Journal
JOURNAL OF CANCER
Volume 9, Issue 2, Pages 375-388Publisher
IVYSPRING INT PUBL
DOI: 10.7150/jca.21044
Keywords
miRNA; miR-149; cancer
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Funding
- National Program on Key Research Project [2016YFC0905900]
- Medical Training Programme Foundation for the Talents by Jiangsu Provincial Department of health [17 [2016]]
- 333 Talent Project of Jiangsu Province [4 [2016]]
- National key clinical specialist construction Programs of China [544 [2013]]
- Major Program of Natural Science Foundation of Jiangsu Province [BL2014090]
- Natural Science Foundation of Jiangsu Province [BK20151579]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) [JX10231802]
- National Natural Science Foundation of China [81602551]
- Key Research Program for the Social Development of Jiangsu Province, China [BE2015718]
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MicroRNAs (miRNAs) are small noncoding RNAs that regulate post-transcriptional gene expression via binding to the 3'-untranslated region (3'-UTR) of targeted mRNAs. They are reported to play important roles in tumorigenesis and progression of various cancers. Among them, miR-149 was confirmed to be aberrantly regulated in various tumors. In this review, we provide a complex overview of miR-149, particularly summarize the critical roles of it in cancers and expect to lay the foundation for future works on this important microRNA.
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