Article
Neurosciences
Christelle Langley, Naoki Masuda, Simon Godwin, Giovanni De Marco, Angela Davies Smith, Rosemary Jones, Jared Bruce, Ngoc Jade Thai
Summary: This study aimed to establish the role of the basal ganglia in fatigue in multiple sclerosis (MS) using functional connectivity measures. The results suggest that decreased local functional connectivity within the basal ganglia plays a key role in cognitive fatigue in MS. Increased global functional connectivity between the basal ganglia and the cortex may serve as a compensatory mechanism to reduce the impact of fatigue in MS.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neuroimaging
Floris B. Tijhuis, Tommy A. A. Broeders, Fernando A. N. Santos, Menno M. Schoonheim, Joep Killestein, Cyra E. Leurs, Quinten van Geest, Martijn D. Steenwijk, Jeroen J. G. Geurts, Hanneke E. Hulst, Linda Douw
Summary: The study found an association between fatigue symptoms in multiple sclerosis patients and dynamic functional connectivity in the brain. Reduced dynamic connectivity may be related to higher fatigue levels, while increased dynamics in non-fatigued patients could represent a protective network organization against fatigue or early network dysfunction.
NEUROIMAGE-CLINICAL
(2021)
Review
Clinical Neurology
Bethany L. Sussman, Sarah N. Wyckoff, Jennifer Heim, Angus A. Wilfong, P. David Adelson, Michael C. Kruer, Maria Jose Gonzalez, Varina L. Boerwinkle
Summary: This article provides a focused review of the resting state fMRI functional and effective connectivity of the human motor network across the lifespan, highlighting its potential implications for network-targeted movement disorder therapies.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Hui Chen, Guofu Miao, Sirui Wang, Jun Zheng, Xin Zhang, Junbin Lin, Chizi Hao, Hailong Huang, Ting Jiang, Yu Gong, Weijing Liao
Summary: The frontal functional network in minimally conscious state (MCS) patients is disrupted, particularly in the frontopolar area and right dorsolateral prefrontal cortex. The nodal clustering coefficient and nodal local efficiency in the left frontopolar area and right dorsolateral prefrontal cortex are significantly reduced in MCS patients. These findings contribute to a better understanding of the pathological mechanism of MCS patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Su Hyoun Park, Anne K. Baker, Vinit Krishna, Sean C. Mackey, Katherine T. Martucci
Summary: The brain corticostriatal circuits play a crucial role in understanding chronic pain. In this study, the authors investigated the connectivity of the nucleus accumbens (NAcc) - medial prefrontal cortex (MPFC) circuit in patients with fibromyalgia. They found that the connectivity of this circuit was significantly reduced in fibromyalgia patients compared to healthy controls. The connectivity between the NAcc and subcortical brain regions was also reduced in fibromyalgia. These findings provide novel evidence of altered corticostriatal and mesolimbic circuits in chronic pain.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
S. Krug, T. Mueller, Oe Kayali, E. Leichter, S. K. Peschel, N. Jahn, L. Winter, T. H. C. Krueger, K. G. Kahl, C. Sinke, I Heitland
Summary: This study examined the functional connectivity of brain networks in major depressive disorder (MDD) patients and found altered connectivity between the hippocampus and the anterior cingulate cortex (ACC) as well as between the insula and the ACC. Additionally, the connectivity between the inferior parietal lobule (IPL) and the superior frontal gyrus (SFG) was also affected.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Neurosciences
Zongxin Tan, Guanya Li, Wenchao Zhang, Jia Wang, Yang Hu, Hao Li, Lei Zhang, Shuai Lv, Zhenzhen Jia, Xiaohua Li, Yu Han, Guangbin Cui, Peter Manza, Nora D. Volkow, Yongzhan Nie, Gang Ji, Gene-Jack Wang, Yi Zhang
Summary: This study found an association between obesity and alterations in intrinsic functional connectivity, with dynamic functional connectivity analysis revealing more detailed node information, uncovering some associations that traditional connectivity analysis cannot see.
Article
Clinical Neurology
Audrey Riou, Jean-Francois Houvenaghel, Thibaut Dondaine, Sophie Drapier, Paul Sauleau, Dominique Drapier, Joan Duprez, Murielle Guillery, Florence Le Jeune, Marc Verin, Gabriel Robert
Summary: The study revealed the involvement of the cerebellum in nonmotor domains of PD, with differential but overlapping patterns of metabolic correlations, suggesting the involvement of cerebello-thalamo-striatal-cortical loops.
Article
Biology
Swati Agrawal, Rinku Sharma, Vijayakumar Chinnadurai
Summary: The study investigates the interactions of learning and memory associated regions using functional connectivity and neurovascular approach, revealing significant connectivity between the medial temporal lobe and basal ganglia during feedback learning and memory retrieval. The results demonstrate the significant role of frontal-parietal EEG powers in MTL-basal ganglia relationships during declarative memory retrieval.
JOURNAL OF BIOSCIENCES
(2021)
Article
Neurosciences
Wenjuan Li, Ke Xie, Ronald K. Ngetich, Junjun Zhang, Zhenlan Jin, Ling Li
Summary: The study demonstrated that bilateral IFG plays a crucial role in the medium use of the reappraisal strategy, particularly in its positive correlation with brain regions like bilateral temporal gyrus, bilateral superior parietal lobe, and middle cingulate cortex.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Stephen J. Suss, Anna Manelis, Joao Paulo Lima Santos, Cynthia L. Holland, Richelle S. Stiffler, Hannah B. Bitzer, Sarrah Mailliard, Madelyn Shaffer, Kaitlin Caviston, Michael W. Collins, Mary L. Phillips, Anthony P. Kontos, Amelia Versace
Summary: Concussion among adolescents is a public health concern, and the differences in brain function between adolescents with and without a history of concussion are not well understood. This study used resting state functional magnetic resonance imaging (fMRI) to investigate these differences and found disrupted functional connectivity between the hippocampal network and the right inferior frontal gyrus in adolescents with concussion.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Hua Yu, Ming-Li Li, Yajing Meng, Xiao-Jing Li, Wei Wei, Yin-Fei Li, Lei Li, Wanjun Guo, Qiang Wang, Wei Deng, Xiaohong Ma, Jeremy Coid, Tao Li
Summary: The study found increased functional connectivity between the right inferior frontal gyrus and other brain regions in bipolar patients, as well as decreased connectivity with sensorimotor areas. Impaired sustained attention was observed in bipolar manic and depressive subgroups compared to healthy controls, with manic and psychotic symptoms significantly impacting sustained attention task performance.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Elisa Canu, Davide Calderaro, Veronica Castelnovo, Silvia Basaia, Maria Antonietta Magno, Nilo Riva, Giuseppe Magnani, Francesca Caso, Paola Caroppo, Sara Prioni, Cristina Villa, Debora Pain, Gabriele Mora, Lucio Tremolizzo, Ildebrando Appollonio, Barbara Poletti, Vincenzo Silani, Massimo Filippi, Federica Agosta
Summary: This study investigated the relationship between emotion processing and resting-state functional connectivity (rs-FC) of the brain networks in frontotemporal lobar degeneration (FTLD). The results showed that in FTLD patients, rs-FC changes associated with emotional processing involve a larger number of brain regions, likely due to functional specificity loss and compensatory attempts.
MOLECULAR PSYCHIATRY
(2022)
Article
Behavioral Sciences
Liu Xinyuan, Chen Ximei, Li Qingqing, Xiang Guangcan, Li Wei, Xiao Mingyue, Du Xiaoli, Song Shiqing, Liu Yong, Chen Hong
Summary: Functional neuroimaging research suggests that overweight individuals may have alterations in reactive inhibition. However, little is known about the functional connectivity that mediates intentional inhibition in overweight individuals. This study found that compared to normal-weight adults, overweight individuals exhibited different patterns of functional connectivity between the medial frontal cortex and other brain regions involved in intentional inhibition. These altered functional connections were associated with poorer performance in food-specific intentional inhibition and weight gain over time.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Sepehr Shirani, Maryam Mohebbi
Summary: This study investigates the effects of MS on the brain's functional connectivity network using EEG resting-state signals and graph theory approach. The results indicate lower cortical activity in the alpha frequency bands and higher activity in the gamma frequency bands for patients with RRMS. Additionally, the functional brain network in RRMS cases shows a higher diameter, global efficiency, and transitivity in certain frequency bands.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Britta Matusche, Ludmila Litvin, Ruth Schneider, Barbara Bellenberg, Mark Muehlau, Viola Pongratz, Achim Berthele, Sergiu Groppa, Muthuraman Muthuraman, Frauke Zipp, Friedemann Paul, Heinz Wiendl, Sven G. Meuth, Philipp Saemann, Frank Weber, Ralf A. Linker, Tania Kuempfel, Ralf Gold, Carsten Lukas
Summary: The aim of this study was to analyze the extent of pseudoatrophy in the upper spinal cord during the first 2 years after therapy initiation and compare this to the brain. The results suggest that pseudoatrophy occurs not only in the brain, but also in the spinal cord during the first year of interferon-beta treatment.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Isabel Lutfullin, Maria Eveslage, Stefan Bittner, Gisela Antony, Martina Flaskamp, Felix Luessi, Anke Salmen, Barbara Gisevius, Luisa Klotz, Catharina Korsukewitz, Achim Berthele, Sergiu Groppa, Florian Then Bergh, Brigitte Wildemann, Antonios Bayas, Hayrettin Tumani, Sven G. Meuth, Corinna Trebst, Uwe K. Zettl, Friedemann Paul, Christoph Heesen, Tania Kuempfel, Ralf Gold, Bernhard Hemmer, Frauke Zipp, Heinz Wiendl, Jan D. Luenemann
Summary: Obesity is associated with higher disease severity and poorer outcome in newly diagnosed patients with multiple sclerosis. The presence of obesity at disease onset is linked to higher disability at baseline and at follow-up periods of 2, 4, and 6 years. Obesity management could potentially improve the clinical outcome of multiple sclerosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Josephine Wauschkuhn, Gilberto Solorza Buenrostro, Lilian Aly, Susanna Asseyer, Rebecca Wicklein, Julia Maria Hartberger, Klemens Ruprecht, Mark Muehlau, Tanja Schmitz-Huebsch, Claudia Chien, Achim Berthele, Alexander U. U. Brandt, Thomas Korn, Friedemann Paul, Bernhard Hemmer, Hanna G. G. Zimmermann, Benjamin Knier
Summary: Thinning of retinal combined ganglion cell and inner plexiform layer (GCIP) as measured by OCT is common in patients with multiple sclerosis. This study aimed to investigate whether a single retinal OCT analysis allows prediction of future disease activity after a first demyelinating event. The results showed that GCIP thickness measurement provides information for early risk stratification and progression of multiple sclerosis after the initial manifestation.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Immunology
Patrick Schindler, Orhan Aktas, Marius Ringelstein, Brigitte Wildemann, Sven Jarius, Friedemann Paul, Klemens Ruprecht
Summary: Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing neuroinflammatory disease characterized by transverse myelitis and optic neuritis. Autoantibodies against aquaporin-4 (AQP4-IgG) are found in about 80% of NMOSD patients. GFAP, a biomarker expressed in astrocytes, is elevated in the blood and cerebrospinal fluid (CSF) of NMOSD patients and could potentially be used to monitor disease activity.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Article
Clinical Neurology
Irina Galperin, Anat Mirelman, Tanja Schmitz-Huebsch, Katherine L. Hsieh, Keren Regev, Arnon Karni, Marina Brozgol, Pablo Cornejo Thumm, Sharon G. Lynch, Friedemann Paul, Hannes Devos, Jacob Sosnoff, Jeffrey M. Hausdorff
Summary: This study found that a combined motor-cognitive virtual reality training program had positive effects on motor and cognitive symptoms in people with multiple sclerosis (pwMS). The virtual reality training improved gait speed and cognitive processing speed more than treadmill training alone. Additionally, it had positive impacts on depressive symptoms, attention, and verbal fluency.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Brenda Banwell, Jeffrey L. Bennett, Romain Marignier, Ho Jin Kim, Fabienne Brilot, Eoin P. Flanagan, Sudarshini Ramanathan, Patrick Waters, Silvia Tenembaum, Jennifer S. Graves, Tanuja Chitnis, Alexander U. Brandt, Cheryl Hemingway, Rinze Neuteboom, Lekha Pandit, Markus Reindl, Albert Saiz, Douglas Kazutoshi Sato, Kevin Rostasy, Friedemann Paul, Sean J. Pittock, Kazuo Fujihara, Jacqueline Palace
Summary: Serum antibodies against MOG can help diagnose MOGAD, which is distinct from multiple sclerosis and neuromyelitis optica. The presence of MOG-IgG is a core criterion for the diagnosis. MOGAD can present with various symptoms and can be either monophasic or relapsing, and diagnostic accuracy relies on MOG-IgG cell-based assays.
Review
Clinical Neurology
Zoe Mendelsohn, Hugh G. Pemberton, James Gray, Olivia Goodkin, Ferran Prados Carrasco, Michael Scheel, Jawed Nawabi, Frederik Barkhof
Summary: This article provides a systematic review of commercial QReports for multiple sclerosis (MS), highlighting limited evidence regarding clinical validation and in-use evaluation, particularly the lack of clinician end-user testing. The review aims to provide clinicians and institutions with the available evidence when considering adopting a quantitative reporting tool for MS.
Article
Clinical Neurology
Sean J. Pittock, Michael Barnett, Jeffrey L. Bennett, Achim Berthele, Jerome de Seze, Michael Levy, Ichiro Nakashima, Celia Oreja-Guevara, Jacqueline Palace, Friedemann Paul, Carlo Pozzilli, Marcus Yountz, Kerstin Allen, Yasmin Mashhoon, Ho Jin Kim
Summary: The CHAMPION-NMOSD study evaluated the efficacy and safety of ravulizumab in adult patients with anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder. Ravulizumab, which has a longer half-life compared to eculizumab, significantly reduced relapse risk in these patients.
ANNALS OF NEUROLOGY
(2023)
Article
Immunology
Mikhail Lebedin, Clara Vazquez Garcia, Lisa Spatt, Christoph Ratswohl, Charlotte Thibeault, Lennard Ostendorf, Tobias Alexander, Friedemann Paul, Leif Erik Sander, Florian Kurth, Kathrin de la Rosa
Summary: Diverse autoantibodies in COVID-19 have unclear functional implications. ACE2 is one of the targets of autoantibodies. Elevated levels of sACE2 and anti-ACE2 IgG were observed in critically ill patients, but they were poorly correlated. IgGs recognizing ACE2, IFN alpha 2, and CD26 correlated strongly in severe COVID-19, with some showing polyreactivity. Promiscuous autoantibodies did not impair ACE2 and IFN alpha 2 activity, while specific anti-IFN alpha 2 IgG compromised cytokine function.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Neurosciences
Kamil Sebastian Rosiewicz, Bakhrom Muinjonov, Severine Kunz, Helena Radbruch, Jessy Chen, Rene Juettner, Janis Kerkering, Julia Ucar, Tadhg Crowley, Ben Wielockx, Friedemann Paul, Marlen Alisch, Volker Siffrin
Summary: Astrocytes play a crucial role in maintaining the blood-brain barrier and supporting neuronal functions. In this study, transgenic mice with astrocyte-specific activation of the hypoxia-response program were investigated. The deletion of oxygen sensors in these mice led to an exacerbation of autoimmune encephalomyelitis, accompanied by immune cell infiltration. The study also highlighted the loss of gap-junctional Connexin-43 in these astrocytes, which was induced by vascular endothelial growth factor-alpha expression.
Letter
Clinical Neurology
Michael Scheel, Harald Pruess, Carsten Finke
Summary: We found the report on unilateral cortical ribboning in a 62-year-old man with NMDA receptor antibodies interesting. Most NMDAR encephalitis patients do not have MRI abnormalities or only have subtle white matter lesions. Cortical ribboning is frequently seen in patients with Creutzfeldt-Jakob disease and those with asymmetric or strictly unilateral presentation. Additionally, NMDAR antibodies have been reported in the serum of patients with CJD, although not in the CSF.
Article
Orthopedics
Tobia Zanotto, Irina Galperin, Anat Mirelman, Lingjun Chen, Keren Regev, Arnon Karni, Tanja Schmitz-Huebsch, Friedemann Paul, Sharon G. Lynch, Abiodun E. Akinwuntan, Hannes Devos, Jeffrey M. Hausdorff, Jacob J. Sosnoff
Summary: The study aimed to examine the relationship between frailty and the quantity and quality of free-living walking in people with multiple sclerosis (MS), as well as the mediating effect of frailty on the relationship between disability and walking performance. The results showed that frailty was associated with poorer free-living walking performance in people with MS, and it may be the primary factor leading to the lower amount of physical activity performed by these individuals in the real world.
Article
Neurosciences
Till Nierhaus, Sara Wesolek, Daniel Pach, Claudia M. Witt, Felix Blankenburg, Timo T. Schmidt
Summary: Using fMRI and multivariate pattern analysis, this study investigates the activation patterns in the brain during tactile mental imagery. The findings suggest that the recruitment of sensory regions during mental tactile imagery involves content-specific activation patterns, particularly in the S1.
Article
Clinical Neurology
Viktor Horst, Vasilis Kola, Coline L. Lemale, Sebastian Major, Maren K. L. Winkler, Nils Hecht, Edgar Santos, Johannes Platz, Oliver W. Sakowitz, Hartmut Vatter, Christian Dohmen, Michael Scheel, Peter Vajkoczy, Jed A. Hartings, Johannes Woitzik, Peter Martus, Jens P. Dreier
Summary: This study demonstrates that there is a relationship between cerebrovascular dysfunction and cerebral infarction, but angiographic vasospasm does not correlate with delayed infarct volume. Angiographic vasospasm is a mediator between intraventricular hemorrhage and delayed infarct volume, while spreading depolarization variables are a mediator between subarachnoid blood volume and delayed infarct volume.
BRAIN COMMUNICATIONS
(2023)
Article
Integrative & Complementary Medicine
Jun J. J. Mao, Claudia M. M. Witt
JOURNAL OF INTEGRATIVE AND COMPLEMENTARY MEDICINE
(2023)
