Duan
Summary: This study proposes a gentle pre-cross-linking strategy to enable cellulose hydrogels with favorable printability and strong network, achieved by mediating cellulose self-assembly. The printed hydrogels exhibit superior mechanical properties, design flexibility, and potential applications in tissue engineering.
Review
Biochemistry & Molecular Biology
Shabnam Anjum, Farheen Rahman, Prashant Pandey, Dilip Kumar Arya, Mahmood Alam, Paruvathanahalli Siddalingam Rajinikanth, Qiang Ao
Summary: This review examines the application of electrospun nanofibrous scaffolds in bone tissue engineering, demonstrating their potential for bone tissue regeneration. Nanofibrous scaffolds provide a natural environment for cell adhesion and function, and drug/growth factor delivery is also highlighted as a significant application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Deyin Kong, Qing Wang, Jiangeng Huang, Zhihui Zhang, Xiebin Wang, Qing Han, Yanbin Shi, Ran Ji, Yiling Li
Summary: This study investigates the mechanical properties and bone reconstruction performance of bionic bone scaffolds, focusing on those that mimic the structural features of natural cancellous bone. The results show that bionic scaffolds with specific structural parameters perform well in bone defect reconstruction and have potential for clinical application.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Polymer Science
Ozgur Basal, Ozlem Ozmen, Aylin M. Deliormanli
Summary: In this study, graphene-coated bioactive glass scaffolds were found to enhance bone formation in rat femur defects. The highest amount of bone formation was observed in the group containing 10 wt% graphene.
Article
Otorhinolaryngology
Seden Akdagli, Matthew K. Lee, Sam P. Most
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2015)
Article
Otorhinolaryngology
Josh Surowitz, Matthew K. Lee, Sam P. Most
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2015)
Article
Surgery
Matthew K. Lee, Sam P. Most
FACIAL PLASTIC SURGERY CLINICS OF NORTH AMERICA
(2015)
Article
Otorhinolaryngology
Ali Razfar, Matthew K. Lee, Guy G. Massry, Babak Azizzadeh
OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA
(2016)
Article
Cell & Tissue Engineering
Jiabing Fan, Hyejin Park, Matthew K. Lee, Olga Bezouglaia, Armita Fartash, Jinku Kim, Tara Aghaloo, Min Lee
TISSUE ENGINEERING PART A
(2014)
Article
Otorhinolaryngology
Adam S. DeConde, Matthew K. Lee, Douglas Sidell, Tara Aghaloo, Min Lee, Sotirios Tetradis, Kyle Low, David Elashoff, Tristan Grogan, Ali R. Sepahdari, Maie St John
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2014)
Article
Otorhinolaryngology
Michela Borrelli, Jonathan Y. Ting, Cyrus C. Rabbani, Bruce K. Tan, Thomas S. Higgins, Evan S. Walgama, Gene C. Liu, Henry H. Chen, Matthew K. Lee, Martin L. Hopp, Elisa A. Illing, James Mirocha, Arthur W. Wu
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2020)
Article
Otorhinolaryngology
Kyohei Itamura, Dennis M. Tang, Thomas S. Higgins, Franklin L. Rimell, Elisa A. Illing, Jonathan Y. Ting, Matthew K. Lee, Arthur Wu
Summary: Virtual otolaryngology clinic visits showed worse evaluations in provider listening, conveyance of information, likelihood to recommend, and overall provider ratings compared to in-person visits, highlighting challenges with interpersonal communication in telehealth practice.
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
(2021)
Article
Otorhinolaryngology
Ariel M. Azhdam, Gene C. Liu, Matthew K. Lee
Summary: Nasal septoplasty and inferior turbinate reduction are common procedures for nasal obstruction and are generally safe with minimal complications. However, a case of transient unilateral mydriasis following these procedures in a 43-year-old female was reported, likely due to sympathomimetic agents used during the surgery.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2021)
Letter
Medicine, Research & Experimental
Ariel M. Azhdam, Amir A. Hakimi, Deborah X. Xie, Matthew K. Lee
Article
Otorhinolaryngology
Tasha S. Nasrollahi, Matthew K. Lee, Gene C. Liu
Summary: Virtual Reality (VR) is an emerging technology that creates simulated experiences for the user, but prolonged use of VR hardware can lead to nasal bone remodeling. This case study highlights the importance of considering the potential physical health effects of VR use.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Article
Medicine, General & Internal
Jonathan Raskin, Kaitlynne Pak, Matthew Kun Lee
Summary: Superficial temporal artery (STA) pseudoaneurysms are rare vascular lesions that typically occur after traumatic head injury. Surgery is the recommended treatment as spontaneous resolution is not commonly observed. This study presents a literature review on STA pseudoaneurysms and reports a case of traumatic STA pseudoaneurysm that resolved spontaneously without direct intervention.
Article
Surgery
Matthew K. Lee, Sam P. Most
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2016)
Article
Dentistry, Oral Surgery & Medicine
Ryan Williams, Matthew K. Lee, Sam P. Most
CRANIOMAXILLOFACIAL TRAUMA & RECONSTRUCTION
(2016)
Article
Otorhinolaryngology
Jason Lee, Alia Tayara, James D. Warren, Boris Kuyeb, Elizabeth McKee, Alexander Velazquez, Oishika Paul, Andrea F. Lewis
Summary: The purpose of the study was to understand the impact of COVID-19 on facial trauma incidence and etiology in Mississippi. The research found a significant increase in facial trauma caused by family members during the pandemic, which may be related to the reported increase in domestic violence. Additionally, there were notable changes in the etiology and insurance payor of facial trauma cases during the COVID-19 pandemic.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Sheila Moran, Cassidy Anderson, Risha Sheni, Monica Azmy, Daniel T. Li, Anthony M. Loizides, Christina J. Yang
Summary: This retrospective study found that a family history of eczema and a dairy-free diet may be associated with an increased risk of future diagnosis of EoE in children with aerodigestive dysfunction.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Robert Brinton Fujiki, Amanda Edith Fujiki, Susan L. Thibeault
Summary: This study examined the number of therapy sessions required for patients with EILO/ILO to sufficiently improve their symptoms. The results showed that patients with comorbid behavioral health diagnosis, higher vocal handicap index score, and reduced physical activity due to EILO/ILO symptoms required more therapy sessions. Patients with secondary environmental triggers also required more sessions. Only a small percentage of patients returned for additional therapy sessions after discharge, and they were mostly from affluent neighborhoods.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Brian W. Herrmann, Salina H. Goff, Juri Boguniewicz, Sarah A. Gitomer
Summary: This retrospective case series analyzed nHiB H. influenzae meningitis cases diagnosed at Children's Hospital Colorado from 2000 to 2020. The results showed that nHiB H. influenzae can cause both transient and permanent postmeningitic hearing loss. The use of steroids may offer otoprotection in nHiB H. influenzae meningitis. Further research is needed to better understand hearing outcomes after nHiB H. influenzae meningitis.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
M. Kovacs, J. Uzsaly, G. Bodzai, I. Pap, B. Lippai, T. Dergez, A. Nemeth, I. Gerlinger, I. Szanyi, P. Bako
Summary: The pathophysiology and treatment of idiopathic sudden sensorineural hearing loss (ISSNHL) are still debated. A randomized controlled trial showed no significant differences in hearing improvement between different treatments, but identified clinical factors such as vertigo, cardiovascular comorbidity, and initial hearing loss severity as significant predictors of hearing outcomes.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Roee Noy, Yotam Shkedy, Nadeem Habashi, Salem Billan, Jacob Cohen
Summary: Salvage cordectomy offers favorable larynx preservation rates and oncological outcomes for recurrent glottic cancer amenable to conservative surgery. Smoking, advanced age, and advanced tumor stages are associated with salvage cordectomy failure.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Pietro De Luca, Ignazio La Mantia, Federico Maria Gioacchini, Massimo Re, Marco Radici, Angelo Camaioni, Arianna Di Stadio
Summary: In this study, the effect of nasal packaging using Fitostimoline (R) gauze on nasal outcomes after septoplasty and FESS surgery was evaluated. The results showed that the use of Fitostimoline (R) gauze improved healing of nasal mucosa and reduced discomfort during tampon removal.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Anna Frants, Antonios N. Varelas, Alexa M. Franco, W. Matthew White, Minas S. Constantinides, Philip J. Miller, Judy W. Lee
Summary: This article introduces DESS as a new educational format to increase the comfort of residents with the surgical evaluation and intraoperative planning of rhinoplasty. Through DESS, residents display significant improvement in their comfort with facial nasal analysis and overall surgical preparation.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Zhengcai Lou, Zihan Lou, Tian Lv, Zhengnong Chen
Summary: This study compared the operation time, graft success, audiometric outcomes, and complications of the over-under technique using temporalis fascia and cartilage grafts for repairing large perforations. The results showed that both techniques had similar graft success rates and hearing outcomes, but the temporalis fascia graft technique prolonged the operation time and increased the risk of re-perforation and graft atelectasis.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Review
Otorhinolaryngology
Ciaran Lane, Maxwell Wright, Janice Linton, Neerav Goyal
Summary: This study systematically reviewed the data on surgical closure of enlarged tracheoesophageal fistula after laryngectomy and compared different reconstruction techniques. The results showed that using vascularized tissue for reconstruction had a higher success rate compared to primary closure.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Review
Otorhinolaryngology
John Q. Odom, Andrew R. Mangan, Anna Celeste Gibson, Michael Larson, John L. Dornhoffer, Robert A. Saadi
Summary: Granulomatosis with polyangiitis is often associated with otolaryngologic complaints, and in rare cases, patients may experience facial nerve palsy. It is important for healthcare professionals to recognize facial nerve palsy as a potential presentation of granulomatosis with polyangiitis.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
R. Bar, A. Mattei, R. Haddad, A. Giovanni
Summary: Office-based flexible interventional laryngoscopy under local anesthesia is a safe and well-tolerated procedure, suitable for various ambulatory and office-based settings.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Review
Otorhinolaryngology
Do Hyun Kim, Soo Whan Kim, Sung Won Kim, Gulnaz Stybayeva, Se Hwan Hwang
Summary: This systematic review and meta-analysis compared the effects of cryotherapy and radiofrequency neurolysis in treating rhinitis-related symptoms caused by ablation of the posterior nasal nerves. The results showed that both cryotherapy and radiofrequency neurolysis significantly improved rhinitis-related symptoms and quality of life. Radiofrequency neurolysis was found to be more effective than cryotherapy in reducing total nasal symptom scores.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Mengdie Gao, Liyu Cheng, Qingcui Wang, Qingwen Yang, Xiaoyi Wang, Yanru Li, Rong Hu, Wen Xu
Summary: This study investigates the clinical characteristics, diagnosis, and prognosis of patients with laryngeal tuberculosis (LTB) combined with respiratory tuberculosis. The study found that LTB commonly affects middle-aged men and presents with symptoms such as hoarseness, abnormal sensation of pharyngeal, and pharyngalgia. The lesions mainly involve multiple subregions, primarily the glottis, and can also involve the pharynx. Half of the patients were complicated with pulmonary tuberculosis (PTB), and chest CT was superior to X-ray in detecting pulmonary lesions. Most patients showed significant improvement in symptoms and morphology of the pharyngeal and laryngeal mucosa after regular anti-tuberculosis treatment.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Alfonso Scarpa, Emilio Avallone, Mario Carucci, Giovanni Salzano, Giuseppe Chiarella, Claudia Cassandro, Pasquale Viola, Filippo Ricciardiello, Massimo Ralli, Pietro De Luca, Francesco Antonio Salzano
Summary: This study assessed the efficacy and safety of low-dose intratympanic gentamicin for vertigo attacks in Meniere's disease. The treatment significantly reduced vertigo attacks without causing hearing deterioration. The method primarily affected vestibular function while preserving cochlear integrity. These findings suggest that a low-dose, clinical symptomatology-based gentamicin treatment regimen could be an effective and safe strategy for managing unilateral Meniere's disease.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)