Article
Ophthalmology
Anne Kari Kvernebo, Morten Carstens Moe, Liv Kristin Wikslund, Luigino Capone, Liv Drolsum, Knut Kvernebo
Summary: In this study, the novel oxygen delivery index (ODIN) concept was applied to the ocular surface in healthy humans to assess microvascular function. The results showed that ODIN is applicable for evaluating microvascular function of the ocular surface, and it can detect increased capillary density and oxygen extraction at the limbal area.
EXPERIMENTAL EYE RESEARCH
(2022)
Editorial Material
Health Care Sciences & Services
James A. Diao, Jayson S. Marwaha, Joseph C. Kvedar
Summary: Vital sign monitoring is crucial in clinical decision-making, but traditional contact-based devices can be inconvenient. Video-based, non-contact monitoring offers a flexible and information-dense alternative that can improve patient care. The study by Jorge et al. demonstrates the reliability of video-based monitoring in capturing heart rate and respiratory rate and overcoming bias in post-operative settings.
NPJ DIGITAL MEDICINE
(2022)
Review
Medicine, General & Internal
Guangjian Wang, Hui Lian, Hongmin Zhang, Xiaoting Wang
Summary: Critical illness is characterized by hemodynamic imbalance and mitochondrial dysfunction. Microcirculatory disorders and impaired tissue oxygen utilization are important factors in critical illness. The microcirculation and mitochondria are closely related and form the critical unit. This review introduces various techniques and devices for real-time monitoring of the critical unit, and proposes the concept of critical unit-guided treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Emanuele Favaron, Can Ince, Matthias P. Hilty, Bulent Ergin, Philip van der Zee, Zuhre Uz, Pedro D. Wendel Garcia, Daniel A. Hofmaenner, Claudio T. Acevedo, Wim Jan van Boven, Sakir Akin, Diederik Gommers, Henrik Endeman
Summary: This study found that critically ill coronavirus disease 2019 patients exhibited sublingual microcirculatory alterations characterized by increased vessel density, capillary hematocrit, and RBC velocity, as well as higher numbers of leukocytes and RBC microaggregates in the microcirculation. The response of the microcirculation to coronavirus disease 2019-induced hypoxemia seems to be to increase its oxygen-extraction capacity by increasing RBC availability, while inflammation and hypercoagulation are apparent in the microcirculation.
CRITICAL CARE MEDICINE
(2021)
Article
Biology
Keith C. Afas, Raashi Vijay, Daniel Goldman
Summary: A model for oxygen transport within an idealized tissue volume, perfused by a continuous distribution of capillaries, is developed to study microvascular oxygen delivery regulation. The model includes separate tissue and capillary compartments, with an O-2-dependent transfer term between them. Results show the utility of the continuous capillary model for studying physiological problems and its expected efficiency in solving problems with time dependence and complex geometry compared to discrete capillary models.
MATHEMATICAL BIOSCIENCES
(2021)
Article
Chemistry, Analytical
Vincenzo Taormina, Giuseppe Raso, Vito Gentile, Leonardo Abbene, Antonino Buttacavoli, Gaetano Bonsignore, Cesare Valenti, Pietro Messina, Giuseppe Alessandro Scardina, Donato Cascio
Summary: Oral capillaroscopy is an important technique for evaluating microcirculation, but it has limitations. This study developed a computerized support system to improve data reliability through stabilization, enhancement, and automatic segmentation. The results showed that the proposed method achieved good performance in oral capillaroscopy.
Article
Anesthesiology
Jonny Coppel, Vassiliki Bountziouka, Daniel Martin, Edward Gilbert-Kawai
Summary: The study compared the image acquisition quality between the new MS-U and old MS-A devices. MS-U showed superior image quality in terms of illumination, focus, and pressure, with good agreement between raters.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2021)
Article
Critical Care Medicine
Marcus E. Broman, Jean-Louis Vincent, Claudio Ronco, Fredrik Hansson, Max Bell
Summary: In critically ill patients, there is a linear relationship between body temperature and heart rate, with females experiencing a faster increase in heart rate per degree Celsius compared to males. The increase in heart rate is also related to the severity of organ dysfunction.
CRITICAL CARE MEDICINE
(2021)
Article
Veterinary Sciences
Ivayla D. Yozova, Leonel A. Londono, Kristina K. Millar, Hiroki Sano, Karin Weidgraaf, Neroli A. Thomson, John S. Munday
Summary: This study evaluated the use of GlycoCheck (R) in estimating endothelial glycocalyx (EG) thickness in healthy cats and found that there is variability in EG thickness in this population.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Cardiac & Cardiovascular Systems
James L. Cox, S. Chris Malaisrie, Andrei Churyla, Chris Mehta, Jane Kruse, Olga N. Kislitsina, Patrick M. McCarthy
Summary: Cryosurgery has been used for treating cardiac arrhythmias for decades, but the mechanisms and techniques for producing optimal cryolesions in atrial fibrillation treatment are still not well understood. The creation of effective cryolesions depends on factors such as cryoprobe temperature, target myocardium temperature, duration of cryothermia application, and the presence of a heat or cooling sink. Cryothermia kills myocardial cells during both freezing and thawing phases, with a critical lethal temperature of -30°C for myocardium.
ANNALS OF THORACIC SURGERY
(2021)
Article
Computer Science, Artificial Intelligence
Nick Koudas, Raymond Li, Ioannis Xarchakos
Summary: This paper examines interactive declarative query processing on video streams. It introduces a set of approximate filters to speed up queries involving specific types of objects and proposes statistical query processing techniques and a framework based on extreme value theory to improve query accuracy and detect unexpected objects.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2022)
Article
Biology
Farhad A. Amiri, Junfeng Zhang
Summary: Hematocrit plays a crucial role in oxygen transfer in the microvasculature. While a higher hematocrit increases the availability of oxygen, it also leads to slower red blood cell motion and reduced oxygen influx. Understanding these complex interactions is important for studying oxygen transport in microcirculation.
BULLETIN OF MATHEMATICAL BIOLOGY
(2023)
Article
Medicine, General & Internal
Roberta Domizi, Elisa Damiani, Claudia Scorcella, Andrea Carsetti, Paolo Giaccaglia, Erika Casarotta, Jonathan Montomoli, Vincenzo Gabbanelli, Marina Brugia, Marco Moretti, Erica Adrario, Abele Donati
Summary: This study did not find a direct correlation between MR-proADM and MFI at ICU admission, but showed a strong correlation between MR-proADM clearance, MFI, and other microvascular variables. The study also supported the prognostic value of the marker, indicating the need for further adequately powered studies to confirm the findings.
FRONTIERS IN MEDICINE
(2021)
Article
Biology
Iara Mota-Silva, Miguel A. R. B. Castanho, Ana Santos Silva-Herdade
Summary: Inflammation is crucial for organism protection and wound repair, but chronic inflammation can lead to microvasculature damage. Therefore, monitoring inflammation is important in testing potential therapeutics. Intravital microscopy (IVM) is a commonly used technique to monitor leukocyte trafficking in vivo and report systemic conditions. This study aims to investigate whether IVM can be performed using the ear lobe instead of the commonly used cremaster muscle. Results showed that the ear lobe protocol for IVM is efficient, non-invasive, more reliable, cost-effective and timesaving, making it a suitable alternative for future studies.
Review
Veterinary Sciences
Edward S. Cooper, Deborah C. Silverstein
Summary: Fluid selection and administration during shock is usually based on macrovascular abnormalities and resuscitative targets, but the microcirculatory unit plays a vital role in delivering oxygen and nutrients to cells. Microcirculation is regulated by both systemic and local factors, potentially leading to functional changes and impacts on tissue perfusion not reflected by macrocirculatory parameters. Understanding how microvascular characteristics influence acute fluid therapy decisions and resuscitative efforts is crucial.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Anesthesiology
Inge T. Bootsma, Fellery De Lange, Thomas W. L. Scheeren, Jayant S. Jainandunsing, E. Christiaan Boerma
Summary: In a mixed population undergoing cardiac surgery with RV dysfunction, norepinephrine-mediated high blood pressure targets did not result in an increase in PAC-derived RVEF compared with normal blood pressure targets.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2021)
Review
Anesthesiology
I. T. Bootsma, E. C. Boerma, T. W. L. Scheeren, F. de Lange
Summary: The classical PAC has a long history of clinical use, evolving into a monitoring tool that provides continuous data on cardiac output, oxygen supply-demand balance, and right ventricular performance. This review discusses the difference between intermittent thermodilution and contemporary PAC measurements, highlighting the importance of understanding measurements for successful application in clinical practice.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2022)
Review
Anesthesiology
I. T. Bootsma, E. C. Boerma, F. de Lange, T. W. L. Scheeren
Summary: This review discusses the history and evolution of classical pulmonary artery catheter (PAC) as well as the differences between intermittent and continuous measurements. It also delves into insertion techniques, waveform interpretation, the interaction of waveforms with respiratory cycle and airway pressure, and potential pitfalls in waveform analysis.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2021)
Article
Critical Care Medicine
Thomas W. L. Scheeren, Jan Bakker, Thomas Kaufmann, Djillali Annane, Pierre Asfar, E. Christiaan Boerma, Maurizio Cecconi, Michelle S. Chew, Bernard Cholley, Maria Cronhjort, Daniel De Backer, Arnaldo Dubin, Martin W. Duenser, Jacques Duranteau, Anthony C. Gordon, Ludhmila A. Hajjar, Olfa Hamzaoui, Glenn Hernandez, Vanina Kanoore Edul, Geert Koster, Giovanni Landoni, Marc Leone, Bruno Levy, Claude Martin, Alexandre Mebazaa, Xavier Monnet, Andrea Morelli, Didier Payen, Rupert M. Pearse, Michael R. Pinsky, Peter Radermacher, Daniel A. Reuter, Yasser Sakr, Michael Sander, Bernd Saugel, Mervyn Singer, Pierre Squara, Antoine Vieillard-Baron, Philippe Vignon, Jean-Louis Vincent, Iwan C. C. van der Horst, Simon T. Vistisen, Jean-Louis Teboul
Summary: The international survey revealed heterogeneity in the use of inotropes in critically ill patients with circulatory shock. International experts formulated 11 strong recommendations on the indications, choice, triggers and targets for the use of inotropes. Future studies should focus on consistent indications for inotrope use and implementation into a guideline for circulatory shock with individualized targets and outcomes.
ANNALS OF INTENSIVE CARE
(2021)
Article
Emergency Medicine
Nienke K. Koopmans, Renate Stolmeijer, Ben C. Sijtsma, Paul A. van Beest, Christiaan E. Boerma, Nic J. Veeger, Ewoud ter Avest
Summary: This study found that in patients with sepsis without shock, three out of four patients do not demonstrate a clinically relevant increase in CI after a standardised fluid challenge. Non-invasive cardiac output monitoring combined with a PLR test has the potential to identify patients who might benefit from fluid resuscitation and contribute to a better tailored treatment for these patients.
EMERGENCY MEDICINE JOURNAL
(2021)
Article
Surgery
Milou E. Noltes, Madelon J. H. Metman, Wido Heeman, Lorne Rotstein, Tessa M. van Ginhoven, Menno R. Vriens, Anton F. Engelsman, E. Christiaan Boerma, Adrienne H. Brouwers, Gooitzen M. van Dam, Jesse D. Pasternak, Schelto Kruijff
Summary: This study aimed to develop a reproducible and generalizable Workflow model of ICG-angiography integrating Standardization and Quantification (WISQ) for application in the surgical innovation realm. Results showed that the WISQ model standardized and quantified ICG-angiography, indicating its potential to support clinical decision-making.
Article
Biochemical Research Methods
Wido Heeman, Hanno Maassen, Joost Calon, Harry van Goor, Henri Leuvenink, Gooitzen M. van Dam, E. Christiaan Boerma
Summary: The study validated the feasibility of visualizing RCM on ex vivo perfused human-sized porcine kidneys using LSCI, which showed better correlation compared to RBF and SDF imaging in ischemia/reperfusion situations. LSCI with high spatial and temporal resolutions can aid in clinical decision-making in transplant surgery.
JOURNAL OF BIOMEDICAL OPTICS
(2021)
Article
Medicine, Research & Experimental
C. C. A. Grim, L. van der Wal, H. J. F. Helmerhorst, D. J. van Westerloo, P. Pelosi, M. J. Schultz, E. de Jonge
Summary: This randomized clinical trial aims to compare the effects of conservative versus conventional oxygenation targets on mortality in ICU patients. The study is expected to provide guidance on oxygen therapy strategies for future ICU patients.
Article
Nutrition & Dietetics
F. Stellingwerf, L. F. E. Beumeler, H. Rijnhart-de Jong, E. C. Boerma, H. Buter
Summary: This study aimed to explore the predictive value of phase angle for 1-year mortality after ICU admission. The study found that a low phase angle was significantly associated with 1-year all-cause mortality, and a low phase angle was an independent predictor of 1-year mortality. This finding is important for assessing the long-term prognosis of ICU patients and designing treatment strategies.
CLINICAL NUTRITION
(2022)
Article
Biology
Aurelia Wildeboer, Wido Heeman, Arne van der Bilt, Christiaan Hoff, Joost Calon, E. Christiaan Boerma, Mandi Al-Taher, Nicole Bouvy
Summary: In this article, a novel laparoscopic laser speckle contrast imaging (LSCI)-based approach is presented for intraoperative assessment of intestinal perfusion. The method enables real-time monitoring of local intestinal perfusion and provides guidance for surgical procedures, showing significant potential for optimizing anastomotic surgery.
Article
Multidisciplinary Sciences
Lise F. E. Beumeler, Anja van Wieren, Hanneke Buter, Tim van Zutphen, Gerjan J. Navis, E. Christiaan Boerma
Summary: This prospective follow-up study aimed to evaluate the changes in Health-Related Quality of Life (HRQoL) in the first year after ICU admission. The study found that over half of the patients did not meet the criteria for full recovery, with impaired overall HRQoL persisting throughout the year. Non-recovery patients had higher healthcare utilization and lower participation in work activities. Baseline HRQoL was identified as an important predictor for long-term outcomes.
Article
Surgery
Wido Heeman, Aurelia C. L. Wildeboer, Mahdi Al-Taher, Joost E. M. Calon, Laurents P. S. Stassen, Michele Diana, Joep P. M. Derikx, Gooitzen M. van Dam, E. Christiaan Boerma, Nicole D. Bouvy
Summary: In this feasibility study, laparoscopic laser speckle contrast imaging (LSCI) was used to evaluate intestinal microperfusion in an experimental ischemic bowel loop model. The results showed that LSCI can achieve real-time visualization of intestinal microperfusion deficits and accurately predict postoperative ischemic complications, thus aiding in surgical decision-making.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Multidisciplinary Sciences
Wido Heeman, Hanno Maassen, Klaas Dijkstra, Joost Calon, Harry van Goor, Henri Leuvenink, Gooitzen. M. van Dam, E. Christiaan Boerma
Summary: This paper studies the effectiveness of real-time, multi-spectral motion artifact correction and compensation in LSCI, and validates its application in flow phantom and kidney models. The results show that this method can effectively reduce perfusion overestimation and improve signal-to-noise ratio. This study opens up new possibilities for the clinical application of LSCI.
SCIENTIFIC REPORTS
(2022)
Article
Critical Care Medicine
Bart G. J. Candel, Wouter Raven, Heleen Lameijer, Wendy A. M. H. Thijssen, Fabian Temorshuizen, Christiaan Boerma, Nicolette F. de Keizer, Evert de Jonge, Bas de Groot
Summary: This study aimed to evaluate the extent to which predicted mortality risk would be affected if the APACHE-IV score was recalculated with the initial physiological variables from the ED. The results showed that the predicted mortality risk was higher when calculated using the ED APACHE-IV, and a longer ED Length of Stay was associated with an increase in APACHE-IV score.
Letter
Critical Care Medicine
Fellery de Lange, Inge T. Bootsma, E. Christiaan Boerma