Article
Virology
Yanqun Xu, Devin Vertrees, Yong He, Sanaz Momben-Abolfath, Xiaohong Li, Yambasu A. Brewah, Dorothy E. Scott, Krishnamurthy Konduru, Maria Rios, Evi B. Struble
Summary: Zika virus has become endemic in multiple regions and has the potential to cause teratogenic effects on fetuses. The mechanisms of viral spread to the placenta remain unknown. While there are no approved treatments or vaccines, appropriate tests can aid in understanding the infection and developing therapeutics.
Review
Immunology
Vincent Dussupt, Kayvon Modjarrad, Shelly J. Krebs
Summary: The unprecedented Zika outbreak in the Americas from 2015-2016 led to global concern and accelerated the deployment of vaccine and therapeutic countermeasures. Several potent neutralizing antibodies against Zika and related flaviviruses have been discovered in recent years. Structure-based approaches have helped identify species-specific and cross-protective epitopes with therapeutic value.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carlos Alessandro Fuzo, Luiz Felipe Lemes de Araujo, Rafael de Souza Pontes, Patricia Martinez Evora, Rodrigo Guerino Stabeli
Summary: The study identified a conserved epitope in the E protein of ZIKV targeted by two nAbs, indicating potential for vaccine and antibody-based interventions. The findings contribute to the development of therapies against ZIKV by providing important information on the binding and neutralization mechanism.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Multidisciplinary Sciences
Ron Yefet, Nadav Friedel, Hadas Tamir, Ksenia Polonsky, Michael Mor, Lilach Cherry-Mimran, Eyal Taleb, David Hagin, Eli Sprecher, Tomer Israely, Natalia T. Freund
Summary: By testing the serum reactivity of the subjects, two antigens related to Monkeypox virus were identified, and it was found that the response to these antigens differed between infected individuals and vaccinated individuals, indicating that A35R and H3L could be used as immune targets for Monkeypox virus infection.
Article
Immunology
Sarah M. Valencia, Eric Rochat, Melissa J. Harnois, Maria Dennis, Helen S. Webster, Bhavna Hora, Amit Kumar, Hsuan-Yuan (Sherry) Wang, Leike Li, Daniel Freed, Ningyan Zhang, Zhiqiang An, Dai Wang, Sallie R. Permar
Summary: The study shows that vaccination with V160 can result in a similar breadth of gB-specific antibodies compared to natural infection, but their binding characteristics and antigenic specificity are different. Antibodies isolated from V160 vaccinees have weaker neutralizing ability against gB compared to those from natural infection.
Article
Immunology
Francisco Javier Martinez-Lobo, Francisco Diez-Fuertes, Isabel Simarro, Jose M. Castro, Cinta Prieto
Summary: This study confirms that PRRSV-1 isolates differ in their ability to induce cross-reactive NAs, and pigs with cross-reactive NAs exhibit better protection against heterologous reinfections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maya Shofa, Tomotaka Okamura, Emiko Urano, Yoshiharu Matsuura, Yasuhiro Yasutomi, Akatsuki Saito
Summary: ZIKV outbreaks in Central and South America were finally controlled through various methods, including mosquito control and herd immunity. This study on cynomolgus monkeys showed that mucosal ZIKV infection can induce protective immunity without causing systemic viremia or symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Seydou Ka, Natacha Merindol, Aissatou Aicha Sow, Amita Singh, Karima Landelouci, Melodie B. Plourde, Genevieve Pepin, Marco Masi, Roberta Di Lecce, Antonio Evidente, Matar Seck, Lionel Berthoux, Laurent Chatel-Chaix, Isabel Desgagne-Penix
Summary: The study found that Amaryllidaceae alkaloids (AAs) from plants of the Amaryllidaceae family have strong antiviral activity, with cherylline specifically inhibiting dengue virus and Zika virus replication. This suggests that AAs, including cherylline, could be a potential source of new antiviral drugs.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Amanda E. Calvert, Kalanthe Horiuchi, Karen L. Boroughs, Yee T. Ong, Kimberly M. Anderson, Brad J. Biggerstaff, Mars Stone, Graham Simmons, Michael P. Busch, Claire Y-H Huang
Summary: The study demonstrates the persistence of IgM neutralizing antibodies after ZIKV infection, with IgM playing a predominant role in ZIKV neutralization and showing lower cross-reactivity compared to IgG.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Renato Kaylan Alves de Oliveira Franca, Jacyelle Medeiros Silva, Lucas Silva Rodrigues, Dimitri Sokolowskei, Marcelo Macedo Brigido, Andrea Queiroz Maranhao
Summary: This study utilized phage display technology to select human antibodies targeting the fusion loop region of the Zika virus. Three antibodies that can neutralize Zika virus infection were obtained through four rounds of selection. Due to the high conservation of the fusion loop region, these new antibodies have the potential to be used in therapeutic interventions against Zika virus and other flavivirus illnesses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Ivo C. C. Martins, Rafaela C. C. Ricardo, Nuno C. C. Santos
Summary: Dengue, West Nile, and Zika viruses are vector-borne flaviviruses that cause disease outbreaks with potentially severe symptoms and socioeconomic repercussions. Currently, there are no specific treatments available, and only generic symptom relief is possible. The effectiveness of the first dengue vaccine, Dengvaxia, is limited. Prophylactic approaches against other viruses are even more restricted. Therefore, there is a need for therapeutic strategies.
Article
Virology
Giuditta De Lorenzo, Rapeepat Tandavanitj, Jennifer Doig, Chayanee Setthapramote, Monica Poggianella, Ricardo Sanchez-Velazquez, Hannah E. Scales, Julia M. Edgar, Alain Kohl, James Brewer, Oscar R. Burrone, Arvind H. Patel
Summary: The study developed ZIKV subunit and virus-like particle (VLP)-based vaccines, which induced antibodies with a higher capacity to neutralize virus infection and protected animals from lethal challenge with both the African and Asian lineages of ZIKV. The engineered immunogens reduced the potential to induce antibody-dependent enhancement (ADE) of infection and showed promising efficacy in comparison with the wild-type derivatives.
JOURNAL OF VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Ron Yefet, Nadav Friedel, Hadas Tamir, Ksenia Polonsky, Michael Mor, Lilach Cherry-Mimran, Eyal Taleb, David Hagin, Eli Sprecher, Tomer Israely, Natalia T. Freund
Summary: Two forms of Monkeypox virus (MPXV), mature and enveloped, were studied and the reactivity of MPXV recoverees' sera to Vaccinia Lister and A35R and H3L antigens was examined. The results showed that the neutralization levels against Vaccinia Lister were detectable in 8 out of 11 recoverees and all recoverees exhibited strong binding to A35R and H3L antigens. The levels of response to A35R were significantly higher in recoverees compared to vaccinated individuals, indicating that A35R and H3L could be used as immune targets for the identification of recent MPXV infection.
Article
Public, Environmental & Occupational Health
Tereza Magalhaes, Clarice N. L. Morais, Elisa A. N. Azevedo, Iracema J. A. A. Jacques, Priscila M. S. Castanha, Marli T. Cordeiro, Cynthia Braga, Thomas Jaenisch, Ernesto T. A. Marques, Brian D. Foy
Summary: It is unclear if humoral immunity to Zika virus following natural infection is long-lasting, and cross-reactivity of antibodies with dengue viruses can have biological implications. In Brazil, researchers measured the decay of Zika virus neutralizing antibodies in individuals who had acute or recent past infections. They also confirmed that the plaque reduction neutralization assay is a reliable method for measuring past exposure to Zika virus in areas with co-endemicity.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Immunology
Fan Zhou, Lena Hansen, Gabriel Pedersen, Gunnveig Grodeland, Rebecca Cox
Summary: Our study demonstrates that the Matrix M adjuvanted virosomal H5N1 vaccine can induce rapid and robust broadly cross-neutralizing antibody responses, providing comprehensive protection. The adjuvanted vaccines also induce multifaceted antibody responses, including hemagglutinin stalk domain specific, neuraminidase inhibiting, and antibody-dependent cellular cytotoxicity inducing antibodies.
FRONTIERS IN IMMUNOLOGY
(2021)
Letter
Immunology
Xinling Wang, Wei Xu, Gaowei Hu, Shuai Xia, Zhiping Sun, Zezhong Liu, Youhua Xie, Rong Zhang, Shibo Jiang, Lu Lu
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Virology
Xiao-Kun Li, Bo Tu, Xiao-Ai Zhang, Wen Xu, Jia-Hao Chen, Guang-Yu Zhao, Biao Xu, Jun-Jie Zheng, Yan-Feng Yan, Peng-Fei Hao, Reginald Cole, Mohamed Boie Jalloh, Qing-Bin Lu, Chang Li, Stephen Sevalie, Wei Liu, Wei-Wei Chen
Summary: Metabolic analysis of COVID-19 patients from Sierra Leone revealed the association between glutamine and glutamate metabolism and disease severity. Further analysis confirmed these findings and suggested that targeting these metabolic pathways could be a potential therapeutic approach for severe COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Materials Science, Ceramics
Adam Bratten, Visharad Jalan, Meng Shi, Tyler Gerczak, Haiming Wen, Peter Doyle, Haiyan Zhao, Xiaoqing He
Summary: Surrogate tristructural-isotropic (TRISO)-coated fuel particles were oxidized in 0.2 kPa O-2 to examine the behavior of the SiC layer. The analysis of the resulting SiO2 layers showed a majority of smooth, amorphous SiO2 with a constant thickness indicative of passive oxidation. The activation energy for oxide growth was consistent across all temperatures and the presence of irregular grain size influenced the oxidation response of the SiC layer.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Dan Zhao, Xiaoyun Li, Mengyu Xu, Yan Jiao, Huan Liu, Xincai Xiao, Haiyan Zhao
Summary: This paper reports the preparation of yellow-green-fluorescent and high-quantum yield carbon dots (4-ACDs) and investigates their optical properties. The 4-ACDs show excellent broad-spectrum antibacterial activity and biocompatibility, making them ideal for cell imaging. The coupling of 4-ACDs and lysozyme (LZM) results in CDs-LZM complex with strong antibacterial activity against Gram-positive bacteria and efficient elimination of biofilm.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Tianjia Sun, Yingquan Zhang, Qingli Yang, Jinfu Ban, Boli Guo, Bo Zhang, Haiyan Zhao
Summary: The study aimed to investigate the spatio-temporal variation of arabinoxylan (AX) and alkylresorcinol (AR) in wheat. The contents of total arabinoxylan (TOT-AX), water-extractable arabinoxylan (WE-AX), and alkylresorcinol (AR) in wheat from the main wheat producing areas of China were analyzed. Factors such as geographical origin, variety, harvest year, and irrigation frequency were found to significantly affect the AX and AR contents in wheat grains. The study identified Xiaoyan 22, Xinmai 18, and Hengguan 35 as the varieties with the highest TOT-AX, WE-AX, and AR contents, respectively.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Chemistry, Physical
Fan Yang, Jiayun Pei, Haiyan Zhao
Summary: This study investigates ultrathin carbon-deficient molybdenum carbide (MoC0.66) as a catalyst for the capture and conversion of carbon dioxide (CO2) to methane (CH4). The results show that MoC(0.66) exhibits remarkable catalytic activity for CO2 hydrogenation to CH4. Unlike conventional catalysts, the limiting step of the MoC0.66 catalyst is determined by the release of *OH species during the CO2 reduction reaction (CO2RR). Increasing the temperature improves the release of H2O and CH4 as well as the selectivity of the CO2RR.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Biochemistry & Molecular Biology
Na Li, Hongyue Zhang, Min Cui, Jujie Ren, Jingru Huang, Bao Sun, Haiyan Zhao, Cong Zhang
Summary: The preparation of covalent polyoxometalate organic frameworks (CPOFs) was introduced using polyoxometalate and covalent organic frameworks. The CPOFs were synthesized by functionalizing polyoxometalate with an amine group and then reacting it with 2,4,6-trihydroxybenzene-1,3,5-tricarbaldehyde. The PtNPs-CPOFs-MWCNTs nanocomposites were formed by incorporating PtNPs and MWCNTs into the CPOFs material, resulting in excellent catalytic activity and electrical conductivity for the electrochemical thymol sensors.
Article
Engineering, Marine
Lepeng Chen, Rongxin Cui, Weisheng Yan, Hui Xu, Haiyan Zhao, Haoquan Li
Summary: Underwater robot has potential to clean ship hull fouling, but design and control are challenging. Use of negative pressure and magnetic adsorption technologies limit utility on rough hulls and warships. We propose a robot with thrusters and crawler belts to adapt to common hulls. A climbing controller guides robot to cover hull without repetition or omission, overcoming difficulties of inconsistent crawler belts and inaccurate depth measurement. Field experiments on giant ship verify effectiveness of proposed solution and controller.
Article
Chemistry, Analytical
Shuang Lin, Xiaoyu Fang, Guoqiang Fang, Fengping Liu, Haoyu Dong, Haiyan Zhao, Jing Zhang, Bin Dong
Summary: In this study, a 3D clean cascade-enhanced nanosensor assisted by machine learning algorithms was developed for accurate and ultrasensitive identification of multiple pollutants. The SERS substrate achieved cascading electromagnetic energy with a remarkable enhancement factor of 8.35 x 109, thanks to the combination of micro-level polystyrene sphere porous array and nano-level Au-Ag clusters. With high cleanliness and ultra-sensitivity, hazardous pollutants with similar geometry and Raman peaks at ultra-low concentration were successfully distinguished using principal component analysis. Therefore, this efficient and clean SERS substrate, coupled with artificial intelligence, could advance the application of SERS technology in accurate identification of trace contaminants.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Virology
Chao Wang, Qing Li, Lujia Sun, Xinling Wang, Huan Wang, Wenpeng Zhang, Jiahui Li, Yang Liu, Lu Lu, Shibo Jiang
Summary: Researchers developed a novel dual-target inhibitor by integrating a small-molecule HIV-1 inhibitor with an artificial peptide. This inhibitor showed improved activity against multiple drug-resistant HIV-1 strains.
Article
Biochemistry & Molecular Biology
Ling Xu, Chao Wang, Wei Xu, Lixiao Xing, Jie Zhou, Jing Pu, Mingming Fu, Lu Lu, Shibo Jiang, Qian Wang
Summary: By replacing the PEG linker in EK1C4 with a short peptide, we designed and synthesized a dePEGylated lipopeptide, EKL1C, which showed potent inhibitory activity against coronaviruses, including SARS-CoV-2, and HIV-1. This indicates that HR1 may serve as a common target for the development of broad-spectrum viral fusion inhibitors, and EKL1C has potential clinical application as a therapeutic or preventive agent against coronavirus, HIV-1, and other class I enveloped viruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xiaojie Su, Ziqi Huang, Wei Xu, Qian Wang, Lixiao Xing, Lu Lu, Shibo Jiang, Shuai Xia
Summary: The peptide-based pan-coronavirus fusion inhibitor EK1 is showing promising clinical application prospects against SARS-CoV-2 and its variants. By conjugating EK1 with the human immunoglobulin G Fc-binding peptide (IBP), the engineered peptide IBP-EK1 demonstrates broad-spectrum inhibitory activity against various coronaviruses with improved in vivo half-life. It also shows synergistic effects when combined with monoclonal neutralizing antibodies, suggesting its potential as a long-acting, broad-spectrum antiviral agent against COVID-19 and future highly pathogenic coronaviruses.
Article
Environmental Sciences
Jiayu Dong, Xianni Song, Shuchi Zhang, Mengyu Tan, Haiyan Zhao, Donglei Wu
Summary: A novel hierarchical Cu/ZSM-5 catalyst with large pore volume and size was prepared for the catalytic ozonation of PVA. The catalyst exhibited excellent mineralization performance, with a TOC removal rate of 47.86% after 60 minutes of reaction. O-1(2) played a more significant role than ·OH in PVA removal. The catalyst showed high catalytic activity and stability, making it promising for the treatment of refractory pollutants via catalytic ozonation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Physical
Muhammad Qasim Zafar, Jinnan Wang, Zhenlin Zhang, Chaochao Wu, Haiyan Zhao, Ghulam Hussain, Ninshu Ma
Summary: Laser cladding is a promising technique for fabrications, remanufacturing, and repair of metallic components. Residual stresses caused by melting and solidification in the process often lead to geometric discrepancies and deterioration of the end product. A hybrid FEM scheme is adopted to efficiently predict the temperature field, residual stress, and distortion in multilayer powder-fed laser cladding. The accuracy of the simulation is validated through experiments, showing precise agreement for residual stress and distortion measurements.
Article
Chemistry, Multidisciplinary
Xiaoming Bai, Guangyu Zhao, Guiye Yang, Ming Wang, Zhaoyu Chen, Naiqing Zhang
Summary: In this study, a high-activity titanium-oxygen cluster was used as a brazing filler to successfully braze LLZTO with a lithium anode into a whole unit, leading to a significant reduction in interfacial impedance and inhibition of lithium dendrite growth.