Journal
IEEE TRANSACTIONS ON NANOBIOSCIENCE
Volume 14, Issue 3, Pages 298-304Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TNB.2015.2402651
Keywords
Flexible; hydrogel; magnetic resonance imaging; micromotor; microfluidics; microparticle; organo-motor; poly (ethylene glycol) diacrylate; self-propulsion; superparamagnetic iron oxide nanoparticles
Funding
- National Research Foundation of Korea (NRF) - Korean government) (MSIP) [2014R1A2A1A01006527, 2011-0030075]
- Industrial Technology Innovation Program - Ministry of Trade, Industry and Energy (MI, Korea) [10048358]
- Industrial Strategic Technology Development Program - Ministry of Trade, Industry and Energy (MI, Korea) [10041913]
- European Research Council under the European Union's Seventh Framework Programme (FP7)/ERC [311529]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10041913, 10041928] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2014R1A2A1A01006527, 2011-0030075] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- ICREA Funding Source: Custom
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In this paper, we fabricate a flexible and location traceable micromotor, called organo-motor, assisted by microfluidic devices and with high throughput. The organo-motors are composed of organic hydrogel material, poly (ethylene glycol) diacrylate (PEGDA), which can provide the flexibility of their structure. For spatial and temporal traceability of the organo-motors under magnetic resonance imaging (MRI), superparamagnetic iron oxide nanoparticles (SPION; Fe3O4) were incorporated into the PEGDA microhydrogels. Furthermore, a thin layer of platinum (Pt) was deposited onto one side of the SPION-PEGDA microhydrogels providing geometrical asymmetry and catalytic propulsion in aqueous fluids containing hydrogen peroxide solution, H2O2 Furthermore, the motion of the organo-motor was controlled by a small external magnet enabled by the presence of SPION in the motor architecture.
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