Article
Biochemistry & Molecular Biology
Alessandra Ferramosca, Stefano Lorenzetti, Mariangela Di Giacomo, Paola Lunetti, Francesco Murrieri, Loredana Capobianco, Vincenza Dolce, Lamberto Coppola, Vincenzo Zara
Summary: Plant bioactives, such as polyphenols, can have differential effects on sperm quality depending on their concentration, with some compounds improving mitochondrial function in asthenozoospermic samples. This study highlights the potential of natural antioxidants in nutraceutical supplementation for male infertility treatment.
Article
Cell Biology
Naoki Okamoto, Yorino Sato, Yuta Kawagoe, Takahiko Shimizu, Kazuhiro Kawamura
Summary: Resveratrol treatment improves oocyte quality and restores fertility in aging mice by enhancing mitochondrial functions, without adverse effects on animals and offspring.
Review
Biochemistry & Molecular Biology
Ivo F. Machado, Raul G. Miranda, Daniel J. Dorta, Anabela P. Rolo, Carlos M. Palmeira
Summary: Reactive oxygen species (ROS) are important second messengers in metabolic processes and signaling pathways. Imbalance between ROS generation and antioxidant defenses leads to overproduction of ROS and subsequent oxidative damage, which disrupt cellular function. Oxidative stress plays a role in liver pathologies such as ischemia-reperfusion injury (LIRI), non-alcoholic fatty liver disease (NAFLD), and hepatocellular carcinoma (HCC). Polyphenols like quercetin, resveratrol, and curcumin have shown therapeutic effects by regulating ROS levels in liver injury conditions. This review summarizes the effects of polyphenols on oxidative damage in LIRI, NAFLD, and HCC.
Review
Obstetrics & Gynecology
Akemi Nishigaki, Hiroaki Tsubokura, Tomoko Tsuzuki-Nakao, Hidetaka Okada
Summary: This study is a literature review that focuses on the changes in SIRT1 and mitochondrial expression during hypoxia, as well as the cytoprotective effects of the SIRT1 activator resveratrol. The findings suggest that hypoxia suppresses SIRT1 and mitochondrial expression, but resveratrol can reverse these effects and suppress the production of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor proteins. Overall, resveratrol exhibits protective activity against hypoxic stress and may be a potential option for infertility therapy.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anna D. Grabowska, Mateusz Watroba, Joanna Witkowska, Agnieszka Mikulska, Nuno Sepulveda, Dariusz Szukiewicz
Summary: The blood-brain barrier (BBB) plays a crucial role in regulating the flow of substances between the blood and the central nervous system. Disruption of the BBB due to imbalanced blood glucose levels can lead to neuroinflammation and increase the risk of neurodegenerative diseases. Resveratrol (RSV), a natural compound with anti-diabetic, anti-inflammatory, and neuroprotective properties, activates SIRT1, a key regulator of metabolism. This study aimed to assess the response of astrocyte SIRT1 to neuroinflammation and RSV treatment in different glycemic backgrounds. The results showed that abnormal glycemic states had a worse prognosis for RSV therapy effectiveness compared to normoglycemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Shani Ben-Zichri, May Meltzer, Shiran Lacham-Hartman, Sofiya Kolusheva, Uzi Hadad, Niv Papo, Raz Jelinek
Summary: Noncationic, amphiphilic dendrimer nanoparticles embedding curcumin and resveratrol effectively target and slowly release the anticancer polyphenols, exhibiting promising potential as an anticancer therapeutic platform.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Plant Sciences
Hanna Fuchs, Arleta Malecka, Adrianna Budzinska, Wieslawa Jarmuszkiewicz, Liliana Ciszewska, Aleksandra M. Staszak, Joanna Kijowska-Oberc, Ewelina Ratajczak
Summary: We present a novel method to measure the oxygen consumption rate in isolated mitochondria of plant seeds. The optimized protocol allows for gradual decrease in respiratory function and provides information on the activity and condition of plant mitochondria.
Article
Food Science & Technology
Bingjing Zheng, Hualu Zhou, David Julian Mcclements, Severino Matias De Alencara
Summary: Plant-based milk can be fortified with multiple polyphenols using pH-driven approaches, which effectively encapsulate the polyphenols and enhance their bioaccessibility. The study highlights the feasibility of using these approaches to create plant-based delivery systems for various polyphenols, offering specific health benefits to consumers.
Article
Chemistry, Medicinal
Yuqing Wang, Lin Long, Linsheng Zhuo, Honghua Zhang, Tian Luo, Jiedan Deng, Yuying Wang, Zhao Li, Zhen Wang, Xue Peng
Summary: In this study, 18 derivatives of 1-styrene-isoquinoline were synthesized from resveratrol and iso-quinoline. Compound 1c exhibited significant anti-tumor activity against Huh7 and SK-Hep-1 cells. It could inhibit cell proliferation, induce apoptosis, and inhibit cell migration and invasion through regulating EMT. Compound 1c also showed potential in inhibiting tumor growth in vivo and could regulate mitochondrial apoptosis pathway and PI3K/Akt/mTOR signaling pathway.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Joana Varlla de Lacerda Alexandre, Yuana Ivia Ponte Viana, Cicera Edna Barbosa David, Pedro Lourenzo Oliveira Cunha, Amanda Cabral Albuquerque, Anna Lidia Nunes Varela, Alicia J. Kowaltowski, Heberty Tarso Facundo
Summary: Quercetin is capable of attenuating cardiac hypertrophy by restoring cellular redox balance and protecting mitochondria.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Roopa, Bhanu Priya, Vandana Bhalla, Manoj Kumar, Naresh Kumar
Summary: Gene expression regulation involves processes beyond genetic mutations, including histone modification. HDACs play a crucial role in histone deacetylation and are upregulated in many cancers, making research on their activity and inhibition essential for therapeutic success. Fluorescent molecular probes are a preferred method for studying HDACs.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Nimatul Izza, Nozomi Watanabe, Yukihiro Okamoto, Yusuf Wibisono, Hiroshi Umakoshi
Summary: This study successfully encapsulated polyphenols with antioxidant activity using nanostructured lipid carriers as a drug delivery system. The results demonstrate that the polyphenols-incorporated NLCs exhibit good performance in terms of particle stability, drug loading capacity, and antioxidant activity.
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2022)
Review
Chemistry, Medicinal
Xiaoyue Zhang, Longqin Wang, Bowen Li, Jiayan Shi, Jia Xu, Minlan Yuan
Summary: Mitochondria, the primary source of energy production in neurons, play a crucial role in neurodegenerative diseases. Recent studies have focused on targeting mitochondria using plant-derived natural products as a potential therapeutic approach. This review discusses the mechanism of these natural products in regulating various aspects of mitochondria, as well as the challenges and potential perspectives in utilizing them for neurotherapeutics.
Article
Biochemistry & Molecular Biology
Matthes Zessin, Marat Meleshin, Zeljko Simic, Diana Kalbas, Miriam Arbach, Philip Gebhardt, Jelena Melesina, Sandra Liebscher, Frank Bordusa, Wolfgang Sippl, Cyril Barinka, Mike Schutkowski
Summary: The research found that Histone deacylase 11 and human sirtuins can remove fatty acid-derived acyl moieties from lysine residues, requiring specific substrates and screening systems. By designing and synthesizing activity probes, highly catalytic super-substrates were created, enabling enzyme measurements down to 100 pM in microtiter plate-based screening formats. The IC50 values of stalled intermediates formed by Sirt2-bound peptides and NAD(+) were demonstrated to be below 200 pM.
BIOORGANIC CHEMISTRY
(2021)
Article
Plant Sciences
Latifeh Pourakbar, Sina Siavash Moghaddam, Hesham Ali El Enshasy, R. Z. Sayyed
Summary: This study investigated the chemical composition and antifungal activity of Gracilariopsis persica, revealing rich phenolic compounds such as rosmarinic acid and quercetin, which exhibited antifungal effects. Experimental results showed that the extract of G. persica had inhibitory effects on the growth of four plant pathogenic fungi at higher concentrations, suggesting potential use as a natural antifungal agent.
Article
Chemistry, Applied
Andreina Bruno, Miriana Durante, Pier Paolo Marrese, Danilo Migoni, Maura N. Laus, Elisabetta Pace, Donato Pastore, Giovanni Mita, Gabriella Piro, Marcello S. Lenucci
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2018)
Article
Food Science & Technology
Mario Soccio, Maura N. Laus, Michela Alfarano, Giuseppe Dalfino, Michele F. Panunzio, Donato Pastore
JOURNAL OF FUNCTIONAL FOODS
(2018)
Review
Biochemistry & Molecular Biology
Mario Soccio, Maura N. Laus, Zina Flagella, Donato Pastore
Article
Agriculture, Dairy & Animal Science
M. G. Ciliberti, M. Soccio, D. Pastore, M. Albenzio, A. Sevi, M. Caroprese
SMALL RUMINANT RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Maura N. Laus, Mario Soccio
Article
Genetics & Heredity
Alessandra Lanubile, Virginia Maria Grazia Borrelli, Mario Soccio, Paola Giorni, Lorenzo Stagnati, Matteo Busconi, Adriano Marocco
Summary: The study investigated the functional characterization of the ZmLOX4 gene to uncover its strategic role in maize resistance against Fusarium verticillioides, as well as its influence on the expression of several LOX, jasmonic acid (JA) and green leaf volatiles (GLV) genes. The results suggest that ZmLOX4 plays a crucial role in controlling defense against F. verticillioides and modulating the expression of key genes involved in plant defense mechanisms.
Article
Plant Sciences
Federica Blando, Stefano Marchello, Gabriele Maiorano, Miriana Durante, Angelo Signore, Maura N. Laus, Mario Soccio, Giovanni Mita
Summary: Black and purple carrots, rich in anthocyanins, exhibit high antioxidant capacities and contain abundant polyphenolic compounds. In contrast, orange carrots lacking anthocyanins have lower nutritional value.
Article
Plant Sciences
Andrea Gomez-Maqueo, Mario Soccio, M. Pilar Cano
Summary: Current in vitro methodologies underestimate the antioxidant contribution of betalains in foods due to a lack of reflection of their in vivo biological mechanisms. This study found that betaxanthin and betanin exhibit strong antiperoxidative and radical scavenging properties, especially in Opuntia stricta var. Dillenii tissues. Traditional antioxidant methods like ORAC and TEAC were less sensitive towards detecting the antioxidant activity of betalains.
PLANT FOODS FOR HUMAN NUTRITION
(2021)
Article
Plant Sciences
Maura Nicoletta Laus, Michele Andrea De Santis, Zina Flagella, Mario Soccio
Summary: Durum wheat, a commonly cultivated species, plays a crucial role in the human diet as it is used to produce various foods. However, drought and soil salinity stress can lead to reduced yield and grain quality. Plants have evolved antioxidant mechanisms to counteract oxidative damage caused by stress, with enhancement of the antioxidant defense system improving tolerance to hyperosmotic stress.
Article
Plant Sciences
Michele Andrea De Santis, Mario Soccio, Maura Nicoletta Laus, Zina Flagella
Summary: Durum wheat is a staple crop in the Mediterranean diet, prized for its adaptability and nutritional value. Environmental stresses such as water deficit and soil salinity can affect the protein and starch composition in durum wheat, in turn impacting yield and quality. Recent studies have discussed the effects of these stresses on various nutritional and health-related components in durum wheat grains.
Article
Plant Sciences
Mario Soccio, Marianna Marangi, Maura N. Laus
Summary: In this study, a comprehensive genome database analysis was performed in durum wheat, identifying 27 candidate GLYI genes. Further analysis revealed that nine of these genes encode for functional GLYI enzymes. The expression of these enzymes was found to be different in roots and shoots under salt and osmotic stress. Interestingly, the study also demonstrated the existence of GLYI activity in purified mitochondrial fraction.
FRONTIERS IN PLANT SCIENCE
(2022)