Article
Oncology
Yousef M. Hawsawi, Anwar Shams, Abdulrahman Theyab, Wed A. Abdali, Nahed A. Hussien, Hanan E. Alatwi, Othman R. Alzahrani, Atif Abdulwahab A. Oyouni, Ahmad O. Babalghith, Mousa Alreshidi
Summary: This article reviews the spectrum of full-length BARD1 genes and their different isoforms, highlighting their anticipated associated risk. Additionally, the study emphasizes the role of BARD1 as an oncogene in breast cancer patients and its potential uses as a prognostic/diagnostic biomarker and therapeutic target for cancer susceptibility testing and treatment.
Review
Biochemistry & Molecular Biology
Da Young Lee, Jung Nyeo Chun, Minsoo Cho, Insuk So, Ju-Hong Jeon
Summary: E2F8 is a multifaceted transcription factor that is involved in various aspects of cancer development and progression. It has the ability to promote cancer cell proliferation and survival while also exhibiting tumor-suppressing activity. This review highlights the recent progress in understanding the role of E2F8 in human cancers and its implications for developing therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Pharmacology & Pharmacy
Robert Eckenstaler, Michael Hauke, Ralf A. Benndorf
Summary: RhoA, RhoB, and RhoC are key regulators of signal transduction in cell biology and have significant roles in tumor biology and vascular biology, regulating various cellular processes and disease pathogenesis.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Physiology
Eva Crosas-Molist, Remi Samain, Leonie Kohlhammer, Jose L. Orgaz, Samantha L. George, Oscar Maiques, Jaume Barcelo, Victoria Sanz-Moreno
Summary: This review examines the role of Rho GTPase signaling in different stages of cancer progression, highlighting its importance in tumor initiation, proliferation, and metastasis, as well as its involvement in cell migration, interaction with the tumor microenvironment, and inflammation regulation.
PHYSIOLOGICAL REVIEWS
(2022)
Article
Cell Biology
Gabriel Kreider-Letterman, Nicole M. Carr, Rafael Garcia-Mata
Summary: Cancer progression and metastasis involve cellular changes, including alterations in Rho GTPase family protein activity. Abnormal Rho GTPase signaling is associated with cancer development. Rho GTPase signaling is regulated by guanine nucleotide-exchange factors (RhoGEFs) and GTPase activating proteins (RhoGAPs). RhoGAP family members are emerging as key regulators of cancer development and progression.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Shahin Alizadeh-Fanalou, Mohsen Khosravi, Fatemeh Alian, Shirin Rokhsartalb-Azar, Ali Nazarizadeh, Maryam Karimi-Dehkordi, Forogh Mohammadi
Summary: miR-1297, a microRNA with dual functions, exhibits abnormal expression in various human cancers, acting as both a tumor suppressor and an oncogene.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, Research & Experimental
Maura Lima Pereira Bueno, Sara Teresinha Olalla Saad, Fernanda Marconi Roversi
Summary: The investigation of tumor microenvironment is crucial for cancer diagnosis, prognosis, and treatment. WNT5A plays a critical role in tumorigenesis by regulating multiple signaling pathways and affecting cell growth, migration, and invasiveness.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Oncology
Richard Morgan, Keith Hunter, Hardev S. Pandha
Summary: HOX genes are highly conserved transcription factors with key roles in early development and are also highly expressed in most cancers. Studies have found strong associations between HOX gene expression in tumors and clinical parameters, with high expression levels often associated with worse patient outcomes.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Cell Biology
Marco Kirchenwitz, Jessica Halfen, Kristin von Peinen, Silvia Prettin, Jana Kollasser, Susanne zur Lage, Wulf Blankenfeldt, Cord Brakebusch, Klemens Rottner, Anika Steffen, Theresia E. B. Stradal
Summary: The study found that RhoB is upregulated after Salmonella infection, and it binds to SopB and localizes on early phagosomes of intracellular Salmonella. RhoB is specifically required for Salmonella-induced upregulation of autophagy, promoting the intracellular survival of the bacterium.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Muhammad Tufail, Changxin Wu
Summary: The WNT5A pathway, a member of the Wnt signaling pathway, is crucial in cancer. It activates non-canonical Wnt signaling pathways by binding to Frizzled (FZD) and Receptor Tyrosine Kinase-Like Orphan Receptor (ROR) family members. WNT5A pathway is involved in various cellular processes and its abnormal activation or inhibition in colorectal cancer (CRC) can have both oncogenic and antitumor effects. WNT5A is also associated with inflammation, metastasis, and altered metabolism in cancer cells.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2023)
Review
Oncology
Suliman Khan, De-Yu Zhang, Ji-Yu Zhang, Mian Khizar Hayat, Jingli Ren, Safyan Nasir, Muhammad Fawad, Qian Bai
Summary: The expression and function of miRNAs play a crucial role in the development of HCC, affecting the biological behavior and clinical pathological features of liver cancer. Despite the unclear regulatory mechanisms, the potential of miRNA-based therapy for HCC warrants further exploration.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dong Wang, Chenchen Xu, Wenyu Yang, Jie Chen, Yuhui Ou, Yuanyuan Guan, Jialiang Guan, Ying Liu
Summary: This study identifies RNF167 and STAMBPL1 as key regulators of Sestrin2 polyubiquitination in response to leucine availability. The decreased expression of RNF167 and increased expression of STAMBPL1 are found in gastric and colorectal tumors. Knockout of STAMBPL1 or correction of the STAMBPL1 mutation suppresses xenograft tumor growth in a human colon cancer cell line. Furthermore, a cell-permeable peptide that blocks STAMBPL1-Sestrin2 interaction inhibits mTORC1 and could be a potential option for cancer therapy.
Article
Biochemistry & Molecular Biology
Francisco Alejandro Lagunas-Rangel
Summary: KDM6B is a histone demethylase that can act as a tumor suppressor or an oncogene depending on the cellular context. This study summarizes the role of KDM6B in different oncological contexts, aiming to guide its clinical application.
Review
Oncology
De-Li Shi
Summary: RBM24 is an RNA-binding protein that plays critical roles in embryonic development and tissue homeostasis. It is frequently dysregulated in human cancers and can act as both a tumor suppressor and oncogene, depending on the context. Its activity is regulated by protein-protein interactions and post-translational modifications. However, the molecular mechanisms underlying its function in tumor growth and metastasis are still unclear.
Review
Oncology
Pontus Aspenstrom
Summary: For many years, the role of RHO GTPases in cancer has been overlooked, but recent studies have shown that they are altered in many cancer types and may have oncogenic effects. This review article summarizes the current knowledge of these mutant RHO GTPases, focusing on how their kinetics can contribute to cancer progression.
Article
Multidisciplinary Sciences
Pei-Hsun Wu, Daniele M. Gilkes, Jude M. Phillip, Akshay Narkar, Thomas Wen-Tao Cheng, Jorge Marchand, Meng-Horng Lee, Rong Li, Denis Wirtz
Article
Oncology
Mahelet Mamo, Chae Ye, Josh W. DiGiacomo, Je Yeon Park, Bradley Downs, Daniele M. Gilkes
Article
Oncology
Josh W. DiGiacomo, Ines Godet, Michael Trautmann-Rodriguez, Daniele M. Gilkes
Summary: Studies have shown that the ECM can play a crucial role in driving ER signaling and resistance to endocrine therapy in breast cancer. By inhibiting FGF2-FGFR1 binding, the sensitivity to ER-targeted therapy can be restored.
MOLECULAR CANCER RESEARCH
(2021)
Correction
Biochemistry & Molecular Biology
H. Zhang, C. C. L. Wong, H. Wei, D. M. Gilkes, P. Korangath, P. Chaturvedi, L. Schito, J. Chen, B. Krishnamachary, P. T. Winnard, V. Raman, L. Zhen, W. A. Mitzner, S. Sukumar, G. L. Semenza
Summary: The paper has been corrected.
Article
Multidisciplinary Sciences
Ru Wang, Ines Godet, Yongkang Yang, Shaima Salman, Haiquan Lu, Yajing Lyu, Qiaozhu Zuo, Yufeng Wang, Yayun Zhu, Chelsey Chen, Jianjun He, Daniele M. Gilkes, Gregg L. Semenza
Summary: This study discovered that HIFs induce the expression of ADAM12, leading to EGFR signaling activation and subsequently promoting breast cancer cell migration, invasion, and metastasis. Inhibition of ADAM12 expression or activity can effectively reduce tumor cell migration, invasion, and lung metastasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Natalie S. Joe, Christine Hodgdon, Lianne Kraemer, Kristin J. Redmond, Vered Stearns, Daniele M. Gilkes
Summary: Breast cancer is the most commonly diagnosed cancer in women worldwide, with a small proportion developing brain metastases and facing a lower survival rate. The challenges lie in developing new approaches to treat, monitor, and prevent breast cancer brain metastasis. Current management includes diagnosis, treatment, and monitoring, along with ongoing translational research focusing on improving survival outcomes and quality of life for patients.
Article
Multidisciplinary Sciences
Heber L. Rocha, Ines Godet, Furkan Kurtoglu, John Metzcar, Kali Konstantinopoulos, Soumitra Bhoyar, Daniele M. Gilkes, Paul Macklin
Summary: Hypoxia plays a critical role in solid tumor progression and aggressiveness. A new hypoxia fate mapping system allows for the tracking of post-hypoxic cells within tumors. Computational modeling was used to investigate the motility and phenotypic persistence of hypoxic and post-hypoxic cells during tumor progression.
Article
Oncology
Ines Godet, Mahelet Mamo, Andrea Thurnheer, D. Marc Rosen, Daniele M. Gilkes
Summary: Intratumoral hypoxia in breast cancer leads to metastasis and chemotherapy resistance. Cells exposed to hypoxia in the primary tumor show decreased sensitivity to doxorubicin and paclitaxel, along with enrichment in cancer stem cell-related pathways. These post-hypoxic cells contribute to resistance and metastatic recurrence.
Article
Cell Biology
Ines Godet, Steven Doctorman, Fan Wu, Daniele M. Gilkes
Summary: The rapid proliferation of cancer cells and hypoxia cause regions of nutrient and oxygen deprivation in solid tumors. Some cancer cells can adapt to hypoxic conditions and promote cancer progression. Hypoxia is associated with worse patient prognosis, highlighting the need for methods to measure oxygen concentrations. This review provides an overview of the main methods utilized to detect hypoxia in cancer cells.
Article
Pharmacology & Pharmacy
Omkar Bhatavdekar, Ines Godet, Daniele Gilkes, Stavroula Sofou
Summary: Understanding the effects of chemotherapy delivery on different hypoxic cell sub-populations is important for controlling tumor growth and metastasis in triple negative breast cancer. In this study, multicellular spheroids were used to evaluate the effects of cisplatin exposure rate and pattern on cell viability and motility. It was found that cell resistance to cisplatin increased with exposure to hypoxia, but not acidosis. Increasing the exposure rate of cisplatin in spheroids enhanced chemotherapy sensitivity and reduced metastatic potential, even in hypoxic cells. This effect was achieved using nanocarriers that quickly released cisplatin and deeply penetrated the spheroid interstitium.
Article
Oncology
Natalie S. Joe, Yuanfeng Wang, Harsh H. Oza, Ines Godet, Nubaira Milki, Gregory J. Riggins, Daniele M. Gilkes
Summary: Mebendazole (MBZ), an FDA-approved anthelmintic, has shown efficacy in reducing solid tumor growth and inhibiting metastasis in preclinical cancer models. This study reveals that MBZ can inhibit the transcriptional activity of HIFs in breast cancer cells and mouse models, thereby blocking the hypoxia response and potentially serving as a therapy for breast cancer.
Correction
Oncology
J. A. Ju, I Godet, J. W. DiGiacomo, D. M. Gilkes
Article
Oncology
Julia A. Ju, Ines Godet, Josh W. DiGiacomo, Daniele M. Gilkes
Meeting Abstract
Oncology
Ines Godet, Yu Jung Shin, Julia A. Ju, Soumitra Bhoyar, I. Chae Ye, Guannan Wang, Saraswati Sukumar, Daniele M. Gilkes
Meeting Abstract
Oncology
Josh W. DiGiacomo, Ines Godet, Michael Trautmann Rodriguez, I. Chae Ye, Daniele M. Gilkes
