Article
Chemistry, Multidisciplinary
Qi Qin, Jing Chen, Changze Wu, Yixue Wang, Yunan Li, Meng Song
Summary: Novel carbon nanostructures, carbon nanobuds and nanoballs, have been successfully synthesized on the surface of graphene using the electrochemical method. Under a certain potential, carbon nanobuds are grown in situ on the surface of graphene, and with the increase of potential, these nanobuds grow into nanoballs and exfoliate from the graphene surface. Graphene undergoes oxidation at higher potentials, resulting in the formation of graphene oxide fragments.
Article
Physics, Multidisciplinary
Young Woo Choi, Marvin L. Cohen
Summary: We investigated the electromigration forces for weakly bonded adsorbates on graphene using density-functional based calculations. The results showed that the nature of electromigration forces depends critically on the energy level alignment between the adsorbate state and the Fermi level of the graphene. For resonant adsorbates, the electromigration force is dominated by the electron wind force, while for nonresonant adsorbates, it is essentially the direct force dependent on the adsorbate charge. Moreover, we demonstrated that the magnitude of electromigration forces can be continuously adjusted through electrostatic gating for resonant adsorbates.
PHYSICAL REVIEW LETTERS
(2022)
Article
Biotechnology & Applied Microbiology
Stefania Sandoval, Gerard Tobias
Summary: Fullerenes are employed as versatile agents to cork the open tips of MWCNTs and to promote the release of inorganic material filled within the nanotubes. Two different strategies using annealing and wet procedure are proposed to trigger the release of the filler.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Yang He, Chenyan Hu, Zhijia Li, Chuan Wu, Yuanyuan Zeng, Cheng Peng
Summary: Early diagnosis of infectious diseases and tumors is crucial for global public health. Carbon nanomaterials have been widely studied and proven to improve the accuracy of diagnosis in various scientific fields. This review focuses on their applications in diagnosing infectious diseases and tumors over the past five years. Recent advances in biosensing, bioimaging, and nucleic acid amplification technologies using carbon nanomaterials are discussed, highlighting their unique properties and the challenges and opportunities for future clinical applications.
MATERIALS TODAY BIO
(2022)
Review
Materials Science, Biomaterials
Emine Nur Ozmen, Enise Kartal, Mehmet Bora Turan, Alperen Yazicioglu, Javed H. Niazi, Anjum Qureshi
Summary: Electrochemical biosensors show potential for developing rapid and accurate diagnostic tools, and integrating carbon nanostructures like graphene and carbon nanotubes can enhance their performance. These nanostructures meet the requirements of rapid diagnostic tools for speed, sensitivity, and cost-effectiveness.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Multidisciplinary Sciences
Sahar Gooneh-Farahani, Seyed Morteza Naghib, M. Reza Naimi-Jamal, Amir Seyfoori
Summary: Smart nanomaterials with stimuli-responsive behavior, such as pH-sensitive BSG/chitosan nanocomposites, show promise for enhanced drug delivery efficiency, particularly in tumor treatment. Physicochemical characterization and drug release studies demonstrated the effectiveness of these nanocomposites in encapsulating anticancer drug DOX and enabling uniform release mechanisms for optimal drug delivery.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Oscar Jover, Alberto Martin-Jimenez, Hannah M. Franklin, Ryan M. Koenig, Jose I. Martinez, Nazario Martin, Koen Lauwaet, Rodolfo Miranda, Jose M. Gallego, Steven Stevenson, Roberto Otero
Summary: This study characterizes the adsorption, self-assembly, and electronic structure of [5,5]-C-90 fullertube molecules on different noble metal surfaces using scanning tunneling microscopy and spectroscopy. The results show that the shape of the molecular orbitals of the adsorbed fullertubes matches the theoretical calculations, and some of the molecular orbitals are influenced by the quantum confinement imposed by the hemifullerene caps. These findings provide a conceptual framework for the design and understanding of custom fullertube molecules.
Article
Biochemistry & Molecular Biology
Andrzej Hudecki, Dorota Lyko-Morawska, Anna Kasprzycka, Alicja Kazek-Kesik, Wirginia Likus, Jolanta Hybiak, Kornelia Jankowska, Aleksandra Kolano-Burian, Patryk Wlodarczyk, Weronika Wolany, Jaroslaw Markowski, Wojciech Maziarz, Iwona Niedzielska, Wojciech Pakiela, Mariusz Nowak, Marek J. Los
Summary: This study developed a new composite biomaterial based on hydroxyapatite with different dopants, which showed good mechanical properties and bacteriostatic effects against Gram-positive bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Polymer Science
Judy Gopal, Manikandan Muthu, Iyyakkannu Sivanesan
Summary: Electricity consumption is essential for everyday life, and energy generation is crucial in meeting the demands of consumers. Energy storage, particularly electrochemical energy storage using various materials and nanomaterials, has gained significant attention in research and development. This review focuses on the utilization of carbon-based polymer nanocomposites, specifically graphene and fullerene-based polymers, for electrochemical energy storage. The achievements and types of polymer nanocomposites used are discussed, highlighting areas with limited information and clarity. Future research directions and recommendations for maximizing the benefits of graphene/fullerene polymer nanocomposites are proposed.
Article
Chemistry, Physical
Arianna Dalla Colletta, Marco Pelin, Silvio Sosa, Laura Fusco, Maurizio Prato, Aurelia Tubaro
Summary: Carbon-based nanomaterials (CBNs) have been extensively studied for various applications due to their excellent physicochemical properties. However, there is a lack of toxicological data on their potential adverse effects at the skin level. Therefore, more research is needed to evaluate the safety of CBNs for skin applications.
Article
Polymer Science
Mario P. Maldonado, Gabriel M. Pinto, Lidiane Cristina Costa, Guilhermino J. M. Fechine
Summary: In this study, a ductile thermoplastic polyurethane (TPU)/graphene nanocomposite with enhanced thermal conductivity was produced via melt compounding technique. Analysis showed that the addition of graphene improved thermal conductivity by about 14% without compromising the composite's ductility, making it a promising material for additive manufacturing processes like 3D printing.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
Mahmut Muhammettursun, Tayfun Bel, Elif Kocacinar, Ecem Erman, Fuat Berke Gul, Andy Augousti, Nilgun Baydogan
Summary: The technique for synthesizing poly (methyl methacrylate) (PMMA) using graphene nanoplatelets (GNPs) has been improved to enhance the elastic properties of the polymer. The addition of GNPs at 2 wt% by mass increased compressive strength by 42.7% and Rockwell hardness by 19.9%. The structural changes due to the addition of GNPs were found to be uniquely linked to improvements in elastic parameters of the PMMA/GNPs nanocomposite.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Chemistry, Physical
Ding-Rui Chen, I-Fan Hu, Hao-Ting Chin, Yu-Chi Yao, Radha Raman, Mario Hofmann, Chi-Te Liang, Ya-Ping Hsieh
Summary: This article investigates the potential of strain engineering to enhance the performance of 2D material-based resonators. By utilizing a liquid-based tension process, the resonance frequency and quality factor of graphene resonators can be improved six-fold. The study reveals that the enhanced wall interaction due to surface energy is the origin of this effect.
NANOSCALE HORIZONS
(2023)
Article
Pharmacology & Pharmacy
Ebru Kahraman, Nalan Erdol Aydin, Gulhayat Nasun-Saygili
Summary: The present study investigates the adsorption and release performance of 5-FU on gelatin incorporated graphene oxide (GO/GEL) composite. The experimental results show that 5-FU adsorption on GO/GEL follows Freundlich model and is an endothermic process. The maximum adsorption capacity of 5-FU on GO/GEL is 108.7 mg/g. The drug release from GO/GEL follows first-order model and is completed in 9 hours under physiological conditions. The GO/GEL composite shows good biocompatibility and has potential as a drug carrier for 5-FU in clinical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Fabiola Lopez-Barajas, Luis Francisco Ramos-deValle, Saul Sanchez-Valdes, Eduardo Ramirez-Vargas, Juan Guillermo Martinez-Colunga, Adriana Berenice Espinoza-Martinez, Luciano da Silva, Jose Francisco Hernandez-Gamez, Oliverio Santiago Rodriguez-Fernandez, Flora Itzel Beltran-Ramirez, Jose David Zuluaga-Parra
Summary: The thermal conductivity of epoxy resins can be greatly improved by adding a hybrid filler of graphene and copper nanoparticles. Wet milling method can be used to obtain the hybrid filler, which can then be used in producing epoxy nanocomposites. XPS results suggest that copper is bonded to the surface nanoparticles of graphene.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Geriatrics & Gerontology
Natalia Barcellos, Laura Reck Cechinel, Louisiana Carolina Ferreira de Meireles, Gisele Agustini Lovatel, Gisele Eva Bruch, Virginia Mendes Carregal, Andre Ricardo Massensini, Teresa Dalla Costa, Lenir Orlandi Pereira, Ionara Rodrigues Siqueira
EXPERIMENTAL GERONTOLOGY
(2020)
Article
Endocrinology & Metabolism
Julliane V. Joviano-Santos, Priscila A. C. Valadao, Matheus P. S. Magalhaes-Gomes, Lorena F. Fernandes, Danuza M. Diniz, Thatiane C. G. Machado, Kivia B. Soares, Marina S. Ladeira, Aline S. Miranda, Andre R. Massensini, Marcus V. Gomez, Cristina Guatimosim
Summary: The study found that Ph alpha 1 beta has a neuroprotective effect and improves motor function in the BACHD mouse model. This paves the way for the development of new approaches to treat Huntington's disease.
Article
Peripheral Vascular Disease
Giana Blume Corssac, Jessica Poletto Bonetto, Cristina Campos-Carraro, Laura Reck Cechinel, Alexsandra Zimmer, Belisa Parmeggiani, Mateus Grings, Virginia Mendes Carregal, Andre Ricardo Massensini, Ionara Siqueira, Guilhian Leipnitz, Adriane Bello-Klein
Summary: This study found that pulmonary arterial hypertension results in oxidative imbalance and mitochondrial dysfunction, particularly impacting the right ventricle. However, the pathological injury may trigger the release of circulating extracellular vesicles that communicate with different organs, such as the brain, helping to protect against further damage.
HYPERTENSION RESEARCH
(2021)
Article
Neurosciences
Rodrigo Ribeiro dos Santos, Tulio C. Bernardino, Maria Carolina Machado da Silva, Antonio C. P. de Oliveira, Luciana E. Drumond, Daniela Rosa, Andre R. Massensini, Marcio F. D. Moraes, Maria C. Doretto, Marco A. Romano-Silva, Helton J. Reis
Summary: In this study, using WAR model, significant alterations in glutamatergic and GABAergic pathways, as well as increased expression of NCS-1 in the hippocampus and inferior colliculus were observed. These changes may be associated with hyperexcitability propagation and recruitment of multiple brain regions.
NEUROSCIENCE LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Sthefanie C. A. Goncalves, Beatriz L. T. Bassi, Lucas M. Kangussu, Daniele T. Alves, Lorena K. S. Ramos, Lorena F. Fernandes, Marco T. R. Alves, Ruben Sinisterra, Gisele E. Bruch, Robson A. S. Santos, Andre R. Massensini, Maria J. Campagnole-Santos
Summary: This study showed, for the first time, a neuroprotective role for Alamandine in different ischemic stroke models. Alamandine is able to protect brain cells from damage and death, and also has anti-inflammatory and antioxidant effects.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jamille Mirelle de Oliveira Cardoso, Rory Cristiane Fortes de Brito, Fernando Augusto Siqueira Mathias, Levi Eduardo Soares Reis, Joao Filipe Pereira Vieira, Thais Lopes Valentim Di Paschoale Ostolin, Helida Monteiro de Andrade, Guilherme Santos Ramos, Frederic Frezard, Rodrigo Dian De Oliveira Aguiar-Soares, Bruno Mendes Roatt, Alexandre Barbosa Reis
Summary: This study compared the therapeutic potential of chemotherapy and immunotherapy for canine visceral leishmaniasis (CVL), finding that both treatments improved clinical symptoms and immune parameters, but the effects did not persist until the end of the experiment.
MOLECULAR IMMUNOLOGY
(2022)
Article
Physiology
Julliane Joviano-Santos, Priscila A. C. Valadao, Matheus P. S. Magalhaes-Gomes, Lorena F. Fernandes, Danuza M. Diniz, Thatiane C. G. Machado, Kivia B. Soares, Marina S. Ladeira, Andre R. Massensini, Marcus Gomez, Aline S. Miranda, Juan C. Tapia, Cristina Guatimosim
Summary: The study demonstrated a novel neuroprotective role of CTK 01512-2 in alleviating motor symptoms of Huntington's disease, specifically acting in the spinal cord and improving motor performance in mice. This finding opens up possibilities for developing therapeutic approaches beyond the brain for neurodegenerative disorders.
EXPERIMENTAL PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Guilherme S. Ramos, Virginia M. R. Vallejos, Gabriel S. M. Borges, Raquel M. Almeida, Izabela M. Alves, Marta M. G. Aguiar, Christian Fernandes, Pedro P. G. Guimaraes, Ricardo T. Fujiwara, Philippe M. Loiseau, Lucas A. M. Ferreira, Frederic Frezard
Summary: This study developed a formulation of PEGylated liposomal AmB and compared its efficacy to AmBisome (R) in a murine model of cutaneous leishmaniasis (CL). The results showed that the PEGylated formulation significantly reduced lesion growth and parasite load in the treatment of CL, both through parenteral and oral routes.
Article
Biotechnology & Applied Microbiology
Izabela Mansur-Alves, Brenda Lorrayne Furtado Lima, Thais Tunes Santos, Naialy F. Araujo, Frederic Frezard, Arshad Islam, Andre L. B. de Barros, Delia C. M. dos Santos, Christian Fernandes, Lucas A. M. Ferreira, Marta M. G. Aguiar
Summary: This study aimed to evaluate the influence of cholesterol on the aggregation state of NE-AmB. The results showed that cholesterol reduced the aggregation state of AmB. NE-AmB was stable and had lower hemolytic toxicity, and it was capable of stabilizing the lesion size and reducing the parasitic load in animals.
Article
Pharmacology & Pharmacy
Juliane S. Lanza, Virginia M. R. Vallejos, Guilherme S. Ramos, Ana Carolina B. de Oliveira, Cynthia Demicheli, Luis Rivas, Sebastien Pomel, Philippe M. Loiseau, Frederic Frezard
Summary: This study evaluates the effectiveness of nanoassemblies made from antimony(V) complexes with octanoyl-N-methylglucamide (SbL8) or decanoyl-N-methylglucamide (SbL10) in targeting infection sites in visceral and cutaneous leishmaniases. The results show that these nanoassemblies are stable at neutral pH and effectively accumulate in macrophages and the liver. SbL10 exhibits higher activity against intramacrophage Leishmania amastigotes and can be further enhanced with co-incorporated miltefosine. In vivo, NanoSb demonstrates high antileishmanial activity in murine models of VL and CL. This study supports the potential of NanoSb as a better delivery system for antimony and co-incorporated drugs compared to conventional antimonial Glucantime (R).
Review
Pharmacology & Pharmacy
Frederic Frezard, Marta M. G. Aguiar, Lucas A. M. Ferreira, Guilherme S. Ramos, Thais T. Santos, Gabriel S. M. Borges, Virginia M. R. Vallejos, Helane L. O. De Morais
Summary: This review discusses the use of liposomal amphotericin B (AmBisome) as the best therapeutic option for leishmaniasis, but its efficacy is influenced by patient immunological status, clinical manifestation, and endemic region. The need for parenteral administration, side effects, and cost limit its use in developing countries. Recent advances in understanding the mechanism responsible for reduced toxicity and the development of more effective liposomal AmB formulations, including topical and oral options, are highlighted. The critical role of AmB aggregation state and release rate in reducing toxicity and improving efficacy by non-invasive routes is emphasized.
Meeting Abstract
Clinical Neurology
B. Bassi, L. Fernandes, M. T. Alves, I. Pereira, G. Bruch, R. A. Santos, A. Massensini
INTERNATIONAL JOURNAL OF STROKE
(2021)