Article
Biochemistry & Molecular Biology
Yusuke Yokoyama, Tomohiro Tamachi, Arifumi Iwata, Yuko Maezawa, Kazuyuki Meguro, Masaya Yokota, Hiroaki Takatori, Akira Suto, Kotaro Suzuki, Koichi Hirose, Noritaka Yamaguchi, Hiroaki Honda, Hiroshi Nakajima
Summary: A20, a ubiquitin-editing enzyme, inhibits NF-kB signaling pathways and has anti-inflammatory effects. Studies have found that the expression of A20 in T cells is associated with asthmatic responses, particularly in the regulation of Th2 cell differentiation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
Wo-Er Jiao, Shan Xu, Yue-Long Qiao, Yong-Gang Kong, Liu Sun, Yu-Qin Deng, Rui Yang, Ze-Zhang Tao, Qing-Quan Hua, Shi-Ming Chen
Summary: This study investigated the role and mechanism of Notch2-dependent GATA3+ Treg cells in allergic rhinitis. The results showed that GATA3+ Treg cells and intracellular Notch2 expression were decreased in the peripheral blood of allergic rhinitis patients. In vitro experiments demonstrated that Notch2 promoted the differentiation and function of GATA3+ Treg cells. Animal experiments confirmed that adoptive transfer of GATA3+ Treg cells reduced allergic inflammatory response. These findings suggest that Notch2 could be a potential therapeutic target for allergic rhinitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dae Woon Choi, Sun Young Jung, Gun-Dong Kim, So-Young Lee, Hee Soon Shin
Summary: MQL exhibits anti-allergic properties by suppressing Th2 cell-mediated allergic responses through multiple pathways, and may serve as a potential therapeutic agent for allergic diseases.
Article
Pharmacology & Pharmacy
He Zhao, Zhaowei Gu, Yunxiu Wang, Meng Wang, Yue Zhan, Xin Zhao, Zhiwei Cao
Summary: Allergic rhinitis is a common nasal mucosa disease that is mainly mediated by IgE after exposure to allergens. IL-9 may play an important role in the development of allergic rhinitis by inhibiting the expression of certain cytokines and signaling pathways. Inhibition of IL-9 activity can significantly reduce the symptoms of allergic rhinitis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Allergy
Tomohisa Iinuma, Masahiro Kiuchi, Kiyoshi Hirahara, Junya Kurita, Kota Kokubo, Hiroyuki Yagyu, Riyo Yoneda, Tomoyuki Arai, Yuri Sonobe, Masaki Fukuyo, Atsushi Kaneda, Syuji Yonekura, Toshinori Nakayama, Yoshitaka Okamoto, Toyoyuki Hanazawa
Summary: This study comprehensively investigated the role and changes of antigen-specific T cells in Japanese cedar pollinosis patients before and after sublingual immunotherapy (SLIT). The results revealed that SLIT led to clonal expansion and differentiation of T(H)2 cells, as well as differentiation of trans-type T(H)2 cells into regulatory T cells. The study also identified musculin (MSC) as a potential biomarker of SLIT for allergic rhinitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Bing Xu, Xiaozhe Liu, Shihao Gao
Summary: The study showed that ibrutinib can ameliorate allergic rhinitis symptoms by suppressing Th2 differentiation in an AR mouse model.
DRUG DEVELOPMENT RESEARCH
(2022)
Article
Immunology
Shu-Bin Fang, Zhi-Rou Zhou, Ya-Qi Peng, Xiao-Qing Liu, Bi-Xin He, De-Hua Chen, Dong Chen, Qing-Ling Fu
Summary: The study revealed that plasma EVs from patients with AR exhibited antigen-presenting characteristics and promoted the differentiation of Th2 cells, providing a new understanding of the pathogenesis of AR.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Thi Van Nguyen, Chun Hua Piao, Yan Jing Fan, Zhen Nan Yu, So-Young Lee, Chang Ho Song, Hee Soon Shin, Ok Hee Chai
Summary: This study investigated the effects of Artemisia gmelinii extracts (AGE) on an ovalbumin-induced CARAS mouse model. The results demonstrated that AGE could alleviate symptoms, regulate immune response, and inhibit mast cell degranulation, suggesting its potential as a therapeutic agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Kon-Young Ji, Dong Ho Jung, Bo-Jeong Pyun, Yu Jin Kim, Joo Young Lee, Susanna Choi, Myung-A Jung, Kwang Hoon Song, Taesoo Kim
Summary: "The study revealed that Angelica gigas extract ameliorates allergic rhinitis by inhibiting Th2 cell activation, suggesting its potential as a treatment for Th2-mediated allergic diseases in the future."
Review
Medicine, General & Internal
Siti Muhamad Nur Husna, Hern-Tze Tina Tan, Norasnieda Md Shukri, Noor Suryani Mohd Ashari, Kah Keng Wong
Summary: Allergic rhinitis is a global health concern, affecting approximately 400 million people worldwide. The prevalence of AR has increased due to urbanization and environmental pollutants. Understanding the pathophysiology of AR is crucial for developing novel therapies.
FRONTIERS IN MEDICINE
(2022)
Article
Allergy
Liyan Yue, Qiaojing Jia, Jinhui Dong, Jianxing Wang, Xiumin Ren, Ou Xu
Summary: In this study, TRIM24 was found to suppress Th2-mediated AR by regulating the acetylation of STAT6. Downregulated expression of TRIM24 was detected in PBMCs and CD4(+) T cells from AR patients. TRIM24 conditional knockout mice exhibited more severe AR symptoms and increased IL-4 production. Knockout of TRIM24 in CD4(+) T cells led to enhanced STAT6 activities after IL-4 stimulation.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)
Article
Allergy
Lu Tan, Lisheng Fu, Li Zheng, Wenjun Fan, Hanyu Tan, Zezhang Tao, Yu Xu
Summary: This study identified the epigenomic distribution of DNA 5-hydroxymethylcytosine (5hmC) in CD4(+)T cells of allergic rhinitis patients and demonstrated the important role of TET2 in the regulation of allergic inflammation.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2022)
Article
Immunology
Enrique Huanosta-Murillo, Marcela Alcantara-Hernandez, Brenda Hernandez-Rico, Georgina Victoria-Acosta, Patricia Miranda-Cruz, Maria Antonieta Dominguez-Gomez, Fermin Jurado-Santacruz, Genaro Patino-Lopez, Vadim Perez-Koldenkova, Alam Palma-Guzman, Paula Licona-Limon, Ezequiel M. Fuentes-Panana, Alicia Lemini-Lopez, Laura C. Bonifaz
Summary: In cutaneous T cell lymphoma (CTCL), a dominant Th2 profile associated with disease progression has been proposed, with TOX+ CD4(+) T cells producing IL-4(+) in early-stage skin lesions. The NLRP3 receptor plays a role in promoting a Th2 response by controlling IL-4 production, which may have significant implications in disease progression. This mechanism of IL-4 regulation mediated by NLRP3 is amplified in late-stage CTCL, indicating its importance in disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhisheng Zheng, Ping Wang
Summary: Serum ATG5 levels are elevated in allergic rhinitis (AR) patients and are positively correlated with disease severity, Th2 cell activity, and symptoms. Additionally, the reduction in ATG5 levels is associated with the improvement of nasal symptoms. These findings suggest that serum ATG5 levels have diagnostic and disease-monitoring value in AR management.
BIOMARKERS IN MEDICINE
(2023)
Review
Immunology
Mohammad-Hossein Shams, Reza Jafari, Nahid Eskandari, Mohsen Masjedi, Farnaz Kheirandish, Mazdak Ganjalikhani Hakemi, Ramin Ghasemi, Ali-Mohammad Varzi, Seyyed-Mohsen Sohrabi, Peyman Amanolahi Baharvand, Mozhgan Safari
Summary: Allergic diseases have significantly increased globally in recent decades, influenced by genetic factors, industrialization, improved hygiene, and climate change. Changes in lifestyle and diet habits also play a key role in the prevalence of allergic diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)