Review
Cardiac & Cardiovascular Systems
Mario Cazzola, Maria Gabriella Matera
Summary: Clinically important deterioration (CID) is a composite tool used for measuring COPD progression, which can improve treatment choices for COPD patients. Studies suggest that dual bronchodilation should be preferred over a single bronchodilator for reducing clinical deterioration, and if ineffective, triple therapy with an inhaled corticosteroid can prevent CID, particularly in patients with high blood eosinophil counts.
RESPIRATORY MEDICINE
(2022)
Article
Respiratory System
MeiLan K. Han, Gerard J. Criner, Mark T. Dransfield, David M. G. Halpin, Christine E. Jones, Sally Kilbride, Peter Lange, Sally Lettis, David A. Lipson, David A. Lomas, Neil Martin, Fernando J. Martinez, Robert A. Wise, Ian P. Naya, Dave Singh
Summary: This study investigated the prognostic value of CID events in COPD patients and the impact of triple versus dual therapy on reducing CID risk. The results showed that patients with CID at week 28 had higher exacerbation rates, smaller improvements in lung function and health status at week 52, and increased risk of all-cause mortality after week 28. FF/UMEC/VI significantly reduced CID risk compared to dual therapies, potentially improving long-term prognosis in this population.
Article
Respiratory System
Yuki Abe, Masaru Suzuki, Hironi Makita, Hirokazu Kimura, Kaoruko Shimizu, Satoshi Konno, Masaharu Nishimura
Summary: This study investigated the relationship between 1-year CID and long-term clinical outcomes in Japanese COPD patients. The results showed that CID was predictive of mortality and exacerbation risk in these patients.
BMC PULMONARY MEDICINE
(2021)
Article
Medicine, Research & Experimental
Klaus F. Rabe, James D. Chalmers, Marc Miravitlles, Janwillem W. H. Kocks, Ioanna Tsiligianni, Alberto de la Hoz, Wenqiong Xue, Dave Singh, Gary T. Ferguson, Jadwiga Wedzicha
Summary: In patients with COPD, including those with low exacerbation history, GOLD 2 patients and maintenance-naive patients, tiotropium/olodaterol reduced the risk of clinically important deterioration compared to tiotropium alone. The study highlights the benefits of treatment optimization with tiotropium/olodaterol over tiotropium monotherapy.
ADVANCES IN THERAPY
(2021)
Review
Respiratory System
Gian Marco Manzetti, Josuel Ora, Arianna Sepiacci, Mario Cazzola, Paola Rogliani, Luigino Calzetta
Summary: The aim of this study was to investigate the impact of aging on clinically important deterioration (CID) in patients with Chronic Obstructive Pulmonary Disease (COPD). Data from a large number of COPD patients were analyzed, and the findings suggest that inhaled therapy can effectively reduce the risk of CID in COPD patients, although this protective effect may be compromised in older patients with impaired lung function. Further research is needed to confirm these results.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Article
Medicine, General & Internal
Konstantinos Bartziokas, Christos Kyriakopoulos, Evangelia Dounousi, Konstantinos Kostikas
Summary: The presence of MAB in patients with AECOPD is associated with more severe COPD, prolonged hospitalization, and increased risk of AECOPD and mortality at 1-year follow-up.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Respiratory System
Konstantinos Kostikas, Katerina Dimakou, Konstantinos Gourgoulianis, Mina Gaga, Dimosthenis Papapetrou, Georgios Tsoukalas, Panagiotis Chatziapostolou, Antonios Antoniadis, Georgios Meletis, Efstathia Evangelopoulou, Panagiota Styliara, Ilektra Karypidou, Athena Gogali, Konstantinos Kalafatakis, Nikolaos Tzanakis
Summary: The purpose of this study was to investigate the prevalence of daily and night symptoms and quality of sleep in Greek COPD patients and evaluate their response to treatment with aclidinium/formoterol. After 3 months of treatment, a significant improvement in symptoms and quality of life was observed, and patients reported high satisfaction and compliance with the treatment.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Respiratory System
Konstantinos Kostikas, Petros Bakakos, Petros Galanakis, Georgios Hillas, George N. Konstantinou, Michael Makris, Nikolas Mathioudakis, Konstantinos Porpodis, Nikoletta Rovina, Eleftherios Zervas, Stelios Loukides
Summary: This study aims to evaluate the clinical effectiveness and patient-perceived impact of benralizumab on severe eosinophilic asthma patients in routine care settings in Greece. Advanced remote patient monitoring technologies will be used to collect data on lung function and physical activity.
Article
Respiratory System
Efthymia Papadopoulou, Jan Hansel, Zsofia Lazar, Konstantinos Kostikas, Stavros Tryfon, Jurgen Vestbo, Alexander G. Mathioudakis
Summary: This meta-analysis explored the safety and effectiveness of mucolytics as an add-on treatment for COPD exacerbations. The analysis included 24 RCTs involving 2192 patients and showed that mucolytics can increase treatment success rate, improve symptom scores, reduce persistent cough, and facilitate expectoration. There is also some evidence suggesting that mucolytics may reduce future exacerbation risk and improve quality of life.
EUROPEAN RESPIRATORY REVIEW
(2023)
Letter
Critical Care Medicine
Konstantinos Kostikas, Athena Gogali, Georgios Hillas
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Respiratory System
Athena Gogali, Konstantinos Kostikas
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Richard N. Van Zyl-Smit, Huib AM. Kerstjens, Jorge F. Maspero, Konstantinos Kostikas, Motoi Hosoe, Ana-Maria Tanase, Peter Andrea, Karen Mezzi, Dominic Brittain, David Lawrence, Kenneth R. Chapman
Summary: This study evaluated the efficacy of a fixed-dose combination therapy of mometasone furoate/indacaterol acetate/glycopyrronium bromide in asthma patients with and without persistent airflow limitation. The results showed that this therapy improved lung function and reduced asthma exacerbations in patients with airflow limitation.
RESPIRATORY MEDICINE
(2023)
Article
Health Care Sciences & Services
Konstantinos Bartziokas, Evgenia Papathanasiou, Andriana I. I. Papaioannou, Ilias Papanikolaou, Emmanouil Antonakis, Ioanna Makou, Georgios Hillas, Theodoros Karampitsakos, Ourania Papaioannou, Katerina Dimakou, Vasiliki Apollonatou, Galateia Verykokou, Spyros Papiris, Petros Bakakos, Stelios Loukides, Konstantinos Kostikas
Summary: In recent years, blood eosinophils have been studied as a biomarker for eosinophilic airway inflammation and a prognostic indicator for COPD outcomes. This study found that low blood eosinophil levels upon admission for COPD exacerbation were associated with more severe disease and predicted the need for NIV. Further research is needed to confirm the use of blood eosinophil levels as a predictor of unfavorable outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Ophthalmology
M. Dominik Fischer, Francesco Patalano, Christel Naujoks, Judit Banhazi, Christine Bouchet, Paul O'Brien, Christine Kay, Jane Green, Todd Durham, Helena Bradley, Nicola Williamson, Melissa Barclay, Joel Sims, Isabelle Audo
Summary: This study explores the psychometric properties of the ViSIO-PRO and ViSIO-ObsRO instruments in RP/LCA. The findings suggest that the questionnaires are reliable and valid measures in RP/LCA, and further research is needed to examine their responsiveness and interpretation of change scores.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Christos Ballas, Lampros Lakkas, Olga Kardakari, Athanasios Konstantinidis, Konstantinos Exarchos, Stavroula Tsiara, Konstantinos Kostikas, Katerina K. Naka, Lampros K. Michalis, Christos S. Katsouras
Summary: This study evaluated non-conventional markers of right ventricular dysfunction in patients with acute pulmonary embolism. The results showed that a majority of patients had abnormal right ventricular function, which was associated with clinical and biochemical prognostic indices.
Article
Respiratory System
Alberto Papi, Diogenes S. Ferreira, Ioana Agache, Eugenio Baraldi, Richard Beasley, Guy Brusselle, Courtney Coleman, Mina Gaga, Carolina Maria Gotera Rivera, Erik Melen, Ian D. Pavord, Deborah Penate Gomez, Daniel Schuermans, Antonio Spanevello, Thomy Tonia, Florence Schleich
Summary: Recent clinical trials have shown that using as-needed ICS/formoterol could be a potential treatment option for mild asthma. The European Respiratory Society's Task Force has provided evidence-based recommendations, suggesting that adults with mild asthma should use as-needed ICS/formoterol instead of regular ICS maintenance treatment plus as-needed SABA, while adolescents can choose either as-needed ICS/formoterol or ICS maintenance treatment plus as-needed SABA.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Konstantinos Kostikas, Jorge F. Maspero, Kenneth R. Chapman, Karen Mezzi, Xavier Jaumont, David Lawrence, Richard van Zyl-Smit
Summary: This study evaluated the impact of baseline eosinophil levels on the efficacy of mometasone/indacaterol/glycopyrronium in patients with asthma. The results showed that eosinophil levels did not affect the effectiveness of the medication.
RESPIRATORY MEDICINE
(2023)
Letter
Respiratory System
Stavros Tryfon, Efthymia Papadopoulou, Maria Bertoli, Konstantinos Exarchos, Alexandros Ginis, Konstantinos Kostikas
Article
Medicine, General & Internal
Vagia Karageorgou, Andriana I. Papaioannou, Maria Kallieri, Myrto Blizou, Stefanos Lampadakis, Maria Sfika, Antonios Krouskos, Vasileios Papavasileiou, Franceska Strakosha, Kalliopi Theoni Vandorou, Pavlos Siozos, Marina Moustaka Christodoulou, Georgia Kontonasiou, Vasiliki Apollonatou, Elvira Markella Antonogiannaki, Christos Kyriakopoulos, Christina Aggelopoulou, Christos Chronis, Konstantinos Kostikas, Evangelia Koukaki, Zoi Sotiropoulou, Athanasia Athanasopoulou, Petros Bakakos, Pinelopi Schoini, Emmanouil Alevrakis, Sotirios Poupos, Evangelia Chondrou, Dionisios Tsoukalas, Alexia Chronaiou, George Tsoukalas, Sofia Koukidou, Georgios Hillas, Katerina Dimakou, Konstantinos Roukas, Ifigeneia Nakou, Diamantis Chloros, Evangelia Fouka, Spyros A. Papiris, Stelios Loukides
Summary: This study compared the baseline characteristics of patients in two phases of the COVID-19 pandemic and evaluated possible predictors of mortality. The study found that patients in the Delta period were younger, required a longer duration of hospitalization, and had more severe disease compared to patients in the Omicron period. The study identified independent predictors of mortality for patients in both periods.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Analytical
Loukia Lypirou, Christos Chronis, Konstantinos Exarchos, Konstantinos Kostikas, Vasilios Sakkas
Summary: This study analyzed volatile organic compounds (VOCs) in exhaled breath of COPD patients using gas chromatography/mass spectrometry, and identified certain molecules associated with the risk of future COPD exacerbation. This provides a promising avenue for the detection and management of COPD.