Journal
HEART FAILURE CLINICS
Volume 14, Issue 2, Pages 147-159Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.hfc.2017.12.002
Keywords
Cardiomyopathies; Primary; Phosphorylation potential; Calcium signaling; Protein stability; Therapeutics
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Funding
- National Institutes of Health [R01 HL075619, R01 HL107046]
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This article focuses on 3 bins that comprise sets of biophysical derangements elicited by cardiomyopathy-associated mutations in the myofilament. Current therapies focus on symptom palliation and do not address the disease at its core. We and others have proposed that a more nuanced classification could lead to direct interventions based on early dysregulation changing the trajectory of disease progression in the preclinical cohort. Continued research is necessary to address the complexity of cardiomyopathic progression and develop efficacious therapeutics.
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