Article
Surgery
Matteo Di Nardo, Lorenzo Del Sorbo, Andrew Sage, Jin Ma, Mingyao Liu, Jonathan C. Yeung, Jerome Valero, Rasheed Ghany, Marcelo Cypel, Shaf Keshavjee
Summary: This study developed a mathematical model (EXPIRE model) using ex vivo lung perfusion technique to predict lung acceptance, which was successfully validated in a separate cohort. The model may help standardize lung assessment and improve transplant rates in centers using the Toronto EVLP technique.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Engineering, Biomedical
Bassam Shukrallah, Asvin M. Ganapathi, Bryan A. Whitson
Summary: The creation of a new pulmonary artery conduit using the donor aorta can alleviate the issue of inadequate pulmonary artery for ex vivo lung perfusion. This technique will become increasingly important as donation after circulatory death donor (DCD) heart procurements become more common. Time constraints associated with DCD recovery approach may lead to the necessity of this new pulmonary artery conduit.
Article
Cell Biology
Stephan Arni, Tatsuo Maeyashiki, Tsogyal Latshang, Isabelle Opitz, Ilhan Inci
Summary: This study found that using diazoxide during ex vivo lung perfusion significantly reduced pulmonary vascular resistance and lung weight loss, while using 5-HD significantly reduced interleukin levels. Diazoxide also decreased levels of calcium, potassium, chlorine, and lactate, although not significantly.
Article
Cell Biology
Stephan Arni, Tatsuo Maeyashiki, Necati Citak, Isabelle Opitz, Ilhan Inci
Summary: The study found that subnormothermic EVLP at 28 degrees Celsius improved lung function and inflammatory parameters, which were also observed post left lung transplantation.
Article
Cardiac & Cardiovascular Systems
Shuji Okahara, Bronwyn Levvey, Mark McDonald, Rohit D'Costa, Helen Opdam, David Pilcher, Gregory Snell
Summary: The study found that 70% of recipients met at least one commonly cited criterion for EVLP initiation, but this did not predict clinical outcomes; acceptable results were seen in both subgroups. Reconsideration of EVLP inclusion criteria is needed to discover its true utility beyond good clinical management.
ANNALS OF THORACIC SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Caterina Lonati, Michele Battistin, Daniele E. Dondossola, Giulia A. Bassani, Daniela Brambilla, Riccardo Merighi, Patrizia Leonardi, Andrea Carlin, Marica Meroni, Alberto Zanella, Anna Catania, Stefano Gatti
Summary: The study found that treatment with the synthetic melanocortin analogue reduced inflammatory mediator release and leukocyte count, as well as lactate production in damaged lungs. Moreover, the treatment increased ATP content in injured lungs and significantly improved vascular and airway parameters in lungs from cardiac death donors. The results suggest that melanocortin system activation during ex vivo lung perfusion could enhance the quality of marginal lungs for transplantation.
Article
Cardiac & Cardiovascular Systems
Robert Qaqish, Yui Watanabe, Konrad Hoetzenecker, Jon Yeung, Manyin Chen, Andrew Pierre, Kazuhiro Yasufuku, Laura Donahoe, Marc de Perrot, Tom Waddell, Shaf Keshavjee, Marcelo Cypel
Summary: Short- and long-term outcomes are similar between recipients of lungs from donation after neurologic determination of death and donation after circulatory determination of death. Different intervals between withdrawal of life-sustaining therapies and cardiac arrest did not impact recipient outcomes, and the maximum acceptable duration of this interval remains to be established.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Surgery
Oliver K. Jawitz, Vignesh Raman, David Becerra, Julie Doberne, Ashley Y. Choi, Samantha E. Halpern, Jacob A. Klapper, Matthew G. Hartwig
Summary: This study examines early lung transplant outcomes following EVLP using a large national transplant registry. The results show that EVLP recipients have comparable early outcomes to non-EVLP recipients with similar baseline characteristics. Long-term follow-up data is needed to further assess the impact of EVLP on post-lung transplant outcomes.
Article
Immunology
Alessandro Palleschi, Lorenzo Rosso, Giulia Maria Ruggeri, Giorgio Alberto Croci, Valeria Rossetti, Giuseppe Citerio, Giacomo Grasselli, Mario Nosotti, Alberto Zanella
Summary: Uncontrolled donation after circulatory death (DCD) donors present a potential source of increased lung transplantation resources, but pose challenges due to warm ischemia and organ preservation issues. Utilizing ex vivo lung perfusion (EVLP) for lung evaluation and reconditioning can help extend the storage time of potentially transplantable lungs.
Review
Cardiac & Cardiovascular Systems
Sarah E. Scheuer, Paul C. Jansz, Peter S. Macdonald
Summary: Heart transplantation from DCD donors is a rapidly expanding practice with excellent outcomes, and is expected to become a major source of heart donation worldwide. Current protocols and methods have contributed to comparable outcomes to DBD heart transplants.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Surgery
Naissa Abdoul, Camille Legeai, Christelle Cantrelle, Olaf Mercier, Anne Olland, Pierre Mordant, Pascal Alexandre Thomas, Jacques Jougon, Adrien Tissot, Jean-Michel Maury, Edouard Sage, Richard Dorent
Summary: Donors whose lungs were transplanted after EVLP had similar profiles to those whose lungs were declined, but were quite different from donors with lungs transplanted without EVLP. Predictors for graft nonuse included age ≥ 50 years, smoking history, PaO2/FiO(2) ratio ≤ 300 mmHg, abnormal chest imaging, and purulent secretions. EVLP was found to increase the utilization of lungs from donors with a smoking history, PaO2/FiO(2) ratio ≤ 300 mmHg, and abnormal chest imaging.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Lars Saemann, Sevil Korkmaz-Icoz, Fabio Hoorn, Gabor Veres, Patricia Kraft, Adrian-Iustin Georgevici, Maik Brune, Yuxing Guo, Sivakkanan Loganathan, Folker Wenzel, Matthias Karck, Gabor Szabo
Summary: The study showed that using HTK-N solution for machine perfusion can improve contractility of CD-hearts, reduce oxidative and nitrosative stress, and prevent cardiomyocyte swelling and necrosis.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Respiratory System
Ei Miyamoto, Akihiro Takahagi, Akihiro Ohsumi, Tereza Martinu, David Hwang, Kristen M. Boonstra, Betty Joe, Juan Mauricio Umana, Ke F. Bei, Daniel Vosoughi, Mingyao Liu, Marcelo Cypel, Shaf Keshavjee, Stephen C. Juvet
Summary: Pre-transplant administration of recipient-derived Tregs through EVLP can maintain their immunomodulatory function within the donor lungs.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Cell Biology
Aizhou Wang, Rafaela V. P. Ribeiro, Aadil Ali, Edson Brambate, Etienne Abdelnour-Berchtold, Vinicius Michaelsen, Yu Zhang, Peter Rahfeld, Haisle Moon, Hemant Gokhale, Anajara Gazzalle, Prodipto Pal, Mingyao Liu, Thomas K. Waddell, Christine Cserti-Gazdewich, Kathryn Tinckam, Jayachandran N. Kizhakkedathu, Lori West, Shaf Keshavjee, Stephen G. Withers, Marcelo Cypel
Summary: The enzymes FpGalNAc deacetylase and FpGalactosaminidase can effectively remove A antigen from donor lungs, potentially expanding ABO-incompatible lung transplantation and improving fairness of organ allocation. The removal of A antigen was achieved through ex vivo lung perfusion treatment and showed positive results in reducing antibody-mediated rejection.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Stephan Arni, Tatsuo Maeyashiki, Isabelle Opitz, Ilhan Inci
Summary: The study compared the effects of EVLP at different temperatures on lung organ preservation and function, finding that 28 degrees Celsius EVLP performed well in terms of biochemical, clinical, and immunological parameters, potentially reducing I/R injuries in DCD lung donors.
Editorial Material
Cardiac & Cardiovascular Systems
Dirk Van Raemdonck, Laurens J. Ceulemans, Robin Vos, Geert M. Verleden
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Editorial Material
Surgery
Michaela Orlitova, Marc Gewillig, Jan Van Slambrouck, Dirk Vlasselaers, Bart Jacobs, Arne P. Neyrinck, Lieven Depypere, Laurent Godinas, Robin Vos, Geert M. Verleden, Dirk E. Van Raemdonck, Laurens J. Ceulemans
Summary: Pulmonary vein stenosis (PVS) and pulmonary vein occlusion (PVO) are rare complications after lung transplantation (LTx) with limited treatment options and a high risk of graft loss. We describe two cases of successful endovascular transatrial stenting following double LTx. Both patients, one with chronic obstructive pulmonary disease and the other with idiopathic pulmonary arterial hypertension, underwent endovascular transatrial dilatation and stenting to treat PVS and PVO respectively, avoiding the need for surgical reintervention. This treatment option appears to be effective and safe for these life-threatening complications after LTx.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Oncology
Tom Vandaele, Jan Van Slambrouck, Viktor Proesmans, Paul Clement, Maarten Lambrecht, Philippe Nafteux, Dirk Van Raemdonck, Laurens J. Ceulemans
Summary: This review provides an overview of the current literature on hyperthermic intrathoracic chemotherapy (HITHOC) for thymoma with pleural dissemination (TPD). The results suggest that combining cytoreductive surgery and HITHOC is feasible and safe for TPD, but there is significant heterogeneity in the literature, calling for further research to better understand the additional benefit of HITHOC in TPD treatment.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Tom Vandaele, Jan Van Slambrouck, Viktor Proesmans, Paul Clement, Maarten Lambrecht, Philippe Nafteux, Dirk Van Raemdonck, Laurens J. Ceulemans
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Laura P. M. H. de Rooij, Lisa M. Becker, Laure Anne Teuwen, Bram Boeckx, Sander Jansen, Simon Feys, Stijn Verleden, Laurens Liesenborghs, Anna K. Stalder, Sasha Libbrecht, Tina Van Buyten, Gino Philips, Abhishek Subramanian, Sebastien J. Dumas, Elda Meta, Mila Borri, Liliana Sokol, Amelie Dendooven, Anh Co K. Truong, Jan Gunst, Pierre Van Mol, Jasmin D. Haslbauer, Katerina Rohlenova, Thomas Menter, Robbert Boudewijns, Vincent Geldhof, Stefan Vinckier, Jacob Amersfoort, Wim Wuyts, Dirk Van Raemdonck, Werner Jacobs, Laurens J. Ceulemans, Birgit Weynand, Bernard Thienpont, Martin Lammens, Mark Kuehnel, Guy Eelen, Mieke Dewerchin, Luc Schoonjans, Danny Jonigk, Jo van Dorpe, Alexandar Tzankov, Els Wauters, Massimiliano Mazzone, Johan Neyts, Joost Wauters, Diether Lambrechts, Peter Carmeliet
Summary: This study provides new insights into the abundance, expression patterns, and interactomes of endothelial cell (EC) subtypes in COVID-19 and idiopathic pulmonary fibrosis (IPF). The findings suggest the importance of ECs in the pathophysiology of both conditions and may contribute to future investigations into the progression and treatment of COVID-19 and IPF.
CARDIOVASCULAR RESEARCH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Jan Van Slambrouck, Marianne S. Carlon, Dirk Van Raemdonck, Laurens J. Ceulemans
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Biophysics
Lauranne Maes, Thibault Vervenne, Lucas Van Hoof, Elizabeth A. V. Jones, Filip Rega, Nele Famaey
Summary: The pulmonary autograft in the Ross procedure is prone to failure due to dilatation caused by tissue degradation and maladaptation triggered by higher mechanical loads. The study presents a model for tissue growth and remodeling of the pulmonary autograft using a mixture theory and equations for mass turnover mediated by immune and mechanical factors. The outcomes of the model suggest that inflammation plays an important role in the autograft dilatation over time.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Cell Biology
Dmitry Bobylev, Alexander Horke, Murat Avsar, Tomislav Cvitkovic, Dietmar Boethig, Mark Hazekamp, Bart Meyns, Filip Rega, Hitendu Dave, Martin Schmiady, Anatol Ciubotaru, Eduard Cheptanaru, Vladimiro Vida, Massimo Padalino, Victor Tsang, Ramadan Jashari, Guenther Laufer, Martin Andreas, Alexandra Andreeva, Igor Tudorache, Serghei Cebotari, Axel Haverich, Samir Sarikouch
Summary: Bovine jugular vein conduits (BJV) and decellularized pulmonary homografts (DPH) are two commonly used options for pulmonary valve replacement (PVR) in congenital heart disease. Comparison of patients receiving DPH and BJV for PVR showed that DPH had a higher survival rate after 10 years, lower rates of endocarditis, explantation, and degeneration. In a subgroup analysis, DPH showed 20% higher freedom from explantation and degeneration compared to BJV. Decellularized pulmonary homografts are superior to bovine jugular vein conduits in PVR based on 10-year results.
CELL AND TISSUE BANKING
(2023)
Article
Virology
Benedict Vanlerberghe, Casper Vrij, Kris Bogaerts, Pieter Vermeersch, Katrien Lagrou, Geert Molenberghs, Filip Rega, Laurens J. Ceulemans, Dirk van Raemdonck, Ina Jochmans, Diethard Monbaliu, Jacques Pirenne, Tim Vanuytsel, Pieter Gillard, Helene Schoemans, Johan Van Cleemput, Dirk Kuypers, Robin Vos, Frederik Nevens, Jef Verbeek
Summary: This observational study investigated the effectiveness of SARS-CoV-2 vaccines and breakthrough infections in transplant recipients. It found significant variations in antibody response rates and rates of severe infections among different transplant types, which were modulated by specific risk factors. These findings highlight the importance of tailored COVID-19 prevention measures for transplant recipients.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Physiology
Michaela Orlitova, Tom Verbelen, Anna E. Frick, Arno Vanstapel, Dieter Van Beersel, Sofie Ordies, Jan Van Slambrouck, Janne Kaes, Xin Jin, Walter Coudyzer, Stijn E. Verleden, Geert M. Verleden, Bart M. Vanaudenaerde, Dirk E. Van Raemdonck, Robin Vos, Laurens J. Ceulemans, Piet Claus, Arne P. Neyrinck
Summary: Lung transplantation is a challenging procedure and can result in severe damage to the transplanted pulmonary graft. The interaction between right ventricular function and lung injury during the transplantation process is poorly understood. Through a translational porcine model, it was found that right ventricular failure can occur as a result of forcing the entire cardiac output through a lung suffering from ischemia-reperfusion injury. The study also revealed a delicate balance between the development of pulmonary ischemia-reperfusion injury and right ventricular function, highlighting the potential benefits of extracorporeal life support technology in these cases.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Meeting Abstract
Critical Care Medicine
C. De Fays, H. Beeckmans, P. Kerckhof, V. Geudens, A. Vermaut, I. Gyselinck, T. Goos, M. Vermant, J. Kaes, J. Van Slambrouck, Y. Mohamady, L. Willems, L. Aversa, K. Maes, C. Aelbrecht, S. Everaerts, J. E. Mcdonough, L. J. De Sadeleer, S. Gohy, J. Ambroise, W. A. Wuyts, W. L. Janssens, L. J. Ceulemans, D. E. M. Van Raemdonck, R. Vos, T. Hackett, J. C. Hogg, N. Kaminski, C. Pilette, G. Gayan-Ramirez, B. Vanaudenaerde
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Annalisa Barbarossa, Dirk Van Raemdonck, Walter Weder, Laurens J. Ceulemans
Summary: Secondary pneumothorax due to emphysema is a life-threatening condition that often requires surgery. In this case, we used LVRS to not only remove part of the lung but also close the fistula. The patient experienced improved lung function and quality of life after urgent and elective LVRS surgeries, with resolution of the air leak.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Villavicencio, A. Kashem, G. Loor, E. D'Silva, M. Hartwig, K. Ghadimi, F. Ius, S. Jawad, N. Langer, A. Osho, S. Chandrashekaran, T. Machuca, P. Sanchez, K. Subramaniam, D. Van Raemdonck, A. Neyrinck, S. Huddleston, A. Shaffer, B. Lahr, Y. Toyoda
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
H. Beeckmans, P. Kerckhof, J. McDonough, L. De Sadeleer, J. Kaes, A. Sacreas, C. Aelbrecht, A. Vanstapel, K. Maes, H. Schoemans, E. Wauters, A. Neyrinck, G. Verleden, L. Dupont, L. Godinas, D. Van Raemdonck, B. Vanaudenaerde, R. Vos
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
N. D. de Manna, D. Van Raemdonck, M. Hartwig, B. Bottiger, G. Loor, A. Leon, M. Villavicencio, N. Langer, A. Emtiazjoo, S. Chandrashekaran, A. Neyrinck, Y. Toyoda, A. Kashem, S. Huddleston, P. Sanchez, K. Subramaniam, G. Warnecke, F. Ius
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
