Review
Medicine, Research & Experimental
Yuan-Hua Wu, Rong-Jane Chen, Hui-Wen Chiu, Li-Xing Yang, Yung-Li Wang, Yu-Ying Chen, Ya-Ling Yeh, Mei-Yi Liao, Ying-Jan Wang
Summary: Immunotherapy is an efficient anticancer strategy that utilizes the host's immune system to fight against cancer cells. Nanotechnology plays a crucial role in enhancing the anticancer effects of immunotherapy by targeting cancer cells and the tumor microenvironment. Autophagy, triggered by nanomaterials, plays a critical role in optimizing immune function and mediating cell-extrinsic homeostatic effects.
Article
Chemistry, Multidisciplinary
Yi Ru, Laizhi Sui, Haoqiang Song, Xingjiang Liu, Zhiyong Tang, Shuang-Quan Zang, Bai Yang, Siyu Lu
Summary: This study reports the synthesis of red- and multicolor-emitting Ch-CPDs using common precursors and a solvothermal approach, achieving high quantum yield and circularly polarized luminescence. Additionally, circularly polarized white-emitting CPDs were fabricated for the first time by tuning the mixing ratio of colored Ch-CPDs in a gel, opening up exciting opportunities for designing functional chiroptical materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Junjun Liu, Lin Yang, Ping Qin, Shiqing Zhang, Ken Kin Lam Yung, Zhifeng Huang
Summary: Inorganic nanoparticles are a versatile platform for biomedical applications, particularly in the study and application of chiral effects. Recent research focuses on characterizing 3D stereochirality, bionic fabrication of hierarchical chirality, studying optical activities, and experimental demonstration in biomedical applications. These studies pave the way for fully understanding and utilizing chiral effects in the design and fabrication of inorganic chiral nanoparticles for practical problem-solving in environment and public health.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Ningyue Yu, Mengbin Ding, Fengshuo Wang, Jianhui Zhou, Xiangyang Shi, Rong Cai, Jingchao Li
Summary: A novel semiconducting polymer nanocomplex (SPNCN) has been developed for enhanced cancer immunotherapy by specifically inhibiting autophagy and immunometabolism in the tumor microenvironment upon near-infrared (NIR) photoactivation.
Article
Biochemistry & Molecular Biology
Christopher A. W. David, M. Estela del Castillo Busto, Susana Cuello-Nunez, Heidi Goenaga-Infante, Michael Barrow, David G. Fernig, Patricia Murray, Matthew J. Rosseinsky, Andrew Owen, Neill J. Liptrott
Summary: Nanomaterials have the potential to interfere with autophagic processes, leading to altered cellular function and viability. The association of particle size with impact on autophagy warrants further investigation.
CELL AND BIOSCIENCE
(2021)
Article
Multidisciplinary Sciences
Yoshiki Nakata, Koji Tsubakimoto, Hiroyuki Shiraga, Noriaki Miyanaga, Yuki Kosaka, Masataka Yoshida
Summary: This paper elucidates the relationship between the distribution of optical radiation force and the formation of chiral structures. It provides necessary conditions for the formation of chiral structures and can guide research on light control devices and molecular chirality discrimination devices.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Shunli Chu, Xiaolu Shi, Ye Tian, Fengxiang Gao
Summary: The complexity of the tumor microenvironment can be overcome by using pH-responsive polymers for targeted drug delivery, improving treatment efficacy and reducing adverse reactions.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Kristyna Gunar, Lenka Kotrchova, Marcela Filipova, Tereza Krunclova, Aneta Dydowiczova, Robert Pola, Eva Randarova, Tomas Etrych, Olga Janouskova
Summary: This study identified a new exosome-mediated route for the delivery of doxorubicin and pHPMA-bound doxorubicin in tumors. The therapeutics were successfully loaded into exosomes and transmitted to tumor cells, providing evidence of pHPMA-drug conjugate secretion by exosomes.
Article
Chemistry, Multidisciplinary
Zhangchuan Wen, Rong Lu, Kai Zheng, Fan Gu, Lijie Zhang, Huile Jin, Yihuang Chen, Shun Wang, Shuang Pan
Summary: A novel electrospinning strategy was developed to construct chiral perovskite nanosheets (PNSs) protected in polymer hybrid nanofibers. The quasi-2D chiral PNS/polymer exhibited inherent chirality and enhanced blue emissive circularly polarized luminescence (CPL) properties at room temperature. The obtained PNS/polymer hybrid nanofiber films showed potential applications in circularly polarized light emitting diode devices.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Ghadah M. Al-Senani, Salhah H. Alrefaee, Ameenah N. Al-Ahmadi, Mohamed M. ElFaham, Awatif Rashed Z. Almotairy, W. B. Elsharkawy, Ayman M. Mostafa
Summary: Adsorption is a promising method for phosphate removal from treated wastewater. Nickel oxide nanoparticles embedded in poly vinyl alcohol were prepared using pulsed laser ablation in liquid media, and their effectiveness in phosphate removal was investigated. The results showed that the nanocomposite with smaller particle size had higher adsorption efficiency, and the adsorbed amount of phosphate decreased with increasing pH. Therefore, the NiO/PVA nanocomposite structure can effectively absorb phosphate from complex solutions.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Wookjin Jung, Junyoung Kwon, Wonjoon Cho, Jihyeon Yeom
Summary: Chirality, a property that objects or systems cannot be superimposed on their mirror images, is prevalent in nature. Chiral-specific interactions play important roles in nanomedicine, and understanding their impacts on functionality and efficiency is facilitated by chiral-sensitive equipment. Studying chiral biomaterials and their applications can lead to new paradigms in biomaterials.
Article
Chemistry, Multidisciplinary
Yingtong Luo, Hanglong Wu, Xuan Zhou, Jianhong Wang, Suleyman Er, Yudong Li, Pascal L. W. Welzen, Roy A. J. F. Oerlemans, Loai K. E. A. Abdelmohsen, Jingxin Shao, Jan C. M. van Hest
Summary: Functionalized polymer vesicles with photothermal-responsive properties have been designed using a new strategy based on near-infrared (NIR) light activation. The resulting vesicles inherit the high photothermal performance of the photothermal agent and maintain their structure and properties after laser irradiation. These polymer vesicles also demonstrate significant loading capacity for hydrophobic and hydrophilic cargos, making them suitable for synergistic therapy in anticancer treatment.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yingtong Luo, Hanglong Wu, Xuan Zhou, Jianhong Wang, Suleyman Er, Yudong Li, Pascal L. W. Welzen, Roy A. J. F. Oerlemans, Loai K. E. A. Abdelmohsen, Jingxin Shao, Jan C. M. van Hest
Summary: In this study, a new strategy for designing near-infrared (NIR) light-mediated photothermal polymer vesicles was proposed. The functionalized polymer vesicles showed high photothermal performance and good loading capacity, making them a robust platform for synergistic therapy in anticancer treatment.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Inorganic & Nuclear
Xiao-Xiao Hou, Ya-Ping Ren, Zhao-Hui Luo, Bing-Li Jiang, Tian-Tian Lu, Fu-Ping Huang, Xiu-Ying Qin
Summary: The novel chiral tetranucleate copper(ii)-based complex TNCu-A exhibits potent anti-cancer activity both in vitro and in vivo by inhibiting angiogenesis, inducing apoptosis in cells, and suppressing tumor growth.
DALTON TRANSACTIONS
(2021)
Article
Materials Science, Multidisciplinary
Shanmugasundaram Kumaraguru, Ravi Nivetha, Kasi Gopinath, Elumalai Sundaravadivel, Bader O. Almutairi, Mikhlid H. Almutairi, Shahid Mahboob, M. R. Kavipriya, Marcello Nicoletti, Marimuthu Govindarajan
Summary: New composites of cerium oxide were successfully incorporated in the copper-based metal organic framework using the precipitation method. The Cu-MOF/CeO2 nanocomposite exhibited excellent electrocatalytic performance towards hydrogen evolution reaction and displayed high biocompatibility for targeted drug delivery applications.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Meeting Abstract
Oncology
Yuting Jin, Long Yuan, Jun Jiang, Xiaowei Qi
Meeting Abstract
Oncology
Qiyun Shi, Juncheng Xuhong, Jia Ge, Feng Liu, Yang Lan, Yi Zhang, Luo Tao, Xiuwu Bian, Xiaowei Qi, Jun Jiang
Article
Oncology
Qiyun Shi, Juncheng Xuhong, Tao Luo, Jia Ge, Feng Liu, Yang Lan, Qingqiu Chen, Peng Tang, Linjun Fan, Li Chen, Yan Liang, Minghao Wang, Ying Hu, Yi Zhang, Xiuwu Bian, Xiaowei Qi, Jun Jiang
Summary: The study suggests that activating mutations in PIK3CA are associated with a reduced response to neoadjuvant therapy with pyrotinib and trastuzumab in HER2-positive breast cancer. Wild-type PIK3CA patients had a significantly higher pCR rate compared to mutated PIK3CA patients. The integrated model showed a high predictive value.
BRITISH JOURNAL OF CANCER
(2023)
Article
Surgery
Andi Wan, Yan Liang, Li Chen, Shushu Wang, Qiyun Shi, Wenting Yan, Xiaozhen Cao, Ling Zhong, Linjun Fan, Peng Tang, Guozhi Zhang, Siyi Xiong, Cheng Wang, Zhen Zeng, Xiujuan Wu, Jun Jiang, Xiaowei Qi, Yi Zhang
Summary: This retrospective cohort study found that long-term therapeutic outcomes following minimal access breast surgery (MABS) were not significantly different from conventional breast surgery (CBS) in patients with early-stage breast cancer.
Article
Oncology
Cheng Wang, Liyong Zhang, Lin Ren, Guozhi Zhang, Andi Wan, Siyi Xiong, Hao Tian, Zaihui Peng, Tingting Zhao, Pingping Gao, Na Sun, Yi Zhang, Xiaowei Qi
Summary: Cell pyroptosis is closely associated with breast cancer, and a prognostic model based on cell-pyroptosis-related genes provides innovative insights into the prognosis and treatment of breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Qiyun Shi, Juncheng Xuhong, Hao Tian, Man Qu, Yi Zhang, Jun Jiang, Xiaowei Qi
Summary: This systematic review and meta-analysis study examines the predictive and prognostic value of PIK3CA mutations in HER2-positive breast cancer treated with TKIs. The analysis of 17 studies involving 1706 patients shows that wild-type PIK3CA patients had higher complete response rates and objective response rates compared to mutated PIK3CA patients. Additionally, PIK3CA mutations were marginally associated with poorer progression-free survival and overall survival in metastatic breast cancer patients. Therefore, PIK3CA mutations can predict treatment response in HER2-positive breast cancer patients treated with TKI-containing regimens.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Biotechnology & Applied Microbiology
Xuejiao Lei, Quan Hu, Hongfei Ge, Xuyang Zhang, Xufang Ru, Yujie Chen, Rong Hu, Hua Feng, Jun Deng, Yan Huang, Wenyan Li
Summary: This study successfully addresses two challenges in neural stem cell transplantation therapy for intracerebral hemorrhage - low survival rate and uncontrolled differentiation - by designing a nanogel system, promoting white matter regeneration and improving behavioral performance in ICH mice.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Pan Ma, Hao Tian, Qiuling Shi, Ruixiang Liu, Yi Zhang, Xiaowei Qi, Yongchuan Chen
Summary: Through the analysis of the FDA Adverse Event Reporting System database, it was found that T-DXd and T-DM1 have differences in adverse events. T-DXd is more likely to induce ILD/pneumonia and myelosuppression, while T-DM1 has a higher risk of hepatotoxicity, cardiotoxicity, and thrombocytopenia. Clinicians need to balance the treatment benefits and risks of antibody-drug conjugates in the treatment of HER2-positive breast cancer and HER2-mutated lung cancer.
EXPERT OPINION ON DRUG SAFETY
(2023)
Article
Oncology
Hao Tian, Man Qu, Guozhi Zhang, Long Yuan, Qiyun Shi, Yinhuan Wang, Ying Yang, Yi Zhang, Xiaowei Qi
Summary: This case report describes the successful treatment of invasive lobular breast cancer carrying HER2 mutations with combined treatment involving the tyrosine kinase inhibitor pyrotinib and the antibody-drug conjugate ado-trastuzumab emtansine. The combination therapy showed promising efficacy and may be a potential treatment option for HER2-mutated advanced breast cancer. Further studies are needed to validate these findings.
Article
Materials Science, Biomaterials
Xin Jin, Zelin Ou, Guowei Zhang, Rong Shi, Jumin Yang, Wenguang Liu, Gaoxing Luo, Jun Deng, Wei Wang
Summary: With the rise of drug-resistant bacteria, photothermal therapy (PTT) is a promising solution for treating infected diabetic skin ulcers. However, tissue damage caused by heat limits its clinical application. A CO-mediated PTT agent (CO@mPDA) was developed to inhibit bacterial growth and promote tissue regeneration. The CO-mediated PTT exhibited higher efficacy in inhibiting drug-resistant bacteria and lower heat resistance in mammalian tissues. It also upregulated tissue-protective proteins to reduce thermal injury. This approach offers a potential way to enhance PTT efficiency and minimize side effects when treating infected skin wounds.
BIOMATERIALS SCIENCE
(2023)
Article
Oncology
Xiang Ai, Peng Sun, Minghao Wang, Peng Tang, Jinping Liu, Jun Jiang
Summary: This study aimed to determine the current status of the diagnosis and treatment of breast cancer with ipsilateral supraclavicular lymph node metastases (ISLM) among Chinese patients. The study found a low overall detection rate of ISLM breast cancer in China and a lack of consensus on the optimal diagnosis and treatment strategies for these patients.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Hao Tian, Man Qu, Guozhi Zhang, Long Yuan, Qiyun Shi, Yinhuan Wang, Ying Yang, Yi Zhang, Xiaowei Qi
Summary: HER2 signaling is activated in response to somatic HER2 mutations, which are associated with poor prognosis in invasive lobular breast cancer (ILC). Tyrosine kinase inhibitors (TKIs) and antibody-drug conjugates (ADCs) have shown promising efficacy in patients with HER2-mutated advanced breast cancer (BC). A case study suggests that a combination of irreversible TKIs and ADCs may be a potential treatment option for HER2-negative/HER2-mutated advanced BC.
Article
Chemistry, Analytical
Zhijia Li, Hongtao Xiao, Junjie Li, Zhongzhu Yang, Jun Jiang, Juan Ji, Cheng Peng, Yang He
Summary: The response to neoadjuvant chemotherapy in breast cancer patients is crucial for their survival. Current techniques for predicting the efficacy of chemotherapy in these patients have limitations in sensitivity and specificity. We developed a highly sensitive method using graphene oxide for early prediction of chemotherapy efficacy in breast cancer patients.
ANALYTICAL CHEMISTRY
(2022)
Article
Oncology
Min Yan, Peng Yuan, Quchang Ouyang, Ying Cheng, Guohui Han, Dewei Wang, Li Ran, Tao Sun, Da Zhao, Yuju Bai, Shun'e Yang, Xiaojia Wang, Rong Wu, Xiaohua Zeng, Herui Yao, Xuening Ji, Jun Jiang, Xiaohua Hu, Haifeng Lin, Liping Zheng, Zhitu Zhu, Wei Ge, Junlan Yang, Tongjian Cui, Xiaozhi Zhang, Fangyang Lu, Wenhui Li, Hongyan Xu, Mafei Kang, Ping Gong, Liqun Zou, Jiang Liu, Hongliang Zhang, Hao Yu, Binghe Xu
Summary: This study evaluated the efficacy and safety of lobaplatin-based chemotherapy in Chinese patients with metastatic breast cancer. The results showed that lobaplatin-based chemotherapy had favorable efficacy and manageable safety profile in advanced breast cancer patients.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)