Article
Environmental Sciences
Tuan-Tuan Wang, Sai Wang, Shuai Shao, Xiao-Di Wang, Ding-Ying Wang, You-Sheng Liu, Cheng-Jun Ge, Guang-Guo Ying, Zhong-Bing Chen
Summary: Researchers have found that exposure to perfluorooctanoic acid (PFOA) negatively affects the growth of the wetland plant Alisma orientale, leading to changes in the structures, compositions, and functions of lipids, proteins, and DNA in plant cells.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Wenke Jonas, Kristin Schwerbel, Lisa Zellner, Markus Jaehnert, Pascal Gottmann, Annette Schuermann
Summary: This study demonstrates that impaired lipophagy contributes to the pathology of NAFLD and is associated with an altered lipid profile. However, the lipid pattern does not appear to be specific for lipophagic alterations, but is more related to fatty liver disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Ying Shi, Meijing Liu, Yufang Pan, Hanhua Hu, Jin Liu
Summary: This study unraveled the function and role of a Delta 6 fatty acid elongase (No Delta 6-FAE) in EPA biosynthesis in N. oceanica, highlighting the potential of manipulating No Delta 6-FAE for improved lipid production.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Kyun Ha Kim, Soyeon Kim, Min Jung Kwun, Ji Yeon Lee, Sei-Ryang Oh, Jun-Yong Choi, Myungsoo Joo
Summary: Alismol, a chemical constituent of the ethanol extract of Alisma orientale, suppresses lung inflammation by activating Nrf2 and ameliorates key features of acute lung injury (ALI).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Minghui Ou, Qian Zhang, Huidong Zhao, Chang Shu
Summary: The study revealed that PUFAs and LXA4 have an impact on PE by regulating LOX and inflammatory responses.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Nutrition & Dietetics
Pei-Chin Lin, Chu-Lin Chou, Shih-Hsiang Ou, Te-Chao Fang, Jin-Shuen Chen
Summary: This systematic review aims to summarize and quantify evidence regarding the prevention effects of nutrition supplements in CKD patients. The results suggest that the beneficial effects of these supplements in CKD patients are mostly supported by low to very low evidence on proteinuria, kidney function, and inflammations without improving CKD prognosis. Further studies and discussions with physicians are needed to clarify the benefits of nutrition supplements in CKD patients.
Article
Biochemistry & Molecular Biology
Wenxin Li, Chi Zhang, Shuhei Aramaki, Lili Xu, Shogo Tsuge, Takumi Sakamoto, Md. Al Mamun, Ariful Islam, Takamitsu Hayakawa, Yusuke Takanashi, Maxime Dubail, Kenta Konishi, Tomohito Sato, Tomoaki Kahyo, Charles Fouillade, Katsumasa Nakamura, Mitsutoshi Setou
Summary: The response of lipids, particularly PUFA chains, in mouse kidney, lung, brain, and liver tissues within 5 min of single high-dose irradiation was investigated. PUFA chains of kidney PC, PE, and TG significantly increased, primarily consisting of C18:2, C20:4, and C22:6. Kidney lipidomes also showed significant changes, with increased PC, PE, TG, and signal lipids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Veterinary Sciences
Luca Palazzese, Federica Turri, Debora Agata Anzalone, Joseph Saragusty, Jacques Bonnet, Marthe Colotte, Sophie Tuffet, Flavia Pizzi, Alessia Luciani, Kazutsugu Matsukawa, Marta Czernik, Pasqualino Loi
Summary: This study adapted a vacuum-drying encapsulation technique to preserve ram spermatozoa, comparing it to traditional lyophilization. The results showed that the encapsulation technique provided better structural stability and higher embryonic development compared to lyophilization. These findings highlight the importance of considering dehydration-related changes in sperm polyunsaturated fatty acids and DNA alterations for successful preservation in large mammals.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Dolores Camacho-Munoz, Magdalena Kiezel-Tsugunova, Orsolya Kiss, Mohib Uddin, Mattias Sunden, Maria Ryaboshapkina, Lars Lind, Jan Oscarsson, Anna Nicolaou
Summary: In this study, the effects of Fibrates and omega-3 polyunsaturated acids on plasma levels of bioactive lipid mediators in patients with obese non-alcoholic fatty liver and hypertriglyceridemia were investigated. The results showed that these two drugs have different effects on the plasma mediator lipidome, with omega-3 promoting lipid mediators potentially affecting chronic inflammation, while Fibrates mainly reducing ceramides. These findings suggest that both treatments could alleviate chronic inflammation and possibly impact disease outcomes, independent of triglyceride reduction.
Article
Nutrition & Dietetics
Mohsen Mazidi, Andre P. Kengne, Mario Siervo, Richard Kirwan
Summary: The study suggests that higher dietary intake of polyunsaturated fatty acids (PUFAs) is associated with improved renal function and lower risk of chronic kidney disease (CKD), while there is no significant association between monounsaturated fatty acids (MUFAs) intake and renal function or CKD risk. Genetically determined serum levels of PUFAs and MUFAs also do not show significant association with renal function and CKD risk.
Article
Nutrition & Dietetics
Mengyi Liu, Ziliang Ye, Sisi Yang, Yanjun Zhang, Qimeng Wu, Chun Zhou, Panpan He, Yuanyuan Zhang, Fanfan Hou, Xianhui Qin
Summary: This study aimed to explore the relationship between habitual fish oil use and the risk of chronic kidney diseases (CKD). A total of 408,023 participants without prior CKD were enrolled from the UK Biobank. Fish oil use and dietary intakes were assessed through questionnaires. The study found that habitual fish oil use was associated with a lower hazard of CKD, and there were consistent inverse relationships between fish consumption and circulating omega-3 PUFA concentration with incident CKD.
Article
Biotechnology & Applied Microbiology
Xuechao Hu, Yangyang Luo, Yanli Man, Xiuyang Tang, Zhiqian Bi, Lujing Ren
Summary: This study investigated the response mechanism of Schizochytrium sp. to temperature stress using transcriptomic and lipidomic approaches. The results showed that high or low temperature inhibited cell growth and affected lipid biosynthesis. Low temperature induced more saturated fatty acids, while high temperature enlarged cell size. Phospholipids were found to be more sensitive to temperature change. The transcriptome analysis revealed the up-regulation of desaturase at low temperature and the up-regulated heat shock proteins at high temperature.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Review
Nutrition & Dietetics
Hsi-Yun Liu, Chen-Hao Lee, Chien-Ning Hsu, You-Lin Tain
Summary: A balanced diet during gestation is crucial for fetal development, and excessive intake of saturated fats during this period is linked to increased risk of offspring kidney disease. Maternal high-fat diet influences kidney health and disease in offspring through renal programming. This review summarizes preclinical research on the connection between maternal high-fat diet during gestation and lactation and offspring kidney disease, the molecular mechanisms behind renal programming, and early-life interventions to mitigate adverse programming effects. Animal models suggest that perinatal supplementation with polyunsaturated fatty acids, changes in gut microbiota, and modulation of nutrient-sensing signals can improve offspring kidney health. These findings emphasize the importance of a balanced maternal diet for offspring kidney health.
Review
Urology & Nephrology
Delal Dalga, Thomas Verissimo, Sophie de Seigneux
Summary: Chronic kidney disease (CKD) is a global health issue with increasing prevalence. Understanding the alterations in metabolism during CKD, particularly in glucose production through gluconeogenesis, is important for developing new therapeutic targets. This review focuses on the metabolic changes in proximal tubular cells during CKD, including the switch from fatty acid oxidation to glycolysis and the loss of tubular gluconeogenesis. The consequences of these metabolic modifications on kidney disease, both locally and systemically, will be discussed. In addition, potential therapeutic interventions will be considered.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Ting Gui, Yunlun Li, Shijun Zhang, Irina Alecu, Qingfa Chen, Ying Zhao, Thorsten Hornemann, Gerd A. Kullak-Ublick, Zhibo Gai
Summary: Chronic kidney disease leads to dyslipidemia through changes in lipid metabolism, ultimately contributing to disease progression and cardiovascular complications. Analysis of lipid metabolites in CKD models and patients revealed an increase in 1-deoxysphingolipids, which was directly correlated with oxidative stress levels in the kidneys.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Psychology, Multidisciplinary
Mike Lin, Fengxiang Zhang, Xiaomin Sun, Nan Zhang, Jiaqi Wang, Yanqiang Tao, Zhenzhen Liu
Summary: This research examines the relationship between procedural fairness and participation in development activities (PDA), the underlying mechanism, and the boundary condition of the relationship, drawing on attribution theory. The results show that procedural fairness positively predicts PDA, and self-attribution mediates their relationship. In addition, self-construal moderates the relationship between self-attribution and PDA.
CURRENT PSYCHOLOGY
(2023)
Article
Fisheries
Jing Wu, Yifan Nie, Jingya Wang, Guoqing Feng, Le Hao, Yanping Ma, Yugu Li, Zhenxing Liu
Summary: This study found the phagocytic ability in largemouth bass B cells and investigated the regulatory mechanism of phagocytosis. The results suggested that the Fc gamma receptor-mediated phagocytosis signaling pathway is involved in the phagocytosis of B cells.
JOURNAL OF FISH BIOLOGY
(2023)
Review
Medicine, Research & Experimental
Siyi Lu, Zhaoyu Chen, Zhenzhen Liu, Zhentao Liu
Summary: NOC2L, a novel inhibitor of histone acetyltransferase (INHAT), regulates histone acetylation in a HDAC-independent manner and has two INHAT function domains. This review summarizes the biological function of NOC2L in histone acetylation regulation, P53-mediated transcription, ribosome RNA processing, certain development events, and carcinogenesis. NOC2L may serve as a potential biomarker and therapeutic target in clinical practice.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xiaopei Zhou, Qingsong Xi, Weimin Jia, Zhou Li, Zhenxing Liu, Geng Luo, Chenxi Xing, Dazhi Zhang, Meiqi Hou, Huihui Liu, Xue Yang, Yalin Luo, Xuejie Peng, Guihua Wang, Tingting Zou, Lixia Zhu, Lei Jin, Xianqin Zhang
Summary: Male infertility is a global public health problem with complex pathogenic causes. Through whole-exome sequencing, we identified a novel homozygous missense mutation in the ACTL7A gene in two infertile brothers with teratozoospermia. In vitro fertilization and intracytoplasmic sperm injection showed fertilization failure, and further analysis revealed irregular perinuclear theca (PT) and acrosomal ultrastructural defects in the sperm of these patients. The mutation also caused abnormal localization and reduced expression of PLCZ1, which may contribute to the fertilization failure. This study expands the understanding of ACTL7A mutations and provides a basis for genetic counseling.
MOLECULAR GENETICS AND GENOMICS
(2023)
Article
Agronomy
Zhendong Liu, Shiyu Wei, Ming Li, Qingfen Zhang, Rui Zong, Quanqi Li
Summary: This study examined the effects of planting density and genotypes on the leaf area index, photosynthetic characteristics, dry-matter accumulation, water-use efficiency, and yield of summer maize. Increasing planting density enhanced light interception and dry-matter accumulation but decreased chlorophyll content, net photosynthetic rate, and transpiration rate. Both high and low planting densities were detrimental to yield and resource-use efficiency. Denghai 605 showed a higher yield potential and water-use efficiency compared to Zhengdan 958.
Article
Medicine, General & Internal
Chunmei Jiang, Zhixiang Xu, Jin Li, Jiaqi Zhang, Xingkui Xue, Jingxia Jiang, Guihua Jiang, Xisheng Wang, Yun Peng, Tian Chen, Zhenzhen Liu, Liu Xie, Haibin Gao, Yingxia Liu, Yang Yang
Summary: In this case study, a 31-year-old immunocompetent adult was diagnosed with aseptic meningitis caused by recombinant echovirus 18. The patient recovered after 4 days of antiviral treatment. This is the first report of echovirus 18-induced meningitis in an immunocompetent adult from mainland China, highlighting the importance of surveillance for echovirus 18 infection in both children and adults.
FRONTIERS IN MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Yunhe Pei, Hailin Chen, Zhenhai Liu, Haozhi Hu
Summary: Environmental pollution is a significant threat to public health, and environmental regulation plays a crucial role in addressing pollution. This study utilizes ologit model and China General Social Survey data to examine the impact and mechanisms of environmental regulation on public health. The findings show that environmental regulation has a positive influence on improving residents' health, which becomes more pronounced over time. The effect varies among residents with different characteristics, with more significant improvements observed among those with higher education levels, urban-registered residences, and residents in economically developed areas. Mechanism analysis reveals that environmental regulation achieves better health outcomes by reducing pollutant emissions and enhancing environmental quality. Additionally, a cost-benefit analysis demonstrates that environmental regulation significantly enhances the welfare of individuals and society as a whole. However, it is crucial to consider the potential negative impact of environmental regulation on residents' employment and income.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Yuyin Li, Yaxin Zhang, Lu Li, Mei Zhang, Ning Song, Qing Zhao, Zhenxing Liu, Aipo Diao
Summary: The transmembrane prostate androgen-induced protein (TMEPAI) is highly expressed in various types of cancer and activates the NF-kappa B signaling pathway through the ubiquitination of I kappa B alpha. This results in the degradation of I kappa B alpha and the subsequent activation of NF-kappa B signaling. Further investigation revealed that TMEPAI-induced cell proliferation and tumor growth in immune deficient mice are mediated by the NF-kappa B signaling pathway. This study provides valuable insights into the role of TMEPAI in tumorigenesis and suggests it as a potential target for cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Ke Ma, Wei Chen, Xiao-Qi Lin, Zhen-Zhen Liu, Tao Wang, Jia-Bao Zhang, Jian-Gang Zhang, Cheng-Kai Zhou, Yu Gao, Chong-Tao Du, Yong-Jun Yang
Summary: Pure cultures of chicken intestinal microbial species are important for understanding gut microbiota function and developing potential probiotics and bioactive metabolites. This study isolated and identified 507 bacterial isolates, including 89 previously uncultured ones, with 63 Lactobacillus strains exhibiting antibacterial activity against S. Pullorum. L. reuteri strain YPG14 showed strong acid tolerance and other probiotic properties, and its consumption significantly improved body weight, reduced S. Pullorum loads, and alleviated damage caused by S. Pullorum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
M. Y. Ruan, Z. L. Guo, Q. C. Luo, L. Wang, X. L. Wei, T. Y. Li
Summary: We investigated the size effect on the magnetocaloric effect (MCE) of Er2BaNiO5, a Haldane spin-chain antiferromagnet. The results showed that the decrease in average crystallite size led to an enhancement of magnetization and paramagnetic-like behavior. The dominant antiferromagnetic (AFM) interactions in the bulk sample were suppressed in the nano-size samples, resulting in a dramatic reduction of the Haldane gap. Additionally, the size effect significantly influenced the MCE, leading to a monotonic increase in MCE in the nano-size samples compared to the disappearance of negative MCE in the bulk sample. The maximum entropy change of the nano-size samples increased nearly 3.2 times compared to the bulk sample. The ESR results confirmed the increasing of paramagnetic (PM) ions in the nano-size samples, as evidenced by the observed ESR signals of Er3+ and Ni2+ ions.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Microbiology
Ting-Ting Du, Xiao-Chen Liu, Yu He, Xiong Gao, Zhen-Zhen Liu, Zheng-Li Wang, Lu-Quan Li
Summary: This study aimed to explore the value of gut microbiota and tricarboxylic acid (TCA) metabolites in early diagnosis of NEC among infants with abdominal manifestations. High-throughput sequencing was used to analyze the gut microbiota, and multiple reaction monitoring (MRM) targeted metabolomics was used to measure TCA metabolites. The results showed that decreased levels of unclassified Staphylococcus, Lactobacillaceae, and Bifidobacterium animalis subsp. lactis at the species level, as well as increased levels of succinate, L-malic acid, and oxaloacetate, have potential value for the early diagnosis of NEC.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hua Miao, Yan-Ni Wang, Xiao-Yong Yu, Liang Zou, Yan Guo, Wei Su, Fei Liu, Gang Cao, Ying-Yong Zhao
Summary: This study identified alterations in gut microbiota and serum metabolites mediating an AhR mechanism in MN rats and IMN patients, providing insights into the pathogenesis of MN.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zhanchen Guo, Qi Zhang, Rongrong Xing, Zhen Liu
Summary: Using two molecularly imprinted and cladded polymers, researchers developed an inexpensive, fast, and portable plasmonic immuno-sandwich assay for highly specific and ultra-sensitive detection of C-peptide in urine. This method, based on dual cMIPs, showed promising potential in clinical diagnosis by distinguishing healthy individuals from diabetes patients and exhibiting significant advantages over existing immunoassays.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Pengfei Li, Shuxin Xu, Yanjie Han, Hui He, Zhen Liu
Summary: A machine learning-empowered mass spectrometry platform was developed for accurate profiling and quantification of cis-diol metabolites associated with liver cancer. The platform improved the detection coverage and demonstrated higher sensitivity and specificity in diagnosing liver cancer compared to protein biomarker-based methods.
Article
Chemistry, Multidisciplinary
Weihua Lu, Jingran Chen, Zhanchen Guo, Yanyan Ma, Zikuan Gu, Zhen Liu
Summary: Hypervalent bispecific gold nanoparticle-anchored aptamer chimeras (AuNP-APTACs) were developed as effective lysosome-targeting chimeras (LYTACs) for reversing multidrug resistance (MDR) in cancer cells by degrading the ABCG2 protein. The AuNP-APTACs improved drug accumulation in resistant cells and showed comparable efficacy to small-molecule inhibitors. This new strategy holds great promise for overcoming MDR and has significant implications for cancer therapy.
CHEMICAL COMMUNICATIONS
(2023)
