Review
Biochemistry & Molecular Biology
Anastasia Kariagina, Andrea I. Doseff
Summary: Flavones, natural phytochemicals found in our diet, possess anti-inflammatory properties that can effectively control the innate immune system and inflammation. They play a significant role in chronic inflammation, particularly in obesity and cancer, by influencing molecular mechanisms. Flavones restore immune landscape by impacting innate immune cell repertoire and reestablish immune homeostasis through NF-kappa B, STAT, COX-2, or NLRP3 inflammasome pathways. With no adverse side effects, flavones could be alternative opportunities for treating and preventing chronic inflammation associated with obesity and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Stephan Culemann, Katharina Knab, Maximilien Euler, Anja Wegner, Hilal Garibagaoglu, Jochen Ackermann, Kim Fischer, Deborah Kienhoefer, Georgiana Crainiciuc, Jonas Hahn, Anika Grueneboom, Falk Nimmerjahn, Stefan Uderhardt, Andres Hidalgo, Georg H. Schett, Markus Hoffmann, Gerhard Kroenke
Summary: The authors have found that the anti-inflammatory effects of clodronate liposomes are not due to the depletion of mononuclear phagocytes, but rather a functional inhibition of polymorphonuclear neutrophils. This finding calls for a critical revision of the current literature on the role of monocytes and macrophages in inflammation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Oncology
Bing-Qing Li, Xin-Yuan Liu, Tao Mao, Tao-Hua Zheng, Peng Zhang, Qi Zhang, Yu Zhang, Xiao-Yu Li
Summary: This article reviews the pathogenesis of chronic pancreatitis (CP) and the research progress on anti-inflammatory and anti-fibrotic therapies. Currently, clinical treatment of CP is mainly symptomatic and lacks effective etiological treatment. However, experiments have shown that some active substances have great potential in the etiological treatment of chronic pancreatitis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Anan Shtaya, Leslie R. Bridges, Rebecca Williams, Sarah Trippier, Liqun Zhang, Anthony C. Pereira, James A. R. Nicoll, Delphine Boche, Atticus H. Hainsworth
Summary: The study identified an anti-inflammatory process occurring alongside neuroinflammation post-sICH in clinical patients, involving native microglia and blood monocytes. This novel pathway offers therapeutic targets and a treatment opportunity window for delivering therapeutics through invading monocytes during 3-5 days post-sICH.
Article
Biochemistry & Molecular Biology
Natalia Lehman, Wioleta Kowalska, Michal Zarobkiewicz, Marek Mazurek, Karolina Mrozowska, Agnieszka Bojarska-Junak, Radoslaw Rola
Summary: Monocyte subpopulations in glioma patients' peripheral blood were analyzed based on CD14, CD16, and SLAN expression. The study found different profiles of monocytes with varying cytokine expression. The presence of these different profiles might hinder the effectiveness of immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Karen Gronemeyer, Carmina Teresa Fuss, Franca Hermes, Armin Plass, Ann-Cathrin Koschker, Anke Hannemann, Henry Voelzke, Stefanie Hahner
Summary: Patients with chronic hypoparathyroidism have a higher prevalence of impaired renal function, which is independent of renal calcifications. Disease duration and serum phosphate or 24-hour urinary calcium excretion are predictors for renal calcifications.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jingxuan Liu, Yueying Yang, Xiao Liu, Andy Samuel Widjaya, Baohong Jiang, Yanyan Jiang
Summary: The study suggests that utilizing nanotherapy, such as PM/TN-CCLP, can significantly prevent and treat aortic dissection by reducing the rupture rate, preventing loss of elastic fibers, and decreasing inflammation at the lesion site.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Daniela Placha, Josef Jampilek
Summary: Inflammatory diseases are becoming a significant issue, causing damage to affected tissues as a physiological response to harmful agents. There is ongoing research to develop new drugs to modulate inflammatory responses, as well as exploring the use of nanodrug delivery systems for targeted treatment.
Article
Cell Biology
Elke M. Muntjewerff, Kristel Parv, Sushil K. Mahata, N. Koen van Riessen, Mia Phillipson, Gustaf Christoffersson, Geert van den Bogaart
Summary: Increased levels of the anti-inflammatory peptide Catestatin (CST) correlate with less severe outcomes in hypertension, colitis, and diabetes, partly due to its regulation of chemotaxis, which reduces the infiltration of monocytes and macrophages in inflamed tissues.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haochen Hui, Meng Gao, Xuerong Zhao, Lianhong Yin, Lina Xu, Lili Li, Jinyong Peng
Summary: Three water soluble polysaccharides, SUSP-1, SUSP-2 and SUSP-3, were isolated and identified from S. uncinata. These polysaccharides exhibited anti-inflammatory activities by inhibiting ROS levels, promoting IL-10 expression and suppressing pro-inflammatory cytokines. This study provides new insights into the development of natural polysaccharides with anti-inflammatory properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Multidisciplinary Sciences
Shinichi Ashida, Aika Yamawaki-Ogata, Masayoshi Tokoro, Masato Mutsuga, Akihiko Usui, Yuji Narita
Summary: This study investigated the effects of M2M administration in an apoE(-/-) mouse model of AA induced by ATII infusion. The intraperitoneal administration of M2Ms reduced AA expansion, decreased expression levels of pro-inflammatory factors, and increased expression levels of anti-inflammatory factors. The findings suggest that M2M administration may be a useful treatment for AA.
SCIENTIFIC REPORTS
(2023)
Review
Materials Science, Multidisciplinary
Gang Tan, Jing Xu, Walter Munesu Chirume, Jieyu Zhang, Hui Zhang, Xuefeng Hu
Summary: Orthopedic implant failure is a common complication of orthopedic surgery, often caused by peri-implant infection and aseptic loosening. There are various methods to treat these complications, such as revision surgery, but preventing peri-implant infection could bring significant social benefits.
Article
Urology & Nephrology
Kate Wiles, Ellen Anckaert, Francesca Holden, Jan Grace, Catherine Nelson-Piercy, Liz Lightstone, Lucy C. Chappell, Kate Bramham
Summary: The study showed that women with chronic kidney disease have lower serum AMH concentrations compared to healthy women, indicating a lower ovarian reserve and potentially reduced response to gonadotrophin stimulation.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Petra Salamunova, Lucie Cupalova, Monika Majerska, Jakub Treml, Gabriela Ruphuy, Karel Smejkal, Frantisek Stepanek, Jaroslav Hanus, Jan Hosek
Summary: The study found that combining several natural compounds with yeast GPs can enhance their anti-inflammatory and antioxidant potential, showing stronger activity in vitro. Composites prepared by spray drying demonstrated better performance than those prepared by slurry evaporation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Nutrition & Dietetics
Amanda Fernandes de Medeiros, Jaluza Luana Carvalho de Queiroz, Bruna Leal Lima Maciel, Ana Heloneida de Araujo Morais
Summary: Chronic low-grade inflammation is associated with obesity, and hydrolyzed proteins and plant peptides have shown potential anti-inflammatory and immunomodulatory effects. Understanding the mechanism of action of these molecules is important for their potential health applications.