Article
Radiology, Nuclear Medicine & Medical Imaging
M. Kiani, A. Chaparian
Summary: The purpose of this study was to assess organ doses, effective dose, and image quality, and to estimate the risk of exposure-induced cancer death (REID) in pediatric brain computed tomography examinations. The study found that brain CT scans in children are associated with an increased potential risk of cancer. Therefore, minimizing unnecessary radiation exposure in pediatric patients and using alternative imaging modalities are of particular importance.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anais Foucault, Sophie Ancelet, Serge Dreuil, Sylvaine Caer-Lorho, Hubert Ducou Le Pointe, Herve Brisse, Jean-Francois Chateil, Choonsik Lee, Klervi Leuraud, Marie-Odile Bernier
Summary: Recent epidemiological studies have reported increased risks of central nervous system (CNS) tumors and leukemia associated with computed tomography (CT) exposure during childhood. However, a previous analysis of the French CT cohort did not provide evidence of increased risks. This study, with an updated cohort and a longer follow-up, confirms the increased risks.
EUROPEAN RADIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Amy Berrington de Gonzalez, Elisa Pasqual, Lene Veiga
Summary: This review examined epidemiological studies on cancer risks from CT scans in children initiated 20 years ago and found wide variability in study methodology, making comparison of findings challenging. Studies showed positive dose-response relationships for leukemia and brain tumors, with ongoing efforts aiming to provide more precise risk quantification. The evidence suggests that CT scans can cause cancer, but the absolute risks to individual patients are likely to be small.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Article
Chemistry, Physical
Samira Kamrani, Nima Kasraie, Fatemeh Jahangiri, Davood Khezerloo, Peyman Sheikhzadeh
Summary: The purpose of this study was to calculate the organ doses, effective doses, and cancer risk from head and neck CT scans. Two techniques were used to determine the effective dose, and organ doses were computed using tissue weighting factors. The study found that females had higher mean effective doses and cancer risk compared to males. These findings will assist physicians in optimizing dose administration for head and neck CT examinations.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Environmental Sciences
Aida Kessara, Nihal Buyukcizmeci, Gonca Kara Gedik
Summary: The aim of this paper was to calculate the effective dose and lifetime attributable risk (LAR) of cancer related to whole-body positron emission tomography (PET)/computed tomography (CT) scan for 193 adult patients. The mean effective dose for a single PET/CT scan was 20.6 mSv. The LAR of cancer incidence for males aged 40 y increased from 0.169% with a single scan to 0.85% with an annual surveillance protocol for 5 y. For female patients aged 40 y, the LAR of cancer mortality increased from 0.126% to 0.63% with the same surveillance protocol. It is important to balance the advantages and risks before conducting PET/CT scans, especially for younger and overweight patients.
RADIATION PROTECTION DOSIMETRY
(2023)
Review
Oncology
Chun-Feng Cao, Kun-Long Ma, Hua Shan, Tang-Fen Liu, Si-Qiao Zhao, Yi Wan, Hai-Qiang Jun-Zhang, Hai-Qiang Wang
Summary: This study suggests that there is an association between ionizing radiation from CT scans and increased cancer risks in adults. The risks are higher with higher radiation dose and multiple CT scan sites.
Article
Oncology
Michael Hauptmann, Graham Byrnes, Elisabeth Cardis, Marie-Odile Bernier, Maria Blettner, Jeremie Dabin, Hilde Engels, Tore S. Istad, Christoffer Johansen, Magnus Kaijser, Kristina Kjaerheim, Neige Journy, Johanna M. Meulepas, Monika Moissonnier, Cecile Ronckers, Isabelle Thierry-Chef, Lucian Le Cornet, Andreas Jahnen, Roman Pokora, Magda Bosch de Basea, Jordi Figuerola, Carlo Maccia, Arvid Nordenskjold, Richard W. Harbron, Choonsik Lee, Steven L. Simon, Amy Berrington de Gonzalez, Joachim Schuz, Ausrele Kesminiene
Summary: The European EPI-CT study aims to assess the risk of brain cancer from CT examinations in children and young adults. Using data from nine European countries, the study found a significant dose-response relationship between CT-related radiation exposure and brain cancer.
Article
Biology
Saeed Bagherzadeh, Nasrollah Jabbari, Hamid Reza Khalkhali
Summary: This study compared radiation doses and cancer risks between abdominopelvic radiotherapy planning computed tomography (RP-CT) and abdominopelvic diagnostic CT (DG-CT) scans. Results showed that RP-CT scans had higher cancer incidence and mortality risks compared to DG-CT scans. It suggests the need to optimize protocols, especially for RP-CT scans, regarding radiation doses.
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2021)
Article
Biology
Atefeh Tahmasebzadeh, Reza Paydar, Mojtaba Soltani-kermanshahi, Asghar Maziar, Reza Reiazi
Summary: The study revealed that the average LAR is higher in females and it decreases with age in both genders. The highest median dose for all age groups was related to eye lens (head scan), thyroid (chest scan), and colon (abdomen-pelvic scan). Breast cancer and colon cancer had the highest average LAR of cancer incidence following specific CT scan procedures.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Parnian Afshar, Moezedin Javad Rafiee, Farnoosh Naderkhani, Shahin Heidarian, Nastaran Enshaei, Anastasia Oikonomou, Faranak Babaki Fard, Reut Anconina, Keyvan Farahani, Konstantinos N. Plataniotis, Arash Mohammadi
Summary: Reverse transcription-polymerase chain reaction is the current gold standard for COVID-19 diagnosis, but it can take days and has a high false negative rate. Chest computed tomography (CT) can assist with diagnosis, but standard dose CT scans expose patients to significant radiation. In this study, a low-dose and ultra-low-dose CT scan protocol combined with an Artificial Intelligence (AI) model achieved human-level performance in COVID-19 diagnosis.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Nan Song, Qi Liu, Carmen L. Wilson, Yadav Sapkota, Matthew J. Ehrhardt, Todd M. Gibson, Lindsay M. Morton, Stephen J. Chanock, Joseph P. Neglia, Michael A. Arnold, J. Robert Michael, Alexander M. Gout, Heather L. Mulder, John Easton, Smita Bhatia, Gregory T. Armstrong, Jinghui Zhang, Angela Delaney, Melissa M. Hudson, Leslie L. Robison, Yutaka Yasui, Zhaoming Wang
Summary: The study evaluated the polygenic contributions to subsequent thyroid cancer (STC) risk and found that integrating the polygenic risk score with clinical factors significantly improved the risk prediction of STC. This suggests the potential utility of polygenic risk score for optimizing screening strategies in survivorship care.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Multidisciplinary Sciences
Justin Malimban, Danny Lathouwers, Haibin Qian, Frank Verhaegen, Julia Wiedemann, Sytze Brandenburg, Marius Staring
Summary: This study focuses on the contouring issue in image-guided small animal irradiations and proposes an automated contouring method using 2D and 3D U-Net models trained on native CTs. The results demonstrate that the 3D models achieve superior segmentation accuracy and resilience to unseen data compared to 2D models, and also significantly reduce the contouring time by 98%.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Fotso Eddy Kamdem, Samba Odette Ngano, Clemence Alla Takam, Alain Jerve Fotue, Serge Abogo, Cornellius Lukong Fai
Summary: The study aimed to assess scan parameters and propose strategies to optimize pediatric examinations on adult scanners in developing countries. By implementing the proposed strategies, dose reductions were achieved during pediatric CT examinations, demonstrating the feasibility of reducing radiation exposure for children on adult machines.
Review
Medicine, General & Internal
Mandeep Garg, Vahid Karami, Javad Moazen, Thomas Kwee, Ashu Seith Bhalla, Daryoush Shahbazi-Gahrouei, Yu-Hsuan Joni Shao
Summary: Since the COVID-19 outbreak, there has been a significant increase in CT scans for the detection of lung disease. However, CT scans expose patients to ionizing radiation, which can increase the risk of cancer. This review discusses the known health effects of radiation, the risk of radiation-induced cancer at CT scan doses, and the potential increase in cancer incidence from CT scans performed during the COVID-19 pandemic.
Article
Nuclear Science & Technology
Choonsik Lee, Tristan Won, Yeon Soo Yeom, Keith Griffin, Choonik Lee, Kwang Pyo Kim
Summary: The study established an organ dose conversion coefficient library for Korean adults, calculated using simulation techniques based on four Korean adult male and two female voxel phantoms. The calculated coefficients were compared with existing data from Caucasian phantoms. Representative organ doses for Korean adults were derived from Korean CT dose surveys and conversion coefficients. The Korean-specific coefficients showed slightly higher values compared to the ICRP reference phantoms.
NUCLEAR ENGINEERING AND TECHNOLOGY
(2022)
Article
Oncology
Vincent M. T. de Jong, Yuwei Wang, Natalie D. ter Hoeve, Mark Opdam, Nikolas Stathonikos, Katarzyna Jozwiak, Michael Hauptmann, Sten Cornelissen, Willem Vreuls, Efraim H. Rosenberg, Esther A. Koop, Zsuzsanna Varga, Carolien H. M. van Deurzen, Antien L. Mooyaart, Alicia Cordoba, Emma J. Groen, Joost Bart, Stefan M. Willems, Vasiliki Zolota, Jelle Wesseling, Anna Sapino, Ewa Chmielik, Ales Ryska, Annegien Broeks, Adri C. Voogd, Sherene Loi, Stefan Michiels, Gabe S. Sonke, Elsken van der Wall, Sabine Siesling, Paul J. van Diest, Marjanka K. Schmidt, Marleen Kok, Gwen M. H. E. Dackus, Roberto Salgado, Sabine C. Linn
Summary: High sTILs (>= 75%) in young patients with chemotherapy-naive N0 TNBC indicate an excellent long-term prognosis, suggesting the consideration of sTILs in prospective clinical trials exploring (neo)adjuvant chemotherapy de-escalation strategies.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Ulrike A. Nitz, Oleg Gluz, Sherko Kuemmel, Matthias Christgen, Michael Braun, Bahriye Aktas, Kerstin Luedtke-Heckenkamp, Helmut Forstbauer, Eva-Maria Grischke, Claudia Schumacher, Maren Darsow, Katja Krauss, Benno Nuding, Marc Thill, Jochem Potenberg, Christoph Uleer, Mathias Warm, Hans Holger Fischer, Wolfram Malter, Michael Hauptmann, Ronald E. Kates, Monika Graeser, Rachel Wuerstlein, Steven Shak, Frederick Baehner, Hans H. Kreipe, Nadia Harbeck
Summary: The WSG-ADAPT-HR+/HER2- study demonstrates the feasibility of guiding systemic treatment for breast cancer using both the recurrence score (RS) and endocrine therapy (ET) response, and avoids the use of chemotherapy in pre- and postmenopausal patients with <= 3 involved lymph nodes.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Sander Roberti, Flora E. van Leeuwen, Cecile M. Ronckers, Inge M. Krul, Florent de Vathaire, Cristina Veres, Ibrahima Diallo, Cecile P. M. Janus, Berthe M. P. Aleman, Nicola S. Russell, Michael Hauptmann
Summary: The study found that mean breast dose predicts the risk of subsequent breast cancer in long-term HL survivors.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Respiratory System
Torsten Gerriet Blum, Rebecca L. Morgan, Valerie Durieux, Joanna Chorostowska-Wynimko, David R. Baldwin, Jeanette Boyd, Corinne Faivre-Finn, Francoise Galateau-Salle, Fernando Gamarra, Bogdan Grigoriu, Georgia Hardavella, Michael Hauptmann, Erik Jakobsen, Dragana Jovanovic, Paul Knaut, Gilbert Massard, John McPhelim, Anne-Pascale Meert, Robert Milroy, Riccardo Muhr, Luciano Mutti, Marianne Paesmans, Pippa Powell, Paul Martin Putora, Janette Rawlinson, Anna L. Rich, David Rigau, Dirk de Ruysscher, Jean-Paul Sculier, Arnaud Schepereel, Dragan Subotic, Paul Van Schil, Thomy Tonia, Clare Williams, Thierry Berghmans
Summary: This guideline provides good quality recommendations in lung cancer care, based on systematic reviews and evidence syntheses. The recommendations cover various quality improvement measures, such as avoiding delays in diagnosis and treatment, integrating multidisciplinary teams, adhering to guidelines, and using specific tools for decision-making. The recommendations should be periodically updated as new evidence becomes available.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Oncology
Michael Hauptmann, Graham Byrnes, Elisabeth Cardis, Marie-Odile Bernier, Maria Blettner, Jeremie Dabin, Hilde Engels, Tore S. Istad, Christoffer Johansen, Magnus Kaijser, Kristina Kjaerheim, Neige Journy, Johanna M. Meulepas, Monika Moissonnier, Cecile Ronckers, Isabelle Thierry-Chef, Lucian Le Cornet, Andreas Jahnen, Roman Pokora, Magda Bosch de Basea, Jordi Figuerola, Carlo Maccia, Arvid Nordenskjold, Richard W. Harbron, Choonsik Lee, Steven L. Simon, Amy Berrington de Gonzalez, Joachim Schuz, Ausrele Kesminiene
Summary: The European EPI-CT study aims to assess the risk of brain cancer from CT examinations in children and young adults. Using data from nine European countries, the study found a significant dose-response relationship between CT-related radiation exposure and brain cancer.
Article
Oncology
Maike Wellbrock, Claudia Spix, Cecile M. Ronckers, Desiree Grabow, Anna-Liesa Filbert, Arndt Borkhardt, Daniel Wollschlaeger, Friederike Erdmann
Summary: Childhood cancer is the leading cause of death among children under 15 in Europe. A long-term assessment of childhood cancer survival in Germany from 1991 to 2016 showed overall improvement in survival rates, but recent progress has slowed down and some cancer types have reached a plateau in survival rates.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Nadia Harbeck, Ulrike A. Nitz, Matthias Christgen, Sherko Kuemmel, Michael Braun, Claudia Schumacher, Jochem Potenberg, Joke Tio, Bahriye Aktas, Helmut Forstbauer, Eva-Maria Grischke, Iris Scheffen, Wolfram Malter, Raquel von Schumann, Marianne Just, Christine zu Eulenburg, Claudia Biehl, Cornelia Kolberg-Liedtke, Regula Deurloo, Sanne de Haas, Katarzyna Jozwiak, Michael Hauptmann, Ronald Kates, Monika Graeser, Rachel Wuerstlein, Hans H. Kreipe, Oleg Gluz
Summary: The WSG-ADAPT-TP trial demonstrated that pathological complete response (pCR) after 12 weeks of chemotherapy-free de-escalated neoadjuvant therapy was associated with excellent survival in hormone receptor-positive/human epidermal growth factor receptor 2-positive early breast cancer (HR+/HER2+ EBC) without further adjuvant chemotherapy (ACT). Patients with pCR had similar 5-year invasive disease-free survival (iDFS) rates whether or not they received ACT. Patient selection based on biomarkers or molecular subtypes may improve efficacy of HER2-targeted approaches without systemic chemotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Jonathan Nuebel, Meike Hoffmeister, Oliver Labrenz, Kerstin Jost, Stefanie Oess, Michael Hauptmann, Julika Schoen, Georg Fritz, Michael Haase, Christian Butter, Anja Haase-Fielitz
Summary: This study aimed to determine whether novel and conventional cardiorenal biomarkers in patients before transcatheter aortic valve implantation may be associated with cardiorenal syndrome (CRS) type 1. Serum NT-proBNP and urine biomarkers (hepcidin-25, NGAL, IL-6) were measured, and it was found that patients with CRS type 1 had longer hospital stay and had higher readmission rate within 6 months after discharge. The NT-proBNP/urine hepcidin-25 ratio was identified as an independent modifier of CRS type 1.
BIOMARKERS IN MEDICINE
(2023)
Review
Health Care Sciences & Services
L. Sollfrank, S. C. Linn, M. Hauptmann, K. Jozwiak
Summary: This study aimed to explore the commonly used biomarker-based tests in clinical studies, and found that most studies evaluated treatment heterogeneity by analyzing biomarker-specific treatment effects and/or multiplicative interaction. However, there is a need for more efficient statistical methods to evaluate treatment heterogeneity in clinical studies.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuehan Wang, Cecile M. Ronckers, Flora E. van Leeuwen, Chaya S. Moskowitz, Wendy Leisenring, Gregory T. Armstrong, Florent de Vathaire, Melissa M. Hudson, Claudia E. Kuehni, Michael A. Arnold, Charlotte Demoor-Goldschmidt, Daniel M. Green, Tara O. Henderson, Rebecca M. Howell, Matthew J. Ehrhardt, Joseph P. Neglia, Kevin C. Oeffinger, Helena J. H. van der Pal, Leslie L. Robison, Michael Schaapveld, Lucie M. Turcotte, Nicolas Waespe, Nadia Haddy, Ibrahima Diallo, K. Scott Baker, Amy Berrington de Gonzalez, Miriam R. Conces, Louis S. Constine, Mike Hawkins, Jacqueline J. Loonen, Marloes Louwerens, Geert O. Janssens, Lene Mellemkjaer, Raoul Reulen, Jeanette F. Winther, Leontien C. M. Kremer, Jop C. Teepen
Summary: In this study, the association between anthracycline-based chemotherapy and subsequent breast cancer risk in female childhood cancer survivors was investigated. The findings suggest that there is a dose-dependent increased risk of subsequent breast cancer associated with doxorubicin, with a more than twofold increased risk for survivors treated with a cumulative doxorubicin dose of 200 mg/m² or higher. Early initiation of breast cancer surveillance may be reasonable for these survivors.
Review
Orthopedics
Nikolai Ramadanov, Katarzyna Jozwiak, Michael Hauptmann, Philip Lazaru, Polina Marinova-Kichikova, Dobromir Dimitrov, Roland Becker
Summary: This study compared cannulated screw fixation, dynamic hip screw fixation, hemiarthroplasty, and total hip arthroplasty in patients with displaced or non-displaced femoral neck fracture, evaluating surgical and functional outcomes, reoperation rates, and postoperative complications. The results showed that total hip arthroplasty and hemiarthroplasty were superior to cannulated screw fixation and dynamic hip screw fixation in terms of life quality and functional outcomes. Thus, hip arthroplasty should be preferred over internal fixation for femoral neck fractures, with internal fixation considered only in individual cases.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Jonathan Nubel, Michael Hauptmann, Julika Schoen, Georg Fritz, Christian Butter, Anja Haase-Fielitz
Summary: This study aimed to assess the neurocognitive function before and after transfemoral aortic valve replacement. The results showed that preoperative memory function was below average, while there was an improvement in memory function after the procedure. However, there were no changes in the digit span test.
JOURNAL OF GERIATRIC CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jonathan Nuebel, Charlotte Buhre, Meike Hoffmeister, Stefanie Oess, Oliver Labrenz, Kerstin Jost, Michael Hauptmann, Julika Schoen, Georg Fritz, Christian Butter, Anja Haase-Fielitz
Summary: This study found that changes in neuron-specific enolase (NSE) levels after TAVR did not significantly impair memory function, but patients with postoperative delirium (POD) had significantly higher levels of NSE.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Oncology
Nina Streefkerk, Jop C. Teepen, Elizabeth A. M. Feijen, Katarzyna Jozwiak, Helena J. H. van der Pal, Cecile M. Ronckers, Andrica C. H. De Vries, Margriet van der van der Loo, Nynke Hollema, Marleen van den Berg, Jacqueline Loonen, Martha A. Grootenhuis, Dorine Bresters, A. Brigitta Versluys, Eline van Dulmen-den Broeder, Marry M. van den Heuvel-eibrink, Flora E. van Leeuwen, Sebastian J. C. M. M. Neggers, Hanneke M. Van Santen, Mike Hawkins, Michael Hauptmann, Daisuke Yoneoka, Joke C. Korevaar, Wim J. E. Tissing, Leontien C. M. Kremer
Summary: This study found that childhood cancer survivors experience a high cumulative burden of clinically relevant outcomes compared to siblings. The burden mainly consists of endocrine and vascular conditions and varies by primary cancer type. However, the ranking of 30-year MCC often does not correspond with levels of care in existing risk stratifications.
Article
Oncology
Yuwei Wang, Annegien Broeks, Daniele Giardiello, Michael Hauptmann, Katarzyna Jozwiak, Esther A. Koop, Mark Opdam, Sabine Siesling, Gabe S. Sonke, Nikolas Stathonikos, Natalie D. ter Hoeve, Elsken van der Wall, Carolien H. M. van Deurzen, Paul J. van Diest, Adri C. Voogd, Willem Vreuls, Sabine C. Linn, Gwen M. H. E. Dackus, Marjanka K. Schmidt
Summary: This study validated the reliability of the PREDICT breast cancer prognostic model and assessed its clinical utility in young women with node-negative breast cancer. The results showed that PREDICT was not reliable in predicting outcomes for this patient subset and further updates are needed.
EUROPEAN JOURNAL OF CANCER
(2023)