Journal
IEEE TRANSACTIONS ON NANOBIOSCIENCE
Volume 14, Issue 6, Pages 660-667Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TNB.2015.2431855
Keywords
Deterministic lateral displacement; immersed boundary; lattice Boltzmann method; microfluidic arrays; spherical particle separation
Funding
- National Natural Science Foundation of China [61271123, 31328009]
- Fundamental Research Funds for the Central Universities [2342013DUT13RC(3)104]
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Deterministic lateral displacement (DLD) arrays containing shaped pillars have been found to be more effective in biomedical sample separation. This study aims to numerically investigate the interplay between particles and microfluidic arrays, and to find out the key factors in determining the critical size of a DLD device with shaped pillars. A new formula is thus proposed to estimate the critical size for spherical particle separation in this kind of new DLD microfluidic arrays. The simulation results show that both rectangular and I-shaped arrays have considerably smaller critical sizes. The ratio of sub-channel widths is also found to play an important role in reducing the critical sizes. This paves a valuable way toward designing high-performance DLD microfluidic arrays.
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