Mitochondrial HTRA2 Plays a Positive, Protective Role in Dictyostelium discoideum but Is Cytotoxic When Overexpressed

Mutation Analysis ofHTRA2Gene in Chinese Familial Essential Tremor and Familial Parkinson’s Disease

(2017) Ya-Chao He et al.   Parkinsons Disease

Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2

(2015) Nicolas Casadei et al.   HUMAN MOLECULAR GENETICS

InterProScan 5: genome-scale protein function classification

(2014) P. Jones et al.   BIOINFORMATICS

Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease

(2014) Hilal Unal Gulsuner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dictyostelium, a microbial model for brain disease

(2013) S.J. Annesley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Heteroplasmic mitochondrial disease in Dictyostelium discoideum

(2011) Lisa M. Francione et al.   BIOCHEMICAL PHARMACOLOGY

Novel variant Pro143Ala in HTRA2 contributes to Parkinson’s disease by inducing hyperphosphorylation of HTRA2 protein in mitochondria

(2011) Chin-Hsien Lin et al.   HUMAN GENETICS

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

A genetic interaction between NDPK and AMPK in Dictyostelium discoideum that affects motility, growth and development

(2011) Sarah J. Annesley et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

MidA is a putative methyltransferase that is required for mitochondrial complex I function

(2010) S. Carilla-Latorre et al.   JOURNAL OF CELL SCIENCE

dictyBase update 2011: web 2.0 functionality and the initial steps towards a genome portal for the Amoebozoa

(2010) P. Gaudet et al.   NUCLEIC ACIDS RESEARCH

The Dictyostelium model for mitochondrial disease

(2010) Lisa M. Francione et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin

(2009) L S Tain et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial quality control: insights on how Parkinson’s disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Loss-of-Function Analysis Suggests That Omi/HtrA2 Is Not an Essential Component of the pink1/parkin Pathway In Vivo

(2009) J. Yun et al.   JOURNAL OF NEUROSCIENCE

A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease

(2009) Rejko Krüger et al.   NEUROBIOLOGY OF AGING

The mitochondrial serine protease HtrA2/Omi: an overview

(2008) L Vande Walle et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response

(2008) N Moisoi et al.   CELL DEATH AND DIFFERENTIATION

Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls

(2008) J. Simon-Sanchez et al.   HUMAN MOLECULAR GENETICS

Genetic variability in the mitochondrial serine proteaseHTRA2contributes to risk for Parkinson disease

(2008) Veerle Bogaerts et al.   HUMAN MUTATION

Accumulation of HtrA2/Omi in Neuronal and Glial Inclusions in Brains With α-Synucleinopathies

(2008) Yasuhiro Kawamoto et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Genetic variation of Omi/HtrA2 and Parkinson's disease

(2008) Owen A. Ross et al.   PARKINSONISM & RELATED DISORDERS