Article
Food Science & Technology
Yangmian Yuan, Chengyu Liu, Xingrui Chen, Yuyan Sun, Mingrui Xiong, Yu Fan, Robert B. Petersen, Hong Chen, Kun Huang, Ling Zheng
Summary: The study suggests that Tet1 plays a crucial role in obesity by promoting lipolysis and reducing obesity. Vitamin C can treat obesity by enhancing Tet1 activity, thus decreasing hepatic steatosis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Food Science & Technology
Lichun Chen, Songwen Xue, Binhao Dai, Huimin Zhao
Summary: This study evaluated the effects of various dietary oils on obese mice and found that coix seed oil (CSO) has anti-obesity properties and can improve lipid metabolism. CSO contains a high content of medium-chain fatty acids, which can modify hepatic fatty acid metabolism and lipid levels.
Article
Biochemistry & Molecular Biology
Junting Xie, Xiaoning Hou, Wanshi He, Jie Xiao, Yong Cao, Xiaojuan Liu
Summary: Although the specific action site and signal pathway of astaxanthin in weight loss remain unclear, this study used Caenorhabditis elegans to shed light on its efficacy and specific action sites. The supplementation of 60 μM astaxanthin significantly reduced fat deposition and triglyceride levels and prevented obesity caused by excessive energy accumulation. These effects were induced by sbp-1/mdt-15 and insulin/insulin-like growth factor pathways, and co-regulated the down-regulation of specific sites fat-6 and fat-7.
Article
Nutrition & Dietetics
Teresa Vezza, Jose Garrido-Mesa, Patricia Diez-Echave, Laura Hidalgo-Garcia, Antonio J. Ruiz-Malagon, Federico Garcia, Manuel Sanchez, Marta Toral, Miguel Romero, Juan Duarte, Enrique Guillamon, Alberto Banos, Rocio Moron, Julio Galvez, Alba Rodriguez-Nogales, Maria Elena Rodriguez-Cabezas
Summary: The study found that propyl propane thiosulfonate (PTSO) helps reduce weight gain, improve plasma markers, and attenuate obesity-associated inflammation, improving gut barrier integrity.
Article
Food Science & Technology
Yan Zhu, Xianghui Zhou, Nan Ling, Qiming Yu, Huijuan Wang, Qizhen Du
Summary: This study aimed to investigate the effect of Guisangyou tea (GSY tea) on abnormal lipid metabolism in mice with obesity induced by a high-fat diet (HFD). The results showed that GSY tea decreased serum lipid levels, regulated antioxidant enzyme activities and inflammatory factors, and modulated mRNA and protein expression levels related to lipid synthesis and bile acid production in the liver. These findings indicate that GSY tea can improve abnormal lipid metabolism by enhancing antioxidant capacity, regulating inflammation, and modulating lipid synthesis and bile acid production.
Article
Agronomy
Tasneem S. Abu Ghazal, Hadil S. Subih, Belal S. Obeidat, Mofleh S. Awawdeh
Summary: The prevalence of obesity is increasing worldwide and is associated with alterations in health biomarkers. Consuming a 2.5:1 ratio of omega-6 and omega-3 helps restore standard health biomarkers. Hemp seed oil (HSO), with its favorable omega-6:omega-3 ratio, is a promising functional food for mitigating obesity-related injuries.
Article
Nutrition & Dietetics
Jiabao Yan, Cuiru Ren, Yunlong Dong, Jibran A. A. Wali, Hongjie Song, Ying Zhang, Hengrui Zhang, Guangning Kou, David Raubenheimer, Zhenwei Cui
Summary: Ketogenic diet combined with moderate aerobic exercise effectively reduces body weight and fat mass, with no significant adverse effects except for an increase in circulating triglyceride level. Aerobic exercise further improves blood parameters and hepatic condition in mice fed with ketogenic diet.
Article
Biochemistry & Molecular Biology
Jing Gao, Li Ma, Jie Yin, Gang Liu, Jie Ma, SiTing Xia, SaiMing Gong, Qi Han, TieJun Li, YongZhong Chen, YuLong Yin
Summary: This study found that Camellia seed oil can improve dyslipidemia and lipid accumulation in mice fed a high-fat diet through the reorganization of gut microbiota. Camellia oil supplementation regulates the composition and functional profiling of gut microbiota, increases the abundance of beneficial bacteria, and reduces lipid levels in serum and liver. Furthermore, Camellia oil supplementation inhibits the mTOR signaling pathway.
Article
Biochemistry & Molecular Biology
Lupe Furtado-Alle, Luciane Tureck, Carolina S. de Oliveira, Joao V. M. Hortega, Ricardo L. R. Souza
Summary: Butyrylcholinesterase (BChE) is an enzyme found primarily in the liver, plasma, and brain, and it has been recognized for its role in the hydrolysis of choline esters. Recent studies have shown its involvement in lipid metabolism, suggesting it plays a crucial role in maintaining lipid homeostasis. However, the relationship between external factors and BChE activity in lipid metabolic pathways is still complex and requires further investigation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Guoqing Zhang, Ran Li, Wu Li, Sijia Yang, Qing Sun, Hongping Yin, Cui Wang, Biyu Hou, Huanhuan Wang, Liping Yu, Rucheng Chen, Liyun Shi, Kezhong Zhang, Chong Wee Liew, Guifen Qiang, Qinghua Sun, Cuiqing Liu
Summary: TLR3 plays a crucial role in obesity and metabolic disorders, as demonstrated by the protective effects of TLR3 deficiency against high-fat diet-induced obesity, glucose intolerance, insulin resistance, and lipid accumulation. These findings provide new mechanistic links between inflammation and obesity-related metabolic abnormalities in lipid/glucose metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Agriculture, Multidisciplinary
Xinbo Zhou, Junjie Zhang, Yutong Sun, Jian Shen, Bo Sun, Qingquan Ma
Summary: This study found that glutamine (Gln) has a positive effect on liver steatosis and promotes hepatic homeostasis by improving glucose metabolism and regulating signaling pathways. Obese mice fed with Gln had higher levels of colonic short-chain fatty acids (SCFAs) and lower levels of inflammation factor proteins, and a decrease in the abundance of Firmicutes bacteria was observed.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Thomas A. Aloysius, Veronika Tillander, Matteo Pedrelli, Simon N. Dankel, Rolf K. Berge, Bodil Bjorndal
Summary: Rest raw materials from chicken, such as chicken protein hydrolysate (CPH) and chicken oil (CO), have beneficial effects on health by reducing cholesterol levels and increasing fatty acid oxidation.
Article
Pharmacology & Pharmacy
Xiaoxian Xie, Mengya Zhang, Lei Sun, Ting Wang, Zhengyan Zhu, Ruonan Shu, Fengchun Wu, Zezhi Li
Summary: This study demonstrates that crocin-I may inhibit obesity by reducing body weight, improving glucose resistance, and alleviating intestinal microbial disorders in HFD-induced obese mice. Crocin-I also helps in restoring SCFAs levels and repairing altered intestinal barrier functioning and inflammation in HFD-induced obese mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Qionghua Long, Hongyan Chen, Wenhui Yang, Li Yang, Lijuan Zhang
Summary: The study found that Dp3-Sam can reduce body weight gain, visceral fat, and hepatic lipid deposits in rats, as well as improving lipid metabolism dysfunction. This indicates the potential of Dp3-Sam as a therapy for the prevention of obesity and dyslipidemia.
Article
Pharmacology & Pharmacy
Shiyue Luo, Lixiao Zhou, Xuejun Jiang, Yinyin Xia, Lishuang Huang, Run Ling, Shixin Tang, Zhen Zou, Chengzhi Chen, Jingfu Qiu
Summary: Asparagus cochinchinensis, a traditional Chinese medicine, has shown anti-inflammatory properties and the ability to regulate gut microbiota. In a study on obese mice, it was found that the aqueous extract from Asparagus cochinchinensis root (ACE) reduced weight gain and relieved dyslipidemia induced by a high-fat diet. ACE treatment also improved glucose tolerance and insulin resistance, reduced inflammation and lipogenesis in the liver and adipose tissues, and reshaped the gut microbiota of obese mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
V. V. Sathibabu Uddandrao, Brahmanaidu Parim, Ravindarnaik Ramavat, Suresh Pothani, S. Vadivukkarasi, P. Ponmurugan, P. Chandrasekaran, Saravanan Ganapathy
Summary: The study evaluated the ameliorative effect of SAC on diabetic nephropathy and found that SAC can protect the kidney by regulating the MEK1/2-ERK1/2-RSK2 signaling pathway.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
A. Jansy Isabella Rani, V. V. Sathibabu Uddandrao, G. Sangeethadevi, G. Saravanan, P. Chandrasekaran, S. Sengottuvelu, P. Tamilmani, P. P. Sethumathi, S. Vadivukkarasi
Summary: This study found that biochanin A (BCA) may attenuate obesity and its associated cardiomyopathy by suppressing oxidative stress and inflammation through activation of the Nrf-2 pathway and inhibition of NF-kappa B activation.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Thiruvengadam Shankar, Subbiah Sankaralingam, Chellapandian Balachandran, Arunachalam Chinnathambi, Omaima Nasif, Sulaiman Ali Alharbi, Sungkwon Park, Kathirvelu Baskar
Summary: The present study successfully purified and characterized an extracellular cellulase from Bacillus pumilus EWBCM1, showing optimal activity at pH 10 and 50 degrees Celsius. Metal ions, particularly CaCl2, had a positive effect on the enzyme activity, while NaCl and surfactants also influenced the activity of the purified cellulase.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Article
Biology
Thiruvengadam Shankar, Selvam Palpperumal, Durairaj Kathiresan, Subbiah Sankaralingam, Chellapandian Balachandran, Kathirvelu Baskar, Abeer Hashem, Abdulaziz A. Alqarawi, Elsayed Fathi Abd-Allah
Summary: The study evaluated the purification and characterization of exopolysaccharides from Lactobacillus paracasei, showing potential antioxidant properties.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Sangeethadevi Govindasami, V. V. Sathibabu Uddandrao, Jansy Isabella Rani Antony Rathinasamy, Saravanan Ganapathy, Ponmurugan Ponnusamy, Chandrasekaran Ponnusamy, Sengottuvelu Singaravel, Vadivukkarasi Sasikumar
Summary: The study showed that Biochanin-A could significantly improve lipid metabolic abnormalities and reduce inflammation in isoproterenol-induced myocardial infarction in rats. By inhibiting the expressions of proinflammatory cytokines and matrix metalloproteinases, BCA has a positive effect on the pathological processes of myocardial infarction.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Nanoscience & Nanotechnology
S. Mohan, M. Vishnu Devan, S. Sambathkumar, V. Shanmugam, K. Ravikumar, R. Marnadu, Baskaran Palanivel, H. H. Hegazy
Summary: Silver-palladium bimetallic nanoparticles were synthesized using Catharanthus leaf extract, showing potential in degrading textile dyes through photocatalysis and possessing high free radical scavenging efficiency.
APPLIED NANOSCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
K. Pavithra, V. V. Sathibabu Uddandrao, P. Chandrasekaran, S. Sengottuvelu, P. Tamilmani, P. P. Sethumathi, S. Vadivukkarasi, G. Saravanan
Summary: Cardiovascular diseases are a major health burden globally, and there has been a growing interest in using natural products for their treatment. This study showed that a partially purified phenolic fraction derived from Kedrostis foctidissima leaves (PFK) had a cardioprotective effect in a rat model of myocardial infarction (MI), highlighting its potential therapeutic value in protecting against cardiac damage.
BIOSCIENCE BIOTECHNOLOGY RESEARCH COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
V. V. Sathibabu Uddandrao, Brahmanaidu Parim, Sengottuvelu Singaravel, Ponmurugan Ponnusamy, Chandrasekaran Ponnusamy, Vadivukkarasi Sasikumar, Ganapathy Saravanan
Summary: This study demonstrated that the polyherbal formulation (PHF) successfully attenuated inflammation and oxidative stress in diabetic cardiomyopathy rats by regulating the NF-kappa B/Nrf-2/HO-1 pathway. The results suggest that PHF may be a potential therapeutic agent for DCM.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Seshathri Eraniappan, Prathap Balasubramaniyan, V. V. Sathibabu Uddandrao, Anitha Roy, Sengottuvelu Singaravel
Summary: The study examined the therapeutic potential of beta-glucan (BG) found in mushrooms and cereals against high-fat-diet-induced obesity. Rats were fed a high-fat diet with BG supplementation for 6 weeks, resulting in reduced body weight gain and improved hyperglycemia. BG also mitigated dyslipidemia by regulating the expressions of key markers associated with obesity. The study concluded that BG is a potential candidate for treating high-fat-diet-induced obesity by modulating obesogenic marker expressions, specifically the master regulator PPAR-gamma.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Tamilmani Periyasamy, V. V. Sathibabu Uddandrao, Chandrasekaran Ponnusamy, Saravanan Ganapathy, Sethumathi Ponnusamy Pudhupalayam, Sengottuvelu Singaravel, Ponmurugan Ponnusamy, Jagadeesan Ramasamy, Kalaivani Aiyasamy, Vadivukkarasi Sasikumar
Summary: Linalool may prevent high-fat diet-induced non-alcoholic fatty liver disease by regulating the intestinal-hepatic axis, alleviating insulin resistance, and anomalies in lipid homeostasis.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Article
Gastroenterology & Hepatology
P. Tamilmani, V. V. Sathibabu Uddandrao, P. Chandrasekaran, G. Saravanan, Parim Brahma Naidu, S. Sengottuvelu, S. Vadivukkarasi
Summary: In a high-fat diet-induced liver disease with lipid accumulation, linalool attenuates lipid accumulation in the liver by inhibiting de novo lipogenesis, promoting fatty acid oxidation, and attenuating oxidative stress through regulating the Sirt1/Akt/PPRA-alpha/AMPK and Nrf-2/HO-1 signaling pathways.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2023)
Article
Chemistry, Medicinal
Sethumathi Ponnusamy Pudhupalayam, V. V. Sathibabu Uddandrao, Chandrasekaran Ponnusamy, Sengottuvelu Singaravel, Tamilmani Periyasamy, Ponmurugan Ponnusamy, Vadivukkarasi Sasikumar, Mustapha Shabana Begum, Saravanan Ganapathy
Summary: This study evaluated the antihyperglycemic effects of biochanin A in a high-fat diet-streptozotocin-induced type 2 diabetes rat model. The results showed that biochanin A significantly reduced glucose levels, insulin resistance, hemoglobin levels, and the activity of certain enzymes, while increasing the activity of hexokinase and glycogen synthase and hepatic levels of glycogen in hyperglycemic rats.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)
Article
Computer Science, Artificial Intelligence
Rajagopal Devarajan, Padmanabhan Rao
Summary: This study discusses the effectiveness of intrusion detection systems and prevention techniques, proposing an efficient algorithm and statistical approach model for achieving effective intrusion detection and prevention in wired, wireless, and cloud networks.
INTERNATIONAL ARAB JOURNAL OF INFORMATION TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
D. Menaga, S. Rajakumar, P. M. Ayyasamy
Summary: The study focused on using spent mushroom substrate (SMS) of Pleurotus florida for ferrous iron (Fe2+) removal, showing high removal efficiency especially with live SMS achieving 100% removal in all tested concentrations. The research confirmed that the live SMS of P. florida may serve as a potential and eco-friendly biosorbent for removal of Fe2+ from iron-contaminated water.
SN APPLIED SCIENCES
(2021)
Article
Electrochemistry
Siva Palanisamy, Naveenkumar Rajendhran, Surendhiran Srinivasan, Arunkumar Prabhakaran Shyma, Vinoth Murugan, Bhoopathy Parasuraman, Soorathep Kheawhom
Summary: Aluminium-air batteries have gained attention for their high specific capacity and low cost; however, corrosion of the aluminium anode is a critical issue. This study showed that adding nano-yttrium-stabilized zirconium (nano-YSZ) can decrease corrosion and improve discharge performance of the Al anode, making it a potential candidate for the Al-air battery electrode.
JOURNAL OF APPLIED ELECTROCHEMISTRY
(2021)
