Article
Neurosciences
Sepehr Shirani, Maryam Mohebbi
Summary: This study investigates the effects of MS on the brain's functional connectivity network using EEG resting-state signals and graph theory approach. The results indicate lower cortical activity in the alpha frequency bands and higher activity in the gamma frequency bands for patients with RRMS. Additionally, the functional brain network in RRMS cases shows a higher diameter, global efficiency, and transitivity in certain frequency bands.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Sasha D'Ambrosio, Diego Jimenez-Jimenez, Katri Silvennoinen, Sara Zagaglia, Marco Perulli, Josephine Poole, Renzo Comolatti, Matteo Fecchio, Sanjay M. Sisodiya, Simona Balestrini
Summary: TMS-EEG can be used to study cortical excitability and structure-function association in the brain. The research found that contralateral homologous cortical areas share similar spectral features, while ipsilateral areas have differences in their waveform and frequency content. These findings are important for understanding brain symmetry and asymmetric brain disorders.
HUMAN BRAIN MAPPING
(2022)
Article
Neuroimaging
Oscar Daniel Ayala, Daisy Banta, Mariam Hovhannisyan, Liliana Duarte, Alfonso Lozano, Juan Raul Garcia, Patricia Montanes, Simon W. Davis, Felipe De Brigard
Summary: Multiple sclerosis (MS) is a progressive disease that affects the white matter in the brain and spinal cord. Patients with MS experience cognitive impairments, particularly in episodic memory and future thinking. This study compared the performance of relapsing-remitting MS patients in mental simulation tasks involving past, future, and counterfactual thoughts. The results showed that MS patients had reduced internal details in all mental simulations and reduced composition ratings for counterfactual events. Diffusion weighted imaging (DWI) measures also revealed differences in white matter integrity between MS patients and healthy controls, with certain pathways associated with deficits in episodic counterfactual thinking.
NEUROIMAGE-CLINICAL
(2022)
Review
Clinical Neurology
Samar S. Ayache, Nicolas Serratrice, Georges N. Abi Lahoud, Moussa A. Chalah
Summary: Fatigue is a common and debilitating symptom in multiple sclerosis (MS), affecting the patients' quality of life. It exhibits motor, cognitive, and psychosocial facets, and can be differentiated from perceived fatigue and fatigability. Despite existing literature, the pathophysiology and management of MS fatigue remain challenging.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Martin Tik, Maria Vasileiadi, Michael Woletz, David Linhardt, Anna-Lisa Schuler, Nolan Williams, Christian Windischberger
Summary: This study aims to establish the dose-response relationship of DLPFC stimulation through concurrent TMS/fMRI. The study found qualitative inter-subject variability in the dose-response relationship to TMS over left DLPFC, suggesting that the motor threshold may not be directly transferable to the excitability of the DLPFC. Therefore, concurrent TMS/fMRI may have the potential to improve response rates to TMS applications.
Editorial Material
Neurosciences
Po-Yu Fong, Danny Spampinato, Kevin Michell, Marco Mancuso, Katlyn Brown, Jaime Ibanez, Alessandro Di Santo, Anna Latorre, Kailash Bhatia, John C. Rothwell, Lorenzo Rocchi
Summary: This commentary article compares the differences between their recently published paper on cerebellar transcranial magnetic stimulation (TMS) induced electroencephalographic responses and Gassmann et al.'s previous work on the same topic. The authors agree that the differences mainly stem from the use of different magnetic stimulation coils but raise two unanswered questions: (1) which method is most likely to achieve optimal activation of cerebellar output, and (2) to what extent are the evoked cerebellar responses contaminated by concomitant sensory input? They emphasize the importance of careful experimental design and combining electrophysiological and behavioral data for obtaining reliable TMS-EEG data.
Review
Anatomy & Morphology
Mohamed L. Seghier
Summary: In this review, the functions of the angular gyrus (AG) were evaluated based on evidence from TMS/TES and EEG/MEG studies. The results showed that the AG plays a causal role in semantic processing, attention, self-guided movement, memory, and self-processing. A three-phase unifying model of sensemaking was proposed, suggesting that the AG is involved early on in defining the current context and later in attention re-orientation and cross-modal integration. However, the evidence for the semantic role of the AG is still weak.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Neurosciences
Enrico De Martino, Adenauer Casali, Silvia Casarotto, Gabriel Hassan, Mario Rosanova, Thomas Graven-Nielsen, Daniel Ciampi de Andrade
Summary: Pain-related changes in cortical excitability were investigated in the dorsolateral prefrontal cortex and primary motor cortex using transcranial magnetic stimulation-electroencephalography. Acute pain decreased peak-to-peak amplitude in both M1 and dorsolateral prefrontal cortex, while only M1 showed a reduction in global-mean field power. Participants with the greatest reduction in local cortical excitability under acute pain showed a negative correlation between dorsolateral prefrontal cortex and M1. These findings highlight the differential effects of acute pain on local and global cortical excitability, as well as individual patterns of cortical excitability changes.
Article
Immunology
Emanuele D'Amico, Aurora Zanghi, Nunziatina Laura Parrinello, Alessandra Romano, Giuseppe Alberto Palumbo, Clara Grazia Chisari, Simona Toscano, Francesco Di Raimondo, Mario Zappia, Francesco Patti
Summary: This study characterized the immune cell phenotypes of patients recently diagnosed with relapsing-remitting multiple sclerosis who had not received disease-modifying therapies. The results revealed differences in myeloid, B, and T cells between these patients and healthy controls.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Clinical Neurology
Zafer Keser, Samuel C. Buchl, Nathan A. Seven, Matej Markota, Heather M. Clark, David T. Jones, Giuseppe Lanzino, Robert D. Brown, Gregory A. Worrell, Brian N. Lundstrom
Summary: Stroke is a major cause of death and disability, and understanding neural recovery patterns and predicting long-term recovery after stroke is challenging. This review discusses the use of EEG and TMS-EEG in characterizing post-stroke recovery mechanisms and predicting treatment response. The findings suggest that stroke leads to decreased high frequency activity and imbalance in interhemispheric connectivity, while balanced interhemispheric activity and enhanced intrahemispheric coherence are associated with better recovery.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Giacomo Guidali, Agnese Zazio, Delia Lucarelli, Eleonora Marcantoni, Antonietta Stango, Guido Barchiesi, Marta Bortoletto
Summary: This study investigates the effect of transcranial magnetic stimulation (TMS) parameters on evoked potentials (TEPs) and motor-evoked potentials (MEP). The results show that TMS parameters significantly affect the amplitude, latency, and replicability of M1-P15 TEPs. The study highlights the importance of controlling stimulation parameters for stable single-subject measurements and developing connectivity biomarkers from TEPs.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Pablo Rodriguez de Vera Gomez, Mariola Mendez Muros, Alberto Torres Cuadro, Francisco Javier Toyos Saenz de Miera, Rocio Lopez Ruiz, Raquel Guerrero Vazquez, Juan Jesus Garcia Gonzalez, Antonio Manuel Garrido Hermosilla, Tomas Martin Hernandez
Summary: This study describes the clinical and biochemical characteristics of GD-ALZ and the clinical course of GO-ALZ cases in patients treated with Alemtuzumab for RRMS. GD-ALZ was observed in 32.6% of the cases, mainly affecting women with an average age of 41.9 years. Having first-degree relatives with hypothyroidism was identified as a risk factor. GO-ALZ was diagnosed in 13.6% of the cases, with 3 cases requiring anti-IL-6 treatment.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Mohd Faizal Mohd Zulkifly, Ornela Merkohitaj, Juergen Brockmoeller, Walter Paulus
Summary: The study investigated the impact of caffeine on brain plasticity and found that it increased motor cortex excitability in caffeine-naive subjects, enhanced PAS 25 effects, and affected alertness and motor evoked potentials under light deprivation. Time of day had no effect on tACS-induced plasticity in caffeine consumers.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Zhizheng Zhuo, Yongmei Li, Yunyun Duan, Guanmei Cao, Fenglian Zheng, Jinli Ding, Decai Tian, Xinli Wang, Jinhui Wang, Xinghu Zhang, Kuncheng Li, Fuqing Zhou, Muhua Huang, Yuxin Li, Haiqing Li, Chun Zeng, Ningnannan Zhang, Jie Sun, Chunshui Yu, Xuemei Han, Sven Haller, Frederik Barkhof, Fudong Shi, Yaou Liu
Summary: Three MRI subtypes of RRMS were identified with distinct clinical and imaging features and different prognoses. The subtypes showed variations in cognitive impairment and conversion rate to SPMS.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Julio C. Hernandez-Pavon, Domenica Veniero, Til Ole Bergmann, Paolo Belardinelli, Marta Bortoletto, Silvia Casarotto, Elias P. Casula, Faranak Farzan, Matteo Fecchio, Petro Julkunen, Elisa Kallioniemi, Pantelis Lioumis, Johanna Metsomaa, Carlo Miniussi, Tuomas P. Mutanen, Lorenzo Rocchi, Nigel C. Rogasch, Mouhsin M. Shafi, Hartwig R. Siebner, Gregor Thut, Christoph Zrenner, Ulf Ziemann, Risto J. Ilmoniemi
Summary: Transcranial magnetic stimulation (TMS) combined with electroencephalography (EEG) is widely used to study cortical reactivity and connectivity. The lack of standardization in equipment, data collection, and analysis methods poses challenges in the field. This review provides methodological recommendations for effective TMS-EEG recordings and analysis, aiming to promote standardization across research groups.
Article
Critical Care Medicine
Carl M. Zipser, Nikolai Pfender, Najmeh Kheram, Andrea Boraschi, Jose Aguirre, Nils H. Ulrich, Jose Miguel Spirig, Alexandre Ansorge, Michael Betz, Florian Wanivenhaus, Markus Hupp, Vartan Kurtcuoglu, Mazda Farshad, Armin Curt, Martin Schubert
Summary: This study investigated the diagnostic value of continuous intraoperative cerebrospinal fluid (CSF) pressure monitoring during surgical decompression in patients with degenerative cervical myelopathy (DCM). The results showed that CSF pulsations increased during surgical decompression in most patients, and this monitoring method could help identify adverse events. Further research on the clinical value of intraoperative guidance for decompression in complex DCM surgery is promising.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Geriatrics & Gerontology
Carl M. Zipser, Tobias R. Spiller, Florian F. Hildenbrand, Annina Seiler, Jutta Ernst, Roland von Kanel, Sharon K. Inouye, Soenke Boettger
Summary: This study systematically assessed the discharge destinations and mortality risk in delirious patients within a large healthcare system. Delirium was associated with reduced odds of returning home, increased odds of discharge to a setting of higher dependency, and excess mortality independent of comorbidity, age, and sex.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Medicine, General & Internal
Alvaro Yanez Touzet, Aniqah Bhatti, Esmee Dohle, Faheem Bhatti, Keng Siang Lee, Julio C. Furlan, Michael G. Fehlings, James S. Harrop, Carl Moritz Zipser, Ricardo Rodrigues-Pinto, James Milligan, Ellen Sarewitz, Armin Curt, Vafa Rahimi-Movaghar, Bizhan Aarabi, Timothy F. Boerger, Lindsay Tetreault, Robert Chen, James D. Guest, Sukhvinder Kalsi-Ryan, Angus G. K. McNair, Mark Kotter, Benjamin Davies
Summary: This study evaluates the measurement properties of outcome measures used in the assessment of degenerative cervical myelopathy (DCM) and highlights the lack of high-quality evidence in this area. There is a need for a set of agreed tools to measure outcomes in DCM.
Article
Clinical Neurology
Benjamin M. Davies, Oliver Mowforth, Helen Wood, Zahabiya Karimi, Iwan Sadler, Lindsay Tetreault, Jamie Milligan, Jamie R. F. Wilson, Sukhvinder Kalsi-Ryan, Julio C. Furlan, Yoshiharu Kawaguchi, Manabu Ito, Carl Moritz Zipser, Timothy F. Boerger, Alexander R. Vaccaro, Rory K. J. Murphy, Mike Hutton, Ricardo Rodrigues-Pinto, Paul A. Koljonen, James S. Harrop, Bizhan Aarabi, Vafa Rahimi-Movaghar, Shekar N. Kurpad, James D. Guest, Jefferson R. Wilson, Brian K. Kwon, Mark R. N. Kotter, Michael G. Fehlings
Summary: This article reviews the importance of raising awareness for Degenerative Cervical Myelopathy (DCM) as the number one research priority. It highlights the low level of awareness, long diagnosis waiting times, and limited research funding for DCM. Drawing parallels from successful cases in stroke and acute coronary syndrome, the article emphasizes the need to raise awareness and make DCM a public health priority internationally.
GLOBAL SPINE JOURNAL
(2022)
Article
Clinical Neurology
Bryn Hilton, Emma L. Gardner, Zhilin Jiang, Lindsay Tetreault, Jamie R. F. Wilson, Carl Moritz Zipser, K. Daniel Riew, James D. Guest, James S. Harrop, Michael G. Fehlings, Ricardo Rodrigues-Pinto, Vafa Rahimi-Movaghar, Bizhan Aarabi, Paul A. Koljonen, Mark R. N. Kotter, Benjamin M. Davies, Brian K. Kwon
Summary: This article discusses the importance of establishing diagnostic criteria for Degenerative Cervical Myelopathy (DCM), including factors that need to be considered and challenges that need to be overcome. Presently, there is no single set of diagnostic criteria for DCM, making it difficult for clinicians to make a diagnosis. Prompt diagnosis of DCM is crucial for early surgical intervention.
GLOBAL SPINE JOURNAL
(2022)
Article
Clinical Neurology
Benjamin M. Davies, Oliver Mowforth, Aref-Ali Gharooni, Lindsay Tetreault, Aria Nouri, Rana S. Dhillon, Josef Bednarik, Allan R. Martin, Adam Young, Hitoshi Takahashi, Timothy F. Boerger, Virginia F. J. Newcombe, Carl Moritz Zipser, Patrick Freund, Paul Aarne Koljonen, Ricardo Rodrigues-Pinto, Vafa Rahimi-Movaghar, Jefferson R. Wilson, Shekar N. Kurpad, Michael G. Fehlings, Brian K. Kwon, James S. Harrop, James D. Guest, Armin Curt, Mark R. N. Kotter
Summary: This study aims to propose a new framework to support the investigation and understanding of the pathobiology of DCM. The results suggest that DCM should be considered as a function of multiple mechanical forces, alongside individual vulnerability and time.
GLOBAL SPINE JOURNAL
(2022)
Article
Engineering, Biomedical
Freschta Mohammadzada, Carl Moritz Zipser, Chris A. Easthope, David M. Halliday, Bernard A. Conway, Armin Curt, Martin Schubert
Summary: This study compared the center of mass (CoM) control during target walking (TW) task in individuals with incomplete spinal cord injury (iSCI) and healthy controls. The results showed that individuals with iSCI had impaired CoM movement when challenged with TW. The ability to cope with gait challenges worsened in individuals with higher levels of injury. This study demonstrated that TW task could be used as a gait challenge paradigm in ambulatory iSCI individuals.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2022)
Article
Medicine, General & Internal
Florian F. Hildenbrand, Fritz R. Murray, Roland von Kaenel, Ansgar R. Deibel, Philipp Schreiner, Jutta Ernst, Carl M. Zipser, Soenke Boeettger
Summary: Cognitive and functional impairments are major predisposing factors for delirium. In gastrointestinal and hepato-pancreato-biliary diseases, cirrhosis may predispose to delirium, while acute renal failure and liver disease may act as precipitating factors. Delirious patients have higher in-hospital mortality rates and higher total costs.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Florian F. Hildenbrand, Soenke Boettger, Tobias Spiller, Maria Schubert, Jutta Ernst, Roland von Kanel, Carl M. Zipser
Summary: There are differences in delirium incidence and phenotype between sexes. This study evaluated the sex-specific responses to non-pharmacological and pharmacological management of delirium. The results showed that non-pharmacological treatment was equally effective in both sexes, while men fared better with supportive care compared to pharmacologic therapies.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Freschta Zipser-Mohammadzada, Marjelle Fredie Scheffers, Bernard A. Conway, David M. Halliday, Carl Moritz Zipser, Armin Curt, Martin Schubert
Summary: Intramuscular high-frequency coherence increases during visually guided treadmill walking due to increased supra-spinal input. The influence of walking speed on intramuscular coherence and its inter-trial reproducibility needs to be established. This study found that intramuscular coherence during target walking is significantly higher than during normal walking across all speeds, and this difference increases at higher walking speeds. The reliability of intramuscular coherence is moderate to excellent for most walking tasks, supporting the use of this measure as a tool to investigate supra-spinal input.
EXPERIMENTAL BRAIN RESEARCH
(2023)
Review
Neurosciences
Valerio Manippa, Annalisa Palmisano, Martina Ventura, Davide Rivolta
Summary: This paper provides an overview of the neuroimaging research on developmental prosopagnosia (DP) over the past 25 years. The findings suggest that individuals with DP exhibit structural and functional abnormalities in the ventral visual stream, particularly in the connectivity between the Fusiform Face Area and other face-sensitive regions.
Review
Clinical Neurology
Zhilin Jiang, Benjamin Davies, Carl Zipser, Konstantinos Margetis, Allan Martin, Stavros Matsoukas, Freschta Zipser-Mohammadzada, Najmeh Kheram, Andrea Boraschi, Elina Zakin, Oke Righteous Obadaseraye, Michael G. Fehlings, Jamie Wilson, Ratko Yurac, Chad E. Cook, Jamie Milligan, Julia Tabrah, Shirley Widdop, Lianne Wood, Elizabeth A. Roberts, Tanzil Rujeedawa, Lindsay Tetreault
Summary: This scoping review examines the diagnostic accuracy and frequency of clinical symptoms in patients with degenerative cervical myelopathy (DCM). The review identified common symptoms in DCM patients, including sensorimotor impairment of the upper extremities, pain, bladder dysfunction, and gait disturbance. Further neuroimaging is recommended for patients presenting with a combination of these symptoms to confirm the diagnosis of DCM.
GLOBAL SPINE JOURNAL
(2023)
Review
Clinical Neurology
Zhilin Jiang, Benjamin Davies, Carl Zipser, Konstantinos Margetis, Allan Martin, Stavros Matsoukas, Freschta Zipser-Mohammadzada, Najmeh Kheram, Andrea Boraschi, Elina Zakin, Oke Righteous Obadaseraye, Michael G. Fehlings, Jamie Wilson, Ratko Yurac, Chad E. Cook, Jamie Milligan, Julia Tabrah, Shirley Widdop, Lianne Wood, Elizabeth A. Roberts, Tanzil Rujeedawa, Lindsay Tetreault
Summary: This systematic review examined the diagnostic accuracy of clinical signs and their association with disease severity in degenerative cervical myelopathy (DCM). The study found that the most sensitive tests for diagnosing DCM were Tromner and hyperreflexia, while the most specific tests were Babinski, Tromner, clonus and inverted supinator sign. However, there was no definite association between Hoffmann sign, Babinski sign or hyperreflexia and disease severity.
GLOBAL SPINE JOURNAL
(2023)
Article
Clinical Neurology
Najmeh Kheram, Andrea Boraschi, Nikolai Pfender, Andreas Spiegelberg, Vartan Kurtcuoglu, Armin Curt, Martin Schubert, Carl Moritz Zipser
Summary: Before the era of spinal imaging, the presence of spinal canal block was tested using manual compression of the jugular veins. This study assesses the feasibility and repeatability of this test to derive descriptors of the cerebrospinal fluid pulsatility curve.
ACTA NEUROCHIRURGICA
(2023)
Article
Clinical Neurology
Najmeh Kheram, Andrea Boraschi, Nikolai Pfender, Susanne Friedl, Maria Rasenack, Benjamin Fritz, Vartan Kurtcuoglu, Martin Schubert, Armin Curt, Carl M. Zipser
Summary: This study investigates the diagnostic utility of lumbar cerebrospinal fluid pressure (CSFP) dynamics in patients with spinal cord injury (SCI) following surgical decompression. The results demonstrate that lumbar CSFP dynamics can effectively assess residual cord compression. Longitudinal studies are needed to further determine the clinical implications. Evaluation: 8 points.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)