Article
Psychology, Educational
Anna Joyce, Helen L. Breadmore
Summary: The study found that parent-reported sleep problems were able to predict children's word and non-word oral reading speeds. Factors such as sleep-disordered breathing, daytime sleepiness, and shorter sleep latency were associated with poorer reading performance in children.
BRITISH JOURNAL OF EDUCATIONAL PSYCHOLOGY
(2022)
Article
Clinical Neurology
Yezhou Li, Jing Wang, Lirong Ji, Chaohong Cheng, Tong Su, Shuqing Wu, Fei Han, Daniel J. Cox, Erlei Wang, Rui Chen
Summary: This study aims to investigate the effects of excessive daytime sleepiness on cortical thickness in patients with obstructive sleep apnoea. It was found that the cortical thickness was significantly thinner in the sleepiness group, particularly in the left temporal, frontal, and parietal lobe, and bilateral pre- and postcentral gyri. There was a significant negative correlation between the cortical thickness and the Epworth Sleepiness Scale score.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
M. Olszowka, C. Held, N. Hadziosmanovic, S. Denchev, A. Manolis, L. Wallentin, H. D. White, R. A. H. Stewart, E. Hagstrom
Summary: In patients with chronic coronary syndrome (CCS), increasing levels of excessive daytime sleepiness (EDS) and morning tiredness (MT) were independently associated with an increased risk of major adverse cardiovascular events (MACE), including mortality. Other sleep-related breathing disorder (SRBD) symptoms were not consistently associated with worse outcomes.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Clinical Neurology
Anatilde Trindade, Catarina Custodio, Jorge Cabral, Telma Lopes, Vera Martins, Margarida Aguiar, Ines Goncalves, Sofia Furtado
Summary: This study aimed to compare the adherence to positive airway pressure (PAP) therapy between patients with or without excessive daytime sleepiness (EDS) in different severities of obstructive sleep apnea (OSA). The results showed that there were differences in adherence between patients with different severities of OSA but without EDS. However, there was no difference in adherence between patients with or without EDS, regardless of the severity.
Article
Clinical Neurology
Henrik Holtstrand Hjalm, Erik Thunstrom, Helena Glantz, Martin Karlsson, Yeliz Celik, Yuksel Peker
Summary: There is an independent and dose-response relationship between the severity of obstructive sleep apnea (OSA) and prevalent atrial fibrillation (AF), especially among individuals without excessive daytime sleepiness (EDS).
Article
Multidisciplinary Sciences
Antonio Martinez-Nicolas, Marc Guaita, Joan Santamaria, Josep M. Montserrat, Juan Antonio Madrid, Maria Angeles Rol
Summary: The study found that circadian rhythms were altered in SDB patients, directly related to the severity of SDB, and that CPAP treatment improved the motor activity pattern. This suggests that circadian ambulatory monitoring, including the integrated variable TAP, can be used to assess circadian alterations caused by SDB and monitor CPAP treatment effects.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Jeong Sik Kim, Do Eon Lee, Hyoeun Bae, Joo Yeon Song, Kwang Ik Yang, Seung Bong Hong
Summary: This study aimed to investigate the long-term effects of vagus nerve stimulation (VNS) on sleep-disordered breathing (SDB), daytime sleepiness, and sleep quality in patients with drug-resistant epilepsy (DRE), as well as the relationships among these effects, clinical characteristics, and VNS parameters. The findings showed that VNS improved seizure control in DRE patients but increased obstructive sleep apnea. Age and epilepsy duration were found to influence the increase in sleep-disordered breathing.
JOURNAL OF CLINICAL NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Changxiu Ma, Ying Zhang, Jiuyu Liu, Gengyun Sun
Summary: The study evaluated the new parameter AHT% for assessing nocturnal hypoxaemia and excessive daytime sleepiness in patients with obstructive sleep apnoea, comparing it with the traditional AHI. Results showed that AHT% was superior to AHI in predicting excessive daytime sleepiness and better reflected the clinical characteristics of patients with obstructive sleep apnoea.
SCIENTIFIC REPORTS
(2021)
Article
Psychiatry
Julia Maruani, Charlotte Boiret, Jeanne Leseur, Alix Romier, Balthazar Bazin, Emilie Stern, Michel Lejoyeux, Pierre A. Geoffroy
Summary: This study highlights the association between excessive daytime sleepiness (EDS), insomnia, and the severity of depressive episodes. Through subjective and objective biomarkers, it was found that depressive episodes with insomnia and EDS are associated with increased suicidal ideation, greater seasonal impacts on mood, and alterations in sleep and daily activities.
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Simon J. Schreiner, Esther Werth, Leonie Ballmer, Philipp O. Valko, Kai M. Schubert, Lukas L. Imbach, Christian R. Baumann, Angelina Maric, Heide Baumann-Vogel
Summary: This study found that excessive daytime sleepiness (EDS) in Parkinson disease (PD) is associated with nocturnal sleep disturbance, as indicated by reduced overnight slow-wave activity (SWA) decline and reduced spindle frequency activity.
Article
Anesthesiology
Carolyne Pehora, David Faraoni, Soichiro Obara, Reshma Amin, Brenda Igbeyi, Adel Al-Izzi, Aman Sayal, Aarti Sayal, Conor Mc Donnell
Summary: The study aimed to determine the incidence and risk factors of PRAEs in children with SDB undergoing general anesthesia. Factors associated with PRAEs were identified, suggesting potential for developing a predictive model and improving preoperative risk assessment.
ANESTHESIA AND ANALGESIA
(2021)
Article
Medicine, General & Internal
Michael A. Grandner, Jae S. Min, Ragy Saad, Eileen B. Leary, Lev Eldemir, Danielle Hyman
Summary: Approximately 1 billion people worldwide have obstructive sleep apnea (OSA) and experience excessive daytime sleepiness (EDS), which has negative impacts on their health, behavioral choices, and lifestyle. This study reveals that people with OSA and EDS have higher rates of anxiety, depression, insomnia, and impairments in daytime functioning. EDS also prevents physical activity and influences dietary choices.
POSTGRADUATE MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Jiahe Wang, Xiang Li, Siyuan Yang, Tianyi Wang, Zhongmou Xu, Jianguo Xu, Heng Gao, Gang Chen
Summary: Pitolisant demonstrated efficacy and controllable safety in treating excessive daytime sleepiness in patients with narcolepsy and OSA, showing reductions in ESS score, increased sleep latency, and improved quality of life. However, treatment with pitolisant may lead to insomnia as a treatment-emergent adverse event, emphasizing the importance of monitoring and management.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Muhammed Tunc, Pinar Soysal, Ozge Pasin, Lee Smith, Masoud Rahmati, Veliye Yigitalp, Sevnaz Sahin, Moustapha Drame
Summary: The aim of this study was to investigate the relationship between serum magnesium levels and insomnia and excessive daytime sleepiness (EDS) in older adults. It found that hypomagnesemia was associated with a higher prevalence of EDS but not insomnia in older outpatients. Other health conditions such as hypertension and diabetes mellitus were also more common in the hypomagnesemia group. These findings suggest that hypomagnesemia should be considered when evaluating older adults with EDS.
Review
Psychiatry
Danwei Zhang, Zhen Zhang, Huihua Li, Kaimo Ding
Summary: The study indicates a significant relationship between excessive daytime sleepiness (EDS), depression, and obstructive sleep apnea (OSA). Continuous Positive Airway Pressure (CPAP) has been proven to be an effective therapy for improving EDS and depression in patients with OSA.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Cardiac & Cardiovascular Systems
Naima Covassin, Prachi Singh, Shelly K. McCrady-Spitzer, Erik K. St Louis, Andrew D. Calvin, James A. Levine, Virend K. Somers
Summary: Sleep deficiency combined with ad libitum food intake promotes excess energy intake without affecting energy expenditure. Weight gain, especially central accumulation of fat, indicates that sleep loss predisposes individuals to abdominal visceral obesity.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Physiology
Jacqueline K. Limberg, Sarah E. Baker, Humphrey G. Petersen-Jones, Winston Guo, An Huang, Michael D. Jensen, Prachi Singh
Summary: This study found that intermittent hypoxia increases plasma ET-1 and FFA concentrations, but bosentan can attenuate the increase in FFA. Bosentan does not affect cellular receptors and proteins involved in lipolysis in adipose tissue.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ana Lopez-Medina, Choudhary Anwar A. Chahal, Jasmine A. Luzum
Summary: Drug-induced long QT syndrome (diLQTS) is a potential adverse effect of commonly prescribed drugs, increasing the risk of lethal ventricular arrhythmias. Genetic variants in pharmacodynamic genes have been associated with diLQTS. Evaluating the strength of evidence for these variants through a semiquantitative scoring system, it was found that KCNE1-D85N and KCNE2-T8A have definitive and strong evidence, supporting their consideration as risk factors for patients prescribed QT-prolonging drugs.
Article
Otorhinolaryngology
Hao Wu, Jiang Xie, Yaxin Guo, Zuoguang Wang
Summary: This study aimed to determine the independent predictive role of nasal obstruction in resistant hypertension (RH) in uncontrolled hypertensive patients with obstructive sleep apnea (OSA). The results showed that nasal obstruction was independently associated with a higher odds of RH, and nasal obstruction treatment improved symptoms and reduced the use of antihypertensive drugs.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Phillip H. Lam, C. Anwar A. Chahal
CIRCULATION-HEART FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Ameesh Ihath, Akil A. Sherif, Gregory P. Siroky, Dhrubajyoti Bandyopadhyay, Sriram D. Rao, Chayakrit Krittanawong, Deepak Padmanabhan, Stuthi Perimbeti, Vaani P. Garg, Anwar A. Chahal, Johanna Contreras, Davendra Mehta
Summary: Orthotopic heart transplantation is the most effective therapy for end-stage heart disease. However, it may lead to an increased prevalence of arrhythmias due to various factors. This study aims to describe the trends, distribution, and clinical impact of arrhythmias in heart transplant recipients.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Prachi Singh, Robbie A. Beyl, Jacqueline M. Stephens, Robert C. Noland, Allison J. Richard, Anik Boudreau, R. Caitlin Hebert, Eric Ravussin, Josiane L. Broussard, Marie-Pierre St-Onge, Kara L. Marlatt
Summary: The aim of this study was to investigate the effect of sleep restriction on insulin sensitivity and energy metabolism in postmenopausal women. The results showed that four nights of sleep restriction reduced insulin sensitivity and fat oxidation in postmenopausal women, highlighting the significant role of insufficient sleep in metabolic dysfunction following menopause.
Review
Biochemistry & Molecular Biology
Sanah S. Munir, Fatima H. Sert H. Kuniyoshi, Prachi Singh, Naima Covassin
Summary: Obstructive sleep apnea (OSA) is a common sleep disorder and a known risk factor for cardiovascular diseases, including hypertension. The mechanisms involved in OSA-induced hypertension are multifactorial, and the gut microbiome is gaining attention as a potential factor. Perturbations in the gut microbiota have been linked to various disorders, and evidence suggests that gut dysbiosis may promote hypertension development in OSA. This review highlights the current research on the implications of altered gut microbiota for hypertension risk in OSA and potential therapeutic considerations.
Letter
Cardiac & Cardiovascular Systems
Nosheen G. Reza, Michael K. Levin, Mahesh E. Vidula, Paco M. Bravo, Scott D. Damrauer, Marylyn Ritchie, Anjali Tiku Regeneron Genetics Ctr, C. Anwar A. Chahal, Anjali Tiku Owens
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Jing Yong Ng, Essa Zarook, Luke Nicholson, Oculi-Cordis Grp, Mohammed Yunus Khanji, Choudhary Anwar Ahmed Chahal
Summary: The eye is often affected by various systemic diseases, including cardiovascular diseases. Common ocular manifestations include retinopathy, corneal arcus, proptosis, episcleritis, scleritis, and ptosis. These conditions can be indicators of underlying diseases such as hypertension, diabetes, dyslipidemia, autoimmune diseases, and neuromuscular diseases.
Article
Biochemistry & Molecular Biology
Jiaxin Hu, Prachi Singh, Jingrui Li, Jing Zhang, Fei Li, Hehe Zhang, Jiang Xie
Summary: The imbalance between Smad3 and MRTF is associated with cellular senescence and pulmonary arterial remodeling induced by PI hypoxia, providing a potential therapeutic target for patients with sleep apnea and chronic obstructive pulmonary disease.
Review
Cardiac & Cardiovascular Systems
Kerrick Hesse, Mohammed Y. Khanji, Nay Aung, Ghaith Sharaf Dabbagh, Steffen E. Petersen, C. Anwar A. Chahal
Summary: Cardiac disease can affect the heart in a non-uniform manner, and cardiovascular magnetic resonance (CMR) imaging can provide detailed information on structural and functional heterogeneity that is not captured by standard global measures. CMR-derived heterogeneity biomarkers have the potential to facilitate early diagnosis, better risk stratification, and more comprehensive prediction of treatment response. However, there are challenges in standardizing CMR imaging protocols and testing radiomic features in small patient samples. A proposed roadmap includes defining normal reference ranges, statistical modeling against diagnosis and outcomes in large studies, and comprehensive validations.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Medicine, General & Internal
Edward C. Mader, Annie Cielo L. Mader, Prachi Singh
Summary: Chronic sleep deficiency (CSD) poses a threat to physical health, mental well-being, and social functioning. Behaviorally induced CSD, now called insufficient sleep syndrome (ISS), is considered a form of central hypersomnolence disorder, with a global rise in voluntary sleep curtailment potentially making ISS the leading cause of CSD. However, ISS is not getting enough attention in contemporary medical practice and public health programs, and it is crucial to prioritize ISS as a public health issue in order to develop effective educational programs and regulations.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Physiology
Prachi Singh, Naima Covassin, Kara Marlatt, Kishore M. Gadde, Steven B. Heymsfield
Summary: This article discusses the role of obesity and sex hormones in determining cardiovascular disease risk, emphasizing the importance of gender differences in cardiovascular risk and the differences in body fat distribution between men and women.
COMPREHENSIVE PHYSIOLOGY
(2022)