Article
Cell Biology
Takashi Higuchi, Akihiko Takeuchi, Seiichi Munesue, Norio Yamamoto, Katsuhiro Hayashi, Ai Harashima, Yasuhiko Yamamoto, Hiroyuki Tsuchiya
Summary: The nonsteroidal anti-inflammatory drug zaltoprofen induces the expression of PPAR gamma in human extraskeletal chondrosarcoma cells and inhibits their proliferation. Zaltoprofen treatment also inhibits tumor growth and induces tumor cell apoptosis in a mouse model of extraskeletal myxoid chondrosarcoma. These findings suggest the potential use of zaltoprofen as an effective treatment for sarcomas.
Review
Peripheral Vascular Disease
J. David Spence, Tilo Grosser, Garret A. FitzGerald
Summary: Recent studies have questioned the safety of using acetaminophen for pain relief and fever reduction in patients with cardiovascular disease and those taking anticoagulants. The studies suggest that acetaminophen, like most nonsteroidal anti-inflammatory drugs, can increase blood pressure and formulations containing sodium can increase cardiovascular risk. The influence of acetaminophen on coagulation through its effects on vitamin K metabolism is also discussed.
Article
Immunology
Jing Zhang, Hongguang Sheng, Xiaoyi Tang, Panpan Xia, Zhangwang Li, Minxuan Xu, Jianyong Ma, Yunfeng Shen, Peng Yu, Xiao Liu
Summary: According to a post-hoc analysis from the ORCHID trial, the use of non-steroidal anti-inflammatory drugs (NSAIDs) in hospitalized American adult COVID-19 patients is not associated with worse clinical outcomes, including 28-day mortality or hospital discharge. Furthermore, a meta-analysis of 14 studies involving 48,788 COVID-19 patients showed that NSAID use had a survival benefit and decreased the risk of severe COVID-19.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Oncology
Kate R. Pawloski, Regina Matar, Varadan Sevilimedu, Audree B. Tadros, Laurie J. Kirstein, Hiram S. Cody, Kimberly J. Van Zee, Monica Morrow, Tracy-Ann Moo
Summary: A retrospective study found that NSAIDs are associated with a low risk of hematoma after lumpectomy and SLNB. Discharge with NSAIDs did not increase the risk of hematoma compared to opioid discharge, and NSAIDs should be prescribed as the preferred option.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Fatemeh Babaei, Mohammadreza Mirzababaei, Alireza Tavakkoli, Marjan Nassiri-Asl, Hossein Hosseinzadeh
Summary: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of musculoskeletal disorders, pain, and fever. This review explores the antifungal effects of NSAIDs alone or in combination with antifungal drugs in vitro and in vivo. Studies have shown that NSAIDs have antifungal activities against various species of fungi, including inhibiting biofilm formation and yeast-to-hypha conversion. Modulating prostaglandin E2 levels during fungal infection may be a possible mechanism. The combination therapy of NSAIDs and antifungal drugs shows potential as a novel therapeutic strategy in clinical studies, reducing resistance and toxicity.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Virology
Fernanda Bellaniza Caminha de Oliveira, Vanessa Paola Alves Sampaio de Sa Freire, Sharton Vinicius Antunes Coelho, Lana Monteiro Meuren, Julys da Fonseca Palmeira, Ana Luisa Cardoso, Francisco de Assis Rocha Neves, Bergmann Morais Ribeiro, Gustavo Adolfo Arganaraz, Luciana Barros de Arruda, Enrique Roberto Arganaraz
Summary: In this study, the researchers compared the effects of two strains of the Zika Virus (ZIKV), derived from African and Asian lineages, on BV2 microglia cells. They found that both strains were able to infect the cells, but the strain from the Asian lineage had higher infectivity and replicative capacity. The Asian strain also induced a stronger inflammatory response and lower expression of anti-viral factors compared to the African strain. These findings provide insight into the mechanisms involved in the pathogenesis of ZIKV-associated diseases.
Article
Nanoscience & Nanotechnology
Hye Jin Cho, Eunyoung Kang, Seonghoon Kim, D. ChangMo Yang, Joohan Nam, Eunji Jin, Jinhyu Lee, Wonyoung Choe
Summary: In this study, a water-stable Zr-based porphyrinic metal-organic framework (MOF), PCN-224, was used for the targeted adsorption of nonsteroidal anti-inflammatory drugs. The results showed high removal efficiencies for NPX and IBP, but lower efficiency for SMX. The strong interaction between the carboxylic acid functional groups in drugs and the open metal sites of PCN-224 was found to be responsible for the high adsorption capacity.
ACS APPLIED NANO MATERIALS
(2023)
Review
Agriculture, Multidisciplinary
Lawrence Mzukisi Madikizela, Tarryn Lee Botha, Ilunga Kamika, Titus Alfred M. Msagati
Summary: This article provides a critical review of the plant uptake, translocation, and toxic effects of pharmaceuticals in contaminated environments, including the presence of metabolites of these drugs in plants. The use of constructed wetlands with plants for remediation is also discussed. Factors influencing the plant uptake and translocation of pharmaceuticals are examined, and future research directions are suggested.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Andrew Y. Hwang, Steven M. Smith
Summary: Prescription NSAID use among patients with CVD has declined from 1988 to 2016, primarily due to reduced COX-2-selective inhibitor use. Nonetheless, the prevalence of prescription NSAIDs has persisted among a subset of high-risk CVD populations.
Review
Orthopedics
Nelson F. Athow, Patrick M. Morgan, Gregory A. Brown
Summary: The study found that hip and/or knee osteoarthritis is associated with an increased risk of cardiovascular disease morbidity and mortality, but did not show a link between nonselective NSAID use and cardiovascular risk. Factors such as the use of walking aids and walking difficulties may increase cardiac risk.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Chemistry, Multidisciplinary
Deqing Lin, Xiaoning Xu, Lin Chen, Lei Chen, Mengyun Deng, Jinrun Chen, Zhibin Ren, Lei Lei, Jiaqing Wang, Jie Deng, Xingyi Li
Summary: A facile method for converting carboxylate-containing indomethacin into a cyclooxygenase-2 selective inhibitor via the amidation of an unnatural peptide sequence is reported. The resulting indomethacin amides have high selectivity for COX-2 and can self-assemble into a supramolecular hydrogel for boosting anti-inflammatory efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Analytical
Ruijuan Zheng, Yingchen Yang, Chang Yang, Yan Xia
Summary: A core-shell material (UiO@TapbTp) has been developed for detecting nonsteroidal anti-inflammatory drugs by MALDI-TOF MS, showing improved enrichment ability and matrix performance. Pre-enrichment under optimized conditions significantly reduces the detection limits of drugs, with good recoveries in complex samples like saliva and environmental water.
Article
Medicine, Research & Experimental
Tarfa Albrahim, Mona A. Alonazi
Summary: The study found that LYC effectively reversed the changes induced by HFD through its antioxidant, anti-inflammatory, and anti-fibrotic properties, showing therapeutic potential in managing obesity and its associated pathologies.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Bofei Li, Ka Shing Cheung, Ian Yu-Hong Wong, Wai Keung Leung, Simon Law
Summary: The study found that nonaspirin nonsteroidal anti-inflammatory drugs (NA-NSAIDs) did not reduce the risk of gastric cancer in patients who underwent Helicobacter pylori eradication, suggesting that the chemopreventive effect of NA-NSAIDs observed in prior studies may have been confounded by immortal time bias.
Article
Biology
Audrey Antoine, Coraline De Sousa Do Outeiro, Coline Charnay, Corinne Belville, Fanny Henrioux, Denis Gallot, Loic Blanchon, Regine Minet-Quinard, Vincent Sapin
Summary: Phthalates, as reprotoxic pollutants, are found everywhere in the environment. They may disrupt the PPAR gamma pathway and lead to premature rupture of fetal membranes.
Review
Biochemistry & Molecular Biology
Shinji Miwa, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Kentaro Igarashi, Hiroyuki Tsuchiya
Summary: Chondrosarcomas develop resistance to standard anticancer drugs, making it challenging to control the disease. New treatment approaches, such as molecule-targeting agents and immunotherapy, are needed. Recent studies have identified promising biomarkers and therapeutic targets for chondrosarcoma, and various molecule-targeting agents and immunotherapies have shown favorable antitumor activity in clinical studies. This review summarizes recent research on biomarkers and therapeutic targets, as well as clinical studies on the treatment of chondrosarcomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Orthopedics
Yuki Yamamuro, Tamon Kabata, Akihiko Takeuchi, Yoshitomo Kajino, Daisuke Inoue, Takaaki Ohmori, Junya Yoshitani, Takuro Ueno, Ken Ueoka, Atsushi Taninaka, Tomoyuki Kataoka, Yoshitomo Saiki, Hiroyuki Tsuchiya
Summary: This case report presents a rare case of a large intraosseous chronic expanding hematoma (CEH) presenting with chronic disseminated intravascular coagulation (DIC), which was successfully treated with a single-stage excision and revision THA.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Oncology
Yohei Asano, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Yuta Taniguchi, Sei Morinaga, Kaoru Tada, Takayuki Nojima, Hiroyuki Tsuchiya
Summary: This study retrospectively investigated the clinical outcomes of limb-sparing tumor resection surgery with vascular reconstruction and discussed reconstruction methods and postoperative complications. The results showed that synthetic grafts may be recommended to reduce the graft occlusion rate. Most postoperative complications can be controlled by conservative treatment.
ANTICANCER RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yoshihiro Araki, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Hirotaka Yonezawa, Sei Morinaga, Yohei Asano, Takayuki Nojima, Junichi Taki, Hiroyuki Tsuchiya
Summary: The viability of devitalized bone grafts in frozen autograft reconstruction after malignant bone tumor excision was evaluated using Tc-99m-MDP scans. The results showed that the viability of bone grafts recovered within 60 months postoperatively, and this method can also predict postoperative complications.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Cell Biology
Takashi Higuchi, Akihiko Takeuchi, Seiichi Munesue, Norio Yamamoto, Katsuhiro Hayashi, Ai Harashima, Yasuhiko Yamamoto, Hiroyuki Tsuchiya
Summary: The nonsteroidal anti-inflammatory drug zaltoprofen induces the expression of PPAR gamma in human extraskeletal chondrosarcoma cells and inhibits their proliferation. Zaltoprofen treatment also inhibits tumor growth and induces tumor cell apoptosis in a mouse model of extraskeletal myxoid chondrosarcoma. These findings suggest the potential use of zaltoprofen as an effective treatment for sarcomas.
Article
Orthopedics
Akihiko Takeuchi, Hiroyuki Tsuchiya, Nokitaka Setsu, Tabu Gokita, Yasunori Tome, Naofumi Asano, Yusuke Minami, Hiroyuki Kawashima, Suguru Fukushima, Satoshi Takenaka, Hidetatsu Outani, Tomoki Nakamura, Satoshi Tsukushi, Teruya Kawamoto, Teruki Kidani, Munehisa Kito, Hiroshi Kobayashi, Takeshi Morii, Toru Akiyama, Tomoaki Torigoe, Koji Hiraoka, Akihito Nagano, Shigeki Kakunaga, Kazuhiko Hashimoto, Makoto Emori, Hisaki Aiba, Yoshikazu Tanzawa, Takafumi Ueda, Hirotaka Kawano
Summary: Tumor-devitalized autografts are a biological reconstruction option that offers advantages such as reduced immunological response, better site match, and no need for a bone bank. However, they also have limitations including inability to assess tumor margins, limited healing potential, and decreased biomechanical strength. Limited data is available on the outcomes of this procedure, making it important for further research.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Editorial Material
Biochemistry & Molecular Biology
Shinji Miwa, Norio Yamamoto, Hiroyuki Tsuchiya
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yohei Asano, Norio Yamamoto, Satoru Demura, Katsuhiro Hayashi, Akihiko Takeuchi, Satoshi Kato, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Yuta Taniguchi, Sei Morinaga, Takashi Sone, Miho Okuda, Isao Matsumoto, Seiji Yano, Hiroyuki Tsuchiya
Summary: This retrospective study investigated the therapeutic effects of immune checkpoint inhibitors (ICIs) and identified predictors of favorable response and prognosis in advanced non-small-cell lung cancer (NSCLC) patients with bone metastases. The study found a response rate of 30.9% and a median survival time of 9.3 months. Factors such as female sex, use of ICIs as first-line therapy, and pretreatment neutrophil-to-lymphocyte ratio (NLR) less than 2.1 were identified as predictors of therapeutic response, while concomitant use of a bone-modifying agent, Katagiri score <= 6 points, and NLR <2.1 were identified as predictors of good prognosis.
Article
Oncology
Munehisa Kito, Keisuke Ae, Masanori Okamoto, Makoto Endo, Kunihiro Ikuta, Akihiko Takeuchi, Naohiro Yasuda, Taketoshi Yasuda, Yoshinori Imura, Takeshi Morii, Kazutaka Kikuta, Teruya Kawamoto, Yutaka Nezu, Ichiro Baba, Shusa Ohshika, Takeshi Uehara, Takafumi Ueda, Jun Takahashi, Hirotaka Kawano
Summary: This study aimed to analyze the clinical outcomes of patients with low-grade myofibroblastic sarcoma (LGMS). Surgical treatment was the main approach, with radiotherapy considered as a viable option in cases where surgery was not feasible or may cause significant functional impairment.
Article
Pediatrics
Hisaki Aiba, Michi Kamei, Yasuhiko Ito, Risa Takeda, Satoshi Yamada, Hideki Okamoto, Katsuhiro Hayashi, Shinji Miwa, Yohei Kawaguchi, Shiro Saito, Takao Sakai, Hideki Murakami, Hiroaki Kimura
Summary: This study reports the use of carboplatin as a substitute for cisplatin in the treatment of osteosarcoma, and the efficacy of a CBDCA-based regimen in the neoadjuvant setting was found to be limited. Therefore, it was considered insufficient for performing adequate surgery.
Article
Oncology
Shinji Miwa, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Kentaro Igarashi, Martin Louie S. Bangcoy, Yuta Taniguchi, Sei Morinaga, Yohei Asano, Hiroyuki Tsuchiya
Summary: This retrospective cohort study investigated predictive factors for graft survival in patients who underwent reconstructions using tumor-bearing frozen autografts after bone tumor resection. The graft survival rates at 5 years and 10 years were 83.2% and 70.2% respectively. Multivariate analysis revealed that BMI≥23.6, tibia, and freezing procedure were independently associated with graft survival. Pedicle or hemicortical freezing techniques are recommended based on the results.
Editorial Material
Pediatrics
Hisaki Aiba, Shinji Miwa, Hideki Murakami, Hiroaki Kimura
