Article
Immunology
Lesha Pretorius, Anton du Preez van Staden, Johannes J. van der Merwe, Natasha Henning, Carine Smith
Summary: This study found that an increase in gastrointestinal trace amine (TA) load may contribute to inflammation and disruption of tight junction proteins in the intestine. Additionally, fluctuating levels of endogenous estrogen may modulate microbially-derived TA levels, potentially explaining the worsening of gastrointestinal symptoms in females during low estrogen phases in irritable bowel syndrome (IBS).
INFLAMMOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
L. Pretorius, C. Smith
Summary: The study aimed to determine the potential of rooibos to prevent gastrointestinal dysregulation caused by high-dose trace-amine (TA) exposure. The results showed that rooibos could reduce the secretion of inflammatory mediators and restore the normal distribution of important proteins in cells.
Article
Immunology
Xiaowu Bai, Weixin Liu, Hongxia Chen, Tao Zuo, Xiaojian Wu
Summary: By analyzing RNA-seq data from patients with IBD (including CD and UC) and healthy individuals, this study revealed increased numbers of immune cells in different intestinal regions and disease-specific immune features in CD and UC. These findings provide important insights into the pathogenesis of IBD and serve as a valuable resource for future targeted studies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sunil Kumar, Awanish Kumar
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal system that is increasing globally. The alteration in intestinal microbiota is associated with IBD, but the role of microbes in IBD is still controversial.
MICROBIAL PATHOGENESIS
(2022)
Review
Nutrition & Dietetics
Yan Jiang, Karolin Jarr, Cosima Layton, Christopher D. Gardner, Judith E. Ashouri, Maria T. Abreu, Sidhartha R. Sinha
Summary: Despite being an important issue for patients, the impact of diet on adult inflammatory bowel disease (IBD) is not well explored, with limited guidance. Current evidence on various diets used in the treatment of IBD is summarized, with potential applications of dietary data from related immune-mediated inflammatory diseases (IMIDs) to inform providers. Multiple diets, including Mediterranean, vegetarian/vegan, and reduced-calorie/fasting diets, have shown positive results in other inflammatory diseases, suggesting potential applicability to IBD, but further well-designed clinical trials are needed for guidance.
Review
Biochemistry & Molecular Biology
Angela Saez, Beatriz Herrero-Fernandez, Raquel Gomez-Bris, Hector Sanchez-Martinez, Jose M. M. Gonzalez-Granado
Summary: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic intestinal inflammation with an unknown cause. Innate immune cells (IICs), such as neutrophils, monocytes, macrophages, and dendritic cells, play a crucial role in defending against pathogens and maintaining immune tolerance. An imbalance in the innate immune response is closely linked to intestinal inflammation and IBD. Understanding the mechanisms and interactions of IICs with other immune cells is essential for developing effective therapies for IBD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Anusha Shirwaikar Thomas, Stephen Hanauer, Yinghong Wang
Summary: Immune checkpoint inhibitors have revolutionized the management of advanced malignancies, but their use is often complicated by immune related adverse events, with immune checkpoint inhibitor enterocolitis being the most common toxicity. This review highlights the similarities and differences in the pathophysiology, clinical presentation, evaluation, and management of immune checkpoint inhibitor enterocolitis and idiopathic inflammatory bowel disorders.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Anusha Shirwaikar Thomas, Stephen Hanauer, Yinghong Wang
Summary: Immune checkpoint inhibitors have greatly advanced cancer treatment, but their use often leads to immune related adverse events (irAEs), with immune checkpoint inhibitor enterocolitis (IMEC) being the most common toxicity. IMEC is a distinct form of bowel inflammation that resembles idiopathic inflammatory bowel disorders. This review compares the pathophysiology, clinical presentation, evaluation, and management of IMEC and inflammatory bowel disorders. IMEC is an immune-related adverse event similar to inflammatory bowel disease, but little is known about its long-term outcomes.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Physiology
Zhiyuan Li, Shuyan Dong, Shichen Huang, Yuhan Sun, Yingzhi Sun, Beibei Zhao, Qiulan Qi, Lei Xiong, Feng Hong, Yuxin Jiang
Summary: Inflammatory bowel disease (IBD) is an autoimmune disease caused by chronic recurrent inflammation of the ileum, rectum, and colon. CD34 is involved in mediating the migration of various immune cells to the inflammatory site during IBD, and its interaction with adhesion molecules contributes to the occurrence and development of IBD. This article aims to explore the structure, biological function, and potential mechanism of CD34 in IBD.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anna V. Glyakina, Constantine D. Pavlov, Julia V. Sopova, Raul R. Gainetdinov, Elena I. Leonova, Oxana V. Galzitskaya
Summary: This study identified conserved motifs characterizing TAARs and studied the docking of different ligands with TAAR1 and TAAR6 receptors. Orthosteric binding sites were revealed for both receptors, and specific binding patterns of different ligands were determined. The findings suggest potential pharmaceutical applications in targeting allosteric and orthosteric sites of TAARs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Samantha Gonzalez Delgado, Idalia Garza-Veloz, Fabiola Trejo-Vazquez, Margarita L. Martinez-Fierro
Summary: This study aims to integrate scientific data on the role of the intestinal microbiota in regulating gut serotonin signaling and reuptake and its involvement in the pathogenesis of IBD. It is found that the use of selective serotonin reuptake inhibitors as an adjuvant therapy can improve disease activity and extraintestinal manifestations in IBD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Giovanni Cirillo, Flor Negrete-Diaz, Daniela Yucuma, Assunta Virtuoso, Sohaib Ali Korai, Ciro De Luca, Eugenijus Kaniusas, Michele Papa, Fivos Panetsos
Summary: This paper provides a comprehensive overview of the pathogenesis and therapeutic approaches for inflammatory bowel diseases. The interaction between the enteric and central nervous systems and the role of the vagus nerve in autoimmune diseases are highlighted. Neuroprosthetic stimulation of the vagus nerve, particularly transcutaneous stimulation of the auricular branch, has been suggested as a potential therapeutic approach for controlling intestinal inflammation.
Article
Immunology
Le Liu, Liping Liang, Chenghai Yang, Ye Chen
Summary: This study found that PDHA1, DLD, and FDX1 genes are closely associated with different immune status in inflammatory bowel disease. The results provide a better understanding and offer potential diagnostic and therapeutic targets for IBD.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Laila Aldars-Garcia, Alicia C. Marin, Maria Chaparro, Javier P. Gisbert
Summary: The gut microbiota plays a crucial role in human health, contributing to the development of the immune system, digestion, metabolism, and barrier against pathogens. Inflammatory bowel disease (IBD) is characterized by an exaggerated immune reaction against intestinal microbiota, with changes in abundance of specific microorganisms associated with the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Iliyan D. Iliev, Ken Cadwell
Summary: The intestinal microbiota is composed of a variety of fungal and viral components in addition to bacteria, which interact with the immune system and impact human physiology. Studies have shown that alterations in fungal and viral species in the gut are associated with inflammatory and autoimmune diseases, with potential to activate host-protective immune pathways while also contributing to inflammatory bowel disease. Modernization and the COVID-19 pandemic have introduced humans to new fungi and viruses, the consequences of which remain unknown. Lessons learned from animal studies on common gut viruses and fungi shed light on their impacts on health and intestinal diseases.
Review
Pharmacology & Pharmacy
Mark D. Berry, Raul R. Gainetdinov, Marius C. Hoener, Mohammed Shahid
PHARMACOLOGY & THERAPEUTICS
(2017)
Review
Pharmacology & Pharmacy
Raul R. Gainetdinov, Marius C. Hoener, Mark D. Berry
PHARMACOLOGICAL REVIEWS
(2018)
Article
Clinical Neurology
Mark D. Berry
JOURNAL OF NEURAL TRANSMISSION
(2011)
Article
Clinical Neurology
Mark D. Berry, Jarrod Nickel, Mithila R. Shitut, Bruno Tomberli
JOURNAL OF NEURAL TRANSMISSION
(2011)
Article
Multidisciplinary Sciences
Bryan W. Holland, Mark D. Berry, C. G. Gray, Bruno Tomberli
Article
Neurosciences
Mark D. Berry, Mithila R. Shitut, Ahmed Almousa, Jane Alcorn, Bruno Tomberli
Article
Multidisciplinary Sciences
Mark D. Berry, Shannon Hart, Anthony R. Pryor, Samantha Hunter, Danielle Gardiner
Scientific Reports
(2016)
Article
Cell Biology
Mallory S. Pitts, Josh N. McShane, Marius C. Hoener, Sherri L. Christian, Mark D. Berry
HISTOCHEMISTRY AND CELL BIOLOGY
(2019)
Article
Pharmacology & Pharmacy
Michael J. Cripps, Marta Bagnati, Tania A. Jones, Babatunji W. Ogunkolade, Sophie R. Sayers, Paul W. Caton, Katie Hanna, Merell P. Billacura, Kathryn Fair, Carl Nelson, Robert Lowe, Graham A. Hitman, Mark D. Berry, Mark D. Turner
BIOCHEMICAL PHARMACOLOGY
(2020)
Article
Medicine, Research & Experimental
Shreyasi Sarkar, Mark D. Berry
Article
Biochemistry & Molecular Biology
David A. Barnes, Dylan A. Galloway, Marius C. Hoener, Mark D. Berry, Craig S. Moore
Summary: The expression of TAAR1 is found to be decreased in MS patients, while its localization and function are altered under different conditions. This suggests a potential important role of TAAR1 in the pathophysiology of MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
David A. Barnes, Marius C. Hoener, Craig S. Moore, Mark D. Berry
Summary: This study reveals the role of Trace amine-associated receptor 1 (TAAR1) in modulating cytokine secretion and metabolic profiles in peripherally-derived macrophages. It also suggests a potential therapeutic target for inflammatory disorders. However, TAAR1 does not have the same effect in CNS-resident macrophages.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2023)
Article
Physiology
Shreyasi Sarkar, Ivan Saika-Voivod, Mark D. Berry
Summary: This study developed mathematical models to describe the transport processes of p-tyramine (TYR) across cell membranes and found that the known transport processes were insufficient to explain the observed TYR passage. By incorporating asymmetry in the apical membrane OCT2 and additional basolateral facilitated diffusion transporters, the models were able to match the experimental data.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
M. D. Berry
REVIEWS ON RECENT CLINICAL TRIALS
(2007)