Article
Biotechnology & Applied Microbiology
Ping Li, Jiyang Jiang, Yifei Li, Yue Lan, Fan Yang, Jiao Wang, Yuxin Xie, Fei Xiong, Jinhui Wu, Hanmin Liu, Zhenxin Fan
Summary: The study observed significant differences in the gut microbiome of obese children compared to controls, with the bacterial pathogen Campylobacter rectus significantly more abundant in obese children. Functional annotation of microbial genes indicated the presence of gut inflammation in obese children, while the gut microbiomes of overweight children were in a transitional state between obese and control children. Additionally, Trichuris trichiura was found to be significantly more abundant in the guts of obese Mexican children compared to obese Chinese children, highlighting differences in gut microbial composition between populations.
Article
Gastroenterology & Hepatology
Baskar Balakrishnan, Vaithinathan Selvaraju, Jun Chen, Priscilla Ayine, Lu Yang, Jeganathan Ramesh Babu, Thangiah Geetha, Veena Taneja
Summary: This study aimed to investigate the differences in gut and oral microbial communities in obese African American and European American children, indicating a specific association between ethnicity and microbial profiles.
Article
Immunology
Ting Ma, Zeyu Wu, Jing Lin, Chao Shan, Aisaiti Abasijiang, Jin Zhao
Summary: This study analyzed the oral and gut microbiota of obese and normal weight children aged 3-5 years using long-range DNA sequencing. The results showed significant differences in the microbial community structure between obesity and controls, as well as specific oral and gut microbial genera in children with obesity. The study highlights the importance of understanding the relationship between childhood obesity and microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Psychiatry
Li-ya Pan, Yuan-yue Zhou, Xue Zhang, Hai-yin Jiang
Summary: This study investigated the longitudinal changes in the microbiome during treatment with atypical antipsychotics and found that the baseline composition of the gut microbiome was associated with the risk of weight gain associated with antipsychotic medication.
PSYCHIATRY RESEARCH
(2022)
Review
Nutrition & Dietetics
Erica G. Soltero, Armando Pena, Veronica Gonzalez, Edith Hernandez, Guisela Mackey, Chishinga Callender, Jayna M. Dave, Debbe Thompson
Summary: This scoping review focused on family-based obesity prevention interventions among Hispanic youth and found that most interventions were culturally-adapted, but there is still a need to further acknowledge the impact of social determinants of health.
Article
Immunology
Shao-rui Hao, Yuan-yue Zhou, Xue Zhang, Hai-yin Jiang
Summary: This study explored the changes in the gut bacterial microbiome in AP-exposed children with obesity. The findings showed that AP users, regardless of their body mass index, had decreased microbial richness and diversity compared to the control group. The AP-exposed children also had differences in microbial functions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Wenqi Du, Linxun Liu, Yan Ma, Qinfang Zhu, Ruhan Jia, Ying Han, Ziyi Wu, Xin Yan, Ainiwaer Ailizire, Wei Zhang
Summary: This study aimed to explore the relationship between intestinal flora and obesity in Tibetan children. The results showed that the levels of triglyceride and low-density lipoprotein cholesterol were lower in obesity groups living at high altitudes compared to those at low altitudes. The composition and relative abundance of gut microbiota were affected by altitude, and different dominant bacterial genera were found in groups with different altitudes and body weights. There were correlations between gut microbiota composition and blood lipid metabolism indicators.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Md Saimul Islam, Shyanne Page-Hefley, Anne P. Hernandez, Luke Whelchel, Chiquito Crasto, Whitney Viator, Treyce Money, Babafela Awosile, Noel Howard, Tetyana L. Vasylyeva
Summary: This study investigates the effects of lifestyle changes on overweight adolescents. The results showed that lifestyle interventions can reduce inflammation and improve mental health. The study also revealed connections between gut microbiota composition, inflammatory markers, and psychological factors.
Article
Pediatrics
John Palla, Santosh Thapa, Alamelu Venkatachalam, Jessica K. Runge, Theresa A. Laguna, Ruth Ann Luna
Summary: Hispanic children with CF have a higher incidence of P. aeruginosa and a greater relative abundance of Saccharimonadales compared to non-Hispanic children. However, there was no significant difference in the airway microbial diversity between the two groups.
PEDIATRIC PULMONOLOGY
(2023)
Article
Endocrinology & Metabolism
Dong D. Wang, Qibin Qi, Zheng Wang, Mykhaylo Usyk, Daniela Sotres-Alvarez, Josiemer Mattei, Martha Tamez, Marc D. Gellman, Martha Daviglus, Frank B. Hu, Meir J. Stampfer, Curtis Huttenhower, Rob Knight, Robert D. Burk, Robert C. Kaplan
Summary: This study reveals that adherence to the Mediterranean diet can affect gut microbiome composition and functions. The association between the Mediterranean diet and diabetes prevalence varies depending on individual gut microbial composition.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Rachele De Giuseppe, Federica Loperfido, Rosa Maria Cerbo, Maria Cristina Monti, Elisa Civardi, Francesca Garofoli, Micol Angelini, Beatrice Maccarini, Eduardo Sommella, Pietro Campiglia, Laura Bertuzzo, Marcello Chieppa, Stefano Ghirardello, Hellas Cena
Summary: Childhood obesity is a strong predictor of adult obesity, with significant health and economic consequences. Early adiposity rebound (EAR) occurring at around 2 years old may be related to early changes in the gut microbiome due to maternal/lifestyle changes and environmental exposures. The LIMIT study aims to identify the interplay between infant gut microbiome, infant/maternal lifestyle, and environmental factors, in order to find modifiable factors for effective and personalized prevention of childhood obesity.
Article
Gastroenterology & Hepatology
Devesha H. Kulkarni, Brigida Rusconi, Alexandria N. Floyd, Elisabeth L. Joyce, Khushi B. Talati, Hrishi Kousik, Dereck Alleyne, Dalia L. Harris, Lorena Garnica, Ryan Mcdonough, Shay S. Bidani, Hrishikesh S. Kulkarni, Elizabeth P. Newberry, Keely G. Mcdonald, Rodney D. Newberry
Summary: Obesity and the metabolic syndrome are complex disorders influenced by various factors including genetics, diet, activity, inflammation, and gut microbes. This study aimed to investigate the specific role of gut microbiota in driving obesity and inflammation, independent of diet and genetics. The findings demonstrate that the gut microbiota from obese individuals alone can cause weight gain and inflammation.
Review
Biochemistry & Molecular Biology
Harshita Shailesh, Ajaz A. Bhat, Ibrahim A. Janahi
Summary: Obesity and asthma are common health issues with increased prevalence worldwide. Obesity exacerbates asthma symptoms and reduces therapeutic response. Recent studies have found that obesity-associated non-T2 factors, including mechanical stress, hyperinsulinemia, systemic inflammation, play a role in worsening asthma symptoms in obese asthmatic individuals. This review also discusses potential future therapies to reduce asthma symptoms in obese individuals by addressing these obesity-associated factors.
Article
Multidisciplinary Sciences
Pamela Thomson, Rodrigo Santibanez, Camila Rodriguez-Salas, Carla Flores-Yanez, Daniel Garrido
Summary: Obesity is a prevalent nutritional disorder in dogs, with over 40% suffering from it. The gut microbiome of obese dogs is different from that of normal weight dogs, with an increase in Firmicutes and a decrease in Bacteroidetes. Additionally, obese dogs show enrichment in pathways related to transport, chemotaxis, and flagellar assembly. Modulating the gut microbiome may be a potential way to improve the health of dogs.
Review
Endocrinology & Metabolism
Yeon Ji Kim, Jack T. Womble, Claudia K. Gunsch, Jennifer L. Ingram
Summary: Evidence suggests a significant association between obesity, metabolic syndrome, and asthma, all of which are related to microbiome dysbiosis. Changes in gut and airway microbiome following bariatric surgery may play a role in ameliorating asthma symptoms.