Review
Surgery
Prapaporn Noparatayaporn, Montarat Thavorncharoensap, Usa Chaikledkaew, Bhavani Shankara Bagepally, Ammarin Thakkinstian
Summary: This systematic review analyzed 28 full economic evaluation studies comparing bariatric surgery with usual care, finding that bariatric surgery is cost-effective for a mixed obesity group and those with diabetes in high-income countries.
Review
Immunology
Giuseppe Santoli, Mario Cesare Nurchis, Giovanna Elisa Calabro, Gianfranco Damiani
Summary: SARS-CoV-2 vaccination has proven highly effective in preventing COVID-19, reducing global deaths and hospitalizations. While vaccine distribution remains unequal, it is crucial to organize mass vaccination campaigns worldwide to control the spread of the virus. This systematic review confirms that COVID-19 vaccination campaigns are cost-effective and sustainable public health measures in fighting the pandemic.
Article
Health Care Sciences & Services
Fei Yuan, Shrikant I. Bangdiwala, Wesley Tong, Andre Lamy
Summary: This study found that using incremental cost-effectiveness ratio (ICER) is more efficient than incremental monetary net benefit (INMB), regardless of disease populations, time horizon, modeling choices, and underlying probability distributions of incremental mean cost and effect. ICER has a small variance and is robust to the choices of models, indicating that a simple and naive model can sufficiently estimate ICER.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2023)
Review
Clinical Neurology
Adnan Qureshi, Yasemin Akinci, Wei Huang, Muhammad F. Ishfaq, Ameer E. Hassan, Farhan Siddiq, Camilo R. Gomez
Summary: This study evaluated the cost-effectiveness of endovascular treatment (EVT) alone compared with EVT following intravenous (IV) recombinant tissue plasminogen activator (r-tPA) in patients with acute ischemic stroke (AIS). The results showed that EVT alone was more cost-effective than EVT and IV r-tPA combined treatment.
JOURNAL OF NEUROSURGERY
(2023)
Article
Public, Environmental & Occupational Health
Shan Jiang, Yitong Wang, Junwen Zhou, Yawen Jiang, Gordon Guo-En Liu, Jing Wu
Summary: The inclusion of future unrelated medical costs can improve the internal and external consistency of economic evaluation and the comparability of results between different jurisdictions. However, more research is needed to further explore this issue.
Article
Public, Environmental & Occupational Health
Hui Jun Zhou, Jing Cao, Hui Shi, Nasheen Naidoo, Sherehe Semba, Pei Wang, Yi Fan Fan, Shui Cheng Zhu
Summary: The study identified SOF/LDV as the most cost-effective treatment for HCV genotype 1, producing more QALYs at a lower cost compared to SOF/VEL and the traditional pegIFN + RBV regimen. SOF/VEL was also economically dominant to pegIFN + RBV, suggesting DAA regimens could be a promising strategy for treating HCV.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Allergy
Matthew Greenhawt, John Oppenheimer, Christopher D. Codispoti
Summary: Cost-effectiveness analysis is a method to evaluate the economic value of medical interventions by assessing the costs to produce beneficial outcomes. These analyses rely on well-researched inputs and sensitivity analysis, but should also consider limitations and be studied from different perspectives.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Environmental Sciences
B. B. Cael, P. Goodwin, C. R. Pearce, D. Stainforth
Summary: All pathways to achieve the Paris Agreement target of limiting global warming require large-scale removal of CO2 from the atmosphere. Different CO2 removal strategies vary in price, storage timescale, and other factors. It is important to assess whether the benefits of deploying these strategies outweigh their costs and to understand how costs depend on socioeconomic assumptions. This study provides a framework to quantitatively evaluate and compare different strategies, guiding future research, development, and policy efforts.
ENVIRONMENTAL RESEARCH LETTERS
(2023)
Article
Mathematical & Computational Biology
Shuai Chen, Jeffrey S. Hoch
Summary: This study focuses on methods for censored cost-effectiveness data in the context of new medical interventions evaluation. The proposed methods include the net-benefit regression framework and a doubly robust estimator for average causal incremental net benefit, showing valid inference in observational studies. Extensive numerical studies confirm the finite-sample performance of these methods and demonstrate their application with real data examples.
STATISTICS IN MEDICINE
(2022)
Review
Health Care Sciences & Services
Mario Cesare Nurchis, Maria Teresa Riccardi, Francesca Clementina Radio, Giovanni Chillemi, Enrico Silvio Bertini, Marco Tartaglia, Americo Cicchetti, Bruno Dallapiccola, Gianfranco Damiani
Summary: This study evaluated the cost-effectiveness of WGS compared to WES and CMA in the diagnostic workup of the pediatric population. The findings suggest that WGS may be a cost-effective option.
Article
Environmental Sciences
Jerrod Penn, Wuyang Hu
Summary: Despite the lack of studies on the benefits and costs of pollinator conservation, a survey was conducted among three US universities to assess the benefits of becoming Bee Campus USA certified. The study also examined the impact of reminders on student sustainability fees on willingness to pay. The results showed that the net benefits for each university were mostly positive, with information reminders having little effect on support for pollinator conservation.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Surgery
Kristine A. Huynh, Alfred P. Yoon, Anne Seyferth, Kevin C. Chung
Summary: The study demonstrated the positive financial return on investment of implementing office-based ultrasound imaging in hand clinics, with the most critical factors being ultrasound machine cost and procedural volume.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Health Care Sciences & Services
Alexandra Chapdelaine, Helen-Maria Vasiliadis, Martin D. Provencher, Peter J. Norton, Pasquale Roberge
Summary: Access to evidence-based psychological treatment is limited due to financial constraints and patient-level barriers. Transdiagnostic cognitive behavioural therapy (tCBT) is effective for anxiety disorders and can enhance dissemination of psychotherapy. Study of treatment moderators is important for identifying cost-effectiveness for different subpopulations.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Nutrition & Dietetics
Virpi Kuvaja-Kollner, Niina Lintu, Virpi Lindi, Elisa Rissanen, Aino-Maija Eloranta, Sanna Kiiskinen, Janne Martikainen, Eila Kankaanpaa, Hannu Valtonen, Timo A. Lakka
Summary: The study evaluated the cost-effectiveness of a 2-year physical activity intervention for primary-school children, showing a significant increase in total physical activity time in the intervention group. Cost-effectiveness depended on the service payer's willingness to pay for increased physical activity.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2021)
Article
Public, Environmental & Occupational Health
Shuxia Qin, Xuehong Wang, Sini Li, Chongqing Tan, Xiaohui Zeng, Meiyu Wu, Ye Peng, Liting Wang, Xiaomin Wan
Summary: This study evaluated the clinical benefits, harms, cost, and cost-effectiveness of the GCRSS screening strategy for gastric cancer in China. The results showed that screening from the age of 40 with the 40-GCRSS strategy provided the greatest reduction in gastric cancer incidence and was cost-effective at a willingness-to-pay threshold.
FRONTIERS IN PUBLIC HEALTH
(2022)
Letter
Pharmacology & Pharmacy
Andrea Messori, Laura Bartoli, Daniele Mengato, Marco Chiumente
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2022)
Letter
Peripheral Vascular Disease
Andrea Messori, Laura Bartoli, Elisa Ferracane, Sabrina Trippoli
JOURNAL OF VASCULAR ACCESS
(2023)
Letter
Oncology
Andrea Messori, Melania Rivano, Daniele Mengato, Luca Cancanelli, Lorenzo Di Spazio, Marco Chiumente
LEUKEMIA & LYMPHOMA
(2022)
Letter
Pharmacology & Pharmacy
Andrea Messori, Sabrina Trippoli, Laura Bartoli, Claudio Marinai
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2023)
Article
Oncology
Andrea Messori, Sabrina Trippoli
Summary: In inoperable pleural mesothelioma, the standard of care is pemetrexed + cisplatin as first line treatment, however, there have been new treatments proposed. This study compared the overall survival (OS) with these new treatments and found that nivolumab + ipilimumab and bevacizumab + pemetrexed + cisplatin showed better OS compared to standard treatment, while pembrolizumab showed a numerical improvement and durvalumab + pemetrexed + cisplatin resulted in worsened OS.
JOURNAL OF CHEMOTHERAPY
(2023)
Article
Immunology
Daniele Mengato, Luca Cancanelli, Melania Rivano, Marco Chiumente, Lorenzo Di Spazio, Andrea Messori
Summary: In PD-L1-negative advanced NSCLC patients, there is limited evidence supporting the efficacy of first-line chemoimmunotherapy compared to chemotherapy alone.
Review
Oncology
Andrea Ossato, Vera Damuzzo, Paolo Baldo, Daniele Mengato, Marco Chiumente, Andrea Messori
Summary: This review summarizes the current data of immune-checkpoint inhibitors (ICIs) in the treatment of advanced melanoma and finds that the combination therapy of pembrolizumab+ipilimumab shows significantly better progression-free survival compared to other treatments. Further investigation is warranted. However, the proposed new standard of care, relatlimab+nivolumab, is not supported by the results of this study.
Article
Pharmacology & Pharmacy
Andrea Messori, Marco Chiumente, Daniele Mengato
Summary: The aim of this study was to investigate the overall survival reported for CAR T-cell products in LBLC and ALL. By analyzing published Kaplan-Meier curves, it was found that CAR T-cell treatment showed a greater survival advantage in adult ALL patients compared to LBCL patients, and axi demonstrated a more substantial survival gain in LBCL compared to tisa. These findings provide useful insights into the use of CAR T-cell therapy in these diseases.
CLINICAL THERAPEUTICS
(2022)
Letter
Hematology
Andrea Messori, Giulia Hyeraci
ANNALS OF HEMATOLOGY
(2023)
Letter
Pharmacology & Pharmacy
Andrea Messori, Sabrina Trippoli, Claudio Marinai
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2023)
Review
Oncology
Andrea Messori, Vera Damuzzo, Melania Rivano, Luca Cancanelli, Lorenzo Di Spazio, Andrea Ossato, Marco Chiumente, Daniele Mengato
Summary: The IPDfromKM-Shiny method is an innovative approach for conducting comparative research in evidence-based medicine, particularly in oncology. It uses reconstructed patient data from previous trials to perform indirect comparisons and determine the most appropriate treatments based on individual characteristics. This method shows promising results and deserves further investigation.
Article
Oncology
Andrea Ossato, Daniele Mengato, Marco Chiumente, Andrea Messori, Vera Damuzzo
Summary: This study compared the efficacy of combination therapies based on PD-1 and VEGF inhibitors for advanced renal cell carcinoma using an innovative method that reconstructed individual patient data. Pembrolizumab + lenvatinib showed the best progression-free survival and was expected to determine the longest overall survival. Pembrolizumab + axitinib, nivolumab + cabozantinib, and nivolumab + ipilimumab showed similar progression-free survival, but pembrolizumab + axitinib also demonstrated better overall survival. Subgroup analysis showed significant improvements in overall survival with pembrolizumab + axitinib and nivolumab + ipilimumab compared to sunitinib in intermediate-poor risk patients. This innovative method provided indirect comparisons of these treatment regimens in the absence of real comparative trials.
Letter
Pharmacology & Pharmacy
Sabrina Trippoli, Valeria Fadda, Andrea Messori
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2023)
Review
Hematology
Luca Cancanelli, Melania Rivano, Lorenzo Di Spazio, Marco Chiumente, Daniele Mengato, Andrea Messori
Summary: Recent studies have examined new treatments for relapsed-refractory multiple myeloma (RRMM), including CAR-T products and non-CAR-T agents. Indirect comparisons have been used since direct comparisons are not available. The reconstruction of individual patient data from Kaplan-Meier graphs has been validated and used in this systematic review, which evaluated six treatments for RRMM. The results showed significant differences in overall survival (OS), with ciltacabtagene autoleucel demonstrating better OS than idecabtagene vicleucel, and isatuximab plus dexamethasone ranking highest among the non-CAR-T treatments.
HEMATOLOGY REPORTS
(2023)
Article
Urology & Nephrology
Melania Rivano, Luca Cancanelli, Lorenzo Di Spazio, Daniele Mengato, Marco Chiumente, Andrea Messori
Summary: This study evaluated the efficacy of second-generation hormone treatments for M0CRPC through indirect comparisons. The results showed that apalutamide, darolutamide, and enzalutamide were all more effective than placebo in terms of overall survival. There was no significant difference in overall survival between these three agents, indicating substantial equivalence.
WORLD JOURNAL OF UROLOGY
(2022)
