Four TRPM4 Cation Channel Mutations Found in Cardiac Conduction Diseases Lead to Altered Protein Stability

TRPM4 regulates Akt/GSK3-β activity and enhances β-catenin signaling and cell proliferation in prostate cancer cells

(2017) Alfredo I. Sagredo et al.   Molecular Oncology

Electron cryo-microscopy structure of a human TRPM4 channel

(2017) Paige A. Winkler et al.   NATURE

Targeted resequencing identifies TRPM4 as a major gene predisposing to progressive familial heart block type I

(2016) Xavier Daumy et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Potential role of melastatin-related transient receptor potential cation channel subfamily M gene expression in the pathogenesis of urinary bladder cancer

(2016) Gülay Güleç Ceylan et al.   Oncology Letters

Variants of Transient Receptor Potential Melastatin Member 4 in Childhood Atrioventricular Block

(2016) Ninda Syam et al.   Journal of the American Heart Association

Glycosylation of TRPM4 and TRPM5 channels: molecular determinants and functional aspects

(2014) Ninda Syam et al.   Frontiers in Cellular Neuroscience

Increased β-Adrenergic Inotropy in Ventricular Myocardium From Trpm4 −/− Mice

(2013) Ilka Mathar et al.   CIRCULATION RESEARCH

ComplexN-Glycosylation Stabilizes Surface Expression of Transient Receptor Potential Melastatin 4b Protein

(2013) Seung Kyoon Woo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Genetics and Functional Anomalies in a Series of 248 Brugada Cases with 11 Mutations in the TRPM4 Channel

(2013) Hui Liu et al.   PLoS One

TRPM4 channels in the cardiovascular system: Physiology, pathophysiology, and pharmacology

(2012) Hugues Abriel et al.   BIOCHEMICAL PHARMACOLOGY

TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis

(2012) Benjamin Schattling et al.   NATURE MEDICINE

Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle

(2011) Christophe Simard et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mutational spectrum in the Ca2+-activated cation channel gene TRPM4 in patients with cardiac conductance disturbances

(2011) Birgit Stallmeyer et al.   HUMAN MUTATION

Gain-of-Function Mutations in TRPM4 Cause Autosomal Dominant Isolated Cardiac Conduction Disease

(2010) Hui Liu et al.   Circulation-Cardiovascular Genetics

Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I

(2009) Martin Kruse et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular mechanisms of microvascular failure in central nervous system injury—synergistic roles of NKCC1 and SUR1/TRPM4

(2009) J. Marc Simard et al.   JOURNAL OF NEUROSURGERY

De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury

(2009) Volodymyr Gerzanich et al.   NATURE MEDICINE

TRPM4 regulates migration of mast cells in mice

(2008) Takahiro Shimizu et al.   CELL CALCIUM

The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells

(2008) Gaëtan Barbet et al.   NATURE IMMUNOLOGY