Mesenchymal Stem Cells in the Musculoskeletal System: From Animal Models to Human Tissue Regeneration?

Epidemiology of sarcopenia and insight into possible therapeutic targets

(2017) Elaine M. Dennison et al.   Nature Reviews Rheumatology

Expression levels of TGF-β1 and CTGF are associated with the severity of Duchenne muscular dystrophy

(2017) Yanmin Song et al.   Experimental and Therapeutic Medicine

Joint morphogenetic cells in the adult mammalian synovium

(2017) Anke J. Roelofs et al.   Nature Communications

Skeletal muscle-derived interstitial progenitor cells (PICs) display stem cell properties, being clonogenic, self-renewing, and multi-potent in vitro and in vivo

(2017) Beverley J. Cottle et al.   Stem Cell Research & Therapy

Ligament-Derived Stem Cells: Identification, Characterisation, and Therapeutic Application

(2017) Katie Joanna Lee et al.   Stem Cells International

The Immunogenicity and Immune Tolerance of Pluripotent Stem Cell Derivatives

(2017) Xin Liu et al.   Frontiers in Immunology

Adipose-Derived Mesenchymal Stem Cells With Microfracture Versus Microfracture Alone: 2-Year Follow-up of a Prospective Randomized Trial

(2016) Yong-Gon Koh et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Comparative transcriptome analysis of muscular dystrophy models Large myd , Dmd mdx /Large myd and Dmd mdx : what makes them different?

(2016) Camila F Almeida et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Current clinical evidence for the use of mesenchymal stem cells in articular cartilage repair

(2016) Dimitris Reissis et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions

(2016) Christopher J. Centeno et al.   INTERNATIONAL ORTHOPAEDICS

Serum miRNA Signatures Are Indicative of Skeletal Fractures in Postmenopausal Women With and Without Type 2 Diabetes and Influence Osteogenic and Adipogenic Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells In Vitro

(2016) Ursula Heilmeier et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Regenerative decline of stem cells in sarcopenia

(2016) Pedro Sousa-Victor et al.   MOLECULAR ASPECTS OF MEDICINE

Efficacy of umbilical cord-derived mesenchymal stem cell-based therapy for osteonecrosis of the femoral head: A three-year follow-up study

(2016) Chun Chen et al.   Molecular Medicine Reports

Stem Cells in Bone Regeneration

(2016) Graham G. Walmsley et al.   Stem Cell Reviews and Reports

Osteoporosis: The Result of an ‘Aged’ Bone Microenvironment

(2016) Bo Yu et al.   TRENDS IN MOLECULAR MEDICINE

Mesenchymal stem cells generate distinct functional hybrids in vitro via cell fusion or entosis

(2016) Francesco Sottile et al.   Scientific Reports

Mechanisms of mesenchymal stem/stromal cell function

(2016) Jeffrey L. Spees et al.   Stem Cell Research & Therapy

Animal models of osteoarthritis: classification, update, and measurement of outcomes

(2016) Emmanuel L. Kuyinu et al.   Journal of Orthopaedic Surgery and Research

Mesenchymal stem cells as therapeutic target of biophysical stimulation for the treatment of musculoskeletal disorders

(2016) Marco Viganò et al.   Journal of Orthopaedic Surgery and Research

Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial

(2016) Yves-Marie Pers et al.   Stem Cells Translational Medicine

Stem Cells in Bone Regeneration

(2016) Graham G. Walmsley et al.   Stem Cell Reviews and Reports

Cartilage Defect Treatments: With or without Cells? Mesenchymal Stem Cells or Chondrocytes? Traditional or Matrix-Assisted? A Systematic Review and Meta-Analyses

(2016) Zhantao Deng et al.   Stem Cells International

Therapeutic Roles of Tendon Stem/Progenitor Cells in Tendinopathy

(2016) Xin Zhang et al.   Stem Cells International

Mesenchymal Stem Cell Alterations in Bone Marrow Lesions in Patients With Hip Osteoarthritis

(2016) T. Mark Campbell et al.   Arthritis & Rheumatology

No Identical “Mesenchymal Stem Cells” at Different Times and Sites: Human Committed Progenitors of Distinct Origin and Differentiation Potential Are Incorporated as Adventitial Cells in Microvessels

(2016) Benedetto Sacchetti et al.   Stem Cell Reports

Comparative Study of Injury Models for Studying Muscle Regeneration in Mice

(2016) David Hardy et al.   PLoS One

Biologics for tendon repair

(2015) Denitsa Docheva et al.   ADVANCED DRUG DELIVERY REVIEWS

Sarcopenia – The search for emerging biomarkers

(2015) Alexander Kalinkovich et al.   AGEING RESEARCH REVIEWS

Unraveling mechanisms of mesenchymal stromal cell-mediated immunomodulation through patient monitoring and product characterization

(2015) Koen Schepers et al.   Annals of the New York Academy of Sciences

Scaffold-Based Cartilage Treatments: With or Without Cells? A Systematic Review of Preclinical and Clinical Evidence

(2015) Elizaveta Kon et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

The effect of concentrated bone marrow aspirate in operative treatment of fifth metatarsal stress fractures; a double-blind randomized controlled trial

(2015) Hanneke Weel et al.   BMC MUSCULOSKELETAL DISORDERS

Nucleostemin- and Oct 3/4-positive stem/progenitor cells exhibit disparate anatomical and temporal expression during rat Achilles tendon healing

(2015) Eva Runesson et al.   BMC MUSCULOSKELETAL DISORDERS

Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential

(2015) Daniel L. Worthley et al.   CELL

Identification and Specification of the Mouse Skeletal Stem Cell

(2015) Charles K.F. Chan et al.   CELL

Mesenchymal Cell Contributions to the Stem Cell Niche

(2015) Youmna Kfoury et al.   Cell Stem Cell

Intra-arterial transplantation of HLA-matched donor mesoangioblasts in Duchenne muscular dystrophy

(2015) G. Cossu et al.   EMBO Molecular Medicine

Mesenchymal stem cell therapy for knee osteoarthritis: 5 years follow-up of three patients

(2015) Fereydoun Davatchi et al.   International Journal of Rheumatic Diseases

Harnessing endogenous stem/progenitor cells for tendon regeneration

(2015) Chang H. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Association Between Circulating Osteogenic Progenitor Cells and Disability and Frailty in Older Persons: The Nepean Osteoporosis and Frailty Study

(2015) Piumali Gunawardene et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division

(2015) Nicolas A Dumont et al.   NATURE MEDICINE

Identification and characterization of an injury-induced skeletal progenitor

(2015) Owen Marecic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment of Lateral Epicondylosis by Using Allogeneic Adipose-Derived Mesenchymal Stem Cells: A Pilot Study

(2015) Sang Yoon Lee et al.   STEM CELLS

Perivascular-Derived Stem Cells with Neural Crest Characteristics Are Involved in Tendon Repair

(2015) Wei Xu et al.   STEM CELLS AND DEVELOPMENT

Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells

(2015) Aurelio Vega et al.   TRANSPLANTATION

Characterization of adipocytes derived from fibro/adipogenic progenitors resident in human skeletal muscle

(2015) N Arrighi et al.   Cell Death & Disease

PW1/Peg3 expression regulates key properties that determine mesoangioblast stem cell competence

(2015) Chiara Bonfanti et al.   Nature Communications

Isolation, selection and culture methods to enhance clonogenicity of mouse bone marrow derived mesenchymal stromal cell precursors

(2015) Claas Baustian et al.   Stem Cell Research & Therapy

Enhanced osteogenic potential of mesenchymal stem cells from cortical bone: a comparative analysis

(2015) Joseph S. Fernandez-Moure et al.   Stem Cell Research & Therapy

Efficacy of autologous stem cell-based therapy for osteonecrosis of the femoral head in sickle cell disease: a five-year follow-up study

(2015) Gildasio Cerqueira Daltro et al.   Stem Cell Research & Therapy

Markers for the identification of tendon-derived stem cells in vitro and tendon stem cells in situ – update and future development

(2015) Pauline Po Yee Lui   Stem Cell Research & Therapy

Adipose derived mesenchymal stem cell therapy in the treatment of isolated knee chondral lesions: design of a randomised controlled pilot study comparing arthroscopic microfracture versus arthroscopic microfracture combined with postoperative mesenchymal stem cell injections

(2015) Julien Freitag et al.   BMJ Open

Human Satellite Cell Transplantation and Regeneration from Diverse Skeletal Muscles

(2015) Xiaoti Xu et al.   Stem Cell Reports

Duchenne muscular dystrophy: current cell therapies

(2015) Dorota Sienkiewicz et al.   Therapeutic Advances in Neurological Disorders

A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis

(2015) Jamil Bashir et al.   Journal of Pain Research

Matrix-induced autologous mesenchymal stem cell implantation versus matrix-induced autologous chondrocyte implantation in the treatment of chondral defects of the knee: a 2-year randomized study

(2014) Isık Akgun et al.   ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY

Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow

(2014) Bo O. Zhou et al.   Cell Stem Cell

Osterix Marks Distinct Waves of Primitive and Definitive Stromal Progenitors during Bone Marrow Development

(2014) Toshihide Mizoguchi et al.   DEVELOPMENTAL CELL

Adult Human Mesenchymal Stem Cells Delivered via Intra-Articular Injection to the Knee Following Partial Medial Meniscectomy

(2014) C Thomas Vangsness et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Human satellite cells have regenerative capacity and are genetically manipulable

(2014) Andreas Marg et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Membrane Nanotubes In Vivo: A Feature of MHC Class II + Cells in the Mouse Cornea

(2014) Holly R. Chinnery et al.   JOURNAL OF IMMUNOLOGY

Mesenchymal stem cells rescue injured endothelial cells in an in vitro ischemia–reperfusion model via tunneling nanotube like structure-mediated mitochondrial transfer

(2014) Kaiming Liu et al.   MICROVASCULAR RESEARCH

Geriatric muscle stem cells switch reversible quiescence into senescence

(2014) Pedro Sousa-Victor et al.   NATURE

Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation

(2014) Yoshiki Omatsu et al.   NATURE

Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia

(2014) Christopher S Fry et al.   NATURE MEDICINE

Lineage Tracing of Resident Tendon Progenitor Cells during Growth and Natural Healing

(2014) Nathaniel A. Dyment et al.   PLoS One

Multivariate biophysical markers predictive of mesenchymal stromal cell multipotency

(2014) Wong Cheng Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intra-Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof-of-Concept Clinical Trial

(2014) Chris Hyunchul Jo et al.   STEM CELLS

An Exploratory Clinical Trial for Idiopathic Osteonecrosis of Femoral Head by Cultured Autologous Multipotent Mesenchymal Stromal Cells Augmented with Vascularized Bone Grafts

(2014) Tomoki Aoyama et al.   TISSUE ENGINEERING PART B-REVIEWS

Identification and characterization of PDGFRα+ mesenchymal progenitors in human skeletal muscle

(2014) A Uezumi et al.   Cell Death & Disease

Human cadaver multipotent stromal/stem cells isolated from arteries stored in liquid nitrogen for 5 years

(2014) Sabrina Valente et al.   Stem Cell Research & Therapy

Synovial fluid and synovial membrane mesenchymal stem cells: latest discoveries and therapeutic perspectives

(2014) Eduardo de Sousa et al.   Stem Cell Research & Therapy

Porcine Skeletal Muscle-Derived Multipotent PW1pos/Pax7negInterstitial Cells: Isolation, Characterization, and Long-Term Culture

(2014) Fiona C. Lewis et al.   Stem Cells Translational Medicine

Management of Fibrosis: The Mesenchymal Stromal Cells Breakthrough

(2014) Benoît Usunier et al.   Stem Cells International

Current Perspectives in Mesenchymal Stem Cell Therapies for Osteoarthritis

(2014) Baldur Kristjánsson et al.   Stem Cells International

The role of animal models in tendon research

(2014) M. W. Hast et al.   Bone & Joint Research

Low/Negative Expression of PDGFR-α Identifies the Candidate Primary Mesenchymal Stromal Cells in Adult Human Bone Marrow

(2014) Hongzhe Li et al.   Stem Cell Reports

Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy

(2014) Justin D Glenn   World Journal of Stem Cells

Injectable Cultured Bone Marrow–Derived Mesenchymal Stem Cells in Varus Knees With Cartilage Defects Undergoing High Tibial Osteotomy: A Prospective, Randomized Controlled Clinical Trial With 2 Years' Follow-up

(2013) Keng Lin Wong et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Improved isolation and expansion of bone marrow mesenchymal stromal cells using a novel marrow filter device

(2013) Satoru Otsuru et al.   CYTOTHERAPY

Defining skeletal muscle resident progenitors and their cell fate potentials

(2013) A. Pannerec et al.   DEVELOPMENT

Benefits of small volume and small syringe for bone marrow aspirations of mesenchymal stem cells

(2013) Philippe Hernigou et al.   INTERNATIONAL ORTHOPAEDICS

PDGFRα and CD51 mark human Nestin+sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion

(2013) Sandra Pinho et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Mesenchymal stem cells in joint disease and repair

(2013) Frank Barry et al.   Nature Reviews Rheumatology

Muscle Side Population Cells from Dystrophic or Injured Muscle Adopt a Fibro-Adipogenic Fate

(2013) Christopher M. Penton et al.   PLoS One

Human Tendon Stem Cells Better Maintain Their Stemness in Hypoxic Culture Conditions

(2013) Jianying Zhang et al.   PLoS One

Osterix-Cre Labeled Progenitor Cells Contribute to the Formation and Maintenance of the Bone Marrow Stroma

(2013) Yaling Liu et al.   PLoS One

Probing Allostery Through DNA

(2013) S. Kim et al.   SCIENCE

Role of Pericytes in Skeletal Muscle Regeneration and Fat Accumulation

(2013) Alexander Birbrair et al.   STEM CELLS AND DEVELOPMENT

Treatment of Knee Osteoarthritis With Autologous Mesenchymal Stem Cells

(2013) Lluis Orozco et al.   TRANSPLANTATION

Self-Renewing Human Bone Marrow Mesenspheres Promote Hematopoietic Stem Cell Expansion

(2013) Joan Isern et al.   Cell Reports

Clinical Therapy Using iPSCs: Hopes and Challenges

(2013) Xiao Lu et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Intraoperative Stem Cell Therapy

(2012) Mónica Beato Coelho et al.   Annual Review of Biomedical Engineering

In Osteoporosis, differentiation of mesenchymal stem cells (MSCs) improves bone marrow adipogenesis

(2012) Ana María Pino et al.   BIOLOGICAL RESEARCH

Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

(2012) Dongsu Park et al.   Cell Stem Cell

Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage

(2012) F. Relaix et al.   DEVELOPMENT

In vivo models of bone repair

(2012) L. A. Mills et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury

(2012) Mohammad Naimul Islam et al.   NATURE MEDICINE

Isolation and Characterization of Multipotential Mesenchymal Cells from the Mouse Synovium

(2012) Ippei Futami et al.   PLoS One

The Transcriptional Profile of Mesenchymal Stem Cell Populations in Primary Osteoporosis Is Distinct and Shows Overexpression of Osteogenic Inhibitors

(2012) Peggy Benisch et al.   PLoS One

Human Stromal (Mesenchymal) Stem Cells from Bone Marrow, Adipose Tissue and Skin Exhibit Differences in Molecular Phenotype and Differentiation Potential

(2012) May Al-Nbaheen et al.   Stem Cell Reviews and Reports

Clinical Use of Bone Marrow, Bone Marrow Concentrate, and Expanded Bone Marrow Mesenchymal Stem Cells in Cartilage Disease

(2012) Francesca Veronesi et al.   STEM CELLS AND DEVELOPMENT

Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity

(2012) Mathilde Latil et al.   Nature Communications

Safety of Mesenchymal Stem Cells for Clinical Application

(2012) Youwei Wang et al.   Stem Cells International

Adipose-Derived Mesenchymal Stromal/Stem Cells: Tissue Localization, Characterization, and Heterogeneity

(2012) Patrick C. Baer et al.   Stem Cells International

Cell therapy medicinal product regulatory framework in Europe and its application for MSC-based therapy development

(2012) Janis Ancans   Frontiers in Immunology

Functional mesenchymal stem cell niches in adult mouse knee joint synovium in vivo

(2011) Tobias B. Kurth et al.   ARTHRITIS AND RHEUMATISM

Treatment of early stage osteonecrosis of the femoral head with autologous implantation of bone marrow-derived and cultured mesenchymal stem cells

(2011) Dewei Zhao et al.   BONE

Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC

(2011) Ralf Hass et al.   Cell Communication and Signaling

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration

(2011) R. Sambasivan et al.   DEVELOPMENT

Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients

(2011) Fereydoun DAVATCHI et al.   International Journal of Rheumatic Diseases

Abcg2 labels multiple cell types in skeletal muscle and participates in muscle regeneration

(2011) Michelle J. Doyle et al.   JOURNAL OF CELL BIOLOGY

Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle

(2011) A. Uezumi et al.   JOURNAL OF CELL SCIENCE

Medical therapies with adult stem/progenitor cells (MSCs): A backward journey from dramatic results in vivo to the cellular and molecular explanations

(2011) Darwin J. Prockop et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ferreting out stem cells from their niches

(2011) Elaine Fuchs et al.   NATURE CELL BIOLOGY

In Vivo Fate Mapping Identifies Mesenchymal Progenitor Cells

(2011) Danka Grcevic et al.   STEM CELLS

Comparison of Potentials of Stem Cells Isolated from Tendon and Bone Marrow for Musculoskeletal Tissue Engineering

(2011) Qi Tan et al.   TISSUE ENGINEERING PART A

Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage

(2011) David Pretzel et al.   ARTHRITIS RESEARCH & THERAPY

Pericytes resident in postnatal skeletal muscle differentiate into muscle fibres and generate satellite cells

(2011) A. Dellavalle et al.   Nature Communications

Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells

(2010) Francesco Saverio Tedesco et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantification of Cells Expressing Mesenchymal Stem Cell Markers in Healthy and Osteoarthritic Synovial Membranes

(2010) T. HERMIDA-GOMEZ et al.   JOURNAL OF RHEUMATOLOGY

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal development

(2010) Kathryn J. Mitchell et al.   NATURE CELL BIOLOGY

Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle

(2010) Akiyoshi Uezumi et al.   NATURE CELL BIOLOGY

Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

(2010) Aaron W. B. Joe et al.   NATURE CELL BIOLOGY

A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone

(2010) Heng Zhu et al.   Nature Protocols

Identification and Clonal Characterisation of a Progenitor Cell Sub-Population in Normal Human Articular Cartilage

(2010) Rebecca Williams et al.   PLoS One

The impact of sarcopenia and exercise training on skeletal muscle satellite cells

(2009) Tim Snijders et al.   AGEING RESEARCH REVIEWS

Isolation and characterization of multipotent stem cells from human cruciate ligaments

(2009) M-T. Cheng et al.   CELL PROLIFERATION

Syndecan-4-Expressing Muscle Progenitor Cells in the SP Engraft as Satellite Cells during Muscle Regeneration

(2009) Kathleen Kelly Tanaka et al.   Cell Stem Cell

Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow

(2009) Satoru Morikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel Method to Isolate Mesenchymal Stem Cells from Bone Marrow in a Closed System Using a Device Made by Nonwoven Fabric

(2009) Kinya Ito et al.   TISSUE ENGINEERING PART C-METHODS

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

(2008) Mihaela Crisan et al.   Cell Stem Cell

Prospective Isolation of Skeletal Muscle Stem Cells with a Pax7 Reporter

(2008) Darko Bosnakovski et al.   STEM CELLS