Review
Medicine, General & Internal
Sylwia Slawek-Szmyt, Katarzyna Kawka-Paciorkowska, Aleksandra Cieplucha, Maciej Lesiak, Mariola Ropacka-Lesiak
Summary: Cardiovascular diseases (CVDs) are the top cause of death in women worldwide. Traditional risk factors and pregnancy-related complications both impact a woman's future CVD risk. Some pregnancy complications and CVDs may share common pathophysiological pathways.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Eun Hui Joo, Young Ran Kim, Nari Kim, Jae Eun Jung, Seon Ha Han, Hee Young Cho
Summary: Oxidative stress, caused by the imbalance between ROS production and detoxification ability, is associated with pregnancy complications. Maintaining normal placental function and vascular network is crucial for a healthy pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Arash Derakhshan, Tuija Mannisto, Liangmiao Chen, Joris A. J. Osinga, Ghalia Ashoor, Xuemian Lu, Sofie Bliddal, Fang-Biao Tao, Suzanne J. Brown, Bijay Vaidya, Andrew T. Hattersley, Sachiko Itoh, Polina Popova, Ashraf Aminorroaya, Reiko Kishi, Maryam Kianpour, Elena A. Vasukova, Abel Lopez-Bermejo, Emily Oken, Leda Chatzi, Marina Vafeiadi, Wichor M. Bramer, Judit Bassols, Aitana Lertxundi, Ana Fernandez-Somoano, Paula Carrasco, Juha Auvinen, Kun Huang, Ulla Feldt-Rasmussen, Elena N. Grineva, Erik K. Alexander, Elizabeth N. Pearce, Layal Chaker, John P. Walsh, Robin P. Peeters, Monica Guxens, Eila Suvanto, Kypros H. Nicolaides, Tim I. M. Korevaar
Summary: This study explores the association between gestational FT3 and TT3 levels and adverse obstetric outcomes. The findings suggest that FT3 and TT3 levels have different associations with various adverse obstetric outcomes, with high TT3 associated with an increased risk of gestational hypertension and low TT3 associated with a higher risk of very preterm birth.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Obstetrics & Gynecology
Anjali Walia, Victoria K. Berger, Juan M. Gonzalez, Nasim C. Sobhani
Summary: Clinicians often choose cesarean delivery instead of trial of labor in cases of preterm severe preeclampsia due to concerns about placental dysfunction. However, this study found that the presence of fetal growth restriction does not affect the mode of delivery or neonatal outcomes in pregnancies undergoing induction of labor at or before 34 weeks. Therefore, induction of labor can be considered a reasonable approach for patients with concurrent preterm severe preeclampsia and fetal growth restriction.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu'uhevaha J. Kaitu'u-Lino, Susan P. Walker, Owen Stock, Katie Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Stephen Tong, Lisa Hui, Natalie J. Hannan
Summary: Elevated levels of OLAH in the placenta may be associated with placental dysfunction in pregnancies complicated by preterm preeclampsia and fetal growth restriction. Further research is required to understand the role of OLAH in the placenta, and whether these changes are a maternal adaptation or consequence of disease.
Article
Public, Environmental & Occupational Health
Daina B. Esposito, Brian Bateman, Martha Werler, Loreen Straub, Helen Mogun, Sonia Hernandez-Diaz, Krista Huybrechts
Summary: Opioids may have an impact on placental abruption, preterm delivery, and small for gestational age, while showing no association with preeclampsia, according to a study using data from the US nationwide Medicaid Analytic Extract.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Katherine M. Nelson, N'Dea Irvin-Choy, Matthew K. Hoffman, Jason P. Gleghorn, Emily S. Day
Summary: Maternal mortality rates in the United States have been steadily increasing, with most deaths attributed to underlying conditions and pregnancy-related diseases. The challenges of treating diseases in pregnant women are further complicated by potential harm to the developing fetus. Engineered nanomedicines offer potential solutions to improve outcomes for pregnant women and their offspring.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Obstetrics & Gynecology
Minori Kasuya, Naoya Akiba, Takayuki Iriyama, Seisuke Sayama, Kaori Kubota, Masatake Toshimitsu, Takahiro Seyama, Kenbun Sone, Keiichi Kumasawa, Takeshi Nagamatsu, Tomoyuki Fujii, Yutaka Osuga
Summary: This study aimed to compare the impact of fetal growth restriction (FGR) and maternal organ dysfunction on the severity of maternal preeclamptic features. The results showed that PE cases preceded by FGR had earlier diagnosis and delivery, but there were no significant differences in maternal morbidities compared to cases without FGR. For early-onset PE, the results were comparable between two groups.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Jezid Miranda, Cristina Paules, Guillaume Noell, Lina Youssef, Angel Paternina-Caicedo, Francesca Crovetto, Nicolau Canellas, Maria L. Garcia-Martin, Nuria Amigo, Elisenda Eixarch, Rosa Faner, Francesc Figueras, Rui Simos, Fatima Crispi, Eduard Gratacos
Summary: This study used machine learning to conduct cluster analysis of FGR, confirming the existence of two distinct subtypes with different molecular and clinical features. The clusters generated by machine learning outperformed single data subtype analysis in predicting adverse maternal and neonatal outcomes, supporting the current clinical classification.
Article
Chemistry, Multidisciplinary
C. M. van Kammen, S. J. van Woudenberg, R. Schiffelers, F. Terstappen, A. T. Lely
Summary: Preeclampsia and fetal growth restriction are pregnancy complications that can be treated with nanomedicines, which regulate drug interaction with the placenta to enhance treatment efficacy and minimize fetal exposure. Liposomes and polymeric drug delivery systems show promising results in preventing trans-placental passage of nanomedicines, while quantum dots and silicon nanoparticles have limited research in placental insufficiency syndromes. Animal studies demonstrate positive effects on maternal and fetal health, but results are influenced by various factors. Further research is needed to understand the pathophysiology of these complex diseases and ensure the safety and efficacy of nanomedicines before clinical implementation.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biochemistry & Molecular Biology
Anita Subramanian, Doria Weiss, Kate Nyhan, Andrew Dewan, Anne Marie Z. Jukic
Summary: This systematic review summarizes the miRNAs associated with early placentation and pregnancy complications, identifying seven potential early biomarkers. These miRNAs can facilitate early detection and interventions for pregnancy complications.
Article
Psychiatry
Julia Izsak, Dimitra Falari, Pia Arnbert, Daniel Pouragheli, Jenny M. Kindblom, Daina Lasaitiene
Summary: This case report describes the development of preeclampsia in a pregnant woman after 3 weeks of treatment with olanzapine, suggesting a potential association between olanzapine and preeclampsia.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Obstetrics & Gynecology
Carlos Jose Molina Perez, Ana Graciela Nolasco Leanos, Reyes Ismael Carrillo Juarez, Maria Guadalupe Berumen Lechuga, Irma Isordia Salas, Alfredo Leanos Miranda
Summary: In gestational hypertension pregnancies, the concentration of serum sEng may be a better predictor to assess the risk of adverse maternal and perinatal outcomes and progression to preeclampsia.
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Ilona Hromadnikova, Katerina Kotlabova, Ladislav Krofta
Summary: The study aimed to determine the diagnostic potential of cardiovascular disease-associated microRNAs for the early detection of SGA and FGR without PE. The findings suggest that these microRNAs could serve as promising biomarkers and improve the detection rate of these conditions.
Article
Endocrinology & Metabolism
Xiujuan Su, Yang Liu, Guohua Li, Xiaosong Liu, Shijia Huang, Tao Duan, Qiaoling Du
Summary: This study found that hypothyroxinemia during pregnancy was associated with an increased risk of preeclampsia-eclampsia, especially in women with persistent hypothyroxinemia in early pregnancy. However, there was no significant association between hypothyroxinemia and gestational hypertension.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ester Kringeland, Grethe S. Tell, Helga Midtbo, Jannicke Igland, Teresa R. Haugsgjerd, Eva Gerdts
Summary: This study found that stage 1 hypertension is a stronger risk factor for acute coronary syndromes (ACS) in women than in men.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Geriatrics & Gerontology
Pierre-Antoine Dugue, Allison M. Hodge, Arve Ulvik, Per M. Ueland, Oivind Midttun, Sabina Rinaldi, Robert J. Macinnis, Sherly X. Li, Klaus Meyer, Anne-Sophie Navionis, Leon Flicker, Gianluca Severi, Dallas R. English, Paolo Vineis, Grethe S. Tell, Melissa C. Southey, Roger L. Milne, Graham G. Giles
Summary: Inflammation is a key feature of aging, and this study investigated the association of 34 blood markers with inflammatory processes, age, and mortality. The research developed a signature of inflammaging based on 10 markers, which was strongly associated with mortality, demonstrating its predictive power.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Mika Hilvo, Indu Dhar, Mitja Laaperi, Vegard Lysne, Gehard Sulo, Grethe S. Tell, Pekka Jousilahti, Ottar K. Nygard, Hermann Brenner, Ben Schoettker, Reijo Laaksonen
Summary: LDL-C as a risk biomarker for cardiovascular disease shows weaker associations with cardiovascular events in middle-aged and older adults, but stronger predictive value for rare events such as premature CHD or ASCVD death in middle-aged adults. The performance of LDL-C also varies depending on the specific cardiovascular endpoint being studied.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Helena Kames Kjeldgaard, Haakon E. Meyer, Martin O'Flaherty, Ellen M. Apalset, Cecilie Dahl, Nina Emaus, Anne Marie Fenstad, Ove Furnes, Jan-Erik Gjertsen, Mari Hoff, Berit Schei, Anne Johanne Sogaard, Grethe S. Tell, Kristin Holvik
Summary: The study found that hip fracture rates in Norway are declining, while rates of total hip replacements have been increasing. The increasing prevalence of hip prostheses significantly contributed to the observed declining trends.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Medicine, General & Internal
Espen O. Bjornestad, Indu Dhar, Gard F. T. Svingen, Eva R. Pedersen, Stein Orn, Mads M. Svenningsson, Grethe S. Tell, Per M. Ueland, Gerhard Sulo, Reijo Laaksonen, Ottar Nygard
Summary: The study found that circulating TMAO did not predict long-term all-cause, CV, or non-CV mortality in patients with coronary heart disease or in community-based adults. This suggests that TMAO may not be useful for patient risk stratification in primary or secondary prevention.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Tonje Teigland, Jannicke Igland, Grethe S. Tell, Johannes Haltbakk, Marit Graue, Anne-Siri Fismen, Kare I. Birkeland, Truls ostbye, Mark Peyrot, Marjolein M. Iversen
Summary: The study aims to estimate the prevalence, incidence, and time trends of pharmacologically treated diabetes among older people receiving home care services (HCS) in Norway from 2009 to 2014. The findings show an increasing prevalence of diabetes among older people receiving HCS, highlighting the importance of treatment and care related to diabetes in home care settings.
BMC ENDOCRINE DISORDERS
(2022)
Correction
Endocrinology & Metabolism
Tonje Teigland, Jannicke Igland, Grethe S. Tell, Johannes Haltbakk, Marit Graue, Anne-Siri Fismen, Kare I. Birkeland, Truls Ostbye, Mark Peyrot, Marjolein M. Iversen
BMC ENDOCRINE DISORDERS
(2022)
Article
Public, Environmental & Occupational Health
Hye Jung Choi, Marissa LeBlanc, Tron Anders Moger, Morten Valberg, Geir Aamodt, Christian M. Page, Grethe S. Tell, Oyvind Naess
Summary: Familial support is crucial for stroke survivors' survival, and it is related to geographical proximity to family members. Having a spouse/partner and living closer to first-degree relatives are strongly associated with better survival, particularly for survivors aged 65 years or younger.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Cell Biology
Stein-Erik H. Solvang, Allison Hodge, Leiv Otto Watne, Otavio Cabral-Marques, Jan Erik Nordrehaug, Graham G. Giles, Pierre-Antoine Dugue, Ottar Nygard, Per Magne Ueland, Adrian McCann, Ane-Victoria Idland, Oivind Midttun, Arve Ulvik, Nathalie B. Halaas, Grethe S. Tell, Lasse M. Giil
Summary: The study investigates the changes in tryptophan and kynurenine metabolism with aging and their associations with adverse health outcomes. The results show an age-related increase in kynurenine and quinolinic acid, as well as their associations with mortality and frailty. The study suggests the activation of the inflammation and stress-driven kynurenine pathway with aging.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Peripheral Vascular Disease
Ester Kringeland, Eva Gerdts, Arve Ulvik, Grethe S. Tell, Jannicke Igland, Teresa R. Haugsgjerd, Per Magne Ueland, Helga Midtbo
Summary: The aim of this study was to examine the associations between sex-specific circulating markers of inflammation and blood pressure in midlife. The results showed that higher levels of hs-CRP were significantly associated with higher systolic and diastolic blood pressure in women, but not in men. Additionally, higher levels of neopterin were associated with higher diastolic blood pressure in women, and higher PAr index was associated with higher blood pressure in both men and women.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Medicine, General & Internal
Indu Dhar, Vegard Lysne, Arve Ulvik, Gard F. T. Svingen, Eva R. Pedersen, Espen O. Bjornestad, Thomas Olsen, Robert Borsholm, Johnny Laupsa-Borge, Per M. Ueland, Grethe S. Tell, Rolf K. Berge, Gunnar Mellgren, Kaare H. Bonaa, Ottar K. Nygard
Summary: In this study, elevated plasma MMA levels were found to be associated with increased risk of acute myocardial infarction (AMI) and mortality in patients with suspected or verified coronary heart disease (CHD). This finding provides new insights for the prevention and treatment of cardiovascular diseases.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Annabel Eide Ohldieck, Ester Kringeland, Helga Midtbo, Grethe S. Tell, Eva Gerdts
Summary: This study aimed to identify modifiable risk factors in early midlife associated with incident hypertension 26 years later in women and men. The results showed that high-normal blood pressure in midlife was a significantly stronger risk factor for the development of hypertension in women than in men during follow-up, independent of body mass index.
Meeting Abstract
Public, Environmental & Occupational Health
Helena K. Kjeldgaard, Haakon E. Meyer, Martin O'Flaherty, Anne Marie Fenstad, Ove Furnes, Jan-Erik Gjertsen, Grethe S. Tell, Kristin Holvik
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Helena K. Kjeldgaard, Kristin Holvik, Martin O'Flaherty, Bo Abrahamsen, Grethe S. Tell, Haakon E. Meyer
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Letter
Cardiac & Cardiovascular Systems
Liv J. Mundal, Anders Hovland, Jannicke Igland, Morten Vetrhus, Marit Bragelien Veierod, Kirsten Bjorklund Holven, Martin Proven Bogsrud, Grethe Seppola Tell, Trond Paul Leren, Kjetil Retterstol
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)