The Mycobacterial Membrane: A Novel Target Space for Anti-tubercular Drugs

Verapamil Targets Membrane Energetics in Mycobacterium tuberculosis

(2018) Chao Chen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Expanding Diversity of Mycobacterium tuberculosis Drug Targets

(2018) Samantha Wellington et al.   ACS Infectious Diseases

Amphiphilic Indole Derivatives as Antimycobacterial Agents: Structure–Activity Relationships and Membrane Targeting Properties

(2017) Tianming Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Semisynthetic Flavone-Derived Antimicrobials with Therapeutic Potential against Methicillin-Resistant Staphylococcus aureus (MRSA)

(2017) Shuimu Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Membrane-Active Hydantoin Derivatives as Antibiotic Agents

(2017) Ma Su et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peripheral modifications of [Ψ[CH 2 NH]Tpg 4 ]vancomycin with added synergistic mechanisms of action provide durable and potent antibiotics

(2017) Akinori Okano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploiting the synthetic lethality between terminal respiratory oxidases to killMycobacterium tuberculosisand clear host infection

(2017) Nitin P. Kalia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding membrane-active antimicrobial peptides

(2017) Huey W. Huang et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Indolylalkyltriphenylphosphonium Analogues Are Membrane-Depolarizing Mycobactericidal Agents

(2017) Ming Li et al.   ACS Medicinal Chemistry Letters

Outcomes, infectiousness, and transmission dynamics of patients with extensively drug-resistant tuberculosis and home-discharged patients with programmatically incurable tuberculosis: a prospective cohort study

(2017) Keertan Dheda et al.   Lancet Respiratory Medicine

Host Antimicrobial Peptides: The Promise of New Treatment Strategies against Tuberculosis

(2017) Javier Arranz-Trullén et al.   Frontiers in Immunology

Dissecting the mycobacterial cell envelope and defining the composition of the native mycomembrane

(2017) Laura Chiaradia et al.   Scientific Reports

New agents for the treatment of drug-resistant Mycobacterium tuberculosis

(2016) Daniel T. Hoagland et al.   ADVANCED DRUG DELIVERY REVIEWS

5-Alkyloxytryptamines are membrane-targeting, broad-spectrum antibiotics

(2016) Katherine C. Faulkner et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Amphiphilic xanthones as a potent chemical entity of anti-mycobacterial agents with membrane-targeting properties

(2016) Jun-Jie Koh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Membrane-targeting AM-0016 kills mycobacterial persisters and shows low propensity for resistance development

(2016) Devika Mukherjee et al.   Future Microbiology

Antibacterial Diamines Targeting Bacterial Membranes

(2016) Bo Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial Peptides: An Emerging Category of Therapeutic Agents

(2016) Margit Mahlapuu et al.   Frontiers in Cellular and Infection Microbiology

Boromycin Kills Mycobacterial Persisters without Detectable Resistance

(2016) Wilfried Moreira et al.   Frontiers in Microbiology

Membrane Permeable Lipophilic Cations as Mitochondrial Directing Groups

(2015) Joseph Madak et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Natural antimicrobial peptides againstMycobacterium tuberculosis

(2015) Maria Abedinzadeh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Nonpeptidic Amphiphilic Xanthone Derivatives: Structure–Activity Relationship and Membrane-Targeting Properties

(2015) Jun-Jie Koh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hit and lead criteria in drug discovery for infectious diseases of the developing world

(2015) Kei Katsuno et al.   NATURE REVIEWS DRUG DISCOVERY

Membrane-Targeting DCAP Analogues with Broad-Spectrum Antibiotic Activity against Pathogenic Bacteria

(2015) Katherine A. Hurley et al.   ACS Medicinal Chemistry Letters

Incorporation of triphenylphosphonium functionality improves the inhibitory properties of phenothiazine derivatives in Mycobacterium tuberculosis

(2014) Elyse A. Dunn et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mycolic Acids: Structures, Biosynthesis, and Beyond

(2014) Hedia Marrakchi et al.   CHEMISTRY & BIOLOGY

Ofloxacin Resistance in Mycobacterium tuberculosis Is Associated with Efflux Pump Activity Independent of Resistance Pattern and Genotype

(2014) Zhaogang Sun et al.   Microbial Drug Resistance

Mycobacterial outer membrane is a lipid bilayer and the inner membrane is unusually rich in diacyl phosphatidylinositol dimannosides

(2014) Ritu Bansal-Mutalik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efflux Inhibition with Verapamil Potentiates Bedaquiline in Mycobacterium tuberculosis

(2013) Shashank Gupta et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design and Synthesis of Amphiphilic Xanthone-Based, Membrane-Targeting Antimicrobials with Improved Membrane Selectivity

(2013) Hanxun Zou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Why are membrane targets discovered by phenotypic screens and genome sequencing in Mycobacterium tuberculosis?

(2013) Robert C. Goldman   TUBERCULOSIS

Targeting Persisters for Tuberculosis Control

(2012) Ying Zhang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rapid bactericidal action of alpha-mangostin against MRSA as an outcome of membrane targeting

(2012) Jun-Jie Koh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Differential Interactions of Rifabutin with Human and Bacterial Membranes: Implication for Its Therapeutic and Toxic Effects

(2012) Marina Pinheiro et al.   JOURNAL OF MEDICINAL CHEMISTRY

DCAP: A Broad-Spectrum Antibiotic That Targets the Cytoplasmic Membrane of Bacteria

(2012) Ye-Jin Eun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Contribution of Efflux to the Emergence of Isoniazid and Multidrug Resistance in Mycobacterium tuberculosis

(2012) Diana Machado et al.   PLoS One

Molecular aspects of bacterial pH sensing and homeostasis

(2011) Terry A. Krulwich et al.   NATURE REVIEWS MICROBIOLOGY

Examination of a synthetic benzophenone membrane-targeted antibiotic

(2011) Sunil K. Vooturi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Thioridazine cures extensively drug-resistant tuberculosis (XDR-TB) and the need for global trials is now!

(2010) Leonard Amaral et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Efflux‐Pump–Derived Multiple Drug Resistance to Ethambutol Monotherapy inMycobacterium tuberculosisand the Pharmacokinetics and Pharmacodynamics of Ethambutol

(2010) Shashikant Srivastava et al.   JOURNAL OF INFECTIOUS DISEASES

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

Targeting Mitochondria with Organelle-Specific Compounds: Strategies and Applications

(2009) Lema F. Yousif et al.   CHEMBIOCHEM

Design, Synthesis, and Structure−Activity Relationships of Benzophenone-Based Tetraamides as Novel Antibacterial Agents

(2009) Sunil K. Vooturi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Decreased outer membrane permeability protects mycobacteria from killing by ubiquitin-derived peptides

(2009) Georgiana E. Purdy et al.   MOLECULAR MICROBIOLOGY

Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells

(2008) Meredith F. Ross et al.   BIOCHEMICAL JOURNAL

Direct Visualization of the Outer Membrane of Mycobacteria and Corynebacteria in Their Native State

(2008) B. Zuber et al.   JOURNAL OF BACTERIOLOGY

Disclosure of the mycobacterial outer membrane: Cryo-electron tomography and vitreous sections reveal the lipid bilayer structure

(2008) C. Hoffmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA