A comprehensive and perspective view of oncoprotein SET in cancer

Histone H1 chaperone activity of TAF-I is regulated by its subtype-dependent intramolecular interaction

(2017) Kaori Kajitani et al.   GENES TO CELLS

PP32 and SET/TAF-Iβ proteins regulate the acetylation of newly synthesized histone H4

(2017) Francisco Saavedra et al.   NUCLEIC ACIDS RESEARCH

SET oncoprotein accumulation regulates transcription through DNA demethylation and histone hypoacetylation

(2017) Luciana O. Almeida et al.   Oncotarget

Directional Migration in Esophageal Squamous Cell Carcinoma (ESCC) is Epigenetically Regulated by SET Nuclear Oncogene, a Member of the Inhibitor of Histone Acetyltransferase Complex

(2017) Xiang Yuan et al.   NEOPLASIA

Regulation of SET Gene Expression by NFkB

(2016) Yi Feng et al.   MOLECULAR NEUROBIOLOGY

Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode

(2016) Donglai Wang et al.   NATURE

Histone chaperone activity of Arabidopsis thaliana NRP1 is blocked by cytochrome c

(2016) Katiuska González-Arzola et al.   NUCLEIC ACIDS RESEARCH

Upregulation of the oncoprotein SET determines poor clinical outcomes in hepatocellular carcinoma and shows therapeutic potential

(2016) M-H Hung et al.   ONCOGENE

MYC-dependent recruitment of RUNX1 and GATA2 on the SET oncogene promoter enhances PP2A inactivation in acute myeloid leukemia

(2016) Raffaella Pippa et al.   Oncotarget

Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia

(2016) Nameeta P. Richard et al.   Oncotarget

The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma

(2015) Shuhei ENJOJI et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Structural basis for inhibition of the histone chaperone activity of SET/TAF-Iβ by cytochromec

(2015) Katiuska González-Arzola et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin

(2015) Alkmini Kalousi et al.   Cell Reports

Deregulation of the PP2A Inhibitor SET Shows Promising Therapeutic Implications and Determines Poor Clinical Outcome in Patients with Metastatic Colorectal Cancer

(2014) I. Cristobal et al.   CLINICAL CANCER RESEARCH

Antagonism of SET Using OP449 Enhances the Efficacy of Tyrosine Kinase Inhibitors and Overcomes Drug Resistance in Myeloid Leukemia

(2014) A. Agarwal et al.   CLINICAL CANCER RESEARCH

Inhibition of FoxO1 acetylation by INHAT subunit SET/TAF-Iβ induces p21 transcription

(2014) Yun-Cheol Chae et al.   FEBS LETTERS

Cytoplasmic Retention of Protein Phosphatase 2A Inhibitor 2 (I2PP2A) Induces Alzheimer-like Abnormal Hyperphosphorylation of Tau

(2014) Mohammad Arif et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models

(2014) Lays M Sobral et al.   Molecular Cancer

Targeting Inhibitors of the Tumor Suppressor PP2A for the Treatment of Pancreatic Cancer

(2014) Amy S. Farrell et al.   MOLECULAR CANCER RESEARCH

Silencing of IFN-stimulated gene transcription is regulated by histone H1 and its chaperone TAF-I

(2014) Shinichi Kadota et al.   NUCLEIC ACIDS RESEARCH

Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer

(2014) M. Janghorban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Ku70 acetylation by INHAT subunit SET/TAF-Iβ regulates Ku70-mediated DNA damage response

(2013) Kee-Beom Kim et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Histone chaperones in nucleosome assembly and human disease

(2013) Rebecca J Burgess et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease

(2013) Guang Yu et al.   NEUROBIOLOGY OF AGING

Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling

(2012) M. Danielle Bareford et al.   CANCER BIOLOGY & THERAPY

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

(2012) Sahar A. Saddoughi et al.   EMBO Molecular Medicine

The Apolipoprotein-E-Mimetic COG112 Protects Amyloid Precursor Protein Intracellular Domain-Overexpressing Animals from Alzheimer's Disease-Like Pathological Features

(2012) Kaushik Ghosal et al.   Neurodegenerative Diseases

SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target

(2011) D. J. Christensen et al.   BLOOD

Role of Template Activating Factor-I as a chaperone in linker histone dynamics

(2011) K. Kato et al.   JOURNAL OF CELL SCIENCE

Apolipoprotein E and Peptide Mimetics Modulate Inflammation by Binding the SET Protein and Activating Protein Phosphatase 2A

(2011) D. J. Christensen et al.   JOURNAL OF IMMUNOLOGY

Phosphoinositide 3-Kinase Enhancer Regulates Neuronal Dendritogenesis and Survival in Neocortex

(2011) C. Bun Chan et al.   JOURNAL OF NEUROSCIENCE

Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling

(2011) Andréia M. Leopoldino et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Inhibition of p53 acetylation by INHAT subunit SET/TAF-Iβ represses p53 activity

(2011) Ji-Young Kim et al.   NUCLEIC ACIDS RESEARCH

Targeting SET/I2PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy

(2011) C H Switzer et al.   ONCOGENE

Multiple Functions of Phosphoinositide-3 Kinase Enhancer (PIKE)

(2011) Chi Bun Chan et al.   TheScientificWorldJOURNAL

Critical roles for Rac GTPases in T-cell migration to and within lymph nodes

(2010) M. Faroudi et al.   BLOOD

The Apolipoprotein E-Mimetic Peptide COG112 Inhibits NF-κB Signaling, Proinflammatory Cytokine Expression, and Disease Activity in Murine Models of Colitis

(2010) Kshipra Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SETBP1 overexpression is a novel leukemogenic mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia

(2009) I. Cristobal et al.   BLOOD

Sp1-mediated transcription regulation of TAF-Iα gene encoding a histone chaperone

(2008) Masamitsu N. Asaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Apolipoprotein E-mimetic Peptide COG112 Inhibits the Inflammatory Response toCitrobacter rodentiumin Colonic Epithelial Cells by Preventing NF-κB Activation

(2008) Kshipra Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective Actions of PIKE-L by Inhibition of SET Proteolytic Degradation by Asparagine Endopeptidase

(2008) Zhixue Liu et al.   MOLECULAR CELL

Activated glucocorticoid receptor interacts with the INHAT component Set/TAF-Iβ and releases it from a glucocorticoid-responsive gene promoter, relieving repression: Implications for the pathogenesis of glucocorticoid resistance in acute undifferentiated leukemia with Set-Can translocation

(2007) Takamasa Ichijo et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY