Article
Medicine, General & Internal
Jesus Abelardo Barea-Mendoza, Mario Chico-Fernandez, Manuel Quintana-Diaz, Lluis Servia-Goixart, Ana Fernandez-Cuervo, Maria Bringas-Bollada, Maria Angeles Ballesteros-Sanz, Iker Garcia-Saez, Jon Perez-Barcena, Juan Antonio Llompart-Pou
Summary: The aim of this study was to analyze the impact of acute kidney injury (AKI) on mortality in patients with isolated traumatic brain injury (TBI) and identify associated risk factors. The results showed that 10.6% of patients developed AKI, which was significantly associated with increased mortality. Age, hemodynamic instability, rhabdomyolysis, trauma-associated coagulopathy, and transfusion of packed red-blood-cell concentrates were identified as the main risk factors for AKI in isolated TBI patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Andrea L. C. Schneider, Carrie B. Peltz, Yixia Li, Amber Bahorik, Raquel C. Gardner, Kristine Yaffe
Summary: This study found that traumatic brain injury (TBI) is associated with long-term stroke risk, with differences observed in age, sex, race and ethnicity, and time since TBI diagnosis. The highest risk of stroke occurs in the first year after TBI diagnosis, but the risk remains elevated for more than 10 years. Both mild and moderate/severe/penetrating TBI increase the risk of stroke compared to individuals without TBI. Older individuals have a stronger association between TBI and stroke, while Black veterans have a weaker association compared to other races and ethnicities. These findings suggest that veterans with prior TBI should be targeted for primary stroke prevention measures.
Review
Medicine, General & Internal
Zara Raza, Syeda F. Hussain, Suzanne Ftouni, Gershon Spitz, Nick Caplin, Russell G. Foster, Renata S. M. Gomes
Summary: Military personnel and veterans are exposed to unique risk factors such as TBI, PTSD, combat, blast exposure, and chemical exposure, which may increase the risk of dementia. Sleep problems have also been associated with dementia risk in this population.
MILITARY MEDICAL RESEARCH
(2021)
Article
Critical Care Medicine
Raj G. Kumar, Daniel Klyce, Risa Nakase-Richardson, Mary Jo Pugh, William C. Walker, Kristen Dams-O'Connor
Summary: Experts have long recognized the importance of studying traumatic brain injury (TBI) among active-duty service members and veterans. Most research has been conducted in Veterans Administration (VA) or Department of Defense settings, but little is known about military personnel who seek medical care outside of these settings. This study aimed to investigate the associations between military history and various health outcomes in the first 5 years after TBI.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Critical Care Medicine
Raj G. Kumar, Daniel Klyce, Risa Nakase-Richardson, Mary Jo Pugh, William C. Walker, Kristen Dams-O'Connor
Summary: For many years, experts have recognized the importance of studying traumatic brain injury (TBI) among active-duty service members and veterans. However, there is limited knowledge about military personnel who seek medical care outside of Veterans Administration (VA) or Department of Defense settings. The purpose of this study was to examine the associations between military history and various health outcomes in the first 5 years after TBI. The findings suggest that individuals with military history and TBI have diverse health outcomes, with some being favorable and others being detrimental, potentially influenced by characteristics of military service.
JOURNAL OF NEUROTRAUMA
(2022)
Review
Critical Care Medicine
Raquel C. Gardner, Amber Bahorik, Erica S. Kornblith, Isabel Elaine Allen, Brenda L. Plassman, Kristine Yaffe
Summary: Traumatic brain injury (TBI) is a known risk factor for dementia, and this meta-analysis found that there is nearly a 70% increased risk of dementia associated with TBI. The risk may be highest among younger adults, men, and cohorts in Asia. Efforts to prevent TBI and post-TBI dementia are of high importance.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Clinical Neurology
Brenda L. Plassman, Marianne Chanti-Ketterl, Carl F. Pieper, Kristine Yaffe
Summary: This study investigated the association between traumatic brain injury (TBI) and dementia using the twin study design. The results suggest that individuals with TBI have a higher risk of non-Alzheimer's disease (non-AD) dementia. Further analysis of twin pairs discordant for both TBI and dementia onset revealed that the association between TBI and non-AD dementia may be related to non-AD mechanisms.
ALZHEIMERS & DEMENTIA
(2022)
Article
Behavioral Sciences
Rael T. Lange, Victoria C. Merritt, Tracey A. Brickell, Clifton L. Dalgard, Anthony R. Soltis, Jamie Hershaw, Sara M. Lippa, Jessica Gill, Louis M. French
Summary: Previous research has shown a relationship between the APOE e4 allele and worse neurobehavioral functioning following MTBI. In the MTBI group, participants with the APOE e4 allele had significantly worse scores on various measures, and consistently had a higher number of elevated measures compared to other subgroups. The APOE e4 allele could potentially be used in screening tools to predict SMVs at risk for poor long-term neurobehavioral outcomes and provide early intervention.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Laura E. Gibbons, Melinda C. Power, Rod L. Walker, Raj G. Kumar, Alia Murphy, Caitlin S. Latimer, Amber L. Nolan, Erica J. Melief, Allison Beller, Marika Bogdani, C. Dirk Keene, Eric B. Larson, Paul K. Crane, Kristen Dams-O'Connor
Summary: Using three sources of TBI ascertainment, this study investigated the neuropathological consequences of traumatic brain injury (TBI) in an autopsy sample, and found an association between TBI and cerebral cortical atrophy.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Leslie Grasset, Melinda C. Power, Fabrice Crivello, Christophe Tzourio, Genevieve Chene, Carole Dufouil
Summary: This study found no evidence of an association between a history of traumatic brain injury (TBI) with loss of consciousness (LOC) and the risk of dementia or Alzheimer's disease (AD) over 12 years of follow-up, as well as brain atrophy or markers of small vessel disease.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Multidisciplinary Sciences
Jieyu Zhang, Yongkang Zhang, Juntao Zou, Fei Cao
Summary: Several epidemiological studies suggest that traumatic brain injury may be associated with an increased risk of Alzheimer's disease, especially in cases of moderate and severe traumatic brain injury. The risk ratio was 1.17.
Article
Nutrition & Dietetics
Ruoran Wang, Min He, Jianguo Xu
Summary: This study reveals an association between initial serum magnesium levels and mortality in TBI patients. Both abnormally low and high levels of serum magnesium are associated with a higher incidence of mortality in TBI patients.
Article
Clinical Neurology
Camilo Toro, Jordan Hatfield, Nancy Temkin, Jason Barber, Geoffrey Manley, Tetsu Ohnuma, Jordan Komisarow, Brandon Foreman, Frederick K. Korley, Monica S. Vavilala, Daniel T. Laskowitz, Joseph P. Mathew, Adrian Hernandez, John Sampson, Michael L. James, Karthik Raghunathan, Benjamin A. Goldstein, Amy J. Markowitz, Vijay Krishnamoorthy
Summary: This study identified emergency department predictors of circulatory shock after moderate-severe traumatic brain injury (TBI) and found that developing circulatory shock after TBI is associated with poor long-term functional outcomes.
Review
Medicine, General & Internal
Ling-Zhuo Kong, Rui-Li Zhang, Shao-Hua Hu, Jian-Bo Lai
Summary: Military psychiatry, a new subcategory of psychiatry, is playing an important role in war. This review examines military research, summarizes epidemiological data, neuropathology, and research achievements in diagnosis and treatment technology, and discusses the comorbidity and sequelae of military traumatic brain injury (TBI). Advances in neuroimaging and molecular biology have greatly enhanced the understanding of TBI, revealing abnormal protein accumulation and brain metabolism abnormalities involved in its development. TBI, based on organic injury, is distinct from other mental disorders and presents a new challenge at the intersection of neurology and psychiatry.
MILITARY MEDICAL RESEARCH
(2022)
Article
Clinical Neurology
Lulu Zhang, Wenzhe Yang, Xuerui Li, Abigail Dove, Xiuying Qi, Kuan-Yu Pan, Weili Xu
Summary: This study found that traumatic brain injury (TBI), especially between ages 50-69, is associated with an increased risk of dementia, and this association is exacerbated among individuals with cardiometabolic diseases (CMDs). Genetic and early-life environmental factors may not fully account for the association between TBI and dementia.
ALZHEIMERS & DEMENTIA
(2023)