Article
Oncology
Beomyoung Cho, Yunan Han, Min Lian, Graham A. Colditz, Jason D. Weber, Cynthia Ma, Ying Liu
Summary: This study examined the differences in treatment and outcomes between African American and White women with TNBC, finding that African American women had lower odds of receiving surgery and chemotherapy compared to White women, leading to a significantly higher risk of breast cancer mortality.
Article
Multidisciplinary Sciences
Rachel Martini, Yalei Chen, Brittany D. Jenkins, Isra A. Elhussin, Esther Cheng, Syed A. Hoda, Paula S. Ginter, Jeffrey Hanover, Rozina B. Zeidan, Joseph K. Oppong, Ernest K. Adjei, Aisha Jibril, Dhananjay Chitale, Jessica M. Bensenhaver, Baffour Awuah, Mahteme Bekele, Engida Abebe, Ishmael Kyei, Frances S. Aitpillah, Michael O. Adinku, Kwasi Ankomah, Ernest B. Osei-Bonsu, Saul David Nathansan, LaToya Jackson, Evelyn Jiagge, Lindsay F. Petersen, Erica Proctor, Petros Nikolinakos, Kofi K. Gyan, Clayton Yates, Rick Kittles, Lisa A. Newman, Melissa B. Davis
Summary: The study indicates that the Duffy-null allele and the ANKLE1 missense variant may have associations with triple-negative breast cancer risk and outcomes among African American women.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Fei Wang, Wei Zheng, Christina E. Bailey, Ingrid A. Mayer, Jennifer A. Pietenpol, Xiao-Ou Shu
Summary: This study found that after considering clinical characteristics, treatment, and care-related factors, the mortality differences between white and black TNBC patients were mainly influenced by these factors. However, the mortality differences between Hispanic and Asian patients compared to white patients were largely unaffected by these factors.
Article
Medicine, General & Internal
Miquel Ensenyat-Mendez, Maria Solivellas-Pieras, Pere Llinas-Arias, Sandra Iniguez-Munoz, Jennifer L. Baker, Diego M. Marzese, Maggie L. DiNome
Summary: This study aims to investigate the epigenetic differences in triple-negative breast cancer (TNBC) of younger African American females and understand the clinical disparities in this patient group. The results suggest that TNBC of younger African American females may have distinct epigenetic characteristics and provide novel insights into the molecular alterations associated with TNBC in this population.
Article
Oncology
Michal Marczyk, Tao Qing, Tess O'Meara, Vesal Yagahoobi, Vasiliki Pelekanou, Yalai Bai, Emily Reisenbichler, Kimberly S. Cole, Xiaotong Li, Vignesh Gunasekharan, Eiman Ibrahim, Kristina Fanucci, Wei Wei, David L. Rimm, Lajos Pusztai, Kim R. M. Blenman
Summary: Differences in the tumor immune microenvironment may exist between African American and NonAA breast cancer patients, which may impact treatment response and prognosis.
Article
Oncology
Rachel Martini, Princesca Delpe, Timothy R. Chu, Kanika Arora, Brittany Lord, Akanksha Verma, Deepa Bedi, Balasubramanyam Karanam, Isra Elhussin, Yalei Chen, Endale Gebregzabher, Joseph K. Oppong, Ernest K. Adjei, Aisha Jibril Suleiman, Baffour Awuah, Mahteme Bekele Muleta, Engida Abebe, Ishmael Kyei, Frances S. Aitpillah, Michael O. Adinku, Kwasi Ankomah, Ernest Baawuah Osei-Bonsu, Dhananjay A. Chitale, Jessica M. Bensenhaver, David S. Nathanson, LaToya Jackson, Lindsay F. Petersen, Erica Proctor, Brian Stonaker, Kofi K. Gyan, Lee D. Gibbs, Zarko Monojlovic, Rick A. Kittles, Jason White, Clayton C. Yates, Upender Manne, Kevin Gardner, Nigel Mongan, Esther Cheng, Paula Ginter, Syed Hoda, Olivier Elemento, Nicolas Robine, Andrea Sboner, John D. Carpten, Lisa Newman, Melissa B. Davis
Summary: Women of sub-Saharan African descent have a higher incidence and mortality rate of triple-negative breast cancer (TNBC). This study conducted RNA sequencing on African Americans and Africans with TNBC, revealing associations between African ancestry and gene expression profiles and immunologic landscapes. These findings may explain the racial differences in clinical outcomes.
Article
Oncology
Katie M. O'Brien, Quaker E. Harmon, Chandra L. Jackson, Mary Diaz-Santana, Jack A. Taylor, Clarice R. Weinberg, Dale P. Sandler
Summary: This study found that women with higher circulating 25-hydroxyvitamin D (25(OH)D) concentrations had a lower risk of breast cancer, especially among Hispanic/Latina women. The association was weaker among Black/African American women. There was no clear association between 24,25-dihydroxyvitamin D (24,25(OH)2D) and breast cancer risk.
Article
Oncology
Jennifer Erdrich, Felina Cordova-Marks, Angela R. Monetathchi, Manxia Wu, Arica White, Stephanie Melkonian
Summary: This study found that NH-AI/AN women have a higher percentage of mastectomy for early-stage breast cancer compared to NHW women, with no significant differences in late-stage disease. Regional disparities were observed, with some regions having higher rates of mastectomy among NH-AI/AN women.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Safaa Turkistani, Bruna M. Sugita, Paolo Fadda, Rafael Marchi, Ali Afsari, Tammey Naab, Victor Apprey, Robert L. Copeland, Michael C. Campbell, Luciane R. Cavalli, Yasmine Kanaan
Summary: This study identified specific miRNAs associated with tumor size, LN, and REC status in AA TNBC patients with high discriminatory power. These miRNAs are involved in proteglycans, glycan, and cancer-associated pathways, and are significantly associated with lower survival rates.
Review
Oncology
Kaixuan Li, Dongjiang Zong, Jianrong Sun, Danxiang Chen, Minkai Ma, Liqun Jia
Summary: This review explores the genomic and non-genomic steroid hormone actions and endocrine-related signals in triple-negative breast cancers, as well as the non-canonical mechanisms detected in common hormone agents, challenging the notion of hormone insensitivity in triple-negative breast cancers.
FRONTIERS IN ONCOLOGY
(2022)
Article
Orthopedics
Marsalis Brown, Thiran Udawatta, Lance Flesch, Gregory J. Strnad, Isaac Briskin, Morgan Jones, Scott Kaar, James T. Rosneck, Lutul D. Farrow
Summary: This study investigates the differences between African American and non-Hispanic White patients in terms of hip-related disabilities. The results show that African Americans have a lower proportion of hip-related disabilities evaluations, and there are disparities in surgery recommendations and MRI usage.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2022)
Article
Geriatrics & Gerontology
Karen D. Lincoln, Ann W. Nguyen
Summary: The study identified three distinct risk types among African Americans, with the high-risk type characterized by chronic health conditions, shorter STL, strained social relationships, and high psychosocial stress. African Americans were also less likely to be assigned to the health risk type, which was characterized by chronic health conditions, shorter STL, optimal social relationships, and low psychosocial stress. The biopsychosocial risk typology provided valuable insights into factors influencing accelerated aging in African Americans.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Surgery
Neha Goel, Sina Yadegarynia, Maya Lubarsky, Seraphina Choi, Kristin Kelly, Raymond Balise, Susan B. Kesmodel, Erin Kobetz
Summary: This comprehensive analysis of breast cancer outcomes among Hispanic patients found that Hispanic Blacks have worse overall survival compared to Hispanic Whites, indicating that race/ethnicity is a complex variable influenced by biological, social, and structural factors. Black race was identified as a marker of vulnerability, while Hispanic ethnicity was a marker of resilience, aiming to address the persistent survival gap in breast cancer.
Article
Biochemistry & Molecular Biology
A. Stone, C. Kalahiki, L. Li, N. Hubig, F. Iuricich, H. Dunn
Summary: The aim of this research was to investigate the morphological differences of breast tumors between African American and Caucasian racial groups using machine learning and artificial intelligence methods. A supervised AI method was used to evaluate these differences, and significant variations were found in tumor and extracellular matrix (ECM) regions between the racial groups. Further analysis and characterization may provide new insight into the disparities associated with breast cancer incidence.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Oncology
Mansoor Saleh, Darshan Shimoga Chandrashekar, Sayed Shahin, Sumit Agarwal, Hyung-Gyoon Kim, Michael Behring, Asim Jamal Shaikh, Zahir Moloo, Isam-Eldin A. Eltoum, Clayton Yates, Sooryanarayana Varambally, Upender Manne
Summary: This study aimed to identify transcriptome differences in TNBC patients of Bantu origin from Kenya compared to African-American and Caucasian TNBC patients. Analysis revealed 45 KE TNBC-specific genes associated with pathways such as apoptosis, cell proliferation, and Wnt signaling. These findings suggest potential molecular determinants and biomarkers specific to KE TNBC patients.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Cynthia X. Ma, Jingqin Luo, Michael Naughton, Foluso Ademuyiwa, Rama Suresh, Malachi Griffith, Obi L. Griffith, Zachary L. Skidmore, Nicholas C. Spies, Avinash Ramu, Lee Trani, Timothy Pluard, Gayathri Nagaraj, Shana Thomas, Zhanfang Guo, Jeremy Hoog, Jing Han, Elaine Mardis, Craig Lockhart, Matthew J. Ellis
CLINICAL CANCER RESEARCH
(2016)
Article
Cell Biology
Petreena S. Campbell, Nicole Mavingire, Salma Khan, Leah K. Rowland, Jonathan V. Wooten, Anna Opoku-Agyeman, Ashley Guevara, Ubaldo Soto, Fiorella Cavalli, Andrea Irene Loaiza-Perez, Gayathri Nagaraj, Laura J. Denham, Olayemi Adeoye, Brittany D. Jenkins, Melissa B. Davis, Rachel Schiff, Eileen J. Brantley
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Medicine, General & Internal
Nicole M. Kuderer, Toni K. Choueiri, Dimpy P. Shah, Yu Shyr, Samuel M. Rubinstein, Donna R. Rivera, Sanjay Shete, Chih-Yuan Hsu, Aakash Desai, Gilberto de Lima Lopes, Petros Grivas, Corrie A. Painter, Solange Peters, Michael A. Thompson, Ziad Bakouny, Gerald Batist, Tanios Bekaii-Saab, Mehmet A. Bilen, Nathaniel Bouganim, Mateo Bover Larroya, Daniel Castellano, Salvatore A. Del Prete, Deborah B. Doroshow, Pamela C. Egan, Arielle Elkrief, Dimitrios Farmakiotis, Daniel Flora, Matthew D. Galsky, Michael J. Glover, Elizabeth A. Griffiths, Anthony P. Gulati, Shilpa Gupta, Navid Hafez, Thorvardur R. Halfdanarson, Jessica E. Hawley, Emily Hsu, Anup Kasi, Ali R. Khaki, Christopher A. Lemmon, Colleen Lewis, Barbara Logan, Tyler Masters, Rana R. McKay, Ruben A. Mesa, Alicia K. Morgans, Mary F. Mulcahy, Orestis A. Panagiotou, Prakash Peddi, Nathan A. Pennell, Kerry Reynolds, Lane R. Rosen, Rachel Rosovsky, Mary Salazar, Andrew Schmidt, Sumit A. Shah, Justin A. Shaya, John Steinharter, Keith E. Stockerl-Goldstein, Suki Subbiah, Donald C. Vinh, Firas H. Wehbe, Lisa B. Weissmann, Julie Tsu-Yu Wu, Elizabeth Wulff-Burchfield, Zhuoer Xie, Albert Yeh, Peter P. Yu, Alice Y. Zhou, Leyre Zubiri, Sanjay Mishra, Gary H. Lyman, Brian Rini, Jeremy L. Warner
Article
Medicine, General & Internal
Justin T. Moyers, Amie Patel, Wendy Shih, Gayathri Nagaraj
Review
Medicine, Research & Experimental
Gayathri Nagaraj, Cynthia X. Ma
Summary: Endocrine therapy is crucial for treating hormone receptor-positive, HER2-negative metastatic breast cancer, but its efficacy can be limited by resistance mechanisms. Recent developments have led to CDK4/6 inhibitors becoming standard care, but the optimal sequencing of treatments remains unknown, especially after disease progression.
ADVANCES IN THERAPY
(2021)
Editorial Material
Oncology
Article
Oncology
Justin T. Moyers, Esther G. Chong, Jiahao Peng, Hsin Hsiang Clarence Tsai, Daniel Sufficool, David Shavlik, Gayathri Nagaraj
Summary: The study showed that patients with melanoma with brain metastasis who received immunotherapy and radiotherapy combination treatment had longer survival. Patients receiving concurrent immunotherapy and radiotherapy showed better survival compared to those receiving radiotherapy alone.
Article
Oncology
P. Grivas, A. R. Khaki, T. M. Wise-Draper, B. French, C. Hennessy, C-Y Hsu, Y. Shyr, X. Li, T. K. Choueiri, C. A. Painter, S. Peters, B. Rini, M. A. Thompson, S. Mishra, D. R. Rivera, J. D. Acoba, M. Z. Abidi, Z. Bakouny, B. Bashir, T. Bekaii-Saab, S. Berg, E. H. Bernicker, M. A. Bilen, P. Bindal, R. Bishnoi, N. Bouganim, D. W. Bowles, A. Cabal, P. F. Caimi, D. D. Chism, J. Crowell, C. Curran, A. Desai, B. Dixon, D. B. Doroshow, E. B. Durbin, A. Elkrief, D. Farmakiotis, A. Fazio, L. A. Fecher, D. B. Flora, C. R. Friese, J. Fu, S. M. Gadgeel, M. D. Galsky, D. M. Gill, M. J. Glover, S. Goyal, P. Grover, S. Gulati, S. Gupta, S. Halabi, T. R. Halfdanarson, B. Halmos, D. J. Hausrath, J. E. Hawley, E. Hsu, M. Huynh-Le, C. Hwang, C. Jani, A. Jayaraj, D. B. Johnson, A. Kasi, H. Khan, V. S. Koshkin, N. M. Kuderer, D. H. Kwon, P. E. Lammers, A. Li, A. Loaiza-Bonilla, C. A. Low, M. B. Lustberg, G. H. Lyman, R. R. McKay, C. McNair, H. Menon, R. A. Mesa, V Mico, D. Mundt, G. Nagaraj, E. S. Nakasone, J. Nakayama, A. Nizam, N. L. Nock, C. Park, J. M. Patel, K. G. Patel, P. Peddi, N. A. Pennell, A. J. Piper-Vallillo, M. Puc, D. Ravindranathan, M. E. Reeves, D. Y. Reuben, L. Rosenstein, R. P. Rosovsky, S. M. Rubinstein, M. Salazar, A. L. Schmidt, G. K. Schwartz, M. R. Shah, S. A. Shah, C. Shah, J. A. Shaya, S. R. K. Singh, M. Smits, K. E. Stockerl-Goldstein, D. G. Stover, M. Streckfuss, S. Subbiah, L. Tachiki, E. Tadesse, A. Thakkar, M. D. Tucker, A. K. Verma, D. C. Vinh, M. Weiss, J. T. Wu, E. Wulff-Burchfield, Z. Xie, P. P. Yu, T. Zhang, A. Y. Zhou, H. Zhu, L. Zubiri, D. P. Shah, J. L. Warner, GdL Lopes
Summary: This study analyzed clinical factors and laboratory measurements of cancer patients with COVID-19, finding that factors such as age, sex, comorbidities, cancer type, and laboratory results were associated with COVID-19 severity. Patients diagnosed early in the pandemic had worse outcomes, and specific anticancer therapies may increase 30-day all-cause mortality. More research is needed to confirm these findings and caution may be needed in using certain anticancer treatments.
ANNALS OF ONCOLOGY
(2021)
Article
Oncology
Alex R. Coffman, Daniel C. Sufficool, Joseph Kang, Chung-Tsen Hsueh, Sasha Swenson, Patrick Q. McGee, Gayathri Nagaraj, Baldev Patyal, Mark E. Reeves, Jerry D. Slater, Gary Y. Yang
Summary: This study retrospectively analyzed the institutional experience of using Proton stereotactic body radiation therapy (SBRT) for liver metastases from September 2012 to December 2017. The results showed promising local control rates and low toxicity, indicating the potential to safely treat multiple lesions with Proton SBRT.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Oncology
Michael J. Wagner, Cassandra Hennessy, Alicia Beeghly, Benjamin French, Dimpy P. Shah, Sarah Croessmann, Diana Vilar-Compte, Erika Ruiz-Garcia, Matthew Ingham, Gary K. Schwartz, Corrie A. Painter, Rashmi Chugh, Leslie Fecher, Cathleen Park, Olga Zamulko, Jonathan C. Trent, Vivek Subbiah, Ali Raza Khaki, Lisa Tachiki, Elizabeth S. Nakasone, Elizabeth T. Loggers, Chris Labaki, Renee Maria Saliby, Rana R. McKay, Archana Ajmera, Elizabeth A. Griffiths, Igor Puzanov, William D. Tap, Clara Hwang, Sachin R. Jhawar, Brandon Hayes-Lattin, Elizabeth Wulff-Burchfield, Anup Kasi, Daniel Y. Reuben, Gayathri Nagaraj, Monika Joshi, Hyma Polimera, Amit A. Kulkarni, Khashayar Esfahani, Daniel H. Kwon, Luca Paoluzzi, Mehmet A. Bilen, Eric B. Durbin, Petros Grivas, Jeremy L. Warner, Elizabeth J. Davis
Summary: Patients with sarcoma have a higher risk of developing complications from COVID-19, and patients with bone sarcoma may be at a greater risk of death from COVID-19. Older age, poor performance status, and lung metastases are risk factors for more severe COVID-19.
Article
Oncology
Eric H. Lee, Salman Otoukesh, Amir Abdi Pour, Gayathri Nagaraj
CASE REPORTS IN ONCOLOGY
(2019)
Article
Hematology
Anthony L. Nguyen, Muhammad Kamal, Ravi Raghavan, Gayathri Nagaraj
HEMATOLOGY REPORTS
(2018)
Review
Oncology
Shagufta Shaheen, Hamid Mirshahidi, Gayathri Nagaraj, Chung-Tsen Hsueh
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2018)
Article
Medicine, General & Internal
Karlos Z. Oregel, Geoffrey P. Shouse, Cyrus Oster, Freddy Martinez, Jun Wang, Michael Rosenzweig, Jeremy K. Deisch, Chien-Shing Chen, Gayathri Nagaraj
AMERICAN JOURNAL OF CASE REPORTS
(2018)