Review
Biochemistry & Molecular Biology
Lea Toury, Diane Frankel, Coraline Airault, Frederique Magdinier, Patrice Roll, Elise Kaspi
Summary: miR-140-5p and miR-140-3p are miRNAs that are associated with the development and progression of cancers and aging-related diseases. They serve as predictive tools and play critical roles in the pathophysiology of aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Dongwei Dou, Xiaoyang Ren, Mingli Han, Xiaodong Xu, Xin Ge, Yuanting Gu, Xinxing Wang, Song Zhao
Summary: This study demonstrated that downregulation of circ_0008039 suppressed breast cancer cell proliferation, migration, invasion, and glycolysis by regulating the miR-140-3p/SKA2 axis. The findings provide an important theoretical basis for the treatment of breast cancer.
MOLECULAR ONCOLOGY
(2021)
Article
Cell Biology
Tao He, Wen Tao, Lei-Lei Zhang, Bang-Yu Wang, Ke Li, Hui-Min Lu, Guo-Jun Tang, Ya-Di He, Liao-Yuan Li
Summary: circRNA circSCAF8 in prostate cancer activates the LIF-STAT3 pathway to promote proliferation, migration, and invasion, and its expression is a strong predictor of progression-free survival.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Jun Yang, Manlong Qi, Xiang Fei, Xia Wang, Kefeng Wang
Summary: The upregulated expression of hsa_circRNA_0088036 in bladder cancer is positively correlated with overall survival and clinicopathologic characteristics. Knockdown of hsa_circRNA_0088036 inhibits the growth, migration, and invasion of bladder cancer cells, acting through the miR-140-3p/FOXQ1 signaling pathway.
CELL DEATH & DISEASE
(2022)
Review
Oncology
Matthew G. Davey, Sean O. Hynes, Michael J. Kerin, Nicola Miller, Aoife J. Lowery
Summary: In breast cancer development, the expression of Ki-67 is a valuable indicator for prognosis and treatment decision making. The advent of molecular medicine has transformed breast cancer management by recognizing the heterogeneity of the disease and using a combination of factors for substratification and personalization of treatment modalities. Routine evaluation of Ki-67 as a proliferation marker in breast cancer patients has limitations, but promising strategies are being explored to enhance its utility in future oncology.
Article
Medicine, Research & Experimental
Behzad Mansoori, Pascal H. G. Duijf, Ali Mohammadi, Elham Safarzadeh, Henrik J. Ditzel, Morten F. Gjerstorff, William Chi-Shing Cho, Behzad Baradaran
Summary: miR-142-3p directly targets the HMGA2 gene in breast cancer cells, leading to apoptosis, cell cycle arrest, and inhibition of cancer stem cell properties. This study provides evidence for miR-142-3p as a potential therapeutic target for breast cancer treatment, highlighting its role in regulating oncogenesis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Li Zhang, Mengyi Shen, Dingyi Zhang, Xin He, Qinglin Du, Nian Liu, Xiaohua Huang
Summary: A nomogram based on dual-sequence MRI radiomic features and clinical characteristics was developed to assess Ki-67 expression in breast cancer. It showed improved prediction efficiency compared to single-sequence models and clinical models.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Oncology
N. Wang, Y. Zheng, X. Zhang, S. W. Xu, X. H. Li, Y. L. Meng, J. Q. Liu
Summary: circ_0000135 plays an anti-tumor role in the occurrence and development of cervical cancer by sponging miR-140-3p to suppress the expression of PDZK1.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Jun You, Yinan Chen, Donghan Chen, Yongwen Li, Tinghao Wang, Jingtao Zhu, Qingqi Hong, Qiyuan Li
Summary: In this study, the highly expressed circRNA circ_0001789 was identified in gastric cancer tissues. Silencing circ_0001789 attenuated the malignancy of gastric cancer cells, and exosomal circ_0001789 was sufficient to regulate the malignant phenotype of gastric cancer cells. miR-140-3p was identified as a downstream target of circ_0001789, negatively correlated with circ_0001789 expression in gastric cancer tissues. Overexpression of miR-140-3p suppressed cell migration, invasion, and epithelial-mesenchymal transition in gastric cancer cells, and PAK2 was identified as the target of miR-140-3p to mediate the malignant phenotype of gastric cancer cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Tsu-Yang Chao, Theresa Kordass, Wolfram Osen, Stefan B. Eichmueller
Summary: The miRNAs miR-134-3p and miR-224-3p were found to directly interact with the SOX9 gene and inhibit its expression in breast cancer cells. These two miRNAs were down-regulated in breast cancer tissues, suggesting their potential role as tumor suppressors in breast cancer progression.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yasemin Kayadibi, Burak Kocak, Nese Ucar, Yesim Namdar Akan, Pelin Akbas, Sibel Bektas
Summary: This study aimed to investigate the value of MRI-based radiomics in predicting Ki-67 expression of breast cancer. The results showed that the combination of ADC map-based selected radiomic features and a generalized linear model could be a promising non-invasive method to determine the Ki-67 expression level of breast cancer.
ACADEMIC RADIOLOGY
(2022)
Article
Cell Biology
Hao Wu, Yile Jiao, Chen Zhou, Xinyi Guo, Zhenru Wu, Qing Lv
Summary: USP36 is highly expressed in breast cancer and predicts poor prognosis. Inhibiting USP36 expression can restrain the malignant behavior of breast cancer cells, and miR-140-3p is an upstream regulator of USP36.
Article
Oncology
Dingsheng Liu, Chunsheng Chen, Mingming Cui, Hong Zhang
Summary: Recent studies have identified miR-140-3p as a tumor suppressor in colorectal cancer (CRC) progression by targeting BCL9 and BCL2, inhibiting cell proliferation, migration, invasion, and promoting apoptosis. This suggests that the miR-140-3p-BCL9/BCL2 axis may be a potential target for miRNA-based therapy and prognostication of CRC.
Article
Radiology, Nuclear Medicine & Medical Imaging
Tao Jiang, Wenyan Jiang, Shijie Chang, Hongbo Wang, Shuxian Niu, Zhibin Yue, Huazhe Yang, Xiaoyu Wang, Nannan Zhao, Siqi Fang, Yahong Luo, Xiran Jiang
Summary: This study aimed to evaluate the Ki-67 level in digital breast tomosynthesis (DBT) images of breast cancer patients using a subregional radiomics approach. Results showed that radiomics features extracted from the inner subregion had higher accuracy compared to the whole tumor region or marginal subregion.
Review
Biochemistry & Molecular Biology
Fuwen Yuan, William Hankey, Eric J. Wagner, Wei Li, Qianben Wang
Summary: Alternative polyadenylation (APA) is a molecular process that generates diversity at the 3' end of RNA polymerase II transcripts from over 60% of human genes, mainly occurring within the untranslated region (3'UTR), leading to significant impact on the regulatory potential of mRNA.