Article
Oncology
Qiang Huang, Yu-Jie Shen, Chi-Yao Hsueh, Yi-Fan Zhang, Xiao-Hui Yuan, Yu-Juan Zhou, Jiao-Yu Li, Lan Lin, Chun-Ping Wu, Chun-Yan Hu
Summary: This study aimed to investigate the potential of plasma extracellular vesicles (EVs) miR-99a-5p as a diagnostic biomarker for head and neck squamous cell carcinoma (HNSCC). The results showed that plasma EVs miR-99a-5p could be used to predict HNSCC.
PATHOLOGY & ONCOLOGY RESEARCH
(2022)
Article
Otorhinolaryngology
Cristiane Pereira Vargas Cousseau, Bruna Pereira Sorroche, Renan de Jesus Teixeira, Ana Carolina de Carvalho, Matias Eliseo Melendez, Renato de Castro Capuzzo, Ana Carolina Laus, Luciane Sussuchi da Silva, Nei Soares de Menezes, Andre Lopes Carvalho, Lidia Maria Rebolho Batista Arantes
Summary: This study identified 8 miRNAs that showed differential expression between pathologically positive and negative lymph nodes in oral squamous cell carcinoma patients without clinical evidence of lymph node metastases. Among them, hsa-miR-99a-5p demonstrated high sensitivity and specificity in predicting the risk of positive lymph nodes.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Genetics & Heredity
Nozomi Tanaka, Chikashi Minemura, Shunichi Asai, Naoko Kikkawa, Takashi Kinoshita, Sachi Oshima, Ayaka Koma, Atsushi Kasamatsu, Toyoyuki Hanazawa, Katsuhiro Uzawa, Naohiko Seki
Summary: The miR-199 family acts as tumor-suppressive miRNAs in head and neck squamous cell carcinoma by regulating the expression of paxillin (PXN) which contributes to cancer cell aggressiveness.
Article
Biochemistry & Molecular Biology
Sachi Oshima, Shunichi Asai, Naohiko Seki, Chikashi Minemura, Takashi Kinoshita, Yusuke Goto, Naoko Kikkawa, Shogo Moriya, Atsushi Kasamatsu, Toyoyuki Hanazawa, Katsuhiro Uzawa
Summary: The miRNAs miR-31-5p and miR-31-3p play important roles in regulating the oncogenic properties of HNSCC cells, affecting patient prognosis by controlling a series of genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Karolina Golabek, Dorota Hudy, Agata Swietek, Jadwiga Gazdzicka, Natalia Dabrowska, Katarzyna Miskiewicz-Orczyk, Natalia Zieba, Maciej Misiolek, Joanna Katarzyna Strzelczyk
Summary: This study analyzed the expression of E2F2 gene and protein, as well as the miRNAs candidate targets (miR-125b-5p, miR-155-3p, and miR-214-5p) in oral squamous cell carcinoma (OSCC) tumor and margin samples. The results showed that E2F2 gene is not the target for analyzed miRNAs in OSCC, while miR-155-3p and miR-125b-5p may play roles in the pathogenesis of OSCC. Additionally, miRNAs expression in response to tobacco smoke and HPV status showed differences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yuehan Wan, Rosalie G. Hoyle, Nan Xie, Wenjin Wang, Hongshi Cai, Ming Zhang, Zhikun Ma, Gan Xiong, Xiuyun Xu, Zhengxian Huang, Xiqiang Liu, Jiong Li, Cheng Wang
Summary: MiR-21-5p, an oncogenic miRNA, is upregulated in many solid cancers through a super-enhancer associated with the MIR21 gene (MIR21-SE). The key transcription factor FOSL1 directly controls miR-21-5p expression by interacting with MIR21-SE in head and neck squamous cell carcinoma (HNSCC). Clinical studies confirmed a positive correlation between miR-21-5p expression and FOSL1 expression, suggesting a potential role of FOSL1-SE in driving miR-21-5p expression to promote malignant progression of HNSCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ayaka Koma, Shunichi Asai, Chikashi Minemura, Sachi Oshima, Takashi Kinoshita, Naoko Kikkawa, Keiichi Koshizuka, Shogo Moriya, Atsushi Kasamatsu, Toyoyuki Hanazawa, Katsuhiro Uzawa, Naohiko Seki
Summary: The study identified downregulated miR-139 in head and neck squamous cell carcinoma and demonstrated its role in attenuating cancer cell aggressiveness by regulating GNA12 and OLR1 expression, which are associated with patient survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiang Li, Shouwei Zhao, Yu Fu, Ping Zhang, Zhenxing Zhang, Jie Cheng, Laikui Liu, Hongbing Jiang
Summary: The study demonstrates that downregulation of miR-34a-5p is associated with the progression of HNSCC tumors and cells. Functionally, miR-34a-5p inhibits proliferation, migratory/invasive activity, and epithelial-mesenchymal transition in HNSCC cells. Mechanistically, miR-34a-5p suppresses FLOT-2 expression and activates the MEK/ERK1/2 pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Li Yuan, Zhiqiang Xiao, Ruohuang Lu
Summary: This study reveals the overexpression of HPRT1 in HNSCC and its role in promoting tumor progression. Additionally, miR-125b-5p inhibits cell proliferation and invasion in HNSCC by directly targeting and downregulating HPRT1 expression. These findings highlight the potential importance of the miR-125b-5p/HPRT1 axis in the diagnosis and treatment of HNSCC.
Article
Genetics & Heredity
Yoshiaki Shinden, Tadahiro Hirashima, Nijiro Nohata, Hiroko Toda, Reona Okada, Shunichi Asai, Takako Tanaka, Yuto Hozaka, Takao Ohtsuka, Yuko Kijima, Naohiko Seki
Summary: Our recent research identified certain passenger strands of miRNAs that function as tumor-suppressive miRNAs in cancer cells, and analyzed the miRNA expression signature of breast cancer (BrCa) to identify oncogenic genes controlled by pre-miR-99a. The study revealed FAM64A as a potential target and highlighted the importance of aberrant expression of FAM64A in the malignant transformation of BrCa.
JOURNAL OF HUMAN GENETICS
(2021)
Article
Genetics & Heredity
Chikashi Minemura, Shunichi Asai, Ayaka Koma, Naoko Kikkawa, Mayuko Kato, Atsushi Kasamatsu, Katsuhiro Uzawa, Toyoyuki Hanazawa, Naohiko Seki
Summary: Analysis of miRNA expression in head and neck squamous cell carcinoma (HNSCC) revealed downregulation of the miR-30 family, especially miR-30e-5p and miR-30c-1-3p, which are associated with shorter patient survival. Further investigation showed that miR-30e-5p suppresses HNSCC cell migration and controls multiple oncogenic genes, including FOXD1. Knockdown of FOXD1 inhibited malignant phenotypes of HNSCC cells. These findings provide potential prognostic markers and therapeutic targets for HNSCC.
Article
Biochemistry & Molecular Biology
Ailing Gu, Xudong Bao
Summary: MiR-99a-5p is lowly expressed in human cervical squamous cell carcinoma (CSCC) and negatively associated with overall survival. Overexpression of miR-99a-5p can inhibit cell activity, migration, invasion, and promote apoptosis in CSCC cells. MiR-99a-5p targets CDC25A/IL-6 to hinder the epithelial-mesenchymal transition (EMT) process, playing an anti-tumor role in CSCC.
MOLECULAR BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Tong Sha, Jia Li, Shiqun Sun, Jianing Li, Xuetao Zhao, Zehua Li, Zhi Cui
Summary: YEATS2 is highly expressed in HNSCC clinical samples, and its knockdown inhibits proliferation, induces apoptosis, and reduces migration and invasion capability in HNSCC cells. Additionally, miR-378a-5p is involved in the regulation of YEATS2 expression.
Article
Biochemistry & Molecular Biology
Neha Khera, Asvika Soodhalaagunta Rajkumar, Khlood Abdulkader M. Alkurdi, Zhiao Liu, Hong Ma, Ahmad Waseem, Muy-Teck Teh
Summary: Through transcriptome datamining, 10 multidrug chemoresistance genes were identified in head and neck squamous cell carcinoma. Among them, NEK2 and INHBA showed significant prognostic values in multiple cancer types. Drug library screens discovered two compounds targeting INHBA and NEK2, which resensitized cisplatin-resistant cells.
Article
Medicine, Research & Experimental
Chi Zhang, Hongfei Wang, Miao Deng, Lihong He, Fan Ping, Yuan He, Zhaona Fan, Bin Cheng, Juan Xia
Summary: miR-411-5p plays a crucial role in promoting metastasis in HNSCC by downregulating RYBP expression levels, indicating it as a potential novel target for HNSCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)