Journal
JOURNAL OF THE AMERICAN HEART ASSOCIATION
Volume 7, Issue 7, Pages -Publisher
WILEY
DOI: 10.1161/JAHA.117.008315
Keywords
arterial stiffness; insulin resistance; left ventricular function; longitudinal strain; population studies
Categories
Funding
- European Union [HEALTH-F7-305507 HOMAGE]
- European Research Council (ERC) [2011-294713-EPLORE]
- European Research Council (PoC) [713601-uPROPHET]
- Fonds voor Wetenschappelijk Onderzoek Vlaanderen, Brussels, Belgium [G.0880.13, G.0881.13, 11Z0916N]
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BackgroundPopulation data on the longitudinal changes of left ventricular (LV) structure and function in relation to insulin resistance are sparse. Therefore, we assessed in a general population whether hyperinsulinemia predicts longitudinal changes in LV and arterial characteristics. Methods and ResultsIn 627 participants (mean age 50.7years, 51.4% women), we assessed echocardiographic indexes of LV structure and function and carotid-femoral pulse wave velocity by applanation tonometry at baseline and after 4.7years. We regressed longitudinal changes in these indexes on baseline insulin and its change during follow-up, and reported standardized effect sizes as a percentage of the SD of LV changes associated with a doubling of insulin. After adjustment, higher baseline insulin predicted a greater temporal increase in LV mass index (effect size: +15.1%) and E/e ratio (+22.1%), and a greater decrease in e peak and longitudinal strain (-11.2% to -17.1%). A greater increase in insulin during follow-up related to a greater increase in LV mass index (+10.7%) and decline in ejection fraction and longitudinal strain (-11.4% to -15.7%). Participants who became or remained insulin resistant during follow-up experienced worse changes in longitudinal strain, E/e, and LV mass index as compared with participants who did not develop or had improved insulin resistance over time (P0.033). Moreover, multivariable-adjusted increase in pulse wave velocity was higher in participants with diabetes mellitus than in participants without diabetes mellitus (+1.46m/s versus +0.71m/s; P=0.039). ConclusionsHyperinsulinemia at baseline and during follow-up predicted worsening of LV function and remodeling over time. Our findings underline the importance of management of insulin resistance.
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