Letter
Hematology
Bianca Serio, Angela Bertolini, Marisa Gorrese, Idalucia Ferrara, Annapaola Campana, Denise Morini, Francesca Picone, Paola Manzo, Carmine Selleri, Valentina Giudice
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Danilo De Novellis, Raffaele Fontana, Valentina Giudice, Bianca Serio, Carmine Selleri
Summary: CD38 and B-cell maturation antigens (BCMAs) are highly expressed on neoplastic plasma cells in multiple myeloma (MM), making them attractive targets for therapy. Anti-CD38 monoclonal antibodies, like daratumumab and isatuximab, have shown significant efficacy in MM treatment by inducing plasma cell apoptosis through various mechanisms. BCMA is also a promising target in MM, with different therapeutic strategies being explored, including antibody-drug conjugates, bispecific T cell engagers, and chimeric antigen receptor-modified T cell therapies. However, resistance mechanisms to these agents have been identified, highlighting the need for further research and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Danilo De Novellis, Valentina Giudice, Vincenzo Ciccone, Paola Erra, Alba De Vita, Francesca Picone, Bianca Serio, Carmine Selleri
Summary: In this article, we report the effective and safe treatment of an old, frail hairy cell leukemia patient with pegylated interferon-alpha-2a as a first-line therapy. After six months of treatment, the patient showed the disappearance of splenomegaly and peripheral hairy cells without any drug-related adverse events.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Pasqualina Scala, Paola Manzo, Erwin Pavel Lamparelli, Joseph Lovecchio, Maria Camilla Ciardulli, Valentina Giudice, Carmine Selleri, Emanuele Giordano, Laura Rehak, Nicola Maffulli, Giovanna Della Porta
Summary: In this study, a 3D environment was created using fibrin scaffold and two cell populations. The addition of peripheral blood mononuclear cells (PBMCs) to the culture system significantly influenced myogenesis. The best cell ratio for the 3D culture was found to be 1:1 (BM-MSCs plus SkMs:PBMCs), resulting in enhanced viability and myogenic gene expression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Hematology
Salvatore Troisi, Valentina Giudice, Mario Troisi, Denise Morini, Andrea Crudele, Bianca Cuffa, Carmine Selleri, Bianca Serio
Summary: Daratumumab, an anti-CD38 monoclonal antibody, is effective for the treatment of multiple myeloma. It is usually administered intravenously but can cause infusion-related reactions. Eye complications, such as refractive shifts, are rare. This case report presents a patient with refractory multiple myeloma who experienced a transient myopic shift during intravenous daratumumab infusion. The condition was successfully treated with cycloplegic collyrium, allowing the patient to undergo stem cell transplantation and achieve complete remission.
ACTA HAEMATOLOGICA
(2023)
Review
Biochemistry & Molecular Biology
Roberta Parente, Valentina Giudice, Chiara Cardamone, Bianca Serio, Carmine Selleri, Massimo Triggiani
Summary: Mast cells (MCs) are immune cells that play a significant role in allergic and inflammatory diseases, releasing pro-inflammatory mediators. MC disorders, including mastocytosis and MC activation syndromes, are heterogeneous conditions characterized by abnormal MC proliferation and hyperactivity. The diagnosis of MC disorders is challenging due to the transient and unspecific symptoms and the similarity with other diseases. Tryptase is currently used as a biomarker for MC activation, but there is a need for further research to identify more reliable biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Endocrinology & Metabolism
Valentina Giudice, Carmelo Gurnari, Simona Pagliuca, Maria Antonietta Castaldi, Carmine Selleri
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Pasqualina Scala, Paola Manzo, Raffaele Longo, Valentina Giudice, Maria Camilla Ciardulli, Bianca Serio, Carmine Selleri, Liberata Guadagno, Laura Rehak, Nicola Maffulli, Giovanna Della Porta
Summary: This study demonstrates that a commercial blood filter can be used to collect PBMCs, which play an important role in stem cell myogenesis and can modulate cytokine expression. These findings support the clinical use of PBMCs in autologous transplantation.
Article
Hematology
Valentina Giudice, Bianca Serio, Santa Errichiello, Idalucia Ferrara, Alessandra Galdiero, Angela Bertolini, Roberta Visconti, Danilo De Novellis, Roberto Guariglia, Serena Luponio, Denise Morini, Anna Maria Della Corte, Anna Maria Sessa, Francesco Verdesca, Maddalena Langella, Barbara Izzo, Carmine Selleri
Summary: This study investigated the clinical significance of mutations in leukemia-related genes in MDS and AML patients, and found that TET2, SETBP1, ASXL1, EZH2, RUNX1, SRSF2, DNMT3A, and IDH1/2 were commonly mutated. The presence of SETBP1 wild-type or two or more simultaneous VUS variants identified a subgroup with better outcome, while a single SETBP1 VUS variant was associated with worse prognosis.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Filomena Napolitano, Valentina Giudice, Carmine Selleri, Nunzia Montuori
Summary: Severe disturbances in blood clotting and fibrinolysis are characteristic of sepsis, and dysregulation of fibrinolysis can lead to septic shock, disseminated intravascular coagulation (DIC), and death. This review aims to summarize the role of the plasminogen activation system (PAS) in sepsis and explore the clinical value of PAS-associated biomarkers in diagnosing and predicting outcomes in patients with septic syndrome. The use of PAS-associated laboratory parameters is expected to progress in the coming years.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Danilo De Novellis, Raffaele Fontana, Salvatore Palmieri, Roberta Della Pepa, Maria Di Perna, Giusy Cetani, Daniela Esposito, Angela Amendola, Giuseppe Delle Cave, Bianca Serio, Denise Morini, Michela Rizzo, Laura Mettivier, Fabio Trastulli, Stefano Rocco, Anastasia Pagano, Serafina Barbato, Aldo Leone, Martina La Magna, Rosario Bianco, Gabriella Rascato, Angela Carobene, Bianca Cuffa, Marialuigia Iannalfo, Valentina Giudice, Gino Svanera, Mario Annunziata, Michele Pizzuti, Ferdinando Frigeri, Catello Califano, Felicetto Ferrara, Fabrizio Pane, Carmine Selleri
Summary: In this retrospective study, the safety of subcutaneous daratumumab in plasma cell disorders was evaluated. The results showed that subcutaneous daratumumab was well-tolerated and safe, even in patients with severe renal failure and advanced disease.
Article
Medicine, General & Internal
Maria Costantino, Valeria Conti, Graziamaria Corbi, Valentina Giudice, Francesco De Caro, Amelia Filippelli
Summary: Oxidative stress, induced by excessive free radicals, shows gender-related differences in cellular redox state and antioxidant responses. A study investigated the efficacy of sulfurous crenotherapy in decreasing oxidant species in patients with osteoarthritis or degenerative joint disease and Vulgar psoriasis. After 2 weeks of treatment, significant clinical improvement and reduction of oxidant species were observed in both sexes, with females showing greater improvement and reduction than males.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Hematology
Matteo D'Addona, Luca Pezzullo, Corradino Campisi, Corrado Cesare Campisi, Valentina Giudica, Vincenzo Ciccone, Roberto Guariglia, Bianca Serio, Carmine Selleri
MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Paola Manzo, Valentina Giudice, Filomena Napolitano, Danilo De Novellis, Bianca Serio, Paolo Moscato, Nunzia Montuori, Carmine Selleri
Summary: The microenvironment is crucial for multiple myeloma development and progression. Macrophages and the urokinase plasminogen activator receptor (uPAR) system play important roles in these processes. Inhibitors of uPAR have shown potential therapeutic effects in primary multiple myeloma cells, reducing interleukein-6 and DKK-1 levels in culture medium. However, further studies are needed to validate these preliminary results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Danilo De Novellis, Veronica Folliero, Valentina Giudice, Luca Pezzullo, Giuseppina Sanna, Raffaele Fontana, Roberto Guariglia, Carla Zannella, Laura Mettivier, Idalucia Ferrara, Giovanni Boccia, Maria Teresa Buonanno, Maria Carmen Martorelli, Serena Luponio, Andrea Crudele, Pasquale Pagliano, Anna Maria Sessa, Francesca Velino, Maddalena Langella, Aldo Manzin, Massimiliano Galdiero, Carmine Selleri, Gianluigi Franci, Bianca Serio
Summary: This retrospective real-life study aimed to evaluate the seropositivity and neutralizing antibody rates against SARS-CoV-2 and its Omicron BA.1 variant in hematological patients. The study found that most hematological patients who received three or more vaccine doses exhibited adequate neutralizing antibody response against both the wild-type virus and the Omicron BA.1 variant. However, patients with B-cell lymphoproliferative disorders and/or those treated with anti-CD20 monoclonal antibodies showed a lower seropositivity rate.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)