The integrated landscape of causal genes and pathways in schizophrenia

A current view on contactin-4, -5, and -6: Implications in neurodevelopmental disorders

(2017) Asami Oguro-Ando et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The schizophrenia- and autism-associated gene, transcription factor 4 regulates the columnar distribution of layer 2/3 prefrontal pyramidal neurons in an activity-dependent manner

(2017) S C Page et al.   MOLECULAR PSYCHIATRY

Knockdown of GATAD2A suppresses cell proliferation in thyroid cancer in vitro

(2017) Zongping Wang et al.   ONCOLOGY REPORTS

Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes

(2016) Tune H. Pers et al.   HUMAN MOLECULAR GENETICS

Chromosome conformation elucidates regulatory relationships in developing human brain

(2016) Hyejung Won et al.   NATURE

Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation

(2016) Jian Zheng et al.   NATURE GENETICS

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Gene expression elucidates functional impact of polygenic risk for schizophrenia

(2016) Menachem Fromer et al.   NATURE NEUROSCIENCE

Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder

(2016) Arjun Krishnan et al.   NATURE NEUROSCIENCE

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

(2016) S. P. Kar et al.   Cancer Discovery

Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function

(2016) Andrew J. Kennedy et al.   Cell Reports

Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits

(2016) Jennifer M. Whitehead Pavlides et al.   Genome Medicine

Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics

(2016) David Lamparter et al.   PLoS Computational Biology

Genome-wide association study of schizophrenia in Ashkenazi Jews

(2015) Fernando S. Goes et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Interactions of innate and adaptive immunity in brain development and function

(2015) Anthony J. Filiano et al.   BRAIN RESEARCH

Prioritization of potential candidate disease genes by topological similarity of protein–protein interaction network and phenotype data

(2015) Jiawei Luo et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Understanding multicellular function and disease with human tissue-specific networks

(2015) Casey S Greene et al.   NATURE GENETICS

Contactin-4 Mediates Axon-Target Specificity and Functional Development of the Accessory Optic System

(2015) Jessica A. Osterhout et al.   NEURON

Transcallosal Projections Require Glycoprotein M6-Dependent Neurite Growth and Guidance

(2014) Sakura Mita et al.   CEREBRAL CORTEX

AlteredGPM6A/M6Dosage Impairs Cognition and Causes Phenotypes Responsive to Cholesterol in Human andDrosophila

(2014) Anne Gregor et al.   HUMAN MUTATION

Dysbindin-Associated Proteome in the P2 Synaptosome Fraction of Mouse Brain

(2014) Meng-Hsuan J. Han et al.   JOURNAL OF PROTEOME RESEARCH

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

A polygenic burden of rare disruptive mutations in schizophrenia

(2014) Shaun M. Purcell et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Selecting causal genes from genome-wide association studies via functionally coherent subnetworks

(2014) Murat Taşan et al.   NATURE METHODS

Genetic variability in the regulation of gene expression in ten regions of the human brain

(2014) Adaikalavan Ramasamy et al.   NATURE NEUROSCIENCE

A Role for Noncoding Variation in Schizophrenia

(2014) Panos Roussos et al.   Cell Reports

Sherlock: Detecting Gene-Disease Associations by Matching Patterns of Expression QTL and GWAS

(2013) Xin He et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Spatial and Temporal Mapping of De Novo Mutations in Schizophrenia to a Fetal Prefrontal Cortical Network

(2013) Suleyman Gulsuner et al.   CELL

Genome-wide meta-analysis identifies new susceptibility loci for migraine

(2013) Verneri Anttila et al.   NATURE GENETICS

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci

(2012) Richa Saxena et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The long-range interaction landscape of gene promoters

(2012) Amartya Sanyal et al.   NATURE

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

Genetic architectures of psychiatric disorders: the emerging picture and its implications

(2012) Patrick F. Sullivan et al.   NATURE REVIEWS GENETICS

Associations between TCF4 Gene Polymorphism and Cognitive Functions in Schizophrenia Patients and Healthy Controls

(2012) Xianghua Zhu et al.   NEUROPSYCHOPHARMACOLOGY

Computational inference of mRNA stability from histone modification and transcriptome profiles

(2012) Chengyang Wang et al.   NUCLEIC ACIDS RESEARCH

Genome-wide meta-analyses of smoking behaviors in African Americans

(2012) S P David et al.   Translational Psychiatry

Contactin 4 as an autism susceptibility locus

(2011) Catherine E. Cottrell et al.   Autism Research

Prioritizing candidate disease genes by network-based boosting of genome-wide association data

(2011) I. Lee et al.   GENOME RESEARCH

Common variants at VRK2 and TCF4 conferring risk of schizophrenia

(2011) Stacy Steinberg et al.   HUMAN MOLECULAR GENETICS

Spatio-temporal transcriptome of the human brain

(2011) Hyo Jung Kang et al.   NATURE

Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia

(2011) Vladimir Vacic et al.   NATURE

Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2

(2011) Wei-Hua Yue et al.   NATURE GENETICS

Common variants on 8p12 and 1q24.2 confer risk of schizophrenia

(2011) Yongyong Shi et al.   NATURE GENETICS

Proteins Encoded in Genomic Regions Associated with Immune-Mediated Disease Physically Interact and Suggest Underlying Biology

(2011) Elizabeth J. Rossin et al.   PLoS Genetics

Cognitive and Sensorimotor Gating Impairments in Transgenic Mice Overexpressing the Schizophrenia Susceptibility Gene Tcf4 in the Brain

(2010) Magdalena M. Brzózka et al.   BIOLOGICAL PSYCHIATRY

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

(2010) David Warde-Farley et al.   NUCLEIC ACIDS RESEARCH

microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs

(2009) Hongping Xia et al.   BRAIN RESEARCH

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Disruption of Contactin 4 (CNTN4) Results in Developmental Delay and Other Features of 3p Deletion Syndrome

(2008) Thomas Fernandez et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Molecular profiles of schizophrenia in the CNS at different stages of illness

(2008) Sujatha Narayan et al.   BRAIN RESEARCH

Disruption of contactin 4 in three subjects with autism spectrum disorder

(2008) J Roohi et al.   JOURNAL OF MEDICAL GENETICS

Long-range chromosomal interactions and gene regulation

(2008) Adriana Miele et al.   Molecular BioSystems

Rare chromosomal deletions and duplications increase risk of schizophrenia

(2008) Jennifer L. Stone et al.   NATURE

Large recurrent microdeletions associated with schizophrenia

(2008) Hreinn Stefansson et al.   NATURE

Strong association of de novo copy number mutations with sporadic schizophrenia

(2008) Bin Xu et al.   NATURE GENETICS

Identification of loci associated with schizophrenia by genome-wide association and follow-up

(2008) Michael C O'Donovan et al.   NATURE GENETICS

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

(2008) Christopher I Amos et al.   NATURE GENETICS

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia

(2008) T. Walsh et al.   SCIENCE

Inhibition of Mouse GPM6A Expression Leads to Decreased Differentiation of Neurons Derived from Mouse Embryonic Stem Cells

(2008) Hideo Michibata et al.   STEM CELLS AND DEVELOPMENT

Human GPM6A Is Associated With Differentiation and Neuronal Migration of Neurons Derived from Human Embryonic Stem Cells

(2008) Hideo Michibata et al.   STEM CELLS AND DEVELOPMENT