Article
Biochemical Research Methods
Shengming Sun, Qianqian Zhao, Cheng Xue, Cheng Zheng
Summary: The research investigated the effects of hypoxia on the testicular function of Macrobrachium nipponense and the underlying molecular mechanisms. It was found that hypoxia altered the phosphorylated protein levels in the testes, potentially causing testicular dysfunction by affecting autophagy, apoptosis, and signaling pathways. Further study on the AMP-activated protein kinase (AMPK) in testes mitochondrial autophagy and apoptosis under hypoxia revealed its potential role in regulating these processes, providing insights into energy metabolism disorders induced by hypoxia in M. nipponense testes.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Lei Xu, Wenyi Zhang, Hui Qiao, Sufei Jiang, Yiwei Xiong, Shubo Jin, Yongsheng Gong, Hongtuo Fu
Summary: This study analyzed the metabolism and transcriptome data of the economically important aquatic animal Macrobrachium nipponense under hypoxia conditions. Several differentially expressed genes and metabolites related to hypoxia were identified. Among them, GTP phosphoenolpyruvate carboxykinase (PEPCK) was considered to play an important role in hypoxic response.
Article
Environmental Sciences
Yiming Li, Zhiquan Liu, Yuan Yang, Qichen Jiang, Donglei Wu, Youhui Huang, Yang Jiao, Qiang Chen, Yinying Huang, Yunlong Zhao
Summary: The study found that exposure to nanoplastics affects the growth, enzyme activity, and gene expression related to energy metabolism in oriental river prawns. Higher concentrations of nanoplastics were found to have a negative impact on energy metabolism in crustaceans.
ENVIRONMENTAL POLLUTION
(2021)
Article
Fisheries
Jing-Wen Wang, Yi-Cheng Che, Miao Sun, Yi-Qing Guo, Bo Liu, Xiang-Fei Li
Summary: This study investigated the effects of different dietary niacin levels on the growth and metabolism of oriental river prawn. The results showed that most parameters reached optimal values in the 176.32 mg/kg group. Appropriate doses of niacin promoted the energy-sensing capability and glycolipid metabolism of this species.
AQUACULTURE NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Xichao Sun, Cheng Xue, Yiting Jin, Chao Bian, Na Zhou, Shengming Sun
Summary: This study identified two highly conserved glucose transporters (GLUT1 and GLUT2) in Macrobrachium nipponense and analyzed their tissue-specific expression patterns. The results showed that under hypoxia, GLUT1 is strongly present in primary hemocytes and acute hypoxia induces glucose uptake and lactate secretion. Knocking down GLUT1 leads to increased reactive oxygen species generation and apoptosis, resulting in decreased hypoxia adaptation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Fisheries
Miao Sun, Xiang-Fei Li, Ya-Ping Ge, Ling Zhang, Bo Liu, Wen-Bin Liu
Summary: This study investigated the optimal dietary thiamine requirement of oriental river prawn and its effects on glycolipid metabolism. The results showed that the growth performance and metabolic indicators of the prawns reached their peak when the dietary thiamine level was 61.40 mg/kg.
Article
Fisheries
Dongsheng Zhou, Chengli Wang, Jinxian Zheng, Jianhua Zhao, Shanshan Wei, Yunfeng Xiong, Samwel Mchele Limbu, Youqin Kong, Fang Cao, Zhili Ding
Summary: This study investigated the effects of thiamine on oriental river prawns under normal and hypoxic conditions. The results showed that an adequate intake of thiamine can improve antioxidant capacity and reduce oxidative damage caused by hypoxia in prawns.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Cell Biology
Katharina M. Eyme, Alessandro Sammarco, Roshani Jha, Hayk Mnatsakanyan, Caline Pechdimaljian, Litia Carvalho, Rudolph Neustadt, Charlotte Moses, Ahmad Alnasser, Daniel F. Tardiff, Baolong Su, Kevin J. Williams, Steven J. Bensinger, Chee Yeun Chung, Christian E. Badr
Summary: Deregulated de novo lipid synthesis (DNLS) is a potential target for therapeutic intervention in glioblastoma (GBM), but the mechanisms underlying susceptibility to DNLS-targeted therapies are unknown and brain-penetrant inhibitors of DNLS are lacking.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Fisheries
Long Wang, Hui Wang, Nan Wu, Chuankun Zhu, Xuejun Wu, Chenlong Ding, Jiale Li
Summary: In this study, the molecular mechanism of M. nipponense response to low temperature stress was investigated using RNA-Seq technology. Results showed that the crab adjusts its metabolism, protein hydrolysis, and gene expression levels to cope with oxidative stress and energy demands under cold conditions, enhancing its survival rate.
AQUACULTURE RESEARCH
(2021)
Article
Fisheries
Shanshan Li, Junbao Wang, Yunfeng Xiong, Jinxian Zheng, Dongsheng Zhou, Jianhua Zhao, Zhili Ding
Summary: Supplementing Macrobrachium nipponense with alpha-lipoic acid (alpha-LA) in a low protein/carbohydrate ratio diet can improve carbohydrate utilization efficiency and energy metabolism, as well as increase the number of hepatopancreas B cells, thereby achieving a protein-sparing effect.
AQUACULTURE RESEARCH
(2023)
Article
Physiology
Hui Qiao, Sufei Jiang, Hongtuo Fu, Yiwei Xiong, Wenyi Zhang, Lei Xu, Dan Cheng, Jisheng Wang
Summary: In this study, a gene-editing platform based on CRISPR/Cas9 was established for Macrobrachium nipponense, an important economic crustacean species. The vitellogenin (Vg) gene and the eyeless (Ey) gene were mutated to study their functions in M. nipponense. The establishment of this platform provides a powerful tool for gene function analysis and molecular-assisted breeding.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Yiming Li, Yucong Ye, Wen Li, Xingguo Liu, Yunlong Zhao, Qichen Jiang, Xuan Che
Summary: This study revealed that salinity significantly affected ion homeostasis, glucose metabolism and gill tissue structure in Macrobrachium nipponense. Salinity stress activated ion transport channels and promoted up-regulation of glucose metabolism. High salinity levels caused damage to the gill tissue of M. nipponense.
Article
Biology
Shubo Jin, Chao Bian, Sufei Jiang, Kai Han, Yiwei Xiong, Wenyi Zhang, Chengcheng Shi, Hui Qiao, Zijian Gao, Ruihan Li, Yu Huang, Yongsheng Gong, Xinxin You, Guangyi Fan, Qiong Shi, Hongtuo Fu
Summary: The researchers obtained the first high-quality chromosome-level genome assembly of the oriental river prawn, predicting the chromosome number and a whole-genome duplication event. By integrating genome and transcriptome data, 21 candidate genes related to sex were predicted.
Article
Environmental Sciences
Long Wang, Jianbin Feng, Guiling Wang, Tianyu Guan, Chuankun Zhu, Jiale Li, Hui Wang
Summary: The study found that cadmium has significant effects on the non-specific immunity and antioxidant defense system of Macrobrachium nipponense, with low concentrations having a positive impact on immunity but high concentrations leading to potential oxidative damage. Histology results showed that cadmium can damage the gill and hepatopancreas tissues of M. nipponense. These findings provide theoretical data for evaluating the influence of heavy metal cadmium on M. nipponense and its toxic mechanism.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Fisheries
Wujiang Fan, Pinhong Yang, Yanping Qiao, Ming Su, Genyu Zhang
Summary: Chronic exposure to environmentally relevant concentrations of polystyrene nanoplastics impairs molting and induces oxidative stress in adult river prawns.
FISH & SHELLFISH IMMUNOLOGY
(2022)