Article
Biochemistry & Molecular Biology
Lilia Arellano-Galindo, Eva Villar-Alvarez, Alejandro Varela, Valeria Figueroa, Javier Fernandez-Vega, Adriana Cambon, Gerardo Prieto, Silvia Barbosa, Pablo Taboada
Summary: The study optimized a metal-based nanoplatform for targeted drug delivery and achieved good pharmacodynamics through the release of drugs in response to dual stimuli. The platform demonstrated stability and excellent therapeutic effects in in vitro experiments under various physiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Cong Tian, Zhe Tang, Yike Hou, Asim Mushtaq, Shafaq Naz, Zhangsen Yu, Jabeen Farheen, Muhammad Zubair Iqbal, Xiangdong Kong
Summary: This study focuses on the design of magnetoplasmonic nanohybrids for biomedical applications. The researchers successfully prepared plasmonic magnetic Au-MnO hybrid nanoparticles for imaging-guided photothermal therapy. The nanoparticles showed enhanced biocompatibility and absorption in the near-infrared region. Additionally, they exhibited promising contrast enhancement in T-1 MR imaging and produced sufficient heat for cancer cell ablation upon laser irradiation.
Article
Materials Science, Multidisciplinary
Mengjie Luo, Chufan Tan, Ruiyun Cao, Chang Xiao, Jiahui Tian, Qi Li, Rushi Liu, Bin Liu
Summary: In order to improve the limitations of hydrophobicity and cardiotoxicity, cinobufagin was loaded into Prussian Blue nanoparticles and combined with photothermal therapy for colorectal cancer (CRC) treatment. This chemotherapy and photothermal therapy not only inhibited CRC growth, but also suppressed the metastasis of primary cancer cells by downregulating the expression of Vimentin, matrix metalloproteinase-9 (MMP-9), and hypoxia-inducible factor1-alpha (HIF-1a).
MATERIALS & DESIGN
(2023)
Article
Biophysics
Shuang-hui Huang, Si Peng, Qiu-yue Wang, Qiu-hui Hu, Run-qin Zhang, Ling Liu, Qiang Liu, Juan Lin, Qing-han Zhou
Summary: The combination of chemo-photothermal therapy using gold nanorods (GNRs) has shown superior therapeutic efficiency compared to mono-chemotherapy in cancer treatment, attracting interest worldwide. pH-sensitively zwitterionic polypeptide conjugated GNRs were designed to overcome challenges such as high cytotoxicity and unsatisfactory therapy effects, displaying positive surface charge transition for enhanced cellular uptake, pH-sensitive drug release, and efficient tumor cell killing through NIR photothermal conversion.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Chuanshuang Chen, Guangyu Chu, Wanting He, Yannan Liu, Kai Dai, Jesus Valdez, Audrey Moores, Pei Huang, Zhaohong Wang, Jiale Jin, Ming Guan, Wenfeng Jiang, Yiyong Mai, Dongling Ma, Yue Wang, Yongfeng Zhou
Summary: This study presents the synthesis of a novel Janus Au-porphyrin polymersome heterostructure with near-field enhancement effect, which enhances the photothermal and photodynamic activities and shows significant therapeutic effects in vivo.
ADVANCED MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Maryam Deinavizadeh, Alireza Kiasat, Nasrin Hooshmand, Mohammad Shafiei, Mohammad Sabaeian, Roya Mirzajani, Seyed Mohammadsaleh Zahraei, Hagar Labouta, Mostafa A. El-Sayed
Summary: A novel biocompatible nanocomposite, consisting of gold nanorods coated with rod-like mesoporous silica particles, has been designed for synergistic thermal and chemotherapeutic delivery in eradicating cancer cells. The nanocomposite demonstrated high potential therapeutic efficacy in ablation of lung cancer cells through a combination of photothermal and chemotherapy treatments.
Article
Engineering, Biomedical
Wenzhao Zhong, Ka Hong Wong, Fujian Xu, Nana Zhao, Meiwan Chen
Summary: This study successfully improved the anticancer efficacy of artesunate (AS) by combining chemical modification and photothermal therapy. Hydrophobic-modified AS was integrated with biomimetic polydopamine and biomineral calcium carbonate to fabricate a high AS-loaded nanomedicine for cancer chemo-photothermal therapy. The hybrid nanoparticles demonstrated a combinational antitumor effect of photothermal therapy and chemotherapy, inhibiting cancer cell growth without systemic toxicity.
ACTA BIOMATERIALIA
(2022)
Article
Pharmacology & Pharmacy
Swati Singh, Kaushik Pal
Summary: This study highlights the use of multifunctional nanoparticles for targeted cancer treatment. By employing polydopamine-based gold nanoparticles as drug carriers, the researchers were able to achieve tumor-targeting abilities. The nanoparticles were modified with folic acid, allowing for precise binding with breast cancer cells. This nanosystem exhibited biocompatibility, strong NIR absorption, and controlled drug release in response to pH and NIR stimulation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Environmental
Pengcheng Gao, Si Sun, Yang Wang, Yingying Wei, Yong Jiang
Summary: Snowman-like Au-BNP Janus nanoparticles are prepared with a facile adsorption-reduction seeds mediated growth method. These nanoparticles, modified with thiol-aptamer AS1411 and NIR dye ICG-NH2, show high tumor inhibition ability and specific tumor-targeting ability, suggesting their potential as a bio-inspired nanoplatform in active tumor-targeting and chemo-photothermal cancer synergistic therapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Meihui Yin, Min Yang, Daoping Yan, Lijiao Yang, Xiaohui Wan, Jipeng Xiao, Yongchao Yao, Jianbin Luo
Summary: In this study, a novel gold-nanorod-based chemo-photothermal-integrated antimicrobial platform was developed, which exhibited surface-charge-switchable and near-infrared-induced size-transformable activities. This platform showed enhanced killing efficiency against multidrug-resistant bacteria and their biofilms, particularly methicillin-resistant Staphylococcus aureus (MRSA) infections.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Medicinal
Gayeon Lee, You Jeong Lee, Yeon-Jeong Kim, Youmie Park
Summary: Versatile nanomaterials, including gold nanospheres and Au-Ag bimetallic nanoparticles, were successfully synthesized through green synthesis strategies. These functionalized nanoparticles exhibited high anticancer activity, especially in chemo-photothermal therapy.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Chun Shan, Yuting Huang, Junhao Wei, Min Chen, Limin Wu
Summary: In this work, gold nanorods embedded in ultra-thick silica shells with radial mesopores (AuNR/R-SiO2) were successfully synthesized in an ethanol/water solution. The AuNR/R-SiO2 exhibited ultra-high thermal stability and outstanding loading capacity, making them promising for drug delivery and tumor therapy. Controlled release behavior via near-infrared (NIR) laser was achieved, and in vitro experiments showed biocompatibility and ease of internalization by cells.
Article
Engineering, Environmental
Guofeng Liu, Zhenxing Wang, Wan Sun, Xiaohui Lin, Rui Wang, Chonghui Li, Li Zong, Zuoling Fu, Hanping Liu, Shicai Xu
Summary: In this study, lanthanide nanoparticles-gold (LNPs-Au) nanoprobes were developed for fluorescence temperature sensing and controlled photothermal therapy (PTT). LNPs doped with rare earth cations were conjugated with gold nanoparticles via electrostatic interactions. The LNPs-Au exhibited temperature-dependent fluorescence in the NIR-II region, allowing non-contact temperature measurements in the biologically relevant range. Furthermore, the LNPs-Au nanoparticles showed excellent photothermal therapy efficiency and tumor tissue inhibition.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Xiaoguang Dai, Xiaoyi Zhao, Yanjun Liu, Beibei Chen, Xiaokang Ding, Nana Zhao, Fu-Jian Xu
Summary: The study developed a series of symmetrical and unsymmetrical chitosan/gold nanoparticles, utilizing the active motion derived from Janus structure, selective surface functionalization of polysaccharide domain, and photothermal effect of gold nanorods to construct Janus-structured chitosan/gold nanohybrids for breast cancer treatment. Investigating the morphology effect of chitosan/gold nanostructures on enhanced PTT, cellular uptake, and gene transfection, as well as exploring the feasibility of PA imaging to track the accumulation of J-ACP and guide PTT.
Article
Nanoscience & Nanotechnology
Xing-Qun Pu, Xiao-Jie Ju, Lei Zhang, Quan-Wei Cai, Yu-Qiong Liu, Han-Yu Peng, Rui Xie, Wei Wang, Zhuang Liu, Liang-Yin Chu
Summary: A novel class of multifunctional responsive nanoparticles was designed and fabricated as drug nanocarriers for synergetic chemo-photothermal therapy of tumors. These nanoparticles demonstrated good biocompatibility and outstanding photothermal conversion efficiency, with controlled drug release under low pH and high temperature conditions. Experimental results showed that the nanoparticles were phagocytosed by tumor cells and released drugs in acidic environments, with higher efficacy in combined chemo and photothermal therapy compared to individual treatments.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Multidisciplinary Sciences
Jianbo He, Lin Zheng, Xiaojuan Li, Furong Huang, Sitao Hu, Lei Chen, Manya Jiang, Xianfeng Lin, Haibo Jiang, Yifan Zeng, Tianshen Ye, Dingkun Lin, Qian Liu, Jiake Xu, Kai Chen
Summary: This study aimed to explore the therapeutic potential of Obacunone (OB) on osteoporosis and its rudimentary mechanisms. In vitro and in vivo experiments showed that OB suppressed the formation and function of osteoclasts. Mechanistically, OB interacted with macrophage migration inhibitory factor (MIF), attenuating receptor activator of nuclear factor kappa B (NF-KB) ligand (RANKL)-induced signaling pathways. This led to a decrease in the expression level of the master transcriptional factor of osteoclastogenesis, nuclear factor of activated T cells 1 (NFATc1), and its downstream osteoclast-specific proteins. OB also alleviated estrogen deficiency-induced osteoporosis by targeting MIF and inhibiting hyperactive osteoclasts.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Medicine, Research & Experimental
Yang Xu, Dezhi Song, Yuangang Su, Junchun Chen, Liwei Wu, Haoyu Lian, Na Hai, Jing li, Jie Jiang, Jinmin Zhao, Jiake Xu, Qian Liu
Summary: 4-Methylcatechol activates Nrf2 to upregulate HO-1 expression, inhibits osteoclast differentiation, scavenges ROS, and alleviates osteoporosis in OVX mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Yiwu Qin, Dezhi Song, Shijie Liao, Junchun Chen, Minglian Xu, Yuangang Su, Haoyu Lian, Hui Peng, Linhua Wei, Kai Chen, Jiake Xu, Jinmin Zhao, Qian Liu
Summary: In this study, it was found that Isosinensetin (Iss) inhibits the formation and hyperactive bone resorption of osteoclasts by reducing intracellular reactive oxygen species (ROS) and activating the Nrf2 antioxidant pathway. Iss also demonstrated the potential to reduce bone loss in ovariectomized (OVX) mice. Therefore, Iss may be a preventive and therapeutic option for osteoporosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Weiguang Lu, Chao Zheng, Hongyang Zhang, Pengzhen Cheng, Sheng Miao, Huanbo Wang, Ting He, Jing Fan, Yaqian Hu, He Liu, Liyuan Jia, Xue Hao, Zhuojing Luo, Jiake Xu, Qiang Jie, Liu Yang
Summary: The imbalance of bone homeostasis leads to bone degenerative diseases, such as osteoporosis. The Hedgehog (Hh) signaling pathway plays a crucial role in limb and joint development, but its specific role in bone homeostasis is not well understood. This study discovered that the Hh signaling pathway is gradually enhanced during osteoclast differentiation, and its inactivation affects osteoclast formation and osteoclast-osteoblast coupling. The study also revealed the positive regulation of osteoclast differentiation by Hh signaling through the transactivation of Traf6 and stabilization of TRAF6 protein. In addition, connective tissue growth factor (CTGF) was identified as a bone formation-stimulating factor regulated by Hh signaling and its loss contributed to osteopenia. This research provides mechanistic and therapeutic insights into osteoporosis by highlighting the importance of Hh signaling in maintaining bone homeostasis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Pei Ying Ng, Amy B. P. Ribet, Qiang Guo, Benjamin H. Mullin, Jamie W. Y. Tan, Euphemie Landao-Bassonga, Sebastien Stephens, Kai Chen, Jinbo Yuan, Laila Abudulai, Maike Bollen, Edward T. T. T. Nguyen, Jasreen Kular, John M. Papadimitriou, Kent Soe, Rohan D. Teasdale, Jiake Xu, Robert G. Parton, Hiroshi Takayanagi, Nathan J. Pavlos
Summary: Using organelle-resolution proteomics, the authors identified Slc37a2 as a sugar transporter in osteoclast secretory lysosomes. They found that Slc37a2 is required for the maintenance of skeletal bone mass and that its deficiency leads to high bone mass in mice. This study provides new insights into the molecular composition and spatiotemporal organization of secretory lysosomes in osteoclasts.
NATURE COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Sipin Zhu, Ping Sun, Samuel Bennett, Oscar Charlesworth, Renxiang Tan, Xing Peng, Qiang Gu, Omar Kujan, Jiake Xu
Summary: This review summarizes the recent research progress of Parthenolide (PTL) as a medicinal compound, including its therapeutic effects on skeletal diseases, cancers, and inflammation-induced cytokine storm. Mechanistic investigations reveal that PTL predominantly inhibits NF-kappa B activation and other signaling pathways. It is also proposed that PTL could inhibit cytokine storms triggered by COVID-19 via blocking the activation of NF-kappa B signaling. Understanding the pharmacologic properties of PTL will assist in developing its therapeutic application for medical conditions such as arthritis, osteolysis, periodontal disease, cancers, and COVID-19-related disease.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Sarah Rashid, Scott G. Wilson, Kun Zhu, John P. Walsh, Jiake Xu, Benjamin H. Mullin
Summary: This study analyzed the transcriptome of human peripheral blood mononuclear cells and their differentiated osteoclast-like cells in culture, identifying differentially expressed genes and associated biological pathways in the progression of osteoporosis. Several well-established osteoclast genes were significantly upregulated in osteoporosis, and the upregulated genes were involved in cell division, migration, adhesion, as well as oxidative phosphorylation, glycolysis, lysosome, and focal adhesion pathways.
Review
Cell Biology
Liwei Mao, Lian Wang, Jiake Xu, Jun Zou
Summary: Integrins play a crucial role in cell-extracellular matrix adhesion and cytokine receptor signal transduction, regulating bone metabolism. Recent studies have uncovered the involvement of integrins in bone metabolism pathways and their interaction with novel cytokines. Integrins act as transducers, mediating the effects of mechanical stress, fluid shear stress, microgravity, hypergravity, and other physical factors on bone-related cells. They also play a role in mediating bone metastasis of various cancers. Targeted therapy involving integrins shows promising potential for bone metabolic diseases. This review provides insights into the latest research on integrins in bone metabolism and metastasis and offers a vision for treatment strategies.
CELL DEATH DISCOVERY
(2023)
Article
Medicine, Research & Experimental
Ran Sun, Na Hai, Biao Yang, JunChun Chen, Jing Li, Qiufei Li, Jinmin Zhao, Jiake Xu, Qian Liu, Bo Zhou
Summary: Osteoporosis is a severe global public health problem that causes damage to bone mass, strength, and microstructure, increasing the risk of fragility fractures. The use of current prescription medications for osteoporosis treatment has adverse effects, so finding natural alternatives is important. Pteryxin (PTX), a natural coumarin, has been found to have antioxidant, anti-inflammatory, and anti-obesity properties. Studies have shown that PTX can reduce osteoclast formation and bone resorption, and partially reverse bone loss in an osteoporosis model. Its mechanism of action involves blocking specific signaling pathways and reducing reactive oxygen species (ROS) levels in osteoclasts. Overall, PTX may offer a new or alternative treatment option for osteoporosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemical Research Methods
Weicong Zhu, Xiaohong Yang, Shaojie Liu, Yiwen Wang, Wenxu Li, Qiguang Zhong, Lihua Zhang, Jiake Xu
Summary: This study demonstrates that silencing the Caspase-3 gene using a lentivirus-based gene delivery system can protect cells from TNF-alpha-mediated apoptosis and limit cartilage damage, suggesting a potential therapeutic strategy for osteoarthritis.
BIOTECHNOLOGY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Minglian Xu, Dezhi Song, Xiaoxiao Xie, Yiwu Qin, Jian Huang, Chaofeng Wang, Junchun Chen, Yuangang Su, Jiake Xu, Jinmin Zhao, Qian Liu
Summary: This study found that CG inhibits osteoclast differentiation and function by inhibiting the activation of NFATc1 and ultimately osteoclast formation by inhibiting RANKL-mediated Ca2+ oscillation and the NF-KB/MAPK signaling pathway. CG also improved bone loss in ovariectomized mice, suggesting its potential for the prevention and treatment of osteoporosis.
Article
Multidisciplinary Sciences
Weilian Bao, Yan You, Jiahui Ni, Hui Hou, Jiaren Lyu, Guize Feng, Yirui Wang, Keyuan You, Sulin Zhang, Lijie Zhang, Xinyue Cao, Xu Wang, Haidong Li, Hong Li, Jiake Xu, Chenying Liu, Xiaomin Luo, Peng Du, Daofeng Chen, Xiaoyan Shen
Summary: Intestinal stem cells (ISCs) play a crucial role in the treatment of inflammatory bowel disease, and the availability of cholesterol is critical for their stemness. This study identifies sorting nexin 10 (SNX10) as essential for maintaining ISCs stemness by increasing intracellular cholesterol synthesis. The inhibition of SNX10 shows potential as a therapeutic strategy for patients with Crohn's disease.
Article
Oncology
Wenyu Feng, Haiyingjie Lin, Emel Rothzerg, Dezhi Song, Wenxiang Zhao, Tingting Ning, Qingjun Wei, Jinmin Zhao, David Wood, Yun Liu, Jiake Xu
Summary: Osteosarcoma (OS) is a common primary cancer in the skeletal system, with a high rate of lung metastasis, local recurrence, and death. The role of TRAIL receptors in OS has not been fully understood. This study used RNA-seq and scRNA-seq to investigate the expression profile of four TRAIL receptors in human OS cells. The results showed that TNFRSF10B and TNFRSF10D are differentially expressed in OS cells, while TNFRSF10A and TNFRSF10C remained stable. Furthermore, these receptors were most abundantly expressed in endothelial cells of OS tissues, providing a potential therapeutic target for OS and other cancers.
CANCER INFORMATICS
(2023)
Review
Cell & Tissue Engineering
Jialong Hou, Jian Liu, Zhixian Huang, Yining Wang, Hanbing Yao, Zhenxin Hu, Chengge Shi, Jiake Xu, Qingqing Wang
Summary: The composition and critical functions of membrane microdomains in osteoclasts need to be further characterized to understand their roles in bone diseases.
Article
Pharmacology & Pharmacy
Xiaoliang Feng, Zhijuan Liu, Yuangang Su, Haoyu Lian, Yijie Gao, Jinmin Zhao, Jiake Xu, Qian Liu, Fangming Song
Summary: In this study, TSG was found to inhibit OCs differentiation and bone resorption by reducing ROS production and mitochondrial function. Additionally, TSG increased ROS scavenging enzymes by inhibiting Nrf2 degradation and thereby reducing RANKL-induced oxidative stress.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
